ライフサイエンスコーパス: alpha

1 ls through primate signal regulatory protein alpha.

2 AG-synthesizing enzyme diacylglycerol lipase alpha.

3 F and pro-inflammatory cytokines such as TNF-alpha.

4 y impulse response function reverberating in alpha.

5 1beta while inhibiting the production of TNF-alpha.

6 to patient plasma samples or exogeneous IFN-alpha.

7 internal consistency reliability (Cronbach's alpha=0.81 vs. 0.88); test-retest reliability (intraclas

8 -0.20; 95% CI, -0.40 to 0.00; P = .05 at an alpha = .001).

9 mouse and human islets, we demonstrated that alpha-1 antitrypsin (AAT; Prolastin-C), a serine proteas

10 biomarkers such as C-reactive protein (CRP), alpha-1-acid glycoprotein (AGP), ferritin, and retinol.

11 Human dendritic cell (DC) response to alpha-(1,3)-glucan polysaccharide of Aspergillus fumigat

12 "alpha-(1,3)-Glucan-educated" DCs stimulated the activati

13 used to measure with high precision the (1)H(alpha)-(13)C(alpha) dipolar tensor and carboxylate chemi

14 closed N-lobe cooperate to recognize a mixed alpha/310 helix in AKAP79.

15 tablished dynamically by oscillations in the alpha (8-13 Hz) and beta (13-18 Hz) bands.

16 in the context of treatment with interferon-alpha, a widely used model to mimic depression in the co

17 er leaflet of the plasma membrane, including alpha-actinin-1, moesin, 14-3-3 protein zeta/delta, anne

18 This suggests that alpha-actinin-3 deficiency reduces muscle performance at

19 d RvD5n-3 DPA reduced cell adhesion onto TNF-alpha-activated human endothelial monolayers.

20 ontinuously administered neurofeedback of P4 alpha activity.

21 also failed to up-regulate IFN-beta and TNF-alpha after treatment with DMXAA or the natural STING li

22 f (hetero)aryl cyclopropyl carbinols to form alpha-alkylidene-gamma-butyrolactones (ABLs) is reported

23 replacement of the amide with oxadiazole and alpha,alpha-dimethylation of the carboxylic acid, improv

24 o peptides allowed expedient preparations of alpha-amino boronic acids, often with high stereoselecti

25 loited to synthesize novel non-proteinogenic alpha-amino esters.

26 Loss of alpha-amino trimethylation causes a reduction in the CEN

27 ted wild-type mice, these compounds blocking alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

28 (NMDA) receptors and decreased expression of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic aci

29 stion of potato starch by porcine pancreatic alpha amylase (PPAA) was investigated using isolated sta

30 he present study investigates the effects of alpha-amylase (6 and 10ppm), xylanase (70 and 120ppm) an

31 wards metabolic syndrome-associated enzymes (alpha-amylase, alpha-glucosidase and lipase) was evaluat

32 ptimization of trienzyme treatment combining alpha-amylase, protease and gamma-carboxy peptidase allo

33 Palmitoylethanolamide is an agonist of PPAR-alpha and an important regulator of pain and innate immu

34 Thyroid hormone (TH) and TH receptors (TRs) alpha and beta act by binding to TH response elements (T

35 to mammalian survival, is that of pancreatic alpha and beta cells producing glucagon and insulin for

36 e, then analyzed at the community level with alpha and beta diversity measures.

37 oselective route in six steps; however, both alpha and beta epimers could be obtained by a nonstereos

38 A combination of alpha and beta provides a tiered system for quantitative

39 se of taurocholic acid and decrease of tauro-alpha and beta-muricholic acid in Tgr5(-/-) mice.

40 ansfer of radiolabels into product from both alpha and gamma phosphates of donor molecules.

41 ls of proinflammatory cytokines, such as TNF-alpha and IL-17.

42 infected with HIV-1 had higher levels of TNF-alpha and IL-1beta than HIV-uninfected children with mea

43 ion of Fshb inhibitory factors (e.g. inhibin alpha and VGF nerve growth factor-inducible), 2) activat

44 emonstrate the prion-like characteristics of alphaS and reveal its efficiency to invade the CNS via m

45 reactivity with its protein targets (low in alpha) and is highly selective (high in beta) in forming

46 itions using chicken interferon-alpha (chIFN-alpha) and the attenuated infectious bursal disease viru

47 ection, without affecting the release of TNF-alpha, and indicated a role for the inflammasome sensor

48 nitric oxide synthase, tumor necrosis factor-alpha, and interleukin 6).

49 We report on East-Asian alpha- and beta-cell gene signatures and substantiate se

50 hagamma) peptide, which is a product of both alpha- and gamma-cleavage events, could also induce TrkB

51 terminal cytosolic tail targeted by the Art1 alpha-arrestin, which is activated via the TORC1 kinase

52 ed by an intermediate temporal regime in the alpha band that likely reflects different underlying com

53 within (10 Hz) or outside (7.5 or 15 Hz) the alpha band.

54 olvement of central theta-band and occipital alpha-band effects are in line with compensatory neural

55 Alpha-band oscillations also carried clear information a

56 EG recordings, both sustained potentials and alpha-band oscillations are present during the delay per

57 erized defensive compounds, the volatile (E)-alpha-bergamotene and trypsin proteinase inhibitors (TPI

58 jasmonate repressor that regulates JAs, (E)-alpha-bergamotene, TPIs, and a defensin.

59 actions on MnO2 with different morphologies (alpha, beta, gamma and delta) was investigated using flo

60 nterferon (IFN-gamma) treatment, but not IFN-alpha, -beta, or -lambda treatment, dramatically decreas

61 the addition of a thiol and an alkene to an alpha,beta-unsaturated aldehyde in a tandem reaction pro

62 r version of this approach also afforded (Z)-alpha,beta-unsaturated amino esters in moderate to good

63 edure for the construction of (hetero)cyclic alpha,beta-unsaturated carboxylic acids from 1,6- and 1,

64 Alpha-beta Hydrolase Domain Containing 5 (ABHD5) is a ke

65 Alpha-beta hydrolase domain-containing 5 (ABHD5), the de

66 Concurrent alpha-beta oscillations were observed over parieto-occip

67 rehensive interface exchange between the TCR alpha/beta constant domain pair and the IgG1 CH3 homodim

68 ndent protein kinase C conventional subclass alpha/beta leading to reduced phosphorylation of NADPH o

69 annel recordings, indicates that heteromeric alpha/beta subunit-containing receptors underlie both sy

70 e disease hallmarks include imbalance in the alpha/beta-globin chain ratio, ineffective erythropoiesi

71 tubulin to fold or become assembled into the alpha/beta-heterodimer, nor did it influence the incorpo

72 In addition, alpha-bis-PCBM resists the ingression of moisture and pa

73 ile access to highly hindered trisubstituted alpha-branched olefins, which when coupled with a cation

74 ly to its local actions in the AD brain, TNF-alpha can also indirectly modulate amyloid pathology as

75 rinated aliphatic (linear or branched at the alpha-carbon) and aromatic ester groups have been synthe

76 Whereas most CCPs catalyze hydrolysis of alpha-carboxyl-linked glutamates, CCP5 uniquely metaboli

77 The same exercise was repeated for human alpha-cardiac myosin S1 and rabbit fast skeletal muscle

78 aimed to accurately characterize intestinal alpha-carotene cleavage and its relative contribution to

79 (providing 27.3 mg beta-carotene and 18.7 mg alpha-carotene).

80 The vitamin A activity of alpha-carotene-containing foods is likely overestimated

81 wed that mTORC1 signaling is dispensable for alpha cell development, but essential for alpha cell mat

82 a positive role of linagliptin in modulating alpha cell function to restore normoglycemia.

83 or alpha cell development, but essential for alpha cell maturation during the transition from a milk-

84 mpensatory hyperglucagonemia or expansion of alpha-cell mass, and that it cannot be given to induce s

85 c deletion of the mTORC1 regulator Raptor in alpha cells (alphaRaptorKO), we showed that mTORC1 signa

86 These experiments showed that alpha-cellular and beta-cellular clocks are oscillating

87 imulated conditions using chicken interferon-alpha (chIFN-alpha) and the attenuated infectious bursal

88 eved by the use of enantioenriched lithiated alpha-chlorosilanes [1-((2'-lithiochloromethyldimethylsi

89 ty of FOXO3A is regulated by Casein Kinase 1 alpha (CK1alpha) in an oncogenic RAS-specific manner, bu

90 ther, these results show that the pattern of alpha coherence across the retinotopic map in V4 matches

91 rrow-derived macrophages produced higher TNF-alpha compared with CD44(-/-) macrophages following TLR2

92 of the IL-4Ralpha and estrogen receptor (ER) alpha compared with macrophages from male mice following

93 alpha-Conotoxins have four cysteines that can have three

94 d for bond C-H activation which promotes the alpha-cyanation of secondary and tertiary amines using m

95 was obtained in high yields (up to 98%) from alpha-diazoesters using 5 mol% of a simple copper(I) sal

96 re with high precision the (1)H(alpha)-(13)C(alpha) dipolar tensor and carboxylate chemical shift ani

97 The prespecified outcome was alpha-diversity (inverse Simpson's alpha-diversity index

98 tcome was alpha-diversity (inverse Simpson's alpha-diversity index), with secondary outcomes of beta

99 ot require POMT1 and/or POMT2 in contrast to alpha-dystroglycan, and moreover, the O-Man glycans on c

100 of total and cell-surface NHE3, NKCC2, NCC, alpha-ENaC and cleaved gamma-ENaC compared to NSD.

101 1, glyceraldehyde-3-phosphate dehydrogenase, alpha-enolase, filamin-A, and heat shock protein 90, wer

102 The C4'alpha epimer was synthesized by a stereoselective route

103 Estrogen receptor alpha (ERalpha) regulates gene transcription through two

104 ha-like (GFRAL), an orphan member of the GFR-alpha family, is a high-affinity receptor for GDF15.

105 popular and viable photocatalyst, hematite, alpha-Fe2O3 that exhibits most of the properties require

106 pping of photoexcited carriers in haematite (alpha-Fe2O3).

107 anowires) based on titania, hematite, and on alpha-Fe2O3/TiO2 heterostructures, for PEC applications.

108 Intraperitoneal injection of alphaS fibrils also induced CNS alphaS pathology in anot

109 ppocampus with wild-type, H50Q, G51D or A53E alphaS fibrils displayed induction of alphaS inclusion p

110 o ketones, esters, nitriles, primary amides, alpha-fluorinated halo-acetates and perfluoroalkyl iodid

111 Anti-TNF-alpha/FNAB/PMMA matrix was then integrated over comb str

112 e for C3 in regulating the production of IFN-alpha following TLR7 activation.

113 Folate receptor alpha (FRalpha) autoantibodies have been associated with

114 modulations of brain oscillations in the EEG alpha frequency band in posterior cortex can dissociate

115 uce a protecting-group-free approach for the alpha-functionalization of cyclic secondary amines.

116 The discovery of alpha-Gal stimulated new discussions and investigations

117 Alpha-gal-sIgE levels were assessed by ImmunoCAP assay.

118 Alpha-gal-sIgE positivity was associated with total IgE

119 xis (IA), six (9%) were found to have IgE to alpha-gal.

120 annel homology models, as exemplified by the alpha-GID:alpha4beta2 nAChR complex, and is extendable t

121 ter of which have given rise to 12 copies of alpha-gliadin genes clustered within a 550-kb region.

122 Alpha-globin levels were not significantly changed.

123 hanisms: concealment of beta-glucans beneath alpha-glucans and enzymatic removal of any exposed beta-

124 syndrome-associated enzymes (alpha-amylase, alpha-glucosidase and lipase) was evaluated.

125 Fractions X1C and X2C notably inhibited alpha-glucosidase, with IC50=9.89 and 8.05mug/mL, respec

126 cytoplasm and Dock7 on the membrane of or in alpha-granules.

127 -HBCD) composed of three main stereoisomers: alpha-HBCD (10%), beta-HBCD (10%), and gamma-HBCD (80%).

128 s of adducted human Hb that revealed loss of alpha-helical content and deoxygenation.

129 However, translocation could be restored by alpha-helical domains in a position- and organism-depend

130 Recombinant mIFN (rmIFN) exhibited an alpha-helical fold characteristic of type I IFNs and bou

131 By combining an alpha-helical peptide that self-assembles into a hexamer

132 The alpha-helical region of separase (also known as Esp1) co

133 a-strand conformation, instead of forming an alpha-helix as observed in the previously solved structu

134 nine R210 on the adjacent subunit's backbone alpha-helix form salt bridges in hexamers and pentamers.

135 shoe-shaped substrate pocket, formed from an alpha-helix, a 310 helix, and a recently evolved tri-pro

136 s and trimers, potentially via a coiled-coil alpha-helix.

137 th factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1alpha) and erythropoietin (EPO) were measure

138 dox-neutral method for the cross-coupling of alpha-hydroxyalkyltrifluoroborates is reported.

139 of a hitherto unprecedented enzyme-promoted alpha-hydroxyketone rearrangement catalysed by vanadium-

140 oid antibiotics, and we demonstrate that the alpha-hydroxyketone rearrangement is potentially a conse

141 ed the expression of inflammatory genes (TNF-alpha, IFN-gamma, IL-1beta, IL-6, and CCL2 mRNAs), and a

142 he pro-inflammatory cytokines IFN-gamma, TNF-alpha, IL-1beta and RANTES and activation of p38/Stat pa

143 tor were protected from diabetes-induced TNF-alpha, IL-1beta, ICAM-1, and NOS2 upregulation.

144 on of proinflammatory cytokines, such as TNF-alpha, IL-1beta, IL-6, and IL-23.

145 erminal pro-B-type natriuretic peptide), TNF-alpha, IL-6, IL-12, IL-17, malondialdehyde, and fetuin-a

146 fic mechanism accounting for the role of IFN-alpha in immunosuppression and predicts that type I IFN

147 iR-155 target gene the liver X receptor (LXR)alpha in lung fibroblasts and macrophages.

148 r A53E alphaS fibrils displayed induction of alphaS inclusion pathology that increased and spread ove

149 We found that AICAR inhibited TNF-alpha-induced CFB expression in ARPE-19 and human primar

150 ts into the mechanisms and allosteric sites [alpha(-)-interface containing] by which prototoxins can

151 oduction of tumor necrosis factor alpha (TNF-alpha)/interleukin-6 (IL-6) in infected kidneys.

152 s induce expression of tumor necrosis factor alpha, interleukin-6, and interleukin-8 in the respirato

153 Serum tumor necrosis factor-alpha, interleukins, hemogram, and liver and renal funct

154 The scope of the radical precursor includes alpha-iodo ketones, esters, nitriles, primary amides, al

155 TNF-alpha is a pluripotent cytokine that has been independen

156 4, the protein product of which recruits the alpha-isoform of protein phosphatase 1 catalytic subunit

157 alphaFXIIa, with support from alpha-kallikrein, subsequently accelerates contact activ

158 at the photochemical reaction mechanisms for alpha-keto acids in aqueous solution are robust and gene

159 terminal alkynes to racemic beta-stereogenic alpha-keto esters was achieved in high levels of stereos

160 ulate the binding free energy of a series of alpha-ketoamide analogues relative to a common warhead s

161 nes with a variety of beta,gamma-unsaturated alpha-ketocarbonyls in neat conditions under MW irradiat

162 d its target DLST-the E2 subcomponent of the alpha-ketoglutarate dehydrogenase complex, a rate-contro

163 s is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate".

164 Inhibition of the conversion of glutamate to alpha-ketoglutaric acid prevented the production of 2-hy

165 On the contrary, hydrolysis with an alpha-l-arabinofuranosidase, removing single terminally-

166 Additionally, BPA and TNF-alpha levels in cord blood were inversely associated wit

167 levels in cord blood as well as maternal TNF-alpha levels were inversely associated with maternal GPx

168 s with high affinity to GDNF family receptor alpha-like (GFRAL), a distant relative of receptors for

169 Here we report that GDNF-family receptor alpha-like (GFRAL), an orphan member of the GFR-alpha fa

170 Mice transgenic for human alphaS (line M20) injected in the hippocampus with wild-

171 ntaenoic acid, and docosahexaenoic acid] and alpha-linolenic acid) and n-6 PUFAs (linoleic acid and a

172 d omega-3 (omega3) fatty acids (linoleic and alpha-linolenic acid, respectively) in the cytochrome P4

173 neering synthetic pathways for production of alpha-methyl acids in Escherichia coli using these enzym

174 plains how the conversion reaction occurs in alpha-MnO2 material.

175 is a humanised, anti-interleukin 5 receptor alpha monoclonal antibody that directly and rapidly depl

176 fiber electrical activity to decode accurate alpha-motor neuron discharges across five lumbosacral se

177 We engineered alphaS mutants incapable of multimerization, leading to

178 been devised by [4 + 1] heterocyclization of alpha-(N-hydroxy/aryl)imino-beta-oxodithioesters with in

179 genome-scale integrated analysis of the HIF-alpha network, we identified the major protein kinase C

180 We propose that future research on alpha neurofeedback should explore reinforcement schedul

181 Neutralization of TNF-alpha normalized neurodevelopmental abnormalities in inf

182 for installing reactive carbonyl groups and alpha-nucleophiles into biomolecules are described.

183 to enhance transcriptional activation by ER-alpha of endogenous estrogen-responsive genes.

184 essed IL-10R, CD206, and CCR2 but little TNF-alpha or CX3CR1.

185 ess than twenty H-atoms available for either alpha- or beta-hydride elimination.

186 It is not clear, however, how alpha oscillations are controlled and how they interact

187 rFEF) exerted feedback control of the visual alpha oscillations.

188 a activity was modulated by the phase of the alpha oscillations.

189 athway checkpoints, p-mTOR (p=0.03) and PI3K-alpha (P = 0.04) were downregulated in treatment respons

190 To discover compounds that have anti-eIF2α-P activity suitable for clinical use, we performe

191 injection of alphaS fibrils also induced CNS alphaS pathology in another alphaS transgenic mouse line

192 that platelet-derived growth factor receptor alpha (PDGFRalpha) and its ligand platelet-derived growt

193 that platelet-derived growth factor receptor alpha (PDGFRalpha) positive ( + ) cells accumulate in CT

194 a far lower temperature than usual beta --> alpha phase transformations in SiC.

195 urface protein expression, as well as IKbeta-alpha phosphorylation.

196 onstrate that the PML retinoic acid receptor-alpha (PML-RARalpha) oncofusion protein, which causes ac

197 lls, platelet-derived growth factor receptor-alpha-positive cells, and alpha-smooth muscle actin-posi

198 Importantly, not only did suppressed alpha power and bottom-up causality correlate with heigh

199 es the leading Pol epsilon below CMG and Pol alpha-primase at the top of CMG at the replication fork.

200 6 caused hypersensitivity to LPS-induced TNF-alpha production in vivo.

201 rotected to yield hydantoins and unsaturated alpha-quaternary amino acids.

202 l processing in 2 distinct regimes, with the alpha range again yielding different patterns.

203 TNF-alpha related apoptosis-inducing ligand (TRAIL) selectiv

204 In photosensitive epilepsy, alpha-related blood oxygen level-dependent signal change

205 potent suppression of tumor necrosis factor alpha release.

206 Blocking of FDC secretion of IFN-alpha restored B cell tolerance and reduced the amount o

207 traditional analytic methods do not separate alpha-retinol derivatives from active retinol.This study

208 active heterodimers with retinoid X receptor alpha (RXRalpha), and phosphorylation of the DNA-binding

209 The configurational stability of the alpha-S-organolithium species was enhanced by using a le

210 This work shows that each human alpha satellite array produces a unique set of non-codin

211 centromeres are composed of tandem arrays of alpha-satellite DNA, which spans up to several megabases

212 s the expression of AD-relevant genes: BDNF, alpha-secretase (ADAM10), MINT2, FE65, REST, SIRT1, BIN1

213 le of independently generating the sustained alpha seen in propofol, which may then be relayed to cor

214 nal and vice versa, suggesting that the AP-2 alpha-sigma2 hemicomplex interacts cooperatively with Ne

215 A wide range of alpha-silylesters and alpha-thioesters was obtained in h

216 ve shown that CD47-signal regulatory protein alpha (SIRPalpha) axis dictates the fate of ingested DNA

217 nhibitory receptor signal regulatory protein-alpha (SIRPalpha) is a myeloid-specific immune checkpoin

218 th factor receptor-alpha-positive cells, and alpha-smooth muscle actin-positive blood vessels were as

219 alpha-SNAP is a crucial component of Orai1 channels, and

220 (through reduced hypoxia-inducible factor 1 alpha stabilization) decrease the expression of the most

221 nian vegetation system, we include symmetric alpha-stable Levy perturbations.

222 It was found that the reaction with alpha-substituted five- to seven-membered cyclic amines

223 Co-expression of the AP-2 alpha subunit enhanced the Nef.AP-2 sigma2 subunit BiFC

224 , a monoclonal antibody directed against the alpha subunit of the interleukin-5 receptor that signifi

225 that noncovalently associates with the small alpha subunit on the intermembrane space side of the inn

226 s encircles the C-terminal segment of the IR alpha-subunit.

227 (+)(BK) channel consists of the pore-forming alpha subunits (BKalpha) and auxiliary subunits.

228 does not contain homologs of bacterial RNAP alpha subunits, it contains, in addition to the beta and

229 t is a heteromeric receptor composed only of alpha subunits.

230 On the other hand, alpha-sulfinyl chlorides are difficult to prepare with h

231 re-introduction into these DNAJB6-KO HEK293T-alpha-syn cells, aggregation is reduced to the level of

232 We document the presence of physiological alpha-syn conformers in human midbrain dopamine neurons

233 tment with different drugs known to regulate alpha-SYN expression; while exogenous promoter-reporter

234 Furthermore, alpha-syn frequently appears to propagate in the brains

235 Although alpha-syn is expressed in the neuroretina, absence of pr

236 amily members, PLK3 is also able to catalyze alpha-syn phosphorylation and degradation in living cell

237 Here, we report that alpha-SYN present in dopaminergic nigral afferents is es

238 alpha-Synuclein (alpha-syn) aggregation is a key event in Parkinson's dis

239 progressive accumulation of alpha-synuclein (alpha-syn) and jointly termed synucleinopathies.

240 Alpha-synuclein (alpha-SYN) is a central molecule in Parkinson's disease

241 alpha-synuclein (alpha-SYN) is a major pathologic contributor to Parkinso

242 cell spreading of misfolded alpha-synuclein (alpha-syn) is suggested to contribute to the progression

243 This vaccine, collectively termed GP+RAP/alpha-syn, is capable of triggering neuroprotective Treg

244 nd mesoscopic self-assembly of amyloid-beta, alpha synuclein, human islet amyloid polypeptide and pri

245 alpha-Synuclein (alpha-syn) aggregation is a key event i

246 characterized by progressive accumulation of alpha-synuclein (alpha-syn) and jointly termed synuclein

247 Alpha-synuclein (alpha-SYN) is a central molecule in Par

248 alpha-synuclein (alpha-SYN) is a major pathologic contri

249 Cell-to-cell spreading of misfolded alpha-synuclein (alpha-syn) is suggested to contribute t

250 rders, such as amyloid-beta (Abeta), tau, or alpha-synuclein (alphaSyn) might be the major deleteriou

251 s mainly in the form of small phosphorylated alpha-synuclein aggregates that are associated with chan

252 ition of MARKs led to increased pathological alpha-synuclein burden.

253 models of disease that support the idea that alpha-synuclein can act as a prion.

254 lity and non-cell-autonomous factors such as alpha-synuclein cell-to-cell propagation and neuroinflam

255 els of alpha-synuclein in part by increasing alpha-synuclein degradation.

256 Nrf2 decreased steady-state levels of alpha-synuclein in part by increasing alpha-synuclein de

257 igated the effect of overexpression of human alpha-synuclein in the substantia nigra of aged (18 to 2

258 Although phosphorylated alpha-synuclein is believed to exert toxic effects at th

259 These results indicate that phosphorylated alpha-synuclein is found at the presynaptic terminals of

260 in leucine-rich repeat kinase 2 (LRRK2) and alpha-synuclein lead to Parkinson's disease (PD).

261 T mice increased levels of potentially toxic alpha-synuclein oligomers, resulting in conformationally

262 einopathy model, Gba(D409V/D409V) and a A53T-alpha-synuclein overexpressing model harboring wild-type

263 oxidative load in response to chronic mutant alpha-synuclein overexpression.

264 n linear regression analysis, but staging of alpha-synuclein pathologic changes was unrelated.

265 vely investigate the synaptic phosphorylated alpha-synuclein pathology in dementia with Lewy bodies.

266 other proteins, including amyloid-beta, tau, alpha-synuclein, and serum amyloid A, misfold into disti

267 Noting that DMV neurons display extensive alpha-synucleinopathies earlier than SN dopamine neurons

268 napse in dementia with Lewy bodies and other alpha-synucleinopathies, direct evidence for the precise

269 Similar changes are present in a mouse alpha-synucleinopathy model and in postmortem brain tiss

270 n postmortem brain tissue from patients with alpha-synucleinopathy.

271 dy, we characterize the Arabidopsis thaliana Alpha Thalassemia-mental Retardation X-linked (ATRX) ort

272 estigated for (225) Ac chelation in targeted alpha therapy (TAT).

273 Recent studies have reported that anti-TNF-alpha therapy or RA itself can modulate AD pathology, al

274 tumor xenografts, we conclude that targeted alpha-therapy regimens may stretch beyond the realm of m

275 A wide range of alpha-silylesters and alpha-thioesters was obtained in high yields (up to 98%)

276 ited the production of tumor necrosis factor alpha (TNF-alpha)/interleukin-6 (IL-6) in infected kidne

277 inflammatory cytokine tumor necrosis factor alpha (TNFalpha) are increased in age-related and chroni

278 Here we identify that tumour necrosis factor-alpha (TNFalpha) selectively reduces BMPR-II transcripti

279 ed elevated amounts of tumor necrosis factor-alpha (TNFalpha) that contributed to the increased tumor

280 phosphorylation) links tumor necrosis factor alpha (TNFalpha) to pro-inflammatory gene expression in

281 ine production was mediated by paracrine TNF-alpha-TNFR1 signaling rather than direct ligand sensing,

282 ately 0.59mg/mL) than commercially available alpha-tocopherol (IC50 0.63mg/mL).

283 antioxidant, even with higher activity than alpha-tocopherol and other carotenoids.

284 Muscle alpha-tocopherol concentration was over 3.5-fold higher

285 tary vitamin E supplementation (1000mg of DL-alpha-tocopheryl acetate/kg of basal diet) on physicoche

286 ion (ECD) as fragmentation techniques, and D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPG

287 yogenes and protected against staphylococcal alpha-toxin-induced keratinocyte cell death.

288 also induced CNS alphaS pathology in another alphaS transgenic mouse line (M20), albeit less robustly

289 Infection of HIV-1 was rescued in IFN-alpha-treated myeloid cells via upregulation of CD169 an

290 es, our meta-analysis suggests that anti-TNF-alpha treatment may improve endothelial function in RA p

291 eptor domain-containing adapter-inducing IFN-alpha (TRIF) and nuclear factor kappaB (NF-kappaB) cause

292 on was demonstrated via increased acetylated alpha-tubulin and SOX9 proteins, the number of primary c

293 Immunofluorescence staining with anti-alpha-tubulin antibodies and cell cycle analysis indicat

294 We conclude that this cell-specific alpha-tubulin isotype dictates the hallmarks of CEM cili

295 bled its incorporation into DHFR and IkappaB-alpha using wild-type ribosomes, and the elaborated prot

296 specifically bind the angiogenesis biomarker alpha V beta 3 integrin.

297 Cronbach alpha values for mean weighted internal consistency were

298 TNF-alpha was not detected in Muller cells from diabetic mic

299 based on detection of onsets and offsets of alpha waves, and employ these statistics for exploration

300 ons of IL-17 and IL-23, but not IL-6 and TNF-alpha, whereas IL-10 levels were increased in peripheral