ライフサイエンスコーパス: alpha particle

1 doses (50 mGy for gamma-rays and 25 mGy for alpha-particles).

2 lls by either a single or an exact number of alpha particles.

3 as produced by fibroblasts after exposure to alpha particles.

4 er, selectively targets bone metastases with alpha particles.

5 ear energy transfer (LET) radiation, such as alpha-particles.

6 ration of 3 new atoms, yielding a total of 4 alpha-particles.

7 i) that lead to the emission of a total of 4 alpha-particles.

8 ighting the higher intrinsic cytotoxicity of alpha-particles.

9 ast cultures exposed to very low fluences of alpha-particles.

10 oid fibroblasts irradiated with 0.3-3 cGy of alpha-particles.

11 es of human cells exposed to low fluences of alpha-particles.

12 in cultures exposed to very low fluences of alpha-particles.

13 one metastases with high-energy, short-range alpha-particles.

14 to the high LET (linear energy transfer) of alpha-particles.

15 optimal biological effectiveness of emitted alpha-particles.

16 ype damage induced by gamma-rays, but not by alpha-particles.

17 ated cells, fibroblasts that were exposed to alpha particles (0.4-19 cGy) had significant increases i

18 Processes such as the scattering of alpha particles ((4)He), the triple-alpha reaction, and

19 opic resolution is achieved for both (241)Am alpha particles (5.49 MeV) and (241)Am gamma-rays (59.5

20 ne population of cells with a lethal dose of alpha-particles, a decreased bystander mutagenesis was u

21 The alpha-particle absolute detection efficiencies ranged fr

22 Published values of alpha-particle absorbed fraction phi in the skeletal tis

23 Furthermore, variations in alpha-particle absorbed fraction with marrow cellularity

24 ines (a) chord-based techniques for tracking alpha-particles across bone trabeculae, endosteum, and m

25 The energy loss of the alpha-particles after traversing the sample was converte

26 ances were measured over this time period by alpha particle and thermal ionization mass spectrometry

27 inciples calculations of processes involving alpha particles and alpha-like nuclei have so far been i

28 ate calculation of the elastic scattering of alpha particles and alpha-like nuclei--nuclei with even

29 current study, AL cells were irradiated with alpha particles and responses of bystander cells were in

30 neighboring cells not directly traversed by alpha particles and that cell-cell communication process

31 eing the daughter and thus the source of the alpha-particle and beta emissions.

32 nanotube conjugates were labelled with both alpha-particle and gamma-ray emitting isotopes, at high

33 the delayed coincidence between the outgoing alpha-particle and the neutron.

34 etal bone are 0.81, 0.80, and 0.55 for 6-MeV alpha-particles and are 0.74, 0.72, and 0.43 for 9-MeV a

35 ormation was initiated using radon simulated alpha-particles and cells evaluated as primary, secondar

36 Using beam currents of 50-60 microA alpha-particles and irradiation times of 1.5-4.5 h, the

37 tors were calculated for electrons, photons, alpha-particles, and for (18)F, (90)Y, (99m)Tc, (111)In,

38 neighboring cells not directly traversed by alpha-particles, and that cell-cell communication proces

39 mage), followed by 400 keV He(+) (simulating alpha-particle annealing).

40 Targeted alpha-particle antivascular therapy is shown for the fir

41 The biological effects of a single alpha particle are currently unknown.

42 alpha-Particles are highly potent, short-range radiation

43 Alpha-particles are of current interest in radionuclide

44 alpha-Particles are suitable to treat cancer micrometast

45 clinical trials emphasize the importance of alpha particles as a new therapeutic modality in patient

46 Our results indicate that alpha particle-associated increases in cell growth corre

47 cell was irradiated with either 1,2,4, or 8 alpha particles at a linear energy transfer of 90 keV/mi

48 In recent years, new alpha-particle-, beta(-)-particle-, and Auger electron-e

49 ss exceeded that of a monoenergetic 5.77-MeV alpha particle, but not for (223)Ra.

50 rved in cell cultures exposed to fluences of alpha-particles by which only a very small fraction of t

51 A single, high linear energy transfer alpha particle can kill a target cell.

52 outcomes, increasing evidence indicates that alpha particles can cause alterations in DNA in the abse

53 densely ionizing alpha-particles (mean of 1 alpha-particle/cell) and analyzed the chromosome aberrat

54 e, implying that cells traversed by multiple alpha particles contribute most of the risk.

55 hondrial dynamics and functions triggered by alpha particle damage to the mitochondria in human small

56 served, but resistance to clustered, complex alpha-particle damage was substantially lower than to eq

57 Radiation damage from the alpha-particle decay of Pu creates numerous defects in t

58 a-particle-emitting radionuclides with 4 net alpha-particle decays that can be used therapeutically.

59 ds of 130-microm diameter yielded an average alpha-particle dose of 3.7 Gy to the spheroids, resultin

60 The results show that, for low alpha-particle dose, the number of apoptotic signals dec

61 The induction of cx43 was observed by mean alpha-particle doses as low as 0.16 cGy, and also in cel

62 tion of radiation-induced recovery caused by alpha-particles during alpha-decay events has not been p

63 and irradiated their nuclei with exactly one alpha particle each.

64 20% of randomly selected A(L) cells with 20 alpha particles each results in a mutant fraction that i

65 domly selected cells were irradiated with 20 alpha particles each.

66 It is generally assumed that alpha-particle emission by the parent radionuclide will

67 l characteristics (short half-life, high LET alpha-particle emissions).

68 h ionization-density radiations, such as the alpha-particles emitted by radon gas or the heavy-ions u

69 tibody 81C6 labeled with the 7.2-h-half-life alpha-particle emitter (211)At might be a valuable endor

70 e rat variant of HER-2/neu, labeled with the alpha-particle emitter (213)Bi to treat widespread metas

71 alpha-Particle emitter (213)Bi-based radioimmunotherapy

72 (89)Zr, and (124)I; beta-emitter (131)I; and alpha-particle emitter (225)Ac for potential use in CLI.

73 s study, we investigated the efficacy of the alpha-particle emitter (225)Ac, parent of (213)Bi, in a

74 escalation study of HuM195, labeled with the alpha-particle emitter 213Bi (half-life = 45.6 min), wer

75 i-PSMA antibody, J591, radiolabeled with the alpha-particle emitter 213Bi (T(1/2), 45.6 min.) has bee

76 contribution of daughter decays in cellular alpha-particle emitter dose calculations.

77 ovide guidance and recommendations for human alpha-particle emitter dosimetry.

78 This is the first trial using an alpha-particle emitter in humans.

79 would be the case for a low-energy beta- or alpha-particle emitter localized on the bone surfaces.

80 of the field that are pertinent to targeted alpha-particle emitter therapy and to provide guidance a

81 ive targeting of hematopoietic cells with an alpha-particle emitter, bismuth-213 ((213)Bi)-labeled an

82 tudy shows that patient imaging of 213Bi, an alpha-particle emitter, labeled to HuM195 is possible an

83 Simulations were performed for the alpha-particle emitters (211)At, (213)Bi, and (225)Ac.

84 Alpha-particle emitters are currently being considered f

85 al of PSMA-targeting liposomes encapsulating alpha-particle emitters for selective antivascular alpha

86 Alpha-particle emitters have a high linear energy transf

87 Targeted alpha-particle emitters hold great promise as therapeuti

88 lication of radionuclides and, specifically, alpha-particle emitters in nuclear medicine has brought

89 However, the dosimetry of alpha-particle emitters is a challenge because the dimen

90 The potential of alpha-particle emitters to treat cancer has been recogni

91 trials of radiopharmaceuticals labeled with alpha-particle emitters.

92 simetry for newly developing therapies using alpha-particle emitters.

93 A novel alpha-particle emitting monoclonal antibody construct ta

94 Preclinical evaluation of alpha particle-emitting 213Bi-labeled antibody construct

95 etriamine pentaacetic acid (DTPA)-HuM195, an alpha particle-emitting anti-CD33 antibody construct for

96 to analyze the therapeutic effectiveness of alpha-particle-emitting (211)At and (213)Bi conjugated t

97 clinical trials for labeling antibodies with alpha-particle-emitting (211)At.

98 r cells in the bone marrow, was labeled with alpha-particle-emitting (225)Ac.

99 at specific ablation of BM-derived EPCs with alpha-particle-emitting anti-VE-cadherin antibody marked

100 zed, antibody-targeted, in vivo generator of alpha-particle-emitting elements.

101 Cellular incorporation of the alpha-particle-emitting radiochemical ((210)Po-citrate)

102 the therapeutic efficacy and limitations of alpha-particle-emitting radiolabeled compounds by means

103 The alpha-particle-emitting radionuclides have several physi

104 (225)Ac(3+) is a generator of alpha-particle-emitting radionuclides with 4 net alpha-p

105 alpha-Particle-emitting radionuclides, such as (211)At,

106 ting the use of beta-particle, electron, and alpha-particle-emitting radiopharmaceuticals is reviewed

107 en the production of high activity levels of alpha-particle-emitting radiotherapeutics is required.

108 ty, toxicity and chemical characteristics of alpha-particle-emitting, 213Bi and 212Bi radiometal conj

109 alpha-Particle--emitting radionuclides are of increasing

110 (225)Ac, (213)Bi, (211)At, and (223)Ra, the alpha-particle--emitting radionuclides of interest in ra

111 to this approach because the short range of alpha-particles enables localized irradiation of tumor c

112 apeutic efficacy and limitations of targeted alpha-particle endoradiotherapeutic strategies.

113 actinium-225 ((225)Ac) in vivo generator of alpha particles exploits the extreme, selective cytotoxi

114 ent study that gamma-irradiation, as well as alpha-particle exposure, dramatically increases the susc

115 an cells are exposed to very low fluences of alpha particles, fluences whereby only 1-3% of the cell

116 d involving DNA damage to bronchial cells by alpha particles from radon progeny.

117 Ever since Ernest Rutherford scattered alpha-particles from gold foils, collision experiments h

118 Conjugates labelled with alpha-particle-generating (225)Ac were found to clear ra

119 evaluates targeted liposomes loaded with the alpha-particle generator (225)Ac to selectively kill pro

120 rtial confinement fusion that determines the alpha-particle heating expected to trigger a burn wave i

121 null functions are significantly reduced for alpha particles if >/=3 attributes are measured or for b

122 first proof-of-concept for systemic targeted alpha particle immunotherapy in humans.

123 Alpha-particle immunotherapy by targeted alpha-emitters

124 r than for a Poisson-distributed mean of one alpha particle, implying that cells traversed by multipl

125 ttributable to charge transfer of solar wind alpha particles in the cometary coma.

126 We have found that a relatively low dose of alpha particles indeed results in the generation of extr

127 Thus, alpha-particle induced annealing occurs and must be cons

128 d to the in vivo condition in the context of alpha-particle-induced carcinogenesis in the respiratory

129 ructure" of each complex exchange we predict alpha-particle-induced damage to be repaired at specific

130 ults indicate that the initiating target for alpha-particle-induced genetic changes can be larger tha

131 These suggested that alpha-particle-irradiated zebrafish embryos could releas

132 more robust to damage created by high-energy alpha-particle irradiation as compared to monolayer grap

133 fertilization (hpf) subjected to a low-dose alpha-particle irradiation can release a stress signal i

134 where the vacancies density is controlled by alpha-particle irradiation or thermal-annealing.

135 ompasses three populations: those exposed to alpha-particle irradiation, those with a cancer diagnosi

136 e findings suggest that internally delivered alpha-particle irradiation-induced loss of tubular epith

137 ed in cells held in confluence for 6 h after alpha-particle irradiation.

138 the biological outcome for cells exposed to alpha-particle irradiation.

139 ous-to-crystalline transition process during alpha-particle irradiations using in situ transmission e

140 The linear energy transfer of alpha particles is several hundredfold greater than that

141 illegitimate repair of damage from a single alpha-particle is a single complex exchange.

142 rmal human lung fibroblasts to a low dose of alpha particles like those emitted by radon/radon progen

143 The mechanism(s) by which alpha particles like those emitted from inhaled radon an

144 The high energy and short range of alpha-particles make them attractive for targeted radiot

145 and fetal tissues where exposure to a single alpha particle may kill or damage critical cells.

146 Although direct nuclear traversals by alpha particles may be involved in mediating these outco

147 In addition, cytoplasmic traversal by alpha particles may be more dangerous than nuclear trave

148 oblasts, we investigated the hypothesis that alpha particles may induce DNA damage via the generation

149 tigated the hypothesis that densely ionizing alpha particles may induce the intracellular generation

150 ks (involving cellular traversal by multiple alpha particles) may overestimate low-level (involving o

151 e and HPRT mutations by very low fluences of alpha particles (mean doses 0.17-0.5 cGy) was measured.

152 ocytes in vitro with 0.5 Gy densely ionizing alpha-particles (mean of 1 alpha-particle/cell) and anal

153 gh activity levels, which can be hindered by alpha-particle-mediated radiolytic effects on labeling c

154 encies of cultured cell studies, we examined alpha-particle microbeam irradiation-induced bystander e

155 -nuclei therapy (with argon, carbon, helium [alpha particles], neon, nitrogen, and silicon) have been

156 However, irradiation, such as from the alpha-particle of the alpha-decay event, can itself indu

157 Since 211 At emits alpha-particles of high linear energy transfer, but with

158 cts of exposure to high and very low fluence alpha-particles on the G1 checkpoint were investigated i

159 effect may contribute to the prompt loss of alpha particles or to crashes and disruptions that are o

160 pRb, p34cdc2, and cyclin B1) was observed in alpha-particle or gamma-irradiated human fibroblasts.

161 of either high linear energy transfer (LET) alpha-particles or low-LET gamma-rays leads to stimulati

162 uent mammalian cell population with a single alpha particle per cell results in a mutant yield simila

163 the short path lengths and high energies of alpha-particles produce optimal cytotoxicity at small ta

164 due to secondary reactions induced by alpha (alpha) particles produced in the primary reactions.

165 Targeted antivascular alpha-particle radiation remodels the glioblastoma vascu

166 mbryo fibroblasts exposed to either gamma or alpha-particle radiation revealed a total lack of G1 arr

167 mode ESI have been subjected to polonium-210 alpha-particle radiation to reduce the average charge st

168 Targeted alpha-particle radiation using the radioisotope (225)Ac

169 PSMA-targeted (211)At- 6: alpha-particle radiotherapy yielded significantly improv

170 verestimate low-level (involving only single alpha particles) radon risks.

171 a significant contribution to the yield from alpha-particle self-heating and evidence for the 'bootst

172 is by exposing cells to very low fluences of alpha-particles, similar to those emitted by radon gas,

173 tively charged) ions generated using a 210Po alpha particle source.

174 ilable alpha-particle spectrometer and 210Po alpha-particle source were used to determine the mass of

175 A commercially available alpha-particle spectrometer and 210Po alpha-particle sou

176 low-level liquid scintillation counting and alpha-particle spectrometry.

177 mple was converted to a mass using tabulated alpha-particle stopping powers.

178 vels of telomerase activity were detected in alpha-particle survivors while robust telomerase activit

179 horter range and more potent cytotoxicity of alpha-particles than of beta-particles, (211)At-labeled

180 Two characteristics of alpha-particles that enhance their potential for targete

181 18 h coculture with cells irradiated with 20 alpha-particles, the fraction of bystander cells with mu

182 These properties make targeted alpha-particle therapy ideal for the elimination of mini

183 afety, feasibility, and activity of targeted alpha-particle therapy in the treatment of small-volume

184 Antivascular alpha-particle therapy of glioblastoma in the transgenic

185 Targeted alpha-particle therapy offers the possibility of selecti

186 m) of alpha-emitting radioisotopes, targeted alpha-particle therapy offers the potential for more spe

187 We previously investigated targeted alpha-particle therapy with (225)Ac-E4G10 as an antivasc

188 A theoretical drawback to alpha-particle therapy with 213Bi is the short range of

189 mately, randomized trials comparing targeted alpha-particle therapy with standard approaches will be

190 e of dasatinib into tumor was enhanced after alpha-particle therapy.

191 easurements for the traversal of exactly one alpha particle through a cell nucleus.

192 targeted radiotherapies can deliver multiple alpha particles to a receptor site dramatically amplifyi

193 s been constructed that selectively delivers alpha-particles to prostate cancer cells for potent and

194 lones radioresistant to either gamma-rays or alpha-particles to understand possible mechanisms in rad

195 The measured distributions of alpha-particle tracks per cell were subjected to statist

196 s developed, thereby resulting in observable alpha-particle tracks that were scored.

197 Although there was indication that alpha particle traversal through cellular cytoplasm was

198 formation is a consequence of direct nuclear alpha-particle traversal and show that the likely produc

199 ial cells are frequently exposed to multiple alpha-particle traversals.

200 A technique to assess the effects of single alpha particles uses a charged-particle microbeam, which

201 The more potent cytotoxicity of alpha-particles warrants their continued investigation a

202 , the measured oncogenicity from exactly one alpha particle was significantly lower than for a Poisso

203 oses as low as 2-mGy gamma-rays and 0.29-mGy alpha-particles were sufficient to produce an observable

204 icles and are 0.74, 0.72, and 0.43 for 9-MeV alpha-particles, where each is evaluated at ICRP referen

205 s are very rarely traversed by more than one alpha particle, whereas at higher radon levels-at which

206 loits the extreme, selective cytotoxicity of alpha particles, while providing a feasible half-life to

207 46 min) radionuclide that emits high energy alpha-particles with an effective range of 0.07-0.10 mm

208 ncogenic transforming effects of exactly one alpha particle without the confounding effects of multip

209 toma with cytotoxic short-range, high-energy alpha-particles would be an effective therapeutic approa

210 composition with approximately 74 wt.% SiO2 (Alpha Particle X-Ray Spectrometer analysis).

211 Chemical analyses of rocks by the Alpha Particle X-ray Spectrometer are consistent with pi

212 "Jake_M," the first rock analyzed by the Alpha Particle X-ray Spectrometer instrument on the Curi

213 Element analyses by Alpha Particle X-ray Spectrometers on the Mars Explorati