ライフサイエンスコーパス: allotype

1 MHC-I molecules, human MHC-I HLA-A and HLA-B allotypes).

2 ial involvement in diseases noted in the EOM allotype.

3 nation of the mec class complex with the ccr allotype.

4 yogenin and is a unique attribute of the EOM allotype.

5 pluripotent stem cells (iPSCs) to the Pro33 allotype.

6 ased on the expression of surface IgM and a2 allotype.

7 ose carrying the G1m3 with no G1m1 (G1m3,-1) allotype.

8 recognize B*4601 as though it were an HLA-C allotype.

9 ficantly associated with the Km(1)- negative allotype.

10 NA clone carrying B*4403 to express a single allotype.

11 ot react with targets carrying any other HLA allotype.

12 o adapt and positively respond to the foetal allotype.

13 sion level of the patient's mismatched HLA-C allotype.

14 ance in C57BL/6 mice that express the FasL.1 allotype.

15 xes bearing common variable segments and MHC allotypes.

16 lebo, these three Papa-B are the only Papa-B allotypes.

17 and 402 was used to identify individual CFH allotypes.

18 compared with the respective related KIR3DL1 allotypes.

19 tide identification of HLA-DRB1, DQB1, and B allotypes.

20 pitope carried by subsets of HLA-A and HLA-B allotypes.

21 that KIR2DL1*003 bound all C2, and only C2, allotypes.

22 elop a protein-based method of detecting CFH allotypes.

23 nd a frictional ratio f/f(o) of 1.2 for both allotypes.

24 ctional differences that distinguish KIR3DL1 allotypes.

25 21 cells transfected with single HLA class I allotypes.

26 o compare the functional properties of the 2 allotypes.

27 Abs can be distinguished based on different allotypes.

28 ere derived from different kappa light chain allotypes.

29 sms shared by DPbeta1*0201 and other DPbeta1 allotypes.

30 erent specificities in downregulation of HLA allotypes.

31 HLA-E, whereas K3 downregulated all four HLA allotypes.

32 ectively expressed 27 high-frequency HLA-A,B allotypes.

33 epitopes presented with various HLA class II allotypes.

34 adjacent regions and presented by different allotypes.

35 topes and restriction by all six MHC class I allotypes.

36 eceptors that recognize HLA-Cw1, 3, 7, and 8 allotypes.

37 iatic family members such as HLA-C and HLA-B allotypes.

38 st melanomas endogenously expressing HLA-Bw4 allotypes.

39 s inhibited by the combination of autologous allotypes.

40 other KIR reacting with both groups of HLA-C allotypes.

41 lanomas co-expressing HLA-A*0201 and HLA-Bw4 allotypes.

42 described binding motif for multiple HLA-DR allotypes.

43 mined as were a more divergent subset of B15 allotypes.

44 discriminate between the two groups of HLA-C allotypes.

45 ectivity by B*4601 is unique among HLA-A,B,C allotypes.

46 ed in the recognition of certain HLA class I allotypes.

47 p70 KIR-11, known to recognize several HLA-B allotypes.

48 itopes presented with different HLA-class II allotypes.

49 NK clones expressing these specific KIR3DL1 allotypes.

50 n fields of developing cells with compatible allotypes.

51 of strongly tapasin-dependent or independent allotypes.

52 cell recognition for several different MHC I allotypes.

53 stricted through one of nine different MHC I allotypes.

54 dome from cells expressing more active ERAP1 allotypes.

55 ity toward closely related or distinct HLA-I allotypes.

56 Bonobo populations have 3-14 Papa-B allotypes.

57 tested for binding to 95 HLA- A, -B, and -C allotypes.

58 To test this hypothesis, we serologically allotyped 100 persons with well-documented clearance of

59 rheumatoid factor activity against IgG2a of allotype a present in BALB/c, but not C57BL/6, mice.

60 We immunized non-lupus-prone mice with 11 allotype "a" of IgG2a (IgG2a(a)) and 4 IgG2c nonadjuvant

61 We hypothesized that GM and KM allotypes affect the outcome of hepatitis C virus (HCV)

62 one lineage of conserved activating KIR3DS1 allotypes, also implicated in Bw4 recognition.

63 Ig allotype analysis revealed that rotavirus-specific IgA w

64 Allotype and isotype exclusion is a property of most lym

65 ge was linked to the Igh(a), but not Igh(b), allotype and was associated with induction of relatively

66 Conversely, Km allotypes and CD32B or CD32C expression on NK cells did

67 antibodies specific for donor and host CD45 allotypes and for CD3.

68 ex stability of a large panel of human MHC-I allotypes and generated a body of data sufficient to dev

69 Gm allotypes and phenotypes were determined by the hemagglu

70 nscriptional pathway for regulation of HLA-A allotypes and provide a link between ubiquitination and

71 urface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expre

72 tly greater self-association than the Tyr402 allotype, and small amounts of dimeric SCR-6/8 were foun

73 amyloid angiopathy, apolipoprotein E (ApoE) allotype, and synaptophysin concentration in entorhinal

74 position 2 or 3 with high variances between allotypes, and a less variable anchor at the C-terminal

75 e inhibited by individual autologous class I allotypes, and every clone was inhibited by the combinat

76 ping, staphylococcal cassette chromosome mec allotyping, and vancomycin and teicoplanin MICs were per

77 fic for HLA-C, but that recognition of HLA-C allotypes appears more permissive than indicated by prev

78 that PIR molecules bearing the paternal PIR allotype are expressed whereas PIR-A and PIR-B molecules

79 R-A and PIR-B molecules bearing the maternal allotype are not.

80 relative lack of heterogeneity for any given allotype are unusual features for a mammalian glycoprote

81 The HPA1a and HPA1b allotypes are defined, respectively, by Leu and Pro at a

82 ts with mutant bas and wild-type parental b9 allotypes are excellent sources for therapeutic monoclon

83 Although a minority of HLA-A and -B allotypes are KIR ligands, HLA-C allotypes dominate this

84 In addition, HLA-C allotypes are recognized by killer cell Ig-like receptor

85 The wide-ranging properties of KIR allotypes arise from substitutions throughout the KIR mo

86 vitro refolded forms of tapasin-independent allotypes assemble more readily with peptides compared t

87 l variation between human IgG subclasses and allotypes at three amino acid positions (Lys/Asn-392, Va

88 to express a superantigen reactive to IgM of allotype b (IgM(b)).

89 er of V(H)n B cells decreases, whereas V(H)a allotype B cells increase in number and become predomina

90 4601 are distinct from those of its parental allotypes B*1501 and Cw*0102 and dominated by three high

91 ogenously processed ligands that bind to the allotypes B*1508, B*1501, and B*1503, but not B*1510.

92 l HSV-1 infection is modified by MHC class I allotypes (B*18, C*15, and the group of alleles encoding

93 , notably Cw*0501 and Cw*0202, and two HLA-B allotypes (B*4601 and B*7301) that share polymorphisms w

94 The assignment of epitopes to class I allotypes based upon analysis of the transfected cells c

95 molecular basis for the appearance of V(H)a2 allotype-bearing B cells in mutant Alicia rabbits.

96 ositive selection results in expansion of a2 allotype-bearing B cells in the appendix of young mutant

97 er competitor for endogenous IgG1 in G1m3,-1 allotype-bearing patients.

98 The V(H)1 gene is the major source of V(H)a allotype because this gene is preferentially rearranged

99 Under conditions of peptide deficiency, both allotypes bound efficiently to TAP and tapasin, and furt

100 peptides, which varies in efficiency between allotypes, but the mechanism of selection is unknown.

101 characterized plasma fibrinogen Aalpha-chain allotypes by electrospray ionization mass spectrometry m

102 This selective downregulation of HLA allotypes by K5 was partly due to differences in amino a

103 ion for differential downmodulation of MHC-I allotypes by Nef.

104 KIR3DL1*004, a common allotype, cannot be detected on the surface of PBLs usin

105 For example, the IgA2m(1) allotype carries an unusual heavy and light chain pairin

106 serine 77 and asparagine 80, bound to HLA-C allotypes carrying either amino acid motif.

107 Using mixed-allotype chimeras and retroviral-mediated gene transduct

108 rvival is partially explained by findings in allotype chimeras that broadly cross-reactive B-1 cell-d

109 ted gnotobiotic and conventionally reared Ig allotype chimeric mice.

110 ipients who have one or two C1-bearing HLA-C allotypes, compared with C2 homozygous recipients, with

111 In this study, PrP allotype composition in protease-resistant prion protein

112 which express the IgM(b) allotype) to IgM(a) allotype congenic mice.

113 g cytoplasmic tail (KIR2DL1), bound to HLA-C allotypes containing asparagine 77 and lysine 80 in the

114 lts show, for the first time, that GM and KM allotypes contribute to the interindividual differences

115 ompatibility leukocyte antigen (HLA) class I allotypes contributes to the array of receptor-ligand in

116 entire MAP repertoire presented by these 27 allotypes covered only 10% of the exomic sequences expre

117 ns (defined by serologic markers known as Gm allotypes), cytokines and their receptors, and certain p

118 es colony of rabbits that were pedigreed, Ig-allotype defined, but not inbred.

119 resonance and KIR binding to a panel of HLA allotypes demonstrated that KIR2DL3*005 differed signifi

120 kappa-chain (IGKC) polymorphisms determining allotypes designated G1m and Km.

121 2 IgA rheumatoid factor bearing the same IgA allotype, developed mesangial deposits consisting of IgA

122 aled little Patr-AL polymorphism: just three allotypes differing only at residues 52 and 91.

123 Allotypes differing solely at the Bw4/Bw6 region were ex

124 notyped for FCGR3A158 (the FcgammaRIIIa-158F allotype displays a lower Fc binding affinity) using the

125 LA-A and -B allotypes are KIR ligands, HLA-C allotypes dominate this regulation, because they all car

126 We found that compatibility of the allotype encoded by the tgrB1 and tgrC1 genes is require

127 ayed in mutant ali/ali rabbits because the a-allotype encoding V(H)1 gene, which is normally used in

128 and instead, most B-lineage cells use the a-allotype encoding V(H)4 gene [V(H)4(a)], which results i

129 psoriatic arthritis susceptibility, and that allotypes encoding P2 pockets that bind side chains oppo

130 Furthermore, CD16A-158V and G1m3 allotypes enhanced ADCC against opsonized HSV-1-infected

131 ith the observation that all orangutan MHC-C allotypes examined have the C1 motif.

132 at uses primarily the long 3'UTR, whereas an allotype expressing only the short form was unaffected.

133 Caucasian subjects with gastric cancer were allotyped for several GM and KM markers.

134 ement for a combination of at-risk DR and DQ allotypes for the initiation of spontaneous autoimmunity

135 d to determine possible protective candidate allotypes for vaccine development.

136 Allotypes from four divergent HLA-B families (B8, B15, B

137 ven T cell receptor by different MHC class I allotypes from separate species.

138 ot necessarily correlate with the potency of allotype function.

139 Because every HLA-C allotype functions as a ligand for KIR, the interactions

140 Comparative peptide mapping of these B15 allotypes further pinpoints endogenously processed ligan

141 weaker for IgG3 than for IgG4 in the case of allotype G3m(c3c5*/6,24*), whereas G3m(s*/15*) was equal

142 ussed, along with the influence of Km and Gm allotype genes on pneumococcal polysaccharide vaccines.

143 gastric cancer is associated with GM and KM allotypes, genetic markers of IgG heavy chains and kappa

144 mined the role that immunoglobulin GM and KM allotypes-genetic markers of gamma and kappa chains, res

145 Immunoglobulin GM and KM allotypes-genetic markers of gamma and kappa chains, res

146 omain, where 3DL1*004 resembles 3DL1*005, an allotype giving low DX9-binding phenotype.

147 Immunoglobulin gamma-chain allotypes Gm(1), Gm(17) (odds ratio for both 11.3, P = 0

148 termine the locus specificity (alphaVal-76), allotype group specificity (a dimorphism alphaAsn-80/Lys

149 The GM 13 allotype has been confirmed as a risk factor in Caucasia

150 sent only on some haplotypes, and each MHC-C allotype has the C1-epitope.

151 ides bound to HLA-DQ and, especially, HLA-DR allotypes have been described in some detail, few ligand

152 The five common Japanese KIR3DLI allotypes have distinguishable inhibitory capacity, freq

153 In contrast, HLA-C allotypes have four glycan structures, comprising those

154 All MHC-B*08 allotypes have the C1-epitope motif recognized by killer

155 HLA-B allotypes having four different Bw4 motifs were examined

156 gnized by killer cell Ig-like receptors, and allotypes having neither epitope.

157 hey are each of a different functional type: allotypes having the Bw4 epitope recognized by killer ce

158 y killer cell Ig-like receptors of NK cells, allotypes having the C1 epitope also recognized by kille

159 Thus, the strict conformation of HLA-Bw4 allotypes, held in place by the Glu(76)-Arg(83) interact

160 /lpr and B6/lpr bone marrows into irradiated allotype heterozygous F1 mice.

161 K) and the presence of its ligand, the HLA-C allotype HLA-C2, expressed by fetal trophoblasts, reduce

162 the specific recognition of the MHC class I allotypes HLA-Cw*0401 and HLA-Cw*0304 by the killer cell

163 However, owing to differences across KIR3DL1 allotypes, HLA-Bw4, and associated peptides, the mechani

164 Compared with other classical MHC-I allotypes, HLA-C has low cell surface expression and an

165 nstrate that the peptides bound by these B15 allotypes i) vary in length from 7 to 12 residues, and i

166 cells transfected with different HLA class I allotypes (i.e., -Cw4, -Cw3, -B7) confirmed that the inh

167 Complete allotype identification and designation of its respectiv

168 However, as Alicia rabbits age, VHa2 allotype Ig is produced at high levels.

169 , IgA1 and IgA2, with IgA2 existing as three allotypes, IgA2m(1), IgA2m(2) and IgA2(n).

170 s, IgA1 and IgA2, with IgA2 present as three allotypes: IgA2m(1), IgA2m(2), and IgA2m(n).

171 bound immunoglobulin E antibodies of the 'b' allotype (IgE(b)) as well as IgG2a and IgG2b antibodies.

172 4 binds to immunoglobulin (Ig)G2a of the "a" allotype (IgG2aa) and not to IgG2ab.

173 eptor is a RF that recognizes IgG2a of the j allotype (IgG2aj), but not the b allotype, was used in t

174 lls in neonatal Alicia rabbits express V(H)n allotype immunoglobulin (Ig)M.

175 HLA-C expression, was assigned to each HLA-C allotype in 1975 patients and their HLA-C-mismatched unr

176 ll response in the context of the Mamu-B*008 allotype in SIV-infected rhesus macaques.

177 ounts of dimeric SCR-6/8 were found for both allotypes in 50 mM, 137 mM and 250 mM NaCl buffers.

178 mbinations were selected in which measurable allotypes in donors were not present in recipients.

179 ic analysis cannot be used for measuring CFH allotypes in some sources of human plasma and other biol

180 emonstrates how a difference between KIR3DL1 allotypes in the D0 domain profoundly affects cell surfa

181 KIR3DL1*004, a common KIR3DL1 allotype, in combination with Bw4(+) HLA-B, slows progre

182 expressing two different Ig kappa L chains (allotype included) have been occasionally observed.

183 mmary, our studies demonstrate that Ig kappa allotype-included B cells are present in the mouse matur

184 Abs, our studies suggest a potential role of allotype-included B cells in both physiological and path

185 Finally, we found that Ig allotype-included B cells that coexpress autoreactive an

186 nt to FcgammaRIIIA (both Phe-158 and Val-158 allotypes), increased ADCC activity in vitro, and strong

187 , along with Ii's compact 118-192 domain, to allotype-independent class II binding.

188 in the heavy chain, as expected, since these allotypes inhibit lysis by NK cells expressing KIR2DL1.

189 Featured among the selected clones with b9 allotype is a rabbit/human Fab that binds with a dissoci

190 The FasL.2 allotype is expressed in BALB/c mice and exhibits increa

191 *004 membrane traffic in NK cells shows this allotype is largely misfolded but stably retained in the

192 The prevalence of specific ERAP1 allotypes is different between AS cases and controls.

193 ression of human leukocyte antigen C (HLA-C) allotypes is mediated by the binding of a microRNA, miR-

194 , reduced aggregation of tapasin-independent allotypes is observed.

195 major pathway for the clearance of all IgA2 allotypes is the liver.

196 arides associated with nine HLA-A, -B, or -C allotypes isolated from EBV-transformed B cell lines and

197 cell lines and mixtures of HLA-A, -B, and -C allotypes isolated from pooled PBLs revealed a very rest

198 l experiment, we found that the rare KIR3DS1 allotype KIR3DS1*014 binds HLA-Bw4 even though it differ

199 (odds ratio 7.3, P = 0.005) and kappa-chain allotype Km(3) (odds ratio 7.3, P = 0.005) were risk fac

200 Allotype-marked chimeras indicated that autoantibody pro

201 system in which mice were reconstituted with allotype-marked mature peritoneal B-1a cells and adult b

202 Using allotype markers, it is possible to adoptively transfer

203 It was concluded that the His402 allotype may self-associate more readily than the Tyr402

204 protein that are presented with diverse HLA allotypes may allow widespread protective immunization w

205 rred from recipient plasma CFH Y402H protein allotype, measured using enzyme-linked immunosorbent ass

206 Because IgG1 allotypes might have different half-lives, their influen

207 ain causes Pt-KIR3DL1/2 to bind Bw4(+) HLA-B allotypes more avidly than does KIR3DL1.

208 nctional similarities to HLA-B*57, the human allotype most strongly associated with delayed HIV-1 pro

209 le rule through interactions with several C2 allotypes, notably Cw*0501 and Cw*0202, and two HLA-B al

210 from donors who were homozygous for the H131 allotype of Fcy receptor IIa (CD32), it was found that L

211 phenotype of mice lacking Ii depends on the allotype of the MHC class II molecule.

212 odies against the human platelet Ag (HPA)-1a allotype of the platelet beta(3) integrin GpIIb/IIIa can

213 (Arg(102)) and disease-linked C3F (Gly(102)) allotypes of C3b were experimentally explained for the f

214 killer (NK) cells are inhibited by specific allotypes of class I major histocompatibility complex li

215 ve Tyr402 and the AMD-risk His402 homozygous allotypes of FH and both the recombinant SCR-6/8 allotyp

216 he unique genes in USA300 clustered in novel allotypes of mobile genetic elements.

217 is a highly polymorphic molecule comprising allotypes of single nucleotide polymorphisms.

218 inding specificities of two Bw4 and four Bw6 allotypes of the B15 family.

219 Allotypes of the natural killer (NK) cell receptor KIR3D

220 r and their HLA ligands, and CD16A and CD32A allotypes of variable affinity for IgG subclasses were a

221 or KIR2DL3 (KIR2DL2/3) with HLA-Cw3-related allotypes on melanomas resulted in decreased tumor cell

222 rscoring the direct influences of Fc gamma R allotypes on receptor function.

223 are codominantly expressed, and analysis of allotype pairs provided clear stratification of individu

224 Functional analyses demonstrated that ERAP1 allotype pairs seen in AS cases were poor at generating

225 ives, their influence on infliximab (G1m17,1 allotype) pharmacokinetics was investigated in a group o

226 Recipient plasma CFH Y402H protein allotype predicted donor CFH Y402H genotype with 100% ac

227 The macaque A2*05 allotype prefers the basic amino acid arginine at the se

228 on, facilitates KIR3DL1 binding, whereas Bw6 allotypes present a platform on the alpha1 helix that is

229 7 substitution represents yet another Ckappa allotype, provisionally designated Km4.

230 tting technique was used to estimate the two allotype PrP fractions in PrP(res) material from BSE-inf

231 long with KIR specificity for particular HLA allotypes, raises the possibility that any given individ

232 that a single KIR specific for several HLA-B allotypes recognizes a subset of peptides bound to HLA-B

233 bset responses were defined by donor KIR/HLA allotypes, reflecting the differences in interaction bet

234 rences in peptide-binding specificity of B15 allotypes related by conversion events that replaced seg

235 tides endogenously bound by a group of HLA-B allotypes related to HLA-B7.

236 m effect is quite different although the ARR allotype remains the least susceptible.

237 ore, endogenous peptide loading into the B15 allotypes requires that a conserved C terminus be anchor

238 n of the NK cell receptor KIR3DL1 by HLA-Bw4 allotypes resulted in inhibition of cytotoxicity against

239 Comparing two MHC allotypes revealed allotype-specific differences in hydr

240 self-associate more readily than the Tyr402 allotype, SCR-6/8 is partly responsible for the folded-b

241 B*1501, B*1503, and B*1508 because these B15 allotypes share identical C-terminal anchoring pockets w

242 The His402 allotype showed a slightly greater self-association than

243 stent with previous findings that some HLA-B allotypes shown to be tapasin independent are associated

244 For some allotypes, single evasins largely abolished T cell recog

245 All isolates had the same speA allotype, speA2.

246 -6.1 and Ly-6.2) Ab with a mouse anti-Ly-6.2 allotype specific Ab, with emphasis on both Ly-6.2 and L

247 lecules are ternary complexes composed of an allotype specific heavy chain, a noncovalently associate

248 ion in these mice was hapten-, carrier-, and allotype-specific as well as MHC restricted.

249 uced by each donor could be distinguished by allotype-specific assays.

250 Comparing two MHC allotypes revealed allotype-specific differences in hydrogen-deuterium exch

251 Allotype-specific ELISA showed that most autoantibody wa

252 her distinguished by its dependence on MHC-I allotype-specific epitope recognition for Ag uptake.

253 t different HCMV evasins exhibited different allotype-specific patterns of interference with CD8 T ce

254 as responsible for the post-transcriptional, allotype-specific regulation of MHC-I.

255 r analysis enables us to provide a model for allotype-specific T cell recognition of Ld vs Kb class I

256 the CD8 T cell evasins of HCMV display MHC I allotype specificity, complementarity, and cooperativity

257 44 of KIR2DL2 and Asn 80 of Cw3 confers the allotype specificity.

258 ttering also showed that both FH and SCR-6/8 allotypes strongly aggregated at >10 muM zinc.

259 th those obtained previously for other HLA-B allotypes, suggest a general trend whereby polymorphism

260 ll lines transfected with HLA-Bw4 80I or 80T allotypes, suggesting that if KIR3DS1 does recognize HLA

261 2DS), did not bind to any of the HLA class I allotypes tested.

262 -life in patients homozygous for the G1m17,1 allotypes than in those carrying the G1m3 with no G1m1 (

263 opes presented by the protective HLA-B*57:01 allotype that facilitate productive interactions with KI

264 RNA increased surface expression of an HLA-A allotype that uses primarily the long 3'UTR, whereas an

265 For those orangutan MHC class I allotypes that are detected by human monoclonal anti-HLA

266 pecific clones recognize two groups of HLA-C allotypes that are distinguished by a dimorphism at resi

267 with peptides compared to tapasin-dependent allotypes that belong to the same supertype, and, during

268 o lineages of polymorphic inhibitory KIR3DL1 allotypes that recognize Bw4 epitopes of protein">HLA-A

269 d seven members of the B15 family shows that allotypes that share sequence identity in the alpha 1 he

270 rtoire presented by a protective HLA class I allotype, thereby enhancing our mechanistic understandin

271 sed STAT5b-CA mice (which express the IgM(b) allotype) to IgM(a) allotype congenic mice.

272 r human subclasses, including polymorphisms (allotypes), using real-time monitoring of Fab arm exchan

273 A set of four allotype variants of adalimumab (G1m17,1; G1m17,-1; G1m3

274 four human IgG subclasses shows subclass and allotype variations but no clear subclass affinity diffe

275 Of interest, the GM 13 allotype was a risk factor for juvenile DM in both Cauca

276 The transgene allotype was also expressed in Abs formed on immunizatio

277 sion level of the patient's mismatched HLA-C allotype was associated with increased risks of grades I

278 autoimmune C57BL/6 background, the transgene allotype was expressed on B cell surfaces and in serum I

279 In addition, although no Gm phenotype or allotype was identified as a risk factor in whites, Gm 2

280 In some instances, an additional allotype was present in a recipient but not in a donor.

281 odies (OR 3.4, Pcorr=0.0031), while the GM 3 allotype was protective in adults with anti-threonyl-tra

282 t epitopes presented by the same given MHC I allotype was uniformly reduced.

283 of expression of patients' and donors' HLA-C allotypes was evaluated in multivariable models.

284 or KIR2DL3 in combination with group 1 HLA-C allotypes was more frequent in exposed seronegative avir

285 2a of the j allotype (IgG2aj), but not the b allotype, was used in this study to investigate how the

286 1 and DQA1 alleles, and immunoglobulin Gm/Km allotypes were compared between 138 Mestizos with IIM an

287 rs for IIM in Mestizos; however, no Gm or Km allotypes were risk or protective factors in Caucasians.

288 and DQB1 oligotyping, as well as C4 and CR1 allotyping, were carried out by standard methods.

289 In contrast, HLA-A allotypes, which have a Bw4 motif identical with one of

290 ll vary with the receptors engaged and their allotypes, which, in turn, reflect properties of the imm

291 ence on peptide-binding specificity of HLA-B allotypes, while amino acid substitutions in the alpha 2

292 C3b, C3u, C3c, and C3d, using the wild-type allotype with Arg(102).

293 this study, was shown to bind Mamu-KIR3DL01 allotypes with an aspartic acid at position 233.

294 resulting in CD16A-valine/phenylalanine-158 allotypes with different IgG affinity, variations condit

295 Thus, genes encoding allotypes with diminished activity have been suggested a

296 s of mAbs, the interaction of different IgG1 allotypes with FcRn was examined using cellular assays a

297 confined to D0, KIR3DS1 is rare and KIR3DL1 allotypes with similar binding sites predominate.

298 types of FH and both the recombinant SCR-6/8 allotypes with Tyr/His402.

299 hierarchies of specificity for each KIR3DL1 allotype, with KIR3DL1*005 recognizing the widest array

300 ed a small number of cells with incompatible allotypes within fields of developing cells with compati