ライフサイエンスコーパス: alpha(2A) adrenergic receptor

1 eraction of the same alphai subunit with the alpha2A-adrenergic receptor.

2 a well-defined allosteric site on the human alpha2A-adrenergic receptor.

3 0, a PC12 cell line overexpressing the human alpha2A-adrenergic receptor.

4 receptor could be replaced by activation of alpha2A-adrenergic receptors.

5 rtion of the third intracellular loop of the alpha(2a) adrenergic receptor.

6 emonstrated noncompetitive inhibition of the alpha(2A)-adrenergic receptor.

7 is thus more complex than that found for the alpha(2A)-adrenergic receptor.

8 a well defined allosteric site on the human alpha(2A)-adrenergic receptor.

9 a well defined allosteric site on the human alpha(2A)-adrenergic receptor.

10 vation of either the P2T(AC) receptor or the alpha(2A)-adrenergic receptor.

11 eurons, while POMC neurons are inhibited via alpha2A - adrenergic receptors.

12 both peptides disrupted Gbetagamma-mediated alpha(2A) adrenergic receptor activation of mitogen-acti

13 onded to both amphetamine and guanfacine, an alpha2A adrenergic receptor agonist.

14 is specifically stimulated by the selective alpha2A-adrenergic receptor agonist UK14304 and by lysop

15 undergo agonist-stimulated endocytosis, the alpha(2A) adrenergic receptor (alpha(2A) AR), with ERK a

16 in the third intracellular (3i) loop of the alpha(2A) adrenergic receptor (alpha(2A)-AR) can fully a

17 gulated by a G protein-coupled receptor, the alpha(2A) adrenergic receptor (alpha(2A)AR).

18 that RGS14 functionally associates with the alpha(2A)-adrenergic receptor (alpha(2A)-AR) in a Galpha

19 Genetic manipulation of the alpha(2A)-adrenergic receptor (alpha(2A)-AR) in mice has

20 arly true for synaptic receptors such as the alpha(2A)-adrenergic receptor (alpha(2A)-AR).

21 at this D79(TM2)-N422(TM7) interface in the alpha(2A)-adrenergic receptor (alpha(2A)AR) affects not

22 beta(1)-adrenergic receptor (beta(1)AR) and alpha(2A)-adrenergic receptor (alpha(2A)AR) heterodimeri

23 sms regulating the surface t(1/2) of various alpha(2A)-adrenergic receptor (alpha(2A)AR) structures.

24 d the direct interaction between DMI and the alpha(2A)-adrenergic receptor (alpha(2A)AR), a key regul

25 alpha(2A)-Adrenergic receptors (alpha(2A)AR) are presyna

26 Alpha(2A)-adrenergic receptors (alpha(2A)AR) regulate mu

27 monitor the recruitment of GRK2 to activated alpha(2A)-adrenergic receptors (alpha(2A)ARs) in living

28 nstrates that agonist-mediated activation of alpha2A adrenergic receptors (alpha(2A)AR) is voltage-de

29 Here, we used the alpha2A-adrenergic receptor (alpha(2A)AR) as a model to

30 intracellular (3i) loop of the heptahelical alpha2A-adrenergic receptor (alpha2A AR) is critical for

31 Previous studies have shown that alpha2A-adrenergic receptor (alpha2A-AR) retention at th

32 The alpha2A adrenergic receptor (alpha2AAR) is directly deli

33 ne expressing a point mutation (D79N) in the alpha2a adrenergic receptor (alpha2aAR) to investigate t

34 was tethered to the carboxyl terminus of the alpha2A adrenergic receptor (alpha2AAR-Galphai2YFP).

35 inent feature of long-term regulation of the alpha2A-adrenergic receptor (alpha2AAR) is a loss of cel

36 novel direct interaction between APP and the alpha2A-adrenergic receptor (alpha2AAR) that occurs at t

37 Truncations and chimeras of the alpha2A-adrenergic receptor (alpha2AAR) were evaluated t

38 C (PKC) to phosphorylate and desensitize the alpha2A-adrenergic receptor (alpha2AAR).

39 etween delta opioid receptors (deltaORs) and alpha2A adrenergic receptors (alpha2AARs) require protei

40 ype Galpha(z) with a specific agonist to the alpha(2A)-adrenergic receptor also attenuated cAMP-induc

41 ulate insulin secretion via the G(i)-coupled alpha(2A)-adrenergic receptor and the G(s)-coupled recep

42 competing at the one allosteric site on the alpha2A-adrenergic receptor and rules out the possibilit

43 alter subsequent radioligand binding to the alpha2a-adrenergic receptor and the dopaminergic D1 rece

44 which was further inhibited by yohimbine, an alpha(2A)-adrenergic receptor antagonist.

45 hich N-terminal hemagglutinin epitope-tagged alpha(2A)-adrenergic receptor (AR) expression was driven

46 The alpha(2A)-adrenergic receptor (AR) undergoes rapid agoni

47 For the alpha(2A)-adrenergic receptor (AR) we determine the rela

48 hips of the amilorides at the alpha(1A)- and alpha(2A)-adrenergic receptors are different.

49 ily member G(alpha)(z) (which couples to the alpha(2A) adrenergic receptor) are deficient in epinephr

50 In COS-7 cells, alpha(2A)-adrenergic receptors (ARs) stimulate ERK phosp

51 293 cells, stimulation of either alpha1B- or alpha2A-adrenergic receptors (ARs) leads to rapid 5-10-f

52 The amyloid precursor protein modulates alpha2A-adrenergic receptor endocytosis and signaling th

53 ith fluorescent proteins and four GPCRs: the alpha2A-adrenergic receptor, GABAB, cannabinoid receptor

54 fluorescently labeled Galphai1 subunits and alpha2A-adrenergic receptor, GABAB, or dopamine receptor

55 receptor complexes between micro-opioid and alpha2A-adrenergic receptors has been demonstrated in tr

56 titution studies with the adenosine A(1) and alpha(2A) adrenergic receptors have reached a similar co

57 Stimulation of the Galpha(i)-linked alpha(2A)-adrenergic receptor induces a conformational c

58 e RVL, 59% of c-Fos-positive cells contained alpha2A-adrenergic receptor-like immunoreactivity in clo

59 uggest that the effects of the overexpressed alpha2A-adrenergic receptor on PLD activity are mediated

60 tion of Gi-coupled lysophosphatidic acid and alpha2A adrenergic receptors or overexpression of Gbeta1

61 We show that mu opioid and alpha2A adrenergic receptors reside in close proximity i

62 ctive stimulation of the P2Y(12) receptor or alpha(2A)-adrenergic receptor, respectively.

63 and 0.97) with the affinities for the human alpha2A adrenergic receptor subtype and poorly correlate

64 this inhibition is relieved by activation of alpha2A-adrenergic receptor, suggesting that the interac

65 rtion of the third intracellular loop of the alpha(2A)-adrenergic receptor to dissect these aspects o

66 amilorides act via an allosteric site on the alpha(2A)-adrenergic receptor to strongly inhibit antago

67 ation of agonist binding and function at the alpha(2A)-adrenergic receptor was explored.

68 f9 cell membranes expressing the recombinant alpha2A-adrenergic receptor were used to assess the cont

69 couple to the inhibition of NHE1, but not in alpha(2A)-adrenergic receptors, which do not regulate NH

70 abeled agonist and antagonist binding to the alpha2a-adrenergic receptor with an IC50 value of 0.5 mi