1 gineered mice deficient in either alpha2b or alpha2c receptors.

2 e able to detect some internalization of the alpha2c-receptor after prolonged agonist treatment.

3  mice lacking the alpha2A-, alpha2B-, or the alpha2C-receptor (alpha2A-R(-/-), alpha2B-R(-/-), alpha2

4 ever, we observed no significant movement of alpha2c-receptor from the intracellular pool to the plas

5 sting that these cells are unable to process alpha2c-receptors in the same way they process the alpha

6 licated by the fact that the majority of the alpha2c receptor resides in the endoplasmic reticulum an

7 by the absence of the alpha2A-, alpha2B-, or alpha2C-receptor subtypes in transgenic mice.

8   Attempts to examine internalization of the alpha2c-receptor were complicated by the fact that the m