ライフサイエンスコーパス: alpha beta T cell

1 e of MHC-peptide antigen presentation to the alpha beta T cell.

2 ontogeny and occurs in both gamma delta and alpha beta T cells.

3 ed by gene targeting so that these mice lack alpha beta T cells.

4 gnificantly augmented by as few as 1 x 10(5) alpha beta T cells.

5 and secondary sites, and is mediated by CD8+ alpha beta T cells.

6 ction have drawn heavily on our knowledge of alpha beta T cells.

7 pus-prone MRL mice congenitally deficient in alpha beta T cells.

8 ut they do so in a way that is distinct from alpha beta T cells.

9 important for the subsequent development of alpha beta T cells.

10 cells while retaining normal frequencies of alpha beta T cells.

11 delta subset of T cells, which may regulate alpha beta T cells.

12 to ligands that are different from those of alpha beta T cells.

13 may not recognize antigen the same way as do alpha beta T cells.

14 o primary infection as mice deficient in all alpha beta T cells.

15 ied by an increase in the percentage of CD4+ alpha beta T cells.

16 V beta usage during T. gondii stimulation of alpha beta T cells.

17 e infection with C. parvum was restricted to alpha/beta T cells.

18 could be induced in gamma/delta T cells and alpha/beta T cells.

19 ecrosis in the ilea after infection are CD4+ alpha/beta T cells.

20 dependent on the collaboration between B and alpha/beta T cells.

21 lpha-/- mice that are congenitally devoid of alpha/beta T cells.

22 IEL were up-regulated in the presence of TCR(alpha beta) T cells.

23 proliferation of normal gamma delta, but not alpha beta, T cells.

24 of diseased recipients are host-derived CD4+ alpha/beta+ T cells.

25 electin, whereas only 30% of gamma/delta and alpha/beta T cells adhered to E-selectin.

26 ly exacerbated GVHD when compared with naive alpha beta T cells alone.

27 cells share many cell surface proteins with alpha beta T cells and are able to secrete lymphokines a

28 lta T cells), and adaptive immune responses (alpha beta T cells and B cells) in infected mice.

29 Cytokine signaling by IL-2 and IL-7 from alpha beta T cells and epithelial cells was necessary fo

30 or suppressor, and identifies roles for both alpha beta T cells and gamma delta T cells in Fas-indepe

31 To explore the mechanisms by which alpha beta T cells and gamma delta T cells regulate syst

32 CD4+ alpha beta T cells and gamma interferon (IFN-gamma) are

33 of the magnitude of major superantigens for alpha beta T cells and may bridge the gap between innate

34 ay inflammation, mediated by accumulation of alpha/beta T cells and driven by DCs, is critical to air

35 NK cells, dendritic cells, alpha beta T cells, and B cells were also recruited to t

36 the ligand for Fas (APO-1, CD95) compared to alpha beta T cells, and induce apoptosis of Fashigh CD4+

37 ing for activated macrophages, the number of alpha beta T cells, and the number of delta gamma epithe

38 with elevated numbers of NK cell, NKT cell, alpha/beta T cell, and macrophage infiltration of the in

39 E alpha 52-68/I-A(b) complex-specific 1H3.1 alpha beta T cell antigen receptor are positively select

40 We found that gamma delta and alpha beta T cells are controlled by partially overlappi

41 d and autoimmune state, both gamma delta and alpha beta T cells are found as infiltrates.

42 These data indicate that alpha beta T cells are important for resistance to C. pa

43 lized autoimmunity, but autoantigen-specific alpha beta T cells are required to cause overt disease.

44 eficiency, suggesting that CD4(+) and CD8(+) alpha/beta(+) T cells are sufficient to mount a protecti

45 gamma delta T cells, like alpha beta T cells, are components of all well-studied v

46 ll maturation was strictly restricted to TCR-alpha beta T cells as the absolute number of thymic dend

47 lly share many common features with adaptive alpha/beta T cells, as both lineages include naive-like

48 n of activated gamma delta T cells and naive alpha beta T cells at the time of bone marrow transplant

49 the interleukin 7 receptor (IL-7R) generate alpha/beta T cells at a detectable but greatly reduced r

50 ifically stained gamma delta T cells and not alpha beta T cells, B cells, neutrophils, or monocytes.

51 d in substantial increases in the numbers of alpha/beta T cells, both CD4+ (150%) and CD8+ (60%), and

52 Purified CD4+ alpha beta T cells but not CD8+ alpha beta T cells proli

53 igher ratios of gamma/delta T cells and CD4+ alpha/beta T cells but lower ratios of CD8+ alpha/beta T

54 rial Ag is dependent on the presence of CD4+ alpha beta T cells, but the requirement for CD4+ alpha b

55 mmunization with this Ag nor the presence of alpha beta T cells, but was enhanced by IL-2.

56 as not due to the direct inhibition of naive alpha beta T cells by gamma delta T cells.

57 ere rendered deficient in CD40 ligand and/or alpha beta T cells by intercrossing CD40L -/- and TCR-al

58 a beta T cells, but the requirement for CD4+ alpha beta T cells can be met by cytokines that use the

59 ld-type or mutant mice shows that 65% of all alpha/beta T cells carry receptors that are normally ass

60 Second, similarly to naive CD8 alpha/beta T cells, CD44(lo) gamma/delta T cells are poo

61 alpha/beta T cells but lower ratios of CD8+ alpha/beta T cells compared to those of infected IL-6(-/

62 mma delta T cells was inhibited by an intact alpha beta T cell compartment, and both populations were

63 Murine NK1.1+ (CD4+ or CD4-CD8-) alpha/beta+ T cells comprise a beta 2-microglobulin (bet

64 atly resemble, and behave like, their CD8(+) alpha/beta T cell counterparts.

65 h commonly occurs in patients suffering from alpha beta T cell deficiencies, such as AIDS.

66 Both neonatal and adult alpha beta-T-cell-deficient mice developed chronic infec

67 t or anti-CD20 B cell-depleted mice, but not alpha/beta T cell-deficient mice, display decreased infl

68 ncluding that MRL autoimmunity requires CD4+ alpha beta T cells, demonstrate that non-alpha beta T ce

69 chanism; 2) identify a role for CD40L in non-alpha beta T cell-dependent autoantibody production and

70 D4+ alpha beta T cells, demonstrate that non-alpha beta T cell-dependent mechanisms are capable of in

71 To investigate the possibility that non-alpha beta T cell-dependent mechanisms can induce system

72 gs demonstrating a role for CD40L-dependent, alpha beta T cell-dependent mechanisms in autoantibody p

73 st of both alpha beta T cell-independent and alpha beta T cell-dependent mechanisms.

74 nd Fyn (lck(-/-)fyn(-/-)) completely arrests alpha beta T cell development at the CD4-CD8- stage.

75 ion of Bcl-2 in these mice partially rescued alpha beta T cell development but not gamma delta T cell

76 The ability of CD16 cross-linking to block alpha beta T cell development was not attributable to to

77 "beta selection." This is the first point in alpha beta T-cell development at which the products of a

78 Although alpha beta T-cell development is observed in IL-7- and I

79 alpha beta T-cell development is restricted to the thymu

80 Lck and Fyn in the absence of Csk uncouples alpha/beta T cell development entirely from engagement o

81 provide genetic evidence for this notion as alpha/beta T cell development is blocked in lck(-/)-fyn(

82 ic organ cultures from Lef1-/- Tcf1-/- mice, alpha/beta T cell differentiation is completely arrested

83 esponse to Eimeria vermiformis, mice lacking alpha beta T cells display defects in protective immunit

84 gly, the requirements for a highly effective alpha beta-T-cell-driven memory response are less string

85 differentiation, and expansion of mainstream alpha/beta T cells during ontogeny depend on the highly

86 Overall, alpha beta T cells exhibited a distinct pattern of NKR e

87 We investigated the mechanism by which alpha/beta T cells expand upon transfer to T cell-defici

88 d splenocytes, more gamma delta T cells than alpha beta T cells expressed CD44 at high levels.

89 tions, 80% of gamma/delta T cells and 53% of alpha/beta T cells formed shear-resistant adhesions to P

90 tro reactivity to Toxoplasma gondii of human alpha beta T cells from T. gondii-seronegative individua

91 (CD45RO+) phenotypes from adults as well as alpha beta T cells from T. gondii-seronegative newborns

92 ues substantially higher than those found on alpha beta T cells from the same donors.

93 Resting alpha beta T cells from these individuals proliferated i

94 ese data show that, whereas less potent than alpha beta T cells, gamma delta T cells are able to prom

95 cells in vitro; however, in contrast to CD4+ alpha beta T cells, gamma delta T cells predominantly pr

96 In contrast, animals containing alpha beta T cells, gamma delta T cells, and/or function

97 CD4 and CD8 alpha/beta T cells, gamma/delta T cells, NKT cells, regu

98 alpha/beta and that the Vbeta1 subset of TCR alpha/beta T cells had a dominant role in protective imm

99 Mice lacking alpha/beta T cells had higher levels of infectious MAV-1

100 t ultimately populate the thymus to generate alpha/beta T cells has been controversial, and their mol

101 , natural killer (NK)1.1 receptor-expressing alpha/beta T cells has recently been identified.

102 Autoantigen-specific, pathogenic alpha beta T cells have been isolated from some lupus-pr

103 Thus, antigen-nonspecific alpha beta T cell help can promote generalized autoimmun

104 n distinguishes gamma delta T cell help from alpha beta T cell help induced under analogous circumsta

105 ntibodies in the absence of conventional TCR alpha beta+ T cell help.

106 Thus, non-alpha/beta T cell help may drive Ig synthesis and autore

107 ncluding autoantibodies) is a product of non-alpha/beta T cell help that can be provided by gamma/del

108 ed both in 293T cells and in 2 different TCR alpha(-)/beta(-) T cell hybridomas.

109 were neighboring epithelial cells (IL-7) and alpha beta T cells (IL-2 and IL-7).

110 arious circumstances, especially in cases of alpha/beta T cell immunodeficiency.

111 that gamma delta T cells can substitute for alpha beta T cells in a virus model of demyelination and

112 oimmune disease, and to address the roles of alpha beta T cells in murine lupus, we analyzed lupus-pr

113 e graft-vs-host (GVH) reactivity mediated by alpha beta T cells in murine recipients transplanted wit

114 mune skin disease; and 3) suggest a role for alpha beta T cells in the down-regulation of autoimmunit

115 mphocytes without altering the repertoire of alpha beta T-cells in the intestine.

116 Although equivalent to alpha/beta T cells in binding to E-selectin, gamma/delta

117 the forces driving polyclonal activation of alpha/beta T cells in lupus is an intrinsically heighten

118 d from the low numbers of CD8alpha/alpha TCR-alpha/beta T cells in mice deficient in Qa-2 genes.

119 an eightfold increase in the CD8+, Db/HY TCR-alpha/beta T cells in the lymph nodes (LN) of delta Nur7

120 the other subsets to naive and memory CD8(+) alpha/beta T cells, in this study, we show that Ly-6C(-

121 transfer of various populations of B and non-alpha/beta T cells including cloned gamma/delta T cells

122 suggest that MRL disease may consist of both alpha beta T cell-independent and alpha beta T cell-depe

123 D4(+) T (NKT) cells, gamma/delta T cells, or alpha/beta T cells indicated that alpha/beta CD4(+) T ce

124 MC completely abrogated the proliferation of alpha beta T cells, indicating the need for processing o

125 These AND alpha beta T cells induced hypergammaglobulinemia and au

126 40L-intact or -deficient (CD40L+ or CD40L-), alpha beta T cell-intact or -deficient (alpha beta+ or a

127 The division of CD4+ alpha beta T cells into Th1 and Th2 subsets has become a

128 g the differentiation of antigenically naive alpha/beta+ T cells into Th2 cells.

129 In both donors alpha beta T cells less frequently expressed the inhibit

130 ect is cell-autonomous and restricted to the alpha beta T cell lineage.

131 The alpha beta T-cell lineage consists of distinct subsets,

132 genic reporter delta deletion construct show alpha/beta T cell lineage-specific use of the transgenic

133 The developmental block is specific to the alpha/beta T-cell lineage at a stage before the completi

134 delta genes were deleted on both alleles in alpha beta T cell lines, thereby indicating conservation

135 d a gamma delta T-cell line, but not in B or alpha beta T-cell lines.

136 were present in CD8 alpha beta+- but not CD8 alpha beta- T cell lines nor in a B cell line.

137 lass of antigens, lipids and glycolipids, to alpha/beta T cells, little is known about the T cell sub

138 First, like memory CD8(+) alpha/beta T cells, Ly-6C(+)CD44(hi) gamma/delta T cells

139 In the principal pathway of alpha/beta T cell maturation, T cell precursors from the

140 n murine lupus, they also: 1) establish that alpha beta T cells may drive autoimmune skin disease by

141 flexibility than the more classical type of alpha beta T cell-mediated cellular immunity.

142 SLE, too, is most commonly regarded as an alpha/beta T cell-mediated condition.

143 r beta 2m 0/0 knockout mice, which lack CD8+ alpha beta T cells, nor C57BL/6 mice depleted of CD8+ T

144 tive and -negative selection of conventional alpha beta T cells occur in anatomically distinct sites

145 d that contained only a single population of alpha beta T cells of foreign specificity by generating

146 ic inhibitory NKR was especially apparent on alpha beta T cells of one donor.

147 CD4+ and CD8+ alpha/beta+ T cells of the T helper cell (Th)2 phenotype

148 ise homologues of the subset of NK1.1(+) TCR-alpha/beta+ T cells, often referred to as NK T cells, wh

149 These mutations block mainstream alpha/beta T cell ontogeny at an early prethymocyte stag

150 ell-deficient mice, unlike mice deficient in alpha beta T cells or B cells, show no severe defects in

151 alpha beta T cells perform all well-characterized T-cell

152 These results indicate that the NK1.1+ alpha/beta+ T cell population, as well as other beta 2m-

153 signature comparable to MDV-transformed CD4+ alpha/beta T cells present in tumors.

154 Generation of gamma/delta and of CD4-8- alpha/beta T cells proceeds normally despite blockade of

155 urified CD4+ alpha beta T cells but not CD8+ alpha beta T cells proliferated in response to these T.

156 cell proliferation occurs after maximal CD4+ alpha beta T cell proliferation.

157 Thus, disruption of CD40L and alpha beta T cells provides a novel dissection of the ph

158 mined for full-length and truncated forms of alpha beta T cell receptor (TCR) heterodimers, both alon

159 he specificity of a T cell is dictated by an alpha beta T cell receptor (TCR) that recognizes a compl

160 Interaction of the alpha beta T cell receptor (TCR) with major histocompati

161 were either CD4+ or CD4+/CD8+, expressed the alpha beta T cell receptor, secreted IFN-gamma, and were

162 fected PTB lungs were T cells expressing the alpha beta T cell receptor.

163 with monoclonal antibodies directed against alpha beta T-cell receptor (TCR)+, CD5+, and CD8+ T-cell

164 T cells that express the alpha beta T-cell receptor are thought to be the T-cell

165 yxoviruses has never been recognized for the alpha beta T-cell receptor-positive subsets.

166 Although alpha(beta)T cell receptor (TCR)+ T cells have been repo

167 uced in the thymus, each expressing a unique alpha/beta T cell receptor (TCR) capable of binding to a

168 The alpha/beta T cell receptor (TCR) HA1.7 specific for the

169 requirements for inducing downregulation of alpha/beta T cell receptor (TCR) molecules on naive majo

170 The alpha/beta T cell receptor (TCR) recognizes peptide frag

171 ority of CD8(+) cells do not express surface alpha/beta T cell receptor alpha/beta(TCR), gamma/deltaT

172 The alpha/beta T cell receptor complex transmits signals fro

173 Natural killer (NK)1.1+ alpha/beta T cell receptor+ T(NT) cells, a unique lineag

174 To investigate the role of CD8+, alpha/beta T-cell receptor (TCR)+ T cells in mucosal imm

175 ty (85%) of CD3+ VL are CD4+ and express the alpha/beta T-cell receptor (TCR), similar to the results

176 lation of CD4- CD8- T cells that express the alpha/beta T-cell receptor (TCR).

177 The NKT cell lines express the alpha/beta T-cell receptor (TCR).

178 iated with a reduced infiltration of CD8 and alpha/beta T-cell receptor-expressing cells, diminished

179 s GVHD are CD8+ T lymphocytes expressing the alpha/beta T-cell receptor.

180 A recent crystal structure of the N15 alpha/beta-T cell receptor (TCR) in complex with an Fab

181 se lines revealed > 99% CD3+, 85 to 95% CD3+ alpha beta T-cell-receptor-positive (TCR+), 5 to 9% CD3+

182 1) RT6+ IELs appear before alpha(beta) T-cell-receptor- expressing IELs in diabetes

183 The ligands for alpha beta T cell receptors (alphabetaTCRs) are usually

184 ative T cells" (DNTs), T lymphocytes bearing alpha beta T cell receptors and expressing neither clust

185 tural killer-1+ natural T cells that express alpha beta T cell receptors requires a conserved beta 2-

186 Engagement of alpha-beta T cell receptors (TCRs) induces many events i

187 The specificity of immunoglobulins and alpha/beta T cell receptors (TCRs) provides a framework

188 These NC16A-responding T lymphocytes express alpha/beta T cell receptors and CD4 memory T cell surfac

189 rther supports the idea that gamma delta and alpha beta T cells recognize antigens differently and su

190 to control L. major, mice with a monoclonal alpha beta T cell repertoire (ABLE TCR-C alpha 0 mice) d

191 n alpha gene to create animals with a single alpha beta T cell repertoire.

192 n of gamma delta T cell replenishment before alpha beta T cell reseeding, thereby indicating the comp

193 This rapid and remarkable alpha beta T cell response may play an important role in

194 This alpha beta T cell response to the parasite was inhibited

195 failure to regulate the consequences of the alpha beta T cell response.

196 The antigen-specific alpha/beta T-cell response that followed the exaggerated

197 Alpha beta T cells secreted significant amounts of IFN-g

198 f autoimmune diseases with only autoreactive alpha beta T cells seem invariably to fall short for lac

199 TCR gene transfer into a TCR-deficient alpha beta T cell showed that besides the TCR, no other

200 alpha beta T cells specifically recognize a ligand compo

201 To address alpha beta T cell specificity in murine lupus, lupus-pro

202 Thus, both alpha beta and non-alpha beta T cells, such as gamma delta T cells, regulat

203 Although mice deficient in all alpha beta T cells (TCR-C alpha 0 mice) failed to contro

204 airway remodeling because mice deficient in alpha/beta T cells (tcra(-/-)) are protected.

205 s effect indirectly through donor BM-derived alpha beta T cells that acted as the proximate regulator

206 NK1 T cells are a specialized population of alpha/beta T cells that coexpress receptors of the NK li

207 1+ (NK1) T cells are a specialized subset of alpha/beta T cells that coexpress surface receptors that

208 We propose that these double-negative alpha/beta T cells that express HIV protein may be a com

209 g-term surviving mouse kidney allografts are alpha/beta-T cells that have downregulated their cell su

210 In contrast with the study of alpha beta T cells, that of gamma delta T cells is relat

211 e cells are derived from mature autoreactive alpha/beta T cells, the significance of coreceptor downr

212 aracterized collaboration between B and "non-alpha/beta T" cells, the phenotype has been reconstitute

213 the ability of MHC-incompatible nontolerant alpha beta T cells to cause GVHD after allogeneic BMT.

214 e able to signal the migration of peripheral alpha beta T cells to the epidermis by secreting specifi

215 e stimuli, though promoting the expansion of alpha beta-T cells, usually do not promote the efficient

216 electin glycoprotein ligand (PSGL-1), as all alpha/beta T cells versus approximately 75% of gamma/del

217 n contrast, when the administration of naive alpha beta T cells was delayed for 2 wk post-BMT, surviv

218 at fetal day 16.5 and is strictly limited to alpha beta T cells, we find that rearrangement under the

219 roperty of gamma delta T cells, as activated alpha beta T cells were incapable of ameliorating the su

220 aftment, indicating that limiting numbers of alpha beta T cells were required in the marrow graft for

221 In contrast, mice specifically lacking only alpha beta-T cells were no more susceptible than wild-ty

222 Thus, alpha/beta T cells were required for clearance of MAV-1.

223 These cells, but not conventional CD4 or CD8 alpha beta T cells, were detected in the central nervous

224 Addition of 2.5 x 10(4) mature alpha beta T cells, which alone were incapable of facili

225 Murine lupus predominantly requires alpha beta T cells, which provide pathogenic help for au

226 Both CD4+ alpha beta T cells with naive (CD45RA+) and memory (CD45