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1 eport 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at l
2 VP increased mRNA and protein levels of AQP2 alongside 14-3-3beta and -zeta, whereas levels of 14-3-3
3 cate MRSA biofilms or non-biofilm persisters alongside 14.
4  samples, 4 different microarray platforms), alongside 17 RNA-Seq data files (7 SCN and 10 WB).
5  The blind cohort comprised 1726 individuals alongside 1726 matched controls; 39% were men, and the m
6 imantan show that 2015 ranked after 1997 and alongside 1991 and 1994 as among the worst episodes on r
7 rs of age (59 by medical record review only) alongside 371 controls.
8 nosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ0) synthesis and D
9  recent changes are discussed in this paper, alongside a brief overview of HbA1c contemporary assays
10    Hence, we argue for a molecular evolution alongside a clinical and phenotypic re-evaluation.
11 alth system perspective using data collected alongside a cluster-randomised trial.
12                             This is compared alongside a comprehensive review of FA profiles of Ulva
13 ial fatty acids have significantly increased alongside a decrease in EPA and DHA levels.
14 heric pCO2 in response to solar brightening, alongside a decrease in hydrothermal exchange between se
15  list of the equipment and reagents required alongside a detailed description of the methodology for
16 ety of antagonistic solid state interactions alongside a distinct dual guest pore system.
17  used a corelative design with full siblings alongside a general Swedish population sample.
18 tially be arranged either as a GluK2 homomer alongside a GluK5 homomer or as two GluK2/K5 heterodimer
19 ssfully shown to exhibit high odour potency, alongside a high potential to influence the overall arom
20 saturation, and sampling depth are presented alongside a high-resolution microendoscopy image of oral
21  model of post-WGD radiation, which occurred alongside a major delay in the rediploidization process.
22 functional magnetic resonance imaging (fMRI) alongside a perceptual oddity task, modified from nonhum
23 airs, each having a unique dilution pattern, alongside a quality control (QC) that serves as a refere
24                                              Alongside a weakening monsoon circulation, the locally a
25 rease in internal CO2 partial pressure (ci ) alongside acclimation of photosynthetic capacity, (ii) v
26 veals how cyclin-substrate specificity works alongside activity thresholds to fine-tune the patterns
27 , preemptively targeting MCL-1 and/or BCL-XL alongside administration of ABT-199 was capable of delay
28 onitoring, insulin pumps, smart algorithms), alongside advances in stem cell biology, cell encapsulat
29  the organic complexing agent cysteine (Cys) alongside Ag only marginally moderated toxicity, implyin
30                               Using TUG-1387 alongside AH-7614, we show that endogenous activation of
31  the result of impaired lysosomal tubulation alongside ALR activation is massive cell death.
32 lecting top-down engagement of the circuitry alongside altered reward processing in pain conditions.S
33 ide an explanation for bacterial coexistence alongside an activate neutrophil infiltrate.
34  damage, visualization might also be reduced alongside an inability to detect the adverse emotional r
35 nd related problems are on the rise globally alongside an increase in the potency of cannabis sold on
36 TR length has expanded approximately tenfold alongside an increased generation of alternative 3'-UTR
37 N: Delivery of personalised risk information alongside an invitation to an introductory session more
38 offered to infants at 2 months and 4 months, alongside an opportunistic catch-up for 3 month and 4 mo
39 ed) burial experiments have been undertaken, alongside analysis of artifacts excavated from the site,
40 y, these highly variable receptive fields go alongside and are in fact required for an invariant repr
41  intubation that we have recently developed, alongside appropriate analgesia and monitoring.
42          Differences in breed susceptibility alongside associations with MHC and other canine immune
43 by social learning and cultural transmission alongside biological evolution.
44 tiation of drug withdrawal and at rejection, alongside blood samples collected during the weaning pro
45 soforms have defective RGC axon organisation alongside brain vascular defects.
46 ls of risk of EOC that may warrant their use alongside BRCA1 and BRCA2 in routine clinical genetic te
47  quality, and supply chains are still needed alongside broader dissemination of work products.
48 al patient choice for psychological therapy, alongside CBT, for adolescents with moderate to severe d
49            The synergistic effect of polymet alongside CDDP demonstrates that polymet-CDDP NPs can ac
50      Recording of circadian behavior in vivo alongside cellular molecular pacemaking in SCN slices in
51 neous and pharmacologically induced seizures alongside changes in the cholinergic pathway genes, impl
52 ement of general infection control measures, alongside chemical disinfection.
53 nd in alternating blocks, to receive placebo alongside chemotherapy and then placebo only maintenance
54  for exosome inhibitors as treatment options alongside chemotherapy for overcoming PDAC chemoresistan
55 ; concurrent), or cediranib 20 mg once-daily alongside chemotherapy then cediranib 20 mg once-daily m
56 rm A; reference), cediranib 20 mg once-daily alongside chemotherapy then placebo only maintenance (ar
57 romide, and brominated analogues were formed alongside chloroform.
58                                              Alongside, chromatin architecture combined with ChIP-seq
59 well as human influence should be considered alongside climate in national wildfire policy and manage
60                    This strategy may operate alongside co-receptor imposed MHC restriction, freeing g
61                  Frailty should be monitored alongside cognitive functioning when assessing risk fact
62 probes have also achieved greater prominence alongside complementary biological reagents for target v
63 demand, and use of BPG should be prioritized alongside congenital syphilis elimination efforts.
64                          Warmer temperatures alongside consecutive droughts could make up to 85% of r
65  benefit of acquiring J-resolved experiments alongside conventional 1D (1)H NMR as part of routine me
66 rain anatomy characteristics across Biotypes alongside conventional diagnoses, examining gray matter
67 ing LC-MS in biopharmaceutical HCP profiling alongside conventional ELISA, because individual species
68 rated modelling of intracellular Mtb killing alongside conventional extracellular Mtb killing data, g
69 e ubiquity of small-world topologies arising alongside cooperation in the real world.
70 ological data were collected on all patients alongside correlating autonomic and cardiac assessments.
71                            Sample clustering alongside correlative assessment revealed variation in t
72 nsignificant predictor of pain when analysed alongside craniocaudal location of lesions.
73 species may be maintained at low frequencies alongside cryptic morphs.
74      In mammals, compartmental domains exist alongside CTCF loop domains to form topological domains.
75 animals to optimize physiology and behaviour alongside daily changes in the environment.
76 ysis of SWOG S8736 and evaluating these data alongside data from similar patients receiving rituximab
77 omen younger than 35 years in SOFT and TEXT, alongside data from the cohort of older premenopausal wo
78 sion of osteoclast-specific genes (p < 0.05) alongside decreased osteoclast formation (p < 0.0001) in
79 , asymmetric and symmetric dimethylarginine, alongside decreases in sphingolipids, indicate that both
80 at evolutionary processes must be considered alongside demographic ones to better understand and pred
81  single dose of 0.25 mg/kg primaquine, given alongside dihydroartemisinin-piperaquine, was safe and e
82                                              Alongside DNA methylation and histone modifications, bro
83 al saliency, visually guided behaviours and, alongside dorsal portions of the posterior thalamic nucl
84 to the microbial community changes occurring alongside drought-driven carbon release from peatlands,
85 cal applications, we have demonstrated that, alongside drug loading, functional proteins can be tethe
86     The topography of these vessels, running alongside dural venous sinuses, recapitulates the mening
87 timally n-doped to support high Q resonances alongside electrochemical processes in situ.
88 G) electrode array and subsequently use this alongside electrophysiology, fluorescence microscopy, op
89 r transcript were detected in the cytoplasm, alongside elevated expression of NF-kappaB pathway genes
90 Fs) within a customized extracellular matrix alongside embedded vasculature, which is subsequently li
91 Tim-4(neg) macrophages are transient, reside alongside embryonically derived T cell immunoglobulin an
92 ng materials or intermediates are discussed, alongside emerging applications such as the use of group
93 formation of anterograde memories, and mood, alongside enhancing hippocampal neurogenesis.
94 t, however, to analyze social collaborations alongside environmental patterns, especially among local
95                    The licensed IP3Rs reside alongside ER-plasma membrane junctions where STIM1, whic
96 as genetic instruments need to be considered alongside established and new methods for undertaking Me
97          We anticipate that PCI will be used alongside established, fluorescence-based techniques to
98  of personal ornamentation and portable art, alongside evidence for pigment processing and use in dep
99 is based on neurological symptoms and signs, alongside evidence of dissemination of CNS lesions in sp
100                       In comparative studies alongside existent MNA techniques, SMAL MNAs were found
101  considered when making treatment decisions, alongside existing evidence that patients with COPD and
102 ction of European strains of M. tuberculosis alongside expansion of selected indigenous strains havin
103                                              Alongside experimental studies, computational models off
104 robes are non-photobleaching and can be used alongside fluorophores without interference.
105 ors, such as RORgammat, Bcl-6, or PPARgamma, alongside Foxp3.
106 ontinued evaluation of FLT3-directed therapy alongside front-line AML treatment.
107 splays profile matches (protein annotations) alongside gene models, exposing how alternative promoter
108 Ra2 in head kidney and spleen of adult fish, alongside genes coding IGF hormones, highlighting a stro
109 gies that incorporate functional information alongside genetic associations have proved successful in
110  discern the impact of obesity, alone versus alongside genetic disruption of the ISR, on mechanisms o
111 sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptome, and DNA methylome analy
112 0), PBC (n = 10), and ALD (n = 10) patients, alongside genomic human leukocyte antigen typing.
113 mall viruses that co-infect eukaryotic cells alongside giant viruses (Mimiviridae) and hijack their m
114  and is compatible with simultaneous imaging alongside green fluorescent protein-based indicators.
115 mation of testosterone, and reduced strength alongside growth arrest for up to 2 years after injury.
116 veal that EP400 deposits H3.3 into chromatin alongside H2AZ and contributes to gene regulation after
117                  Enhanced coral respiration, alongside high particulate organic content of the lagoon
118 with high intra-population diversity coexist alongside high-abundance populations with low genomic di
119 ith decreased water intake and urine volume, alongside higher urine osmolality.
120 complex II succinate dehydrogenase subunit A alongside hyperpigmentation suggested coregulation of ac
121                                              Alongside IL-17 induction, we observed induction of IFN-
122 n on regulatory T cells, and CTLA-4 blockade alongside IL-2 treatment in vivo prevented the decrease
123  proliferated and secreted TH1/TH2 cytokines alongside IL-22 after drug stimulation.
124  into plumage arrangement and microstructure alongside immature skeletal remains.
125                                              Alongside implementation of an autofocus unit that compe
126    Clear guidelines are needed for retesting alongside improved diagnostic tests.
127 ss had substantial weight loss over 5 years, alongside improvements in comorbidities and risk factors
128 , low-sodium fresh water should be developed alongside improvements in MAR and evaluated in "real-lif
129 , lost P flows must be recovered and reused, alongside improvements in P-use efficiency.
130                                              Alongside in vivo and in vitro techniques, it is instruc
131 ession of GH release in MC4RKO mice occurred alongside increased adiposity and the progressive worsen
132 affic injuries and fatalities have increased alongside increased use of motorised transport in China,
133 sula is well documented [1-5], with warming, alongside increases in precipitation, wind strength, and
134 of hypertension increased from 1996 to 2013, alongside increases in traditional hypertension risk det
135  that this increase in performance can occur alongside increasing temporal autocorrelation and should
136 sive regional phylogeny for 39 000 species alongside information on dispersal strategies and climat
137 hods and synthetic applications are analyzed alongside innate advantages as well as future challenges
138 ed loci, causing unwanted mutations (indels) alongside intended changes.
139                                              Alongside its high performance, NaviSE is able to provid
140 with resting-state functional MRI (rs-fMRI), alongside its structural and metabolic integrity, aiming
141 , odonates, amphibians, crayfish and turtles alongside key features within and between catchments, su
142                       Genetic data were used alongside landscape data to examine the influence of the
143                                              Alongside, latest developments on computational side bas
144 from the sand fly are egested into host skin alongside Leishmania parasites.
145 photosynthetic parameters were characterized alongside lipid accumulation.
146  with transmission to contact-exposed birds, alongside long incubation periods, may enable unrecogniz
147 tes in patients with first-episode psychosis alongside matched controls.
148 e no consistent fitness benefits of breeding alongside mites.
149 ines, and explored phenotypes of these lines alongside models of pan-cellular or CNS-specific heteroz
150 iginated and evolved over thousands of years alongside modern human populations.
151 widespread identification of parental biases alongside monoallelic expression in brain tissues, discu
152                Increased activity and energy alongside mood change are identified in the DSM-5 as car
153            Evaluating statistical hypotheses alongside more interesting ecological ones is important
154 se the emergence and evolution of eukaryotes alongside more rapidly evolving prokaryotes, archaea, an
155 nant skin featured mature IgG and CD22 mRNA, alongside mRNA for the transiently-expressed enzyme Acti
156 gh high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cas
157 rd1a) cells with an intrinsic period of 24 h alongside non-Drd1a cells with 20-h clocks.
158  fibers encompassing internal porous domains alongside non-porous insulating and conductive materials
159 These imprinted monoliths were characterized alongside nonimprinted monoliths by a variety of techniq
160 egulated in HLHS-iPSC-derived cardiomyocytes alongside NOTCH target genes confirming downregulation o
161  we provide a set of predictive tools to use alongside NSP ELISAs to help target persistently infecte
162 commencing important intersectoral dialogue, alongside opportunities for future disease-specific refi
163 er of cases alkyne trans-haloboration occurs alongside, or instead of, borylative cyclization and the
164 ion and genetic variation deserves attention alongside other factors that promote or constrain evolut
165 through the Levant and into Europe, possibly alongside other lineages from a Levantine refugium; and
166 ective well-being (r g = -0.68, s.e. = 0.03) alongside other mental health traits.
167 ective well-being (r g = -0.68, s.e = 0.03) alongside other mental health traits.
168 served transcriptional response to adversity alongside other proposed measurements of biological embe
169 at researchers can readily access these data alongside other relevant information.
170  is often considered an important component, alongside other renewables, to mitigate global warming a
171                                   Considered alongside other robust determinants, dietary carbohydrat
172 ion involving health and education agencies, alongside other social and educational changes, has prob
173 th equality is increasingly being considered alongside overall health gain when assessing public heal
174                      Thus, PAR2 can be added alongside PAR1 and PAR4 to the targets, whereby thrombin
175 g a single visit, with infants receiving IPV alongside pentavalent vaccine (which covers diphtheria,
176 ndings suggest that IIV should be considered alongside personality in studies of predator-prey intera
177  use in vivo electrophysiological recordings alongside pharmacological inactivation or optogenetic ex
178 wever, mercury methylation is known to occur alongside photochemical and microbial mercury reduction
179  (e.g., goodness-to-badness) are represented alongside physical dimensions of the external world.
180 s injected with the rhlI/lasI mutant PAO-MW1 alongside plasma treated N-butyryl-homoserine lactone an
181 eed to expand malaria diagnosis capabilities alongside policy requirements for mandatory testing befo
182                                              Alongside population fluctuations, we found that communi
183                                              Alongside post-mortem Pt determination in the tissues, t
184 lth should be promoted as a topic of enquiry alongside poverty and health.
185              The CA model was therefore used alongside predictions of exposure for different European
186                          Predators coevolved alongside prey bacteria and so encode diverse predatory
187 ed by public TCRs present in all individuals alongside private TCR repertoires specific to each indiv
188 inated during the late Palaeogene (30-40 Ma) alongside progenitors of other desert marsupials, and th
189 r biodiversity protection and carbon storage alongside promoting areas of high-yield cattle productio
190                How homeostasis is maintained alongside protective mechanisms against damage is unclea
191 the mitochondrial complex I assembly complex alongside proteins ACAD9, ECSIT, NDUFAF1, and TIMMDC1.
192                                     Finally, alongside protracted conflicts, widening of health and s
193 patients remaining on treatment at month 24, alongside rapid decreases in LIC in this heavily iron-ov
194 rmance, and so results need to be considered alongside real-world, long-term safety and effectiveness
195 orted to control cell motility in monocytes, alongside reduced VLA-4 expression, an integrin predomin
196 genes involved in oxidative phosphorylation, alongside reduction in absolute gene expression levels a
197 ions and delivery methods for existing drugs alongside research into novel pharmacological entities.
198 ss spectrometry has added a third dimension (alongside retention time and exact mass) to aid in the i
199 sks of drug-related or alcohol-related death alongside risks of suicide.
200  considers environmental impacts of products alongside risks to human health, which is consistent wit
201 ns Asp4 and Asp5 have been suggested to work alongside SecY2 to form the translocon, similar to the a
202 annotate such models with estimated accuracy alongside sequence and structural properties including p
203 a) samples and 166 Gt3a samples and analyzed alongside sequences from public databases.
204 complex and compact lightwave circuits in LN alongside Si photonics with fabrication ease and low cos
205  isolectin B4 (IB4) or laminin (LN) are used alongside simultaneous immunofluorescence on the same se
206 arable to levels in CRC cells, but increased alongside SLC4A2 expression under stimulation with trans
207 hesis by deploying pairs of surface drifters alongside small green (Chelonia mydas) and Kemp's ridley
208 e for patients, carers and specialist nurses alongside some unique features, specific to the end of l
209 that temporal structure should be considered alongside spatial structure as an important process affe
210   Targeting comorbidities with interventions alongside specific AML therapy might improve survival.
211 u Raman and ultraviolet-visible spectroscopy alongside spectroelectrochemistry and quantum chemical c
212 essed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN-gam
213      We mapped six distinct glacial moraines alongside Stocking Glacier in the McMurdo Dry Valleys, A
214 s cofactors in specific biological pathways, alongside studies that attempted to dissect these activi
215 exchange is the optimal management approach, alongside supportive care.
216  of functional and patient-reported outcomes alongside survival.
217 ds with wide-ranging synthesis requirements, alongside synthesis development efforts.
218 apable of supporting the development of SIgA alongside systemic immunity and delivery systems that im
219 on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cel
220 en (MSM) completed behavioral questionnaires alongside tests for HIV and sexually transmissible infec
221 ost of treating conjunctivitis was evaluated alongside that of AR.
222 omatal (gs) and mesophyll (gm) conductances, alongside the 53 data profiles from primary metabolism o
223 rrelative microscopy are discussed in detail alongside the advantages, limitations, and the potential
224           The synthesis of 2-AP is discussed alongside the attempts that have been made to stabilise
225 r Adherence Support Evaluation (CASE) Index, alongside the background data sheet.
226  approach to concurrently survey the archaea alongside the bacteria with high-resolution 16S rRNA gen
227 ded further prognostic information when used alongside the Bronchiectasis Severity Index (BSI).
228 mtomolar binding affinity, placing it firmly alongside the CB[7].Diam(NMe3)2 complex.
229                                  Since then, alongside the continued extraction of data from the medi
230  sequence variations in 23S rRNA nucleotides alongside the difference in the lengths of the eukaryoti
231 r the evidence of the effects of whole foods alongside the evidence of the effects of individual nutr
232 quality of life (QoL) substudy was performed alongside the EXCEL trial.
233                                              Alongside the FN pillars, long filopodia protrude from t
234  that their activity involves torque dipoles alongside the force dipoles usually considered.
235 sive transcription factor, dFOXO, that works alongside the heat shock transcription factor to activat
236 nt of small populations of free-living algae alongside the hosts with endosymbionts, suggesting that
237  static magnetic field calculations are used alongside the images to quantify the amount of the growi
238 nal Visual Field and existing similar ideas, alongside the importance of items, covert attention, and
239 ne these critical conditions in a copolymer, alongside the inevitable chemical composition distributi
240                                              Alongside the known postfusion conformation, a novel one
241 he remote effects on monsoonal precipitation alongside the large local impacts on temperatures.
242 d the safety and immunogenicity of IPV given alongside the measles-rubella and yellow fever vaccines
243 th effects of whole dairy foods is warranted alongside the more traditional approach of studying the
244  95% CI: 65, 100), tumor growth was observed alongside the needle tract.
245 ties of mood, sleep and cognition recognised alongside the neurological symptoms of seizures and auto
246 e prospectively collected detailed cost data alongside the Newhints trial, which tested the effect of
247                                              Alongside the outstanding sensitivity and selectivity, t
248     CRY1 docks onto the transcription factor alongside the PAS domains, extending above the DNA-bindi
249 rs performed a prospective economic substudy alongside the PEGASUS-TIMI 54 (Prevention of Cardiovascu
250                    Furthermore, we show that alongside the phosphorylation of S601, the phosphorylati
251 expressed in the germline where it localizes alongside the piRNA and siRNA machinery at P granules.
252 s a unique opportunity for conservation, but alongside the presence of loggerhead turtles and other e
253 nce among growing segments of the workforce, alongside the recent era of severe economic upheaval, ha
254 ting the novel risk variants identified here alongside the refined data for existing association sign
255                    The hominin fossils occur alongside the remains of an insular fauna and a simple s
256  artifacts, particularly split-based points, alongside the remains of Neanderthals is a result of pos
257                   Placing these observations alongside the reported conservation of mid-development w
258                                              Alongside the scientific interest, molecular or genetic
259                                              Alongside the sheer growth in the amount and variety of
260 tact for Treg cell-mediated ILC2 suppression alongside the suppressive cytokines TGF-beta and IL-10.
261  and a process evaluation will be undertaken alongside the trial.
262                                              Alongside the typical bacterial IleRS (such as Escherich
263                                              Alongside the universal health-care services that are gu
264 rometry and gas chromatography-olfactometry, alongside the use of sensory studies, is also discussed.
265 nome-wide single-cell map of mRNA abundance, alongside the well-studied life history and fate of each
266 ically designed to give improved performance alongside the wide bandgap donor poly(3-hexylthiophene),
267 y evolved shortly after, but not necessarily alongside, the emergence of multicellularity.
268 epared as single stereoisomers and evaluated alongside their 4'' congeners against cultured malaria p
269  of this hybrid approach are then discussed, alongside their advantages and disadvantages.
270 ve CBD (1000 mg/day; N=43) or placebo (N=45) alongside their existing antipsychotic medication.
271       The optimized geometries of the meshes alongside their HOMO and LUMO orbitals were calculated u
272  that can be incorporated into nucleic acids alongside their natural counterparts have emerged as a p
273 tematic assessment of multiple flow sorters, alongside their operational parameters using the same ce
274 revealing clonal relationships between cells alongside their transcriptional profiles.
275  (Poecilochirus carabi complex), which breed alongside them on the carcass.
276 n concert with their host genes and function alongside them to regulate cholesterol, fatty acid, and
277 ort workers and 24 staff managing or working alongside them) and 4 healthcare support worker training
278                                              Alongside these observations, we also found that the ele
279                                     However, alongside these purely state-value-based computations we
280 eatments for tremor are presented separately alongside this article.
281                 Although these changes occur alongside those at alpha-motor axons in SOD1(G93A) mice,
282                                    In crumb, alongside those compounds, hexanal, 1-octen-3-ol and non
283      We review reports of precision oncology alongside those of precision diagnostics and novel radio
284 somal scanning process can therefore feature alongside transcriptional bursting as a source of noise.
285 mics study in human tissues is now displayed alongside transcriptomics data in the same tissues.
286  the betaproteobacterium Snodgrassella alvi, alongside transient parasites such as the protozoan Lotm
287 provide additional cardiovascular protection alongside treatment of both traditional and non-traditio
288 m analysis are presented in dynamic displays alongside user-controlled statistical tests, supporting
289 continuing surveillance of sexual behaviors, alongside vaccine status, to predict future disease burd
290                  How best should OCT be used alongside visual fields, and how often should OCT be per
291 e was imaged by using dedicated MR sequences alongside wall motion and delayed enhancement imaging.
292                                              Alongside, we report that the gene expression of AHRR in
293                    Our results indicate that alongside well-documented effects on ecosystem functioni
294 es with T g and generates an additional peak alongside with (BiPb)FeO3 at a high T g of 700 degrees C
295 obligate peptidolytic oligotrophic lifestyle alongside with anaplerotic carbon assimilation.
296                                       Hence, alongside with demonstrating the importance of NLRC5 in
297 antitoxin loci, which encode a toxic protein alongside with either RNA or a protein able to counterac
298 ent aspects of transition-state theory (TST) alongside with kinetic gas theory (KGT) relevant to the
299 single giant droplet toward stationary phase alongside with new droplets emerging.
300 earch is still nascent but develops rapidly, alongside with the growth of neuroimaging and deep brain

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