ライフサイエンスコーパス: allosterically

1 in which its catalytic active sites operate allosterically.

2 o conclude that the former exerts its effect allosterically.

3 and phosphoUb activates the E3 ligase Parkin allosterically.

4 independently, but are coupled to each other allosterically.

5 s to oligomerization by acting indirectly or allosterically.

6 d during recycling facilitate lipid exchange allosterically.

7 olymerase active site, inhibiting the enzyme allosterically.

8 o the pore, and are poised to control gating allosterically.

9 gion of the enzyme and affects transcription allosterically.

10 the Fc binding site, whereas the other acts allosterically.

11 lock the transamidation activity of hTG2 and allosterically abolish its GTP binding ability with a hi

12 hanging the level of basal activity with the allosterically acting anesthetics propofol, pentobarbita

13 ranes and that binding of oxLDL to LOX-1 can allosterically activate AT1-dependent signaling events.

14 n addition to Fe(II), both Zn(II) and Mn(II) allosterically activate BsFur-DNA binding.

15 se processes, identifying compounds that can allosterically activate GK may address this issue.

16 G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and tr

17 ch accumulate following a loss of DnaK, also allosterically activate Lon to degrade DnaA, thereby ens

18 c bacteria, have evolved peptide motifs that allosterically activate N-WASP, leading to localized act

19 rmediate state, whereas acidic phospholipids allosterically activate SecA for ATP-dependent protein t

20 s have suggested that location-specific cues allosterically activate Set1.

21 glutamate flux, lumenal protons and chloride allosterically activate vesicular glutamate transport.

22 tions and that during signaling, NEMO may be allosterically activated by binding to long M1-linked po

23 is an unusual metallopeptidase in that it is allosterically activated by both small peptides and anio

24 ykAencodes an active pyruvate kinase that is allosterically activated by glucose 6-phosphate (Glc-6-P

25 y that the binding of Eaf3 to H3K36me can be allosterically activated by Rco1.

26 Ss from lower organisms, human CBS (hCBS) is allosterically activated by S-adenosylmethionine (AdoMet

27 ous findings showed that the Tec kinases are allosterically activated by the adjacent N-terminal link

28 The esterification reactions are allosterically activated by their sterol substrates, the

29 esult in a GC-B conformation that mimics the allosterically activated conformation, 2) GC-B phosphory

30 Our data support the hypothesis that PrfA is allosterically activated during intracellular infection

31 Protein kinase C-delta (PKCdelta) is an allosterically activated enzyme that acts much like othe

32 The biosensor is based on an engineered, allosterically activated fusion protein, which contains

33 s when it localizes to centrosomes, AURKA is allosterically activated on the mitotic spindle via bind

34 e of Phe, is different from a Phe-stabilized allosterically activated PAH tetramer.

35 an explanation of how an inactive pseudo DUB allosterically activates a cognate DUB partner and impli

36 Binding of AMP to AMPK not only allosterically activates AMPK but also promotes phosphor

37 Heparin allosterically activates antithrombin as an inhibitor of

38 into a cyclic oligoadenylate product, which allosterically activates Csm6 by binding to its CRISPR-a

39 n RhoGEF activation, as it both recruits and allosterically activates cytosolic ARHGEF25 isoforms.

40 Independently, K-Ras4B allosterically activates p110.

41 Thus, FtsN allosterically activates peptidoglycan synthesis by two

42 Thus we report the mechanism by which RAM allosterically activates RNMT, allowing it to function a

43 to a defined site in a target RNA, but also allosterically activates the enzyme by presenting a mono

44 Calcium binding allosterically activates the enzyme, but the detailed me

45 f kinase domains, in which one kinase domain allosterically activates the other.

46 he intracellular H8 helix region of PAR1 and allosterically activates the receptor through the adjace

47 s of this protein experimentally shown to be allosterically active exhibit higher network coupling re

48 We have trapped this "allosterically active" state for the E. coli Hsp70, DnaK

49 s, lacking such well-defined structures, can allosterically affect function.

50 es might create a surface on the helicase to allosterically affect its function.

51 utations in the cytosolic loops reciprocally/allosterically affect nucleotide occupancy of the NBDs.

52 how how mutations at the hinge regions could allosterically affect the binding-site dynamics or induc

53 its ability to accommodate lipid A, which is allosterically affected by bound TLR4.

54 h the mutated residue, and thus the mutation allosterically affects multiple regions of the monomer.

55 suggest that RAS phosphorylation at Tyr(137) allosterically alters protein conformation and effector

56 Computer modeling predicts that N(1575)Y allosterically alters PyR2 via a small shift of IIS6.

57 Thus occupancy of the active sites of ClpP allosterically alters sites on the surfaces thereby affe

58 During mechanotransduction, force allosterically alters the functions of mechanosensitive

59 mes showed that the antibiotic in the tunnel allosterically alters the properties of the catalytic ce

60 ing human INSR demonstrated that XMetA acted allosterically and did not compete with insulin for bind

61 Zn(2+) binding allosterically and negatively regulates the serine prote

62 it is thought that these clamp sites operate allosterically and promote translocation via an alloster

63 Several of these Fabs allosterically and selectively modulated the interaction

64 cal transmembrane domains (TMs) of CRF1R and allosterically antagonize peptide binding and receptor a

65 ompetitive regulation of CsrA by sRNAs, FliW allosterically antagonizes CsrA in a noncompetitive mann

66 on of nucleosides or nucleotide analogues or allosterically at a number of well-defined sites.

67 AR) agonists) to enhance radioligand binding allosterically at the human dopamine (DA) transporter (D

68 fourth fragment)] disrupted the association, allosterically augmented 5-HT(2C)R-mediated signaling in

69 Usp14 inhibits these processes allosterically because a catalytically inactive Usp14 mu

70 rom the Camelid family was recently found to allosterically bind and stabilize an active conformation

71 5 as a specific antagonist of HIF2alpha that allosterically blocks its dimerization with the HIF1alph

72 ly, substrate binding does not activate EccC allosterically but, rather, by stimulating its multimeri

73 ecificity of a bHLH protein being controlled allosterically by a domain outside of the bHLH region.

74 AMPK activity is regulated allosterically by AMP and by the phosphorylation of resi

75 w that the eIF4E/eIF4G inhibitor 4EGI-1 acts allosterically by binding to a site on eIF4E distant fro

76 ion and suggests that caspase-9 is activated allosterically by binding to the apoptosome backbone.

77 that potent pharmacophore trans-Ned-19 acts allosterically by clamping the pore domains to VSD2.

78 Together, our findings show that EL4 allosterically can modulate inhibitor binding within the

79 Abl by assembling onto the catalytic domain, allosterically clamping it in an inactive state.

80 ere, we show a mechanism by which an IDP can allosterically control function by simultaneously tuning

81 These novel structures, which exhibit allosterically controllable electronic properties, are m

82 Here we demonstrate the rational design of allosterically controllable, metal-ion-triggered molecul

83 Target binding is allosterically controlled by Ca(2+) over a distance of a

84 hosphohydrolase (dNTPase) activity, which is allosterically controlled by the combined action of GTP

85 switching between two bound states, possibly allosterically controlled by the opposing tetramer end.

86 r to structural rearrangements that occur in allosterically controlled enzymes.

87 nt following PAR activation and how PARs are allosterically controlled within the plasma membrane wil

88 Our data suggest that AQP2 phosphorylation allosterically controls its interaction with LIP5, illus

89 served extensive conformational changes that allosterically couple the extracellular regulatory and a

90 xperiments revealed that these two sites are allosterically coupled and exert reciprocal modulation.

91 show that Hv1 contains two intracellular and allosterically coupled gates.

92 the extracellular substrate binding site are allosterically coupled in BtuB, and that TonB binding ma

93 onsequences of binding of each ligand to its allosterically coupled site(s).

94 The stimuli sensors are allosterically coupled to a pore domain, increasing the

95 elix responsible for chi recognition that is allosterically coupled to a structural latch.

96 were tight and identified computationally as allosterically coupled to active sites.

97 irs using nonhydrophilic interactions and is allosterically coupled to charged residues near the site

98 Several gating processes, allosterically coupled to each other, control BK channel

99 tivation, which defeats transmission, and is allosterically coupled to protonation of key channel act

100 cytoplasmic domains of the protein that are allosterically coupled to transmembrane helices so as to

101 leotide binding cleft, is either part of, or allosterically coupled to, the dimer interface.

102 tionally, we found that kinase protomers are allosterically coupled, conveying inhibition across the

103 of the Escherichia coli biotin repressor are allosterically coupled.

104 opening and that these gating mechanisms are allosterically coupled.

105 evealing a quaternary structural switch that allosterically couples and synchronizes initial ligand b

106 ry") proteins orchestrate these responses by allosterically coupling the selective binding of target

107 o CP and induce a conformational change that allosterically decreases but does not abolish its actin-

108 castor oil seeds (Ricinus communis) a novel, allosterically desensitized 910-kD Class-2 PEPC hetero-o

109 wo cancer-related mutations, G40E and S118I, allosterically destabilize the monomer and stabilize an

110 We found that glutathionylation of C408 allosterically destabilizes the active-like state of BAK

111 We propose that Ca(2+) binding allosterically destabilizes the terminal regions of C2al

112 dicate that S620T or S631A substitutions can allosterically disrupt drug binding by a mechanism that

113 affect its nanoclustering response and thus allosterically effector recruitment and downstream signa

114 lluminate how adaptive substrate binding can allosterically enhance enzyme activity.

115 istered leukadherin-1, a small molecule that allosterically enhances alphaMbeta2-dependent cell adhes

116 The G2BR allosterically enhances RING:Ube2g2 binding and ubiquiti

117 nding activates autophosphorylated eEF-2K by allosterically enhancing k(cat)(app) for peptide substra

118 equired for its DRC role and propose that it allosterically facilitates Rad53 activation to ensure a

119 ns, such as phosphorylation, can directly or allosterically fine-tune phospholipid-protein interactio

120 are regulated by a signal that is propagated allosterically from inside the viral shell to the motor

121 sical substrate for extracellular stimuli to allosterically gate the channel.

122 related compounds bind to the alpha face and allosterically impact proteasome function.

123 Our results demonstrate that ClpP allosterically impacts the polypeptide translocation act

124 BiP and J-protein co-factors but appears to allosterically impair J protein-stimulated ATP-hydrolysi

125 Allosterically impaired CzrA mutants are characterized b

126 nine in the cytosolic AMT1 C terminus, which allosterically inactivates AMT1 trimers.

127 or compositions suggest that MmTX1 and MmTX2 allosterically increase GABAA receptor susceptibility to

128 Three coexisting nucleotide states allosterically induce distinct positioning of tyrosines

129 Dihydropyridine binding allosterically induces an asymmetric conformation of the

130 190723 suppresses the disassembly switch and allosterically induces closure of the intermonomer inter

131 hibits most of these conformational changes, allosterically inducing a GMPCPP-like state.

132 Asn in a position that was recently shown to allosterically influence MscS inactivation, N117.

133 IKs by binding to an intersubunit space and allosterically influencing pore conductance and gating t

134 extracellular loop 3 (ECL3) is sufficient to allosterically inhibit agonist signaling at a GPCR.

135 nd binding specifically to this position may allosterically inhibit cation conduction by preventing t

136 ding di-, tri- and tetrasulfide bonds, which allosterically inhibit cst operator DNA binding by CstR.

137 NSAIDs allosterically inhibit cytosolic sulfotransferases (SULT

138 nase-Inhibiting RNase Attenuators-KIRAs-that allosterically inhibit IRE1alpha's RNase by breaking oli

139 vinylogous urea, NSC727447, was proposed to allosterically inhibit ribonuclease H (RNase H) activity

140 D2 receptor (D2R) dimer in a bitopic mode to allosterically inhibit the binding of dopamine at the ot

141 CBR703 series antimicrobials allosterically inhibit transcription by binding to a con

142 esolution structures have been solved for an allosterically inhibited and agonist-bound form of a fun

143 where the binding of tetraphenylborate also allosterically inhibited anion binding in the cube's cav

144 ll translation regulator Musashi-1 (MSI1) is allosterically inhibited by 18-22 carbon omega-9 monouns

145 ubunit is that their ion channel activity is allosterically inhibited by a nano-molar concentration o

146 he pyrimidine pathway in Escherichia coli is allosterically inhibited by cytidine triphosphate.

147 uctokinase (BsPFK) is a homotetramer that is allosterically inhibited by phosphoenolpyruvate (PEP), w

148 by reestablishing the catalytic activity of allosterically inhibited enzyme via modulation of the wo

149 onformational transition pathway between the allosterically inhibited form and the active form, we pr

150 rationalized by crystallographic analysis of allosterically inhibited L-lactate dehydrogenase.

151 osteric inhibitor, ifenprodil, represent the allosterically inhibited state.

152 9 activation, whereas binding to active MMP9 allosterically inhibits activity.

153 hiobarbituric acid derivative, 5376753, that allosterically inhibits Epac activity and used Swiss 3T3

154 ly for alpha5beta1 complexed with a Fab that allosterically inhibits ligand binding by stabilizing th

155 how the central regulatory protein EIIA(Glc) allosterically inhibits maltose uptake in E. coli.

156 to capital ES, Cyrillicys256 in one monomer allosterically inhibits the covalent binding of BV to th

157 of an autoinhibitory module, which in Ets-1 allosterically inhibits the DNA binding activity.

158 on a synthetic molecular pentafoil knot that allosterically initiates or regulates catalyzed chemical

159 g and CaM-binding sites are distinct but are allosterically interacting RyR2 sites.

160 classes of drugs bind to three separate, but allosterically interacting, receptor sites on CaV1.2 cha

161 hibits nicotinic acetylcholine receptors and allosterically interacts with muscarinic acetylcholine r

162 rs of PU.1 that we developed specifically to allosterically interfere with PU.1-chromatin binding thr

163 Therefore, there appear to be three allosterically linked binding sites on FFA1 with agonist

164 sylation of separate Cys residues, which are allosterically linked.

165 a and IL-2:IL-2Rgamma interactions, but also allosterically lowered the IL-2:IL-2Ralpha affinity thro

166 at most likely increases Li(+) permeation by allosterically lowering Na2 affinity.

167 Although the disruption of this complex, allosterically mediated process has long been implicated

168 wed that formation of GHSR1a:DRD2 heteromers allosterically modifies canonical DRD2 dopamine signalin

169 D2 antagonists allosterically modulate cannabinoid-induced CB1 coupling

170 tivity and support the hypothesis that RAMPs allosterically modulate CTR peptide affinity.

171 boxy-terminal domains that are positioned to allosterically modulate cytoplasmic Ca(2+) activation.

172 e in activating structural fluctuations that allosterically modulate functional signals.

173 , palliation, insomnia, and sedation as they allosterically modulate gamma-amino-butyric acid type A

174 Benzodiazepines (BZs) allosterically modulate gamma-aminobutyric acid type-A r

175 Last, we show that some SNPs allosterically modulate PCSK9's substrate sequence speci

176 le ligands are unaltered in their ability to allosterically modulate signaling from peptide ligands,

177 ate that individual lipid-binding events can allosterically modulate the interactions of integral mem

178 We demonstrate that wALADins allosterically modulate the PBGS homooligomeric equilibr

179 Lateral receptor interactions can allosterically modulate the receptor response to a ligan

180 ranscription factors, and nucleic acids that allosterically modulate the RNAP during the transcriptio

181 ransfer into the membrane, a process that is allosterically modulated by cotransin binding to the plu

182 TR of mRNA by HSC70, and its activity can be allosterically modulated by DCB-3503.

183 NMDARs can be allosterically modulated by numerous compounds, includin

184 in fast inhibitory neurotransmission and are allosterically modulated by the anxiolytic, anticonvulsa

185 uggest that hDAT transport properties may be allosterically modulated under conditions promoting dime

186 o the macrocyclic lactone, ivermectin, which allosterically modulates both ion conduction and channel

187 the molecular mechanism by which AMP and FBP allosterically modulates EcAGPase enzymatic activity sti

188 Cyclic AMP allosterically modulates HCN through the cAMP-dependent

189 Specifically, the lipid membrane allosterically modulates the activity of the embedded ki

190 eotide-controlled conformational switch that allosterically modulates the catalytic activity of eukar

191 exhibit a multimodal mechanism of action by allosterically modulating IN multimerization and interfe

192 anscription by binding to RNA polymerase and allosterically modulating its activity.

193 on and partitioning during photosynthesis by allosterically modulating the activity of cytosolic fruc

194 ted analogue, 51, was as effective as S-1 in allosterically modulating the binding of [(3)H]S-1 via S

195 th traditional ligands and ligands that bind allosterically outside the orthosteric receptor binding

196 gle disease associated amino acid change may allosterically perturb several functional sites in an ol

197 elonging to the Na(+)-binding site which may allosterically perturb the specificity sites.

198 in which the intracellular helix arrangement allosterically pinches the SF.

199 Currents elicited by betaine or choline were allosterically potentiated by nM concentrations of monep

200 nctional assays propose that these compounds allosterically prevent narrowing of the drug-binding poc

201 e ultimate selectivity: They target MMP-9 by allosterically preventing activation of its zymogen.

202 ting nucleotides (iNTPs) indicate that ppGpp allosterically prevents the conformational changes assoc

203 In agreement with RasGRP allosterically priming SOS, exponential ERK activation i

204 other monomer, whereas the presence of Cys15 allosterically promotes BV binding to Cys256 in both mon

205 to Poz1 elicits structural changes in Poz1, allosterically promoting Rap1 binding to Poz1.

206 Changes in dynamics can allosterically propagate to the channel gate.

207 onformational changes in the active site are allosterically propagated into rotations of the motor do

208 t causes a global conformational change that allosterically realigns active-site residues, accelerati

209 ification tested that removes the ability to allosterically reduce the level of Phe binding.

210 335 increases potassium flow through KcsA by allosterically reducing inactivation of the channel.

211 Riboswitches are RNA elements that allosterically regulate gene expression by binding cellu

212 Biological photosynthetic machinery allosterically regulate light harvesting via conformatio

213 e Ezh2 motif that responds to stimulation to allosterically regulate the active site.

214 centrations, providing a unique mechanism to allosterically regulate the activity of human GCK under

215 Mammalian alphaE-catenin is an allosterically regulated actin-binding protein that bind

216 By disrupting this allosterically regulated assembly mechanism, R7BP ablati

217 omplex associated with SET1)-like complex is allosterically regulated by a four-subunit complex compo

218 AGPase activity is allosterically regulated by a series of metabolites in t

219 s alphabetagamma trimeric complexes that are allosterically regulated by AMP, ADP, and ATP.

220 In addition, PdcA PDE activity is allosterically regulated by GTP, further linking c-di-GM

221 rtantly, the PopP2-RRS1-RWRKY association is allosterically regulated by InsP6 binding, suggesting a

222 through three orthosteric binding sites and allosterically regulated by ivermectin (IVM), a broad-sp

223 We conclude that Brag2 is allosterically regulated by PIP(2) binding to the PH dom

224 spread in proteobacteria and that the use of allosterically regulated C-terminal motifs could be a co

225 ity of the identified sites, we construct an allosterically regulated Cas9 by insertion of the estrog

226 efficiency of the resulting stereoselective, allosterically regulated catalyst, nicknamed AlleyCatE,

227 Enzymes in heteromeric, allosterically regulated complexes catalyze a rich array

228 early stages of CME and show how sequential, allosterically regulated conformational changes activate

229 ., softening the hinges), thus impairing the allosterically regulated dynamics.

230 ntrally positioned within the alpha face and allosterically regulated element responsible for the int

231 edded within a coordination framework can be allosterically regulated in situ by controlling oligomer

232 in vitro, suggesting that this enzyme may be allosterically regulated in vivo as well.

233 nd also demonstrate the modular design of an allosterically regulated protease receptor following rec

234 3 tumour suppressor is an example of such an allosterically regulated protein.

235 Rgg-type receptors are allosterically regulated through direct pheromone bindin

236 atalyzes the final step in glycolysis and is allosterically regulated to control flux through the pat

237 rrents through AMPA receptor channels can be allosterically regulated via different sites on the rece

238 ies differences in the effector sites of the allosterically regulated yeast enzyme and the other two

239 dependent cytidine deaminase family as being allosterically regulated, activated by dCTP, and inhibit

240 An allosterically regulated, asymmetric receptor featuring

241 ome evidence that cadherin adhesion might be allosterically regulated, testing of this has been hinde

242 e GlgC/GlgA glycogen pathway is distinct and allosterically regulated.

243 A-bound and the ligand-bound form, which are allosterically regulated.

244 These two conformations allow the TCRs to be allosterically regulated.

245 w Escherichia coli pyruvate kinase type 1 is allosterically regulated: the "domain rotation model" su

246 Mammalian alphaE-catenin is allosterically regulated: the monomer binds the beta-cat

247 ite is essential for magnesium chelation and allosterically regulates Mg(2+) and MgATP(2-) binding.

248 ia coli aspartate transcarbamoylase (ATCase) allosterically regulates pyrimidine nucleotide biosynthe

249 activation indicates that half-site spacing allosterically regulates RAR function.

250 r how substrate DNA bound to one active site allosterically regulates the activity of the other.

251 he phosphorylation state of beta2-syntrophin allosterically regulates the affinity of beta2S-PDZ for

252 DCB-3503 allosterically regulates the ATPase and chaperone activi

253 Extracellular zinc allosterically regulates the NMDA receptor by binding to

254 studies indicate that the RXRA substitution allosterically regulates the PPAR AF2 domain via an arom

255 rent activation, indicating that the DII-VSD allosterically regulates the rate of INa activation and

256 nucleotide binding pocket of TCL capable of allosterically regulating nucleotide exchange and thus i

257 ich NMR approaches are best suited for which allosterically relevant questions.

258 Each TM substitution allosterically rescued the ATP sensitivity of CFTR gatin

259 e response regulator, Escherichia coli CheY, allosterically responds to phosphorylation with a change

260 second coordination shell hydrogen bonds at allosterically responsive sites in zinc-sensing transcri

261 de binding region and alpha3 domain of MHC I allosterically, resulting in enhanced peptide selector f

262 er-substrate complexes or T-Hg(2+)-T bridges allosterically stabilize and activate the DNAzymes, thus

263 l during transcription likely occurs through allosterically stabilized histone-histone interactions.

264 ose that the C-terminal region of dystrophin allosterically stabilizes an optimal actin binding confo

265 pendent mechanism whereby mechanical stretch allosterically stabilizes specific beta-arrestin-biased

266 The peptide lead, LR (LSCQLYQR), allosterically stabilizes the inactive form of the prote

267 c complex between integrase and viral DNA by allosterically stabilizing an inactive multimeric form o

268 was found to affect the motions of E2~Ub and allosterically stimulate Ub transfer.

269 the U-box:E2-binding affinity, and the other allosterically stimulates the formation of catalytically

270 we identified the two separate elements that allosterically suppress otherwise constitutively active

271 Bifacial PNA binding was thus used to allosterically switch-on protein and small-molecule bind

272 um cations to the tetratopic ion-pair host 1 allosterically switched "on" chloride binding that is ot

273 large number of drugs are being developed to allosterically target this receptor.

274 m by which the dynamic TTD-PHD module can be allosterically targeted with small molecules to modulate

275 uggest their respective roles in controlling allosterically the conformation of the ligand binding po

276 s of a supramolecular cube served to inhibit allosterically the encapsulation of a neutral or anionic

277 hat membrane curvature could likely regulate allosterically the structure and function of transmembra

278 gested that pharmaceuticals activate CYP46A1 allosterically through binding to a site on the cytosoli

279 forming a ternary complex likely facilitated allosterically through DNA.

280 e N-terminal phosphorylation that functioned allosterically to induce cis-autophosphorylation of the

281 esults indicate that many BAP1 mutations act allosterically to inhibit ASXH binding, thereby leading

282 gh affinity and that many BAP1 mutations act allosterically to inhibit BAP1-ASXL2 binding.

283 ures show that class-bridging mutations work allosterically to open up conformational plasticity at t

284 ilar pheromone-binding domain that functions allosterically to regulate receptor activity.

285 3)H]NMS further support that LY2119620 binds allosterically to the M2 and M4 mAChRs and was positivel

286 d receptors are vital membrane proteins that allosterically transduce biomolecular signals across the

287 receptors (GPCRs) are membrane proteins that allosterically transduce the signal of ligand binding in

288 We show that MD-2 allosterically transmits this conformational plasticity,

289 spacing where linker DNA sensing by Acf1 is allosterically transmitted to Snf2h through the H4 tail

290 We propose that DNA binding to the ARL allosterically triggers ATP hydrolysis in PriA.

291 example, polyglutamine expansion in ataxin-3 allosterically triggers the aggregation of the catalytic

292 The ligand binding pockets are allosterically tuned by monoprotonation of the tren unit

293 scenario in which procaspase-9 is activated allosterically upon binding to the apoptosome backbone,

294 o motor domains in solution and is displaced allosterically upon microtubule binding, which allows it

295 uorenyl coordination motif, can be regulated allosterically via the binding of metal ions.

296 and Na2) and the I(-) binding site interact allosterically: when Na(+) binds to a Na(+) site, the af

297 olecular receptor can be tuned and modulated allosterically, where the association of a heterotropic

298 RhoA displaces liprin-alpha3 allosterically, whereas DAD competes with liprin-alpha3

299 P-activated protein kinase (AMPK), interacts allosterically with AMP to maintain an active state.

300 5-hydroxymethyl-2-furfural (5HMF) interacts allosterically with the abnormal form of haemoglobin (Hb