ライフサイエンスコーパス: allosteric regulation

1 enzyme is essential for optimal activity and allosteric regulation.

2 o be implicated in substrate recognition and allosteric regulation.

3 ne tethering and provide a mechanism for its allosteric regulation.

4 s crucial for catalysis, ligand binding, and allosteric regulation.

5 ers new opportunities for drug discovery and allosteric regulation.

6 ential for catalysis, they are important for allosteric regulation.

7 er dimers, which are presumed to function in allosteric regulation.

8 ent BmrR ligands is in line with promiscuous allosteric regulation.

9 ssibility of an as yet undiscovered means of allosteric regulation.

10 of the classic two-state, concerted model of allosteric regulation.

11 , and helix D is a site (in antithrombin) of allosteric regulation.

12 OR can activate G proteins and be subject to allosteric regulation.

13 ikely through a combination of targeting and allosteric regulation.

14 implies that the enzyme might be subject to allosteric regulation.

15 ct with distinct partners and be involved in allosteric regulation.

16 ding a structural rationale for loss of this allosteric regulation.

17 ils of this important regulatory element for allosteric regulation.

18 in plays a critical role in the mechanism of allosteric regulation.

19 tetrapeptide for both catalysis and negative allosteric regulation.

20 m the active site, suggesting a mechanism of allosteric regulation.

21 likely forms the kinetic foundation for the allosteric regulation.

22 st a role of the C-terminal region of IDE in allosteric regulation.

23 active site, consistent with a mechanism of allosteric regulation.

24 dentify regions in the subunits important in allosteric regulation.

25 is the participation of distant residues in allosteric regulation.

26 n of the role of correlated dynamics in this allosteric regulation.

27 ), are examined for their potential roles in allosteric regulation.

28 ew functions for GDH through the addition of allosteric regulation.

29 characteristics of the catalytic process and allosteric regulation.

30 ains and may shed light on the energetics of allosteric regulation.

31 binding activities are subject to intricate allosteric regulation.

32 lin contacting regions of Ska1 suggesting an allosteric regulation.

33 unable fluorescent behaviours via long-range allosteric regulation.

34 ordinated in time and space owing to complex allosteric regulation.

35 plemented with a single protein, by means of allosteric regulation.

36 pable of high turnover rates and amenable to allosteric regulation.

37 exes, which we suggest is closely related to allosteric regulation.

38 l membrane curvatures can enforce a dramatic allosteric regulation (1000-fold inhibition) of alpha-HL

39 l beta helix that is involved in cooperative allosteric regulation and a unique oligomerization.

40 tion factors but also at the enzyme level by allosteric regulation and feedback inhibition.

41 ein-protein interaction that are involved in allosteric regulation and genetic suppression.

42 n either ATP binding or hydrolysis, to study allosteric regulation and intersubunit communication.

43 ing, macromolecular binding, ligand binding, allosteric regulation and post-translational modificatio

44 e have analyzed the relationship between the allosteric regulation and processive catalysis of DNA me

45 NTD, is loosely arranged, mediating complex allosteric regulation and providing a rich target for dr

46 tionally by an intricate interaction between allosteric regulation and reversible protein phosphoryla

47 vides a unique, synthetic context to explore allosteric regulation and should pave the way to sophist

48 ) complex, studied for decades as a model of allosteric regulation and substrate channeling within pr

49 ynamic processes are responsible for ATP-PRT allosteric regulation and that similar mechanisms might

50 endosperm AGPase to determine their roles in allosteric regulation and thermal stability.

51 rplay between PARP-1 DNA damage recognition, allosteric regulation, and catalytic activity.

52 iciency, reduced aggregation, amenability to allosteric regulation, and greater adaptability.

53 , including spatial and temporal expression, allosteric regulation, and heat stability.

54 catalytic mechanism, substrate specificity, allosteric regulation, and inhibition by a class of smal

55 ed us to differentiate defects in catalysis, allosteric regulation, and membrane targeting of individ

56 The quaternary structure, allosteric regulation, and properties of the diiron-oxo/

57 tory mechanisms, including redox modulation, allosteric regulation, and protein oligomerization, that

58 cal processes including enzymatic catalysis, allosteric regulation, and the mediation of protein-prot

59 preference for different DNA substrates, its allosteric regulation, and to provide a basis for compar

60 e propose a new strategy that targets PARP-1 allosteric regulation as a selective way of inhibiting P

61 We used directed evolution to explore allosteric regulation as a source of latent catalytic po

62 In AtCM1, mutations of Gly-213 abolish allosteric regulation, as observed in AtCM2.

63 necessity of interpreting the cAMP-dependent allosteric regulation at the whole-channel level.

64 These observations rule out models of allosteric regulation based on modulation of substrate b

65 The key event of integrin signaling is the allosteric regulation between its ligand-binding site an

66 t and calcium flux, which suggests a form of allosteric regulation between the receptors.

67 speculated that there exists a mechanism for allosteric regulation between the two monomers.

68 d the motor protein myosin, show evidence of allosteric regulation between two domains, but it remain

69 DA receptor function is subject to extensive allosteric regulation both by endogenous compounds and b

70 e process of glycine receptor activation and allosteric regulation by anesthetics.

71 ets in Cox5a (T65 and S43) that modulate its allosteric regulation by ATP.

72 it 4-isoform 1 (COX4i1), which modulates COX allosteric regulation by ATP.

73 the catalytic site suggests a mechanism for allosteric regulation by binding to protein partners.

74 higher affinity, but it is less sensitive to allosteric regulation by CBFbeta.

75 e the basis for cooperative O(2) binding and allosteric regulation by coupling the effects of ligand

76 lecular-level insights into the mechanism of allosteric regulation by CzrA and demonstrate the import

77 n which binding of Brh2 to DNA is subject to allosteric regulation by Dss1.

78 ipeptide substrate hydrolysis, demonstrating allosteric regulation by FVa.

79 associated and left open the possibility for allosteric regulation by Gbetagamma.

80 mpose on this cleft, providing insights into allosteric regulation by GTP.

81 itor of this enzyme by mimicking its natural allosteric regulation by lysine, and obtained a crystal

82 rtance of the 1-methoxy region of Fru-6-P in allosteric regulation by MgADP.

83 xhibit differential blocker pharmacology and allosteric regulation by Na(+).

84 Allosteric regulation by pH gradients modulated the swit

85 onic amphiphiles, raising the possibility of allosteric regulation by positively charged phospholipid

86 on is not essential for this function or for allosteric regulation by S-adenosyl-L-methionine.

87 ure of these receptors is their capacity for allosteric regulation by small molecules, such as zinc,

88 s increased enzymatic activity and decreased allosteric regulation by the glycolytic pathway intermed

89 Yet, the mechanisms of substrate binding and allosteric regulation by the various LOX isoforms remain

90 ism may prove to be a useful method by which allosteric regulation can be introduced into biosensors,

91 As it is becoming accepted that allosteric regulation can occur through a change in loca

92 ving cooperative binding of ligand or robust allosteric regulation cannot account for the extremely n

93 trikingly different and opposing kinetics of allosteric regulation characterized by a time-dependent

94 the data are consistent with a mechanism of allosteric regulation described by the interdomain commu

95 visual excitation, the direct, inter-domain allosteric regulation described in this study may play a

96 iation with the translocon dimer and for its allosteric regulation during cotranslational glycosylati

97 ry, these findings shed light on the role of allosteric regulation during tumorigenesis and provide a

98 As shown here, the antenna and some of the allosteric regulation first appears in the Ciliates.

99 in the case of NikA protein and examples of allosteric regulation for HypA, NikR, and RcnR, employed

100 The molecular basis for the ATD-mediated allosteric regulation has been enigmatic because of a co

101 In cases of multimeric proteins, such allosteric regulation has often been described by the co

102 all of the previously proposed mechanisms of allosteric regulation in aspartate transcarbamoylase.

103 n than that of the wild type, confirming the allosteric regulation in capsid assembly.

104 The DRH-3 ATPase may have allosteric regulation in cis that is controlled by the s

105 This suggests a new type of allosteric regulation in divergent cyclophilins, involvi

106 n has crucial ramifications in understanding allosteric regulation in enzymes and proteins, in genera

107 ever, the in vivo functional significance of allosteric regulation in eukaryotes is poorly defined.

108 ype and mutant systems to develop a model of allosteric regulation in IGP synthase that is monitored

109 rrelation analyses to probe the mechanism of allosteric regulation in imidazole glycerol phosphate (I

110 a step forward in understanding the role of allosteric regulation in metabolic control.

111 While this enzyme does not exhibit allosteric regulation in plants, bacteria, or fungi, its

112 This phenomenon is analogous to allosteric regulation in proteins, where a conformationa

113 rmational changes previously associated with allosteric regulation in rabbit muscle pyruvate kinase (

114 We describe a theoretical model for allosteric regulation in receptors that addresses a fund

115 used by G-proteins are predicted to mediate allosteric regulation in response to nucleotide binding

116 Conservation of allosteric regulation in the alpha X I domain points to

117 istyl binding pocket may serve as a site for allosteric regulation in the C-subunit.

118 To understand the molecular basis of allosteric regulation in the plant chorismate mutases, w

119 ght into the mechanisms of cooperativity and allosteric regulation in this human cytochrome P450.

120 ssibility of as-yet unidentified or untapped allosteric regulation in this PDZ domain and is a very c

121 The structure-function relationship of allosteric regulation in this system is still not fully

122 ccomplishes different physical mechanisms of allosteric regulation, involving either the dissociation

123 uctural analysis revealed that the decreased allosteric regulation is a result of the altered FBP bin

124 As in nature, allosteric regulation is afforded by coupling the confor

125 f the bacterial IDHa enzyme, suggesting that allosteric regulation is also important for optimal grow

126 Allosteric regulation is mediated by a cytosolic C-termi

127 on by the substrate phenylalanine (Phe); the allosteric regulation is necessary to maintain Phe below

128 is perspective, we present the argument that allosteric regulation is underappreciated in the systems

129 Allosteric regulation is used as a very efficient mechan

130 a residue shown earlier to be important for allosteric regulation, is disrupted, thereby strengtheni

131 ease-associated mutations may impair dynamic allosteric regulations, leading to loss of function.

132 lteration of conformational dynamics through allosteric regulation leads to functional changes.

133 This inverse allosteric regulation likely underlies the ability of PG

134 rbon partitioning rapidly through short-term allosteric regulation may contribute to plant performanc

135 This allosteric regulation may explain how cancer cells coord

136 Thus, the allosteric regulation may result from a discrete inhibit

137 esults are consistent with an intermolecular allosteric regulation mechanism for the phosphatase acti

138 To increase our understanding of this allosteric regulation mechanism, we present the 2.6A cry

139 in the crystal structure, which suggests an allosteric regulation mechanism.

140 be linked with specificity and diversity of allosteric regulation mechanisms.

141 oteases with enhanced catalytic activity and allosteric regulation mediated by monovalent cation bind

142 The allosteric regulation model has been applied for the act

143 ction but rather are more consistent with an allosteric regulation model in which the presence of sma

144 erization or induced proximity model and the allosteric regulation model.

145 role in the inter-subunit communication and allosteric regulation observed in GDH.

146 tion may also be important to understand how allosteric regulation occurs in related viral polymerase

147 rable conditions a normal [Ca(2+)]-dependent allosteric regulation occurs.

148 ve demonstrated substrate-selective negative allosteric regulation of 2-AG oxygenation.

149 eport evidence for an unconventional type of allosteric regulation of a biomotor.

150 in regard to G protein activation and strong allosteric regulation of agonist binding by G proteins.

151 show that both subunits are involved in the allosteric regulation of AGPase.

152 LY404187 are not identical and indicate that allosteric regulation of AMPA receptors can arise from m

153 erpesvirus proteases are an example in which allosteric regulation of an enzyme activity is achieved

154 Allosteric regulation of an intramolecular interaction b

155 rk helps to explain the previously described allosteric regulation of assembly and functional propert

156 reveal that directional activation involves allosteric regulation of ATP turnover through coordinate

157 link between observed conformations and the allosteric regulation of binding events at distal sites

158 iable Cu coordination or plays a key role in allosteric regulation of biological function, or both?

159 Allosteric regulation of biological macromolecules, howe

160 but these results directly demonstrated the allosteric regulation of cell surface E-cadherin by p120

161 h ion conductance by RyRs and the long-range allosteric regulation of channel activities.

162 40 mV and is noncompetitive, consistent with allosteric regulation of channel function.

163 iguration suggests a molecular mechanism for allosteric regulation of channel gating by intracellular

164 racterize the dynamic events involved in the allosteric regulation of cystic fibrosis transmembrane c

165 of the lid upon holoenzyme formation suggest allosteric regulation of deubiquitination.

166 ing represents an important parameter in the allosteric regulation of diverse cell surface receptors.

167 structural conformational changes linked to allosteric regulation of DNA binding in vitro, irrespect

168 nal repressors and the mechanism of negative allosteric regulation of DNA binding is poorly understoo

169 ciated with metal binding and metal-mediated allosteric regulation of DNA binding to varying degrees.

170 the CzrA homodimer that leads to significant allosteric regulation of DNA binding.

171 Allosteric regulation of DNA-PK by DNA termini protrudin

172 would account for a physiologically relevant allosteric regulation of E. coli GlmS.

173 Here we monitored for the first time allosteric regulation of enzymatic activity at the singl

174 Allosteric regulation of enzymatic activity forms the ba

175 ion transport, transcription regulation, and allosteric regulation of enzyme function.

176 inding sites are commonly used by nature for allosteric regulation of enzymes controlling the product

177 P binding sites and their widespread use for allosteric regulation of enzymes in metabolic pathways h

178 nces can be caused by mutations altering the allosteric regulation of enzymes involved in dNTP biosyn

179 shape and dynamics in a manner analogous to allosteric regulation of enzymes.

180 biomimetic control mechanism that mimics the allosteric regulation of enzymes.

181 putational approach to identify a domain for allosteric regulation of Epac and a novel compound that

182 omain, providing evidence for Pin1-dependent allosteric regulation of ERalpha function.

183 Here, we addressed the allosteric regulation of FAK by performing all-atom mole

184 We speculate that the allosteric regulation of FVIIa activity by TF binding fo

185 bstrate binding domains, suggesting that the allosteric regulation of GK may involve a direct structu

186 Positive allosteric regulation of glutamate AMPA receptors involv

187 e-4 (PFKFB4) controls metabolic flux through allosteric regulation of glycolysis.

188 provide the first evidence of a functional, allosteric regulation of GRD by CSRD, which requires neu

189 ified membrane-permeant molecule that causes allosteric regulation of Hb oxygen binding affinity.

190 istatically interacting sites that alter the allosteric regulation of Hb-O2 affinity.

191 We found that functional sites involved in allosteric regulation of Hsp70 may be characterized by s

192 reversible binding of protons is key to the allosteric regulation of human hemoglobin.

193 Allosteric regulation of human lipoxygenase (hLO) activi

194 at phosphorylation at Thr-34 is critical for allosteric regulation of human MTHFR activity by AdoMet.

195 olecular basis for substrate recognition and allosteric regulation of IDE could aid in designing IDE-

196 tory mechanism of hTS activity that involves allosteric regulation of interactions of hTS with its ow

197 rotein bound to both dGTP and dATP suggested allosteric regulation of its enzymatic activity by dGTP

198 F1's chromatin-binding properties, including allosteric regulation of its histone binding.

199 ed a novel role for the I-like domain in the allosteric regulation of LFA-1 function and signaling.

200 ns provide a framework for understanding the allosteric regulation of lipid kinase activity.

201 molecules with high affinity involved in the allosteric regulation of LVIS553, a MarR member from Lac

202 structural insight into the target-specific allosteric regulation of mAChRs by "three-finger" snake

203 al cofactor recycling, a potential system of allosteric regulation of metabolite transport and the me

204 mational selection, the mechanism underlying allosteric regulation of monomeric enzymes is poorly und

205 Thus, our data support allosteric regulation of monomeric enzymes to operate vi

206 At last, we briefly outline the allosteric regulation of myosins with synthetic compound

207 omains (CBD1 and CBD2) are essential for the allosteric regulation of Na(+)/Ca(2+) exchange activity.

208 These results indicate that the allosteric regulation of nAChR results in the potentiati

209 ence of an autoinhibitory region involved in allosteric regulation of NCX by intracellular Na+, Ca2+,

210 result from reduced Ca2+ sensitivity of the allosteric regulation of NCX.

211 l cells, we hypothesize that this long-range allosteric regulation of NHERF1 by ezrin enables the mem

212 red cytoplasmic domain are important for the allosteric regulation of NMDA receptor gating.

213 ion events into fluorescence changes through allosteric regulation of noncovalent interactions with a

214 emerged as a model system for understanding allosteric regulation of operator DNA binding by transit

215 Allosteric regulation of organometallic catalysts could

216 A recently introduced model for allosteric regulation of PAH involves major domain motio

217 We conclude that allosteric regulation of PDE6 is more complex than for P

218 at the mobility of ATP lid is central to the allosteric regulation of PDHK2 activity serving as a con

219 tions and show they have distinct effects on allosteric regulation of PFKP activity and lactate produ

220 acterization of W139G PGDH suggests that the allosteric regulation of PGDH is mediated not only by ch

221 ts support a role of N-myristoylation in the allosteric regulation of PKA-C.

222 We further find that allosteric regulation of PleC observed in vitro does not

223 to the chaperone activity is an ATP-induced allosteric regulation of polypeptide substrate binding a

224 protease-like beta-chain as a "hot spot" for allosteric regulation of pro-HGF and have broad implicat

225 und transcription from this DNA construct by allosteric regulation of promoter clearance at the point

226 ilayer properties or to specific binding and allosteric regulation of protein activity.

227 ng, enzymatic catalysis, or protein folding, allosteric regulation of protein conformation and dynami

228 Allosteric regulation of protein function is a critical

229 Allosteric regulation of protein function is recognized

230 Allosteric regulation of protein function, the process b

231 plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly

232 (SOD1), which previously were implicated in allosteric regulation of protein maturation and also pat

233 Allosteric regulation of proteins by conformational chan

234 ha)8 barrel are involved in proline-mediated allosteric regulation of PutA-membrane binding.

235 dy the molecular changes associated with the allosteric regulation of RecA.

236 ormational dynamics orchestrates function in allosteric regulation of recognition and catalysis remai

237 The mechanism likely involves the allosteric regulation of ribonucleotide reductase and se

238 ults in a concurrent decrease of dGTP due to allosteric regulation of ribonucleotide reductase.

239 ctors - interactions that often result in an allosteric regulation of RNAP activity.

240 ing a stunning molecular explanation for the allosteric regulation of RNR activity in E. coli.

241 Although long known that allosteric regulation of RNR activity is vital for cell

242 alytically relevant complex and suggest that allosteric regulation of SepSecS might play an important

243 We found that the allosteric regulation of SERCA depends on the conformati

244 nteractions or mutations, thereby conferring allosteric regulation of structure and function.

245 data are explained by a model of reciprocal allosteric regulation of TCR phosphorylation by choleste

246 Allosteric regulation of tetramerically symmetric protei

247 of the SH3C, a region of Crk involved in the allosteric regulation of the Abl kinase.

248 scherichia coli We demonstrate HPr-dependent allosteric regulation of the activities of pyruvate kina

249 ICs and implicate the three-fold axis in the allosteric regulation of the channel.

250 with crystal structures the atomic basis for allosteric regulation of the conformation and affinity f

251 l control of overall structural dynamics and allosteric regulation of the drug-binding pocket.

252 Our results provide insight into the allosteric regulation of the enzyme and support a physio

253 We postulate this region as critical for the allosteric regulation of the enzyme, participating in th

254 nsights into the mechanism for catalysis and allosteric regulation of the enzyme.

255 Here, we unravel the mechanism and allosteric regulation of the highly cooperative alarmone

256 We are just beginning to understand the allosteric regulation of the human cytosolic sulfotransf

257 and these changes could directly affect the allosteric regulation of the interaction between the I-l

258 FR) involves ligand-induced dimerization and allosteric regulation of the intracellular tyrosine kina

259 mational change in p110alpha consistent with allosteric regulation of the kinase domain by nSH2.

260 ation of biomolecular recognition-triggered, allosteric regulation of the LCST phase transition of a

261 this result highlights a dynamic network for allosteric regulation of the M2 receptor activation.

262 ely varying environments is made possible by allosteric regulation of the metabolic network, interpla

263 Allosteric regulation of the pore by the cytoplasmic dom

264 f a protein to predict directionality in the allosteric regulation of the protein fluctuations.

265 We provide evidence for novel mechanisms of allosteric regulation of the Rac-GEF activity of the Coo

266 From these studies, we conclude that allosteric regulation of the SH3-GK intramolecular inter

267 Moreover, the allosteric regulation of the three GP isozymes (muscle,

268 different tropomyosins to actin and suggest allosteric regulation of the tropomyosin/actin interacti

269 We have developed a quantitative model of allosteric regulation of the Wiskott-Aldrich syndrome pr

270 ted helicases that should be involved in the allosteric regulation of these motor proteins.

271 ons, but the molecular mechanisms underlying allosteric regulation of these transitions are still elu

272 s, and we present a structural model for the allosteric regulation of this enzyme.

273 rscoring a remarkable intra- and interdomain allosteric regulation of this trypsin-like protease.

274 his study establishes a new paradigm for the allosteric regulation of thrombin and other Na(+)-activa

275 s of topo II, and reveals a new mode for the allosteric regulation of topo II through modulation of A

276 nal helix of Arl3*GTP would be available for allosteric regulation of UNC119a cargo release only insi

277 to develop a structural model describing the allosteric regulation of uPAR.

278 Here, we show that the allosteric regulation of WASP can be quantitatively desc

279 Allosteric regulation often controls key branch points i

280 Sites for allosteric regulation on the protease complex allow sele

281 Allosteric regulation plays an important role in a myria

282 The allosteric regulation produced by glucose is postulated

283 These include allosteric regulation, product inhibition, and covalent

284 Allosteric regulation promises to open up new therapeuti

285 Allosteric regulation provides highly specific ligand re

286 Many aspects of allosteric regulation remain incompletely understood.

287 The molecular basis of allosteric regulation remains a subject of intense inter

288 and affinity, specificity, catalysis, and/or allosteric regulation) remains a challenge.

289 e to the tumorigenesis, and have revealed an allosteric regulation site for its RhoGAP activity.

290 Here we describe an approach to confer allosteric regulation specifically on the catalytic acti

291 psid and glycoprotein assembly is subject to allosteric regulation, that is regulation at the level o

292 (KSR) is a MAPK scaffold that is subject to allosteric regulation through dimerization with RAF.

293 We propose that allosteric regulation through modification of specific r

294 one binding site reciprocally influenced the allosteric regulation through nucleotides interacting wi

295 tiadhesive and antimicrobial therapies using allosteric regulation to inhibit FimH.

296 The allosteric regulation triggering the protein's functiona

297 Allosteric regulation usually involves a switch in prote

298 a therefore support an emerging model of PAH allosteric regulation, whereby Phe binds to PAH-RD and m

299 volving post-translational modifications and allosteric regulation with other protein partners.

300 ind that DNA binding triggers an interdomain allosteric regulation within the GR, leading to tetramer