ライフサイエンスコーパス: alpha,beta-methylene ATP

1 press P2X2 receptors and fails to respond to alpha,beta-methylene ATP.

2 charge to the P2X selective receptor agonist alpha,beta-methylene-ATP.

3 s to the algesic markers capsaicin, AITC and alpha, beta-methylene ATP.

4 rapidly inactivating currents were evoked by alpha,beta-methylene ATP (0.1-30 micrometer) and were se

5 NCTs were abolished by alpha,beta-methylene ATP (1 microM), but not by nifedipi

6 ents were mimicked by UTP and ADP but not by alpha,beta-methylene-ATP (1-10 microm) or CTP (30 microm

7 ATP (0.01-10 mg kg-1, i.a.) and alpha,beta-methylene-ATP (1-30 microg kg-1, i.a.) each i

8 Application of ATP (10 microM) or alpha,beta-methylene ATP (10 microM) to pyramidal neuron

9 ation of the selective P2X receptor agonist, alpha, beta-methylene ATP (100 microM), also increased g

10 tion of the selective P2X; receptor agonist, alpha, beta-methylene ATP (100 microM), increased glycin

11 burst of afferent nerve activity elicited by alpha,beta-methylene-ATP (30 microg kg-1, i.a.).

12 ases in afferent nerve discharge elicited by alpha,beta-methylene-ATP (30 microg kg-1, i.a.).

13 he ex vivo retina, the P2X1 receptor agonist alpha,beta-methylene ATP (300 nm) evoked sustained vasoc

14 6096 (100 nM), a potent P2TAC antagonist and alpha, beta-methylene-ATP (40 microM), a P2X1 receptor a

15 tors tested responded to the maximal dose of alpha,beta-methylene ATP (5 mM).

16 nyl-piperazinium iodide (DMPP, 20 microM) or alpha,beta-methylene ATP (50-100 microM) stimulated both

17 2',4'-disulphonic acid (PPADS, 10 microM) or alpha,beta-methylene ATP (50-100 microM) to the intermed

18 P2X receptor agonists ATP (0.1-7 microM) or alpha,beta-methylene ATP (6 microM) were examined separa

19 Our data show that alpha, beta-methylene ATP (a P2X receptor agonist), in t

20 The P2 receptor agonists alpha,beta-methylene ATP, adenosine, adenosine 5'-O-(2-t

21 ns was ATP > 2-methylthio-ATP (2-MeSATP) > > alpha, beta-methylene ATP (alpha, beta-me ATP) > beta, g

22 enosine pentaphosphate (AP5A), adenosine and alpha, beta-methylene ATP (alpha, beta-Me-ATP) did not i

23 ctions of P2X purinoceptor agonists (ATP and alpha,beta-methylene ATP (alpha, beta-meATP)) on sensory

24 The non-degradable analogue of ATP alpha,beta-methylene ATP (alpha,beta-mATP) was tenfold m

25 alpha,beta-Methylene ATP (alpha,beta-mATP)(an agonist at

26 ssing the homomeric P2X1 receptor, 30 microM alpha,beta-methylene ATP (alpha,beta-me-ATP) evoked robu

27 K) in smooth muscles, the effects of suramin/alpha,beta-methylene ATP (alpha,beta-meATP) (purinergic

28 vestigated the effects of the P2X(3) agonist alpha,beta-methylene ATP (alpha,beta-meATP) and antagoni

29 A subpopulation of neurons (10-15%) were alpha,beta-methylene ATP (alpha,beta-meATP) sensitive, a

30 vestigated the ability of TNP-ATP to inhibit alpha,beta-methylene ATP (alpha,beta-meATP)-evoked respo

31 t desensitisation and were also activated by alpha,beta-methylene ATP (alpha,beta-meATP, 40 microM; P

32 The P2X receptor agonist alpha,beta-methylene ATP (alpha,beta-meATP; 10 muM) evok

33 om dorsal roots in the presence of muscimol, alpha,beta-methylene-ATP (alpha,beta-meATP) or capsaicin

34 Application of ATP and alpha,beta-methylene ATP (alphabeta-MeATP) produced fast

35 owed that the activation of P2X receptors by alpha,beta-methylene-ATP (alphabetam-ATP) resulted in a

36 re depolarized by application of ATP but not alpha,beta-methylene ATP, an agonist of P2X3 subunit-con

37 2-Methylthio ATP, alpha,beta-methylene ATP and ADP activated current with

38 UTP and the analogues alpha,beta-methylene-ATP and 2-methylthio-ATP also inhib

39 The effects of alpha,beta-methylene-ATP and 2-methylthio-ATP were deter

40 presses P2X2 and P2X3 receptors, responds to alpha,beta-methylene ATP, and expresses TRKB, GFRalpha1

41 ever, the desensitizing P2X receptor agonist alpha,beta-methylene ATP, and the purinergic antagonist,

42 2-Methylthio-ATP, alpha,beta-methylene-ATP, and adenosine 5'-O-(thio)triph

43 A single binding site for the ATP analog, alpha,beta-methylene ATP (Ap(CH2)pp), was also detected

44 harmacologic rank order of ADP > > ATP > > > alpha,beta-methylene-ATP as measured by Ca(++) influx.

45 ATP analogues alpha,beta-methylene ATP, beta,gamma-methylene ATP, and

46 On the other hand, alpha,beta-methylene-ATP, beta,gamma-methylene-ATP, and

47 ATP, but not alpha,beta-methylene ATP, caused depolarization of AH ne

48 t and C-mechanonociceptors were activated by alpha,beta-methylene ATP doses as low as 50 microM.

49 In summary, ATP and alpha,beta-methylene-ATP each evoke excitation of mesent

50 P2X receptor stimulation by alpha,beta-methylene ATP enhanced the pressor response t

51 The time course of alpha,beta-methylene ATP-evoked discharges in nociceptor

52 The P2X receptor selective agonist, alpha, beta-methylene ATP, failed to activate p38 MAP ki

53 icroM): UTP = 2MeSATP > 2ClATP = ATP > ADP > alpha, beta-methylene-ATP > adenosine > ITP, with beta,

54 ATP > adenosine 5'-O-(3-thiotriphosphate) > alpha,beta-methylene ATP > ADP > CTP.

55 and that of the normally low-potency agonist alpha, beta-methylene-ATP in a use- and voltage-independ

56 ent responses to ATP and its stable analogue alpha,beta-methylene ATP in normal and carrageenan-infla

57 Furthermore, alpha, beta-methylene ATP increased the amplitude of evo

58 ATP and alpha,beta-methylene ATP induced depolarization of AH (s

59 the desensitization of P2-purinoceptors with alpha, beta-methylene ATP (m-ATP; 10 microM).

60 of adenosine 5'-triphosphate (ATP, 1 mM) or alpha,beta-methylene ATP (mATP, 100 microM), respectivel

61 sor responses to intra-arterial injection of alpha,beta-methylene ATP or lactic acid.

62 ude that the rapid increase in the number of alpha,beta-methylene ATP responsive nociceptors and the

63 ther supports the conclusion that the native alpha,beta-methylene ATP-sensitive receptor is a P2X2/3

64 cretion, whereas the P2X(3) receptor agonist alpha,beta methylene ATP significantly increased them.

65 The fast UP is blocked by alpha-beta methylene ATP tachyphylaxis, by reactive blue

66 ic agonists ATP, benzoylbenzoyl ATP (BzATP), alpha,beta methylene ATP, UTP, 2-methylthioATP (MeSATP),

67 ng the initial phase of agonist stimulation, alpha,beta-methylene-ATP, UTP, and ATP inhibited forskol

68 se in inhibitory neurotransmission evoked by alpha, beta-methylene ATP was abolished by the selective

69 the cells with adenosine, AMP, ADP, UTP, or alpha,beta-methylene ATP was without effect; however, MA

70 Both ATP and alpha,beta-methylene ATP were found to specifically acti

71 Adenosine and alpha,beta-methylene ATP were ineffective, and ATP respo

72 Inhibition by alpha,beta-methylene-ATP, which activates ligand-gated P