ライフサイエンスコーパス: alpha B-crystallin

1 and was observed, which comigrated with lens alpha B-crystallin.

2 its purified subunits alpha A-crystallin and alpha B-crystallin.

3 d by alpha-crystallin, alpha A-crystallin or alpha B-crystallin.

4 finally treated with the heat shock protein alpha-B crystallin.

5 ion of highest homology between alpha A- and alpha B-crystallins.

6 was designed to investigate if TM expresses alpha B-crystallin, a small heat-shock protein with chap

7 alpha A-crystallin (alpha A) and alpha B-crystallin (alpha B) are among the predominant p

8 of the protective small heat shock protein, alpha B-crystallin (alpha BC), in cultured cardiac myocy

9 PKN induced phosphorylation of alpha B crystallin and increased cardiac proteasome acti

10 PKN mediates phosphorylation of alpha B crystallin and stimulation of proteasome activit

11 -> Arg, Thr144-->Arg, Ser59-->Ala mutants of alpha B-crystallin and double mutants Ser45-->Ala/Ser59-

12 used by small heat shock proteins, including alpha B-crystallin, and (ii) fragmentation due to mechan

13 Small heat shock proteins (sHSP), HSP27 and alpha-B-crystallin are co-localized to synapses and astr

14 much of the serological data used to assign alpha B-crystallin as an autoantigen.

15 nduces genes for heat shock proteins (HSP70, alpha B-crystallin), as well as enzymes and transporters

16 also demonstrate that ectopic expression of alpha B-crystallin, but not the closely related small he

17 rived from these eyes, were investigated for alpha B-crystallin by immunohistochemistry, two-dimensio

18 In both species, alpha B-crystallin could be detected in fresh and cultur

19 nse mutation in the small heat shock protein alpha-B-crystallin (CryAB(R120G)) causes desmin-related

20 nse mutation in the small heat shock protein alpha-B-crystallin (CryAB) causes desmin-related cardiom

21 The R120G mutation in alpha-B-crystallin (CryAB) causes DRM and is characteriz

22 Furthermore, the patterns of alpha A- and alpha B-crystallin expression in the lens are distinctiv

23 amma amino butyric acid and the lens protein alpha B crystallin, have intriguing and distinct functio

24 For 15 y, alpha B-crystallin (heat shock protein [Hsp] B5) has bee

25 ocardium, confocal laser microscopy revealed alpha-B crystallin in subsarcolemmal aggresomes.

26 Taken together, our findings indicate that alpha B-crystallin is a novel negative regulator of myog

27 e expression of the small heat shock protein alpha B-crystallin is selectively induced in C2C12 myobl

28 ed exercise-dependent increases in HSP27 and alpha-B-crystallin levels.

29 Semiquantitation of alpha B-crystallin messenger RNA (mRNA) or protein was o

30 Overexpression of alpha B-crystallin might be an important mechanism for T

31 ts are most abundant in the fiber cells, and alpha B crystallin mRNA is preferentially expressed in e

32 An increase in alpha B-crystallin mRNA also was observed after oxidativ

33 ally processed, and assayed for alpha A- and alpha B-crystallin mRNA expression by in situ hybridizat

34 two sizes (approximately 0.8 and 1.1 kb) of alpha B-crystallin mRNA in Northern blots.

35 heat shock caused a significant increase in alpha B-crystallin mRNA with a peak after 4 hours.

36 ore, we show that the myopathy-causing R120G alpha B-crystallin mutant is partly impaired in its cyto

37 ve function, whereas a pseudophosphorylation alpha B-crystallin mutant that mimics stress-induced pho

38 ardiomyocyte-specific expression of a mutant alpha-B-crystallin, mutant CryAB (CryAB(R120G)), which s

39 Finally, we demonstrate that alpha B-crystallin negatively regulates apoptosis during

40 Transcription of alpha B-crystallin precedes the expression of alpha A-cr

41 igh cardiomyocyte stiffness was corrected by alpha-B crystallin probably through relief of titin aggr

42 eins: two members of the HSP70 family, three alpha B-crystallin-related small heat shock proteins (HS

43 alpha-B crystallin shifted the Fpassive-sarcomere length

44 In contrast, alpha B-crystallin transcripts are present in retinal pi

45 During ocular development, alpha B-crystallin transcripts are present in the lens p

46 ohistochemistry of fresh samples showed that alpha B-crystallin was expressed predominantly in the cr