ライフサイエンスコーパス: allylsilane

1 oped for the synthesis of highly substituted allylsilanes.

2 used to access densely functionalized chiral allylsilanes.

3 hat normally observed with alkyl-substituted allylsilanes.

4 Attaching a modified allylsilane 29a-c to C(2)OH of methyl mannoside 15 impro

5 Si(tBuN)]}2) precatalysts in the presence of allylsilane, 3-butenylsilane, 5-hexenylsilane, and 7-oct

6 It was then possible to convert acetal 28 to allylsilane 32 followed by cyclization to the alkaloid t

7 allylic transposition yielding the exocyclic allylsilane 3a with excellent diastereoselectivity.

8 lective Mukaiyama-type [3 + 2]-annulation of allylsilane 5 with the unsaturated aldehyde 9a to assemb

9 done reduction followed by a stereoselective allylsilane addition to a N-sulfonyliminium ion.

10 Allylsilanes afforded tetrahydropyrans in 34-67% yields,

11 nship between Mn and [alkenylsilane](-1) for allylsilane and 3-butenylsilane, and a superlinear relat

12 annulation reaction between a C1-C8 hydroxy allylsilane and an aldehyde comprising C9-C13.

13 This pyran was transformed to a new hydroxy allylsilane and then coupled with a preformed C ring ald

14 The Prins cyclization of syn-beta-hydroxy allylsilanes and aldehydes gives cis-2,6-disubstituted 4

15 eta-(triethylsilyloxy)aldehydes with several allylsilanes and crotyldimethylphenylsilane is described

16 ions of cyclization reactions between chiral allylsilanes and N-acyliminium ions, it was discovered t

17 c substitutions of 3 with Grignard reagents, allylsilane, and triethyl phosphite gave N,N'-disubstitu

18 Arylated alkenes, dienes, allylsilanes, and enynes are accessed using this procedu

19 luated and enhanced utilizing diastereomeric allylsilanes anti-5 and syn-5 to establish an efficient

20 er N-heterocyclic carbene (NHC) ligands, and allylsilanes are produced via palladium catalysis with s

21 When the anti-beta-hydroxy allylsilanes are used, the Prins cyclization gives predo

22 ionalized compounds such as the alpha-ureido allylsilanes as well as carbamate derivatives.

23 reoselective fluoride-initiated additions of allylsilanes (aza-Sakurai reaction).

24 pyrans as mixtures of two diastereomers with allylsilane, but only a single diastereomer was observed

25 nolide K (1) based on asymmetric addition of allylsilane C1-C8 to enal C9-C22 is reported.

26 The divergent reactivity of the allylsilanes can be controlled to afford a range of nove

27 a suitably positioned benzyloxy group on the allylsilane component caused a reversal in the diastereo

28 osomi-Sakurai coupling of complex acetal and allylsilane coupling partners, followed by DDQ-promoted

29 fficient asymmetric synthesis of alpha-amino allylsilane derivatives is reported.

30 ith silyl enol ethers, silyl ketene acetals, allylsilanes, enamino esters, and diazomethanes have bee

31 nd accounts for the observed selectivity for allylsilane formation.

32 atalyst, providing vastly improved yields of allylsilanes from simple alkene starting materials.

33 Allylsilanes generated through these processes are susce

34 thermal Claisen rearrangement to provide the allylsilanes in excellent yields and diastereoselectivit

35 alternatively, the reactivity of the cyclic allylsilane intermediate can be harnessed to introduce a

36 The synthesis of E allylsilanes is accomplished with palladium NHC catalyst

37 st catalytic asymmetric carboannulation with allylsilanes is presented.

38 e for crotylsilanes was longer than that for allylsilanes likely due to the increased steric hindranc

39 ion to the alkaloid tricyclic core 33 via an allylsilane/N-sulfonyliminium ion cyclization.

40 derstood by intramolecular allylation of the allylsilane on to the activated anomeric center, followe

41 1-yl)-1-substituted-pyrrolidin-2-ones 9 with allylsilanes, organozinc reagents, and phosphorus compou

42 Ring-closing alkene metathesis of allylsilanes provides intermediates that can be protodes

43 subsequent S(E)' electrophilic desilylation (allylsilane RCM/S(E)') to construct exo-methylidenecyclo

44 The development of a strategy consisting of allylsilane ring-closing metathesis and subsequent S(E)'

45 ate nucleophiles to carbon analogues such as allylsilane, silyl enol ether, and silyl ketene iminal b

46 in 8 with NaBH(4), NaCN, triethyl phosphite, allylsilanes, silyl enol ether and Grignard reagents aff

47 es 4a and 4b react with nucleophiles such as allylsilanes, silyl ethers, and organozinc reagents to a

48 ns 18 and 27 reacted with Grignard reagents, allylsilanes, silyl ethers, and triethyl phosphite to pr

49 ss of the aldehyde (R'') or syn-beta-hydroxy allylsilane substituent (R') used.

50 ocyclization of an N-acyliminium ion with an allylsilane to form the A/C rings as the key step.

51 ddition reactions of allyl and 3-substituted allylsilanes to indolizidine and quinolizidine alpha,bet

52 to lie between that of an enol ether and an allylsilane trapping group.

53 y enol silanes, ketene acetals, alkenes, and allylsilanes using chiral transition metal-phosphine com

54 tert-butyl)phosphine, for the preparation of allylsilanes using the palladium-catalyzed silyl-Heck re

55 The Sakurai reaction of an allylsilane with an azido-containing enone under Lewis a

56 trans-4-octene also exclusively produces the allylsilane with the silicon located at the terminus of

57 lefins to selectively form the corresponding allylsilanes with commercially relevant tertiary silanes