ライフサイエンスコーパス: alpha-actinin

1 teins, including DEB-1 (vinculin) and ATN-1 (alpha-actinin).

2 ICAM-2 with the cytoskeletal linker protein alpha-actinin.

3 nt with observations of cells overexpressing alpha-actinin.

4 erconnected Z lines and were cross-linked by alpha-actinin.

5 itin in the Z-disk is the actin cross-linker alpha-actinin.

6 actin networks crosslinked with palladin and alpha-actinin.

7 low tract expressed the cardiomyocyte marker alpha-actinin.

8 focal adhesions and binds to both actin and alpha-actinin.

9 This process in mutant cells depended on alpha-actinin.

10 activation contained syndecan-4, PIP(2), and alpha-actinin.

11 ed with other myosin isoforms and sarcomeric alpha-actinin.

12 a high-affinity complex with alphaCaMKII and alpha-actinin.

13 n, vasodilator-stimulated phosphoprotein and alpha-actinin.

14 ion of ALP-1 at dense bodies is dependent on alpha-actinin.

15 nd an interaction with the actin crosslinker alpha-actinin.

16 a1 activation in the presence and absence of alpha-actinin.

17 signals accumulate in the caps together with alpha-actinin.

18 toplasmic domain of ICAM-2 binds directly to alpha-actinin.

19 t 14-3-3 binding blocks its interaction with alpha-actinin.

20 h factor receptor (EGFR) and found that both alpha-actinin 1 (ACTN1) and alpha-actinin 4 (ACTN4) were

21 proteins of microbial pathogens or the human alpha-actinin 1 (HuACTN1) homolog.

22 We show that perturbations to formin and alpha-actinin 1 activity selectively inhibited stress fi

23 low levels of smn, cofilin 1, profilin 2 and alpha-actinin 1 did not affect smn morphant motor axon o

24 CTN1, which encodes the cytoskeletal protein alpha-actinin 1, in 10 of 239 consecutive probands with

25 In this study, we assessed the role of alpha actinin-1 (ACTN1), one of the two alpha actinin is

26 CLP36 interacted with both alpha-actinin-1 and -4 in breast cancer cells.

27 Decreases in actin-binding proteins alpha-actinin-1 and alpha-actinin-4 and actin-related pr

28 interacting with actin-cross-linking protein alpha-actinin-1 and increasing its affinity to filamento

29 herin EC1 ectodomain, or alternatively of an alpha-actinin-1 mutant that inhibits F-actin bundling, i

30 Depletion of either alpha-actinin-1 or -4 inhibited breast cancer cell migra

31 Time-lapse imaging reveals that alpha-actinin-1 puncta within actomyosin bundles move mo

32 er leaflet of the plasma membrane, including alpha-actinin-1, moesin, 14-3-3 protein zeta/delta, anne

33 the expression and activation of moesin and alpha-actinin-1, which associate with actin filaments an

34 rk and rescued by the actin bundling protein alpha-actinin-1.

35 f cytoskeleton remodeling factors, including alpha-actinin-1.

36 in which a novel disease-causing variant in alpha-actinin 2 (ACTN2) was identified by next-generatio

37 ional evidence that the primary sequences of alpha-actinin-2 and alpha-actinin-3 evolved differences

38 ebrafish can be rescued by overexpression of alpha-actinin-2 but not by alpha-actinin-3 mRNAs from ze

39 We have further demonstrated that alpha-actinin-2 competes with calcineurin for binding to

40 n between actn2 and actn3, the phenotypes of alpha-actinin-2 deficient zebrafish can be rescued by ov

41 ete high-resolution structure of the 200 kDa alpha-actinin-2 dimer from striated muscle and explore i

42 ounts of other sarcomeric proteins including alpha-actinin-2, alpha-sarcomeric actin and tropomyosin

43 alpha-Actinin-2, which is differentially expressed in al

44 ociated with dose-dependent up-regulation of alpha-actinin-2, z-band alternatively spliced PDZ-motif

45 A premature stop codon in ACTN3 resulting in alpha-actinin-3 deficiency (the ACTN3 577XX genotype) is

46 on null polymorphism (R577X) in ACTN3 causes alpha-actinin-3 deficiency in approximately 18% of the g

47 here is no associated disease phenotype, but alpha-actinin-3 deficiency is detrimental to sprint and

48 alpha-Actinin-3 deficiency occurs in approximately 16% o

49 This suggests that alpha-actinin-3 deficiency reduces muscle performance at

50 Here, we have shown that alpha-actinin-3 deficiency results in increased calcineu

51 Mechanistically, we show that alpha-actinin-3 deficiency triggers an increase in oxida

52 the primary sequences of alpha-actinin-2 and alpha-actinin-3 evolved differences to optimize their fu

53 Here, we investigate the effects of alpha-actinin-3 expression level by comparing the muscle

54 Loss of alpha-actinin-3 is associated with reduced power and enh

55 We show reduction in alpha-actinin-3 mRNA and protein in HET muscle compared

56 overexpression of alpha-actinin-2 but not by alpha-actinin-3 mRNAs from zebrafish or human.

57 X individuals, suggesting dose-dependency of alpha-actinin-3, while others have shown no difference b

58 inin-2, which is differentially expressed in alpha-actinin-3-deficient muscle, has higher binding aff

59 In this study, we demonstrated that alpha actinin 4 (ACTN4), an actin-cross-linking protein

60 Mutations in alpha-actinin 4 (ACTN4) are linked to familial forms of

61 e binding affinity of the actin cross-linker alpha-actinin 4 (ACTN4) in cells modulates cytoplasmic m

62 found that both alpha-actinin 1 (ACTN1) and alpha-actinin 4 (ACTN4) were phosphorylated on tyrosine

63 Mutations in the actin-binding protein, alpha-actinin 4 (ACTN4), are linked to focal segmental g

64 in, integrin-linked kinase, laminin-521, and alpha-actinin 4.

65 n and mass spectrometric analysis identified alpha-actinin-4 (ACTN4) as an MTBP-interacting protein.

66 the homodimeric actin cross-linking protein alpha-actinin-4 (ACTN4) during cell migration involves s

67 l role in disease; for example, mutations in alpha-actinin-4 (Actn4), a dynamic actin cross-linking p

68 alpha-Actinin-4 (ACTN4), a key regulator of the actin cy

69 lin further increased binding of MICAL-L2 to alpha-actinin-4 (ACTN4), a protein involved in GLUT4 tra

70 Furthermore, a point mutation of alpha-actinin-4 (K255E) associated with FSGS failed to s

71 ce using antibodies to a conserved domain of alpha-actinin-4 (present in both wild-type and mutant pr

72 Functional silencing of alpha-actinin-4 abolished spine elongation and turnover

73 We found that mechanical force induces alpha-actinin-4 and actin accumulation at the cell junct

74 n actin-binding proteins alpha-actinin-1 and alpha-actinin-4 and actin-related protein 2/3 complex su

75 Synaptopodin forms a complex containing alpha-actinin-4 and beta-catenin and interacts with myos

76 fy a close correlation between the levels of alpha-actinin-4 and CLP36, which form a complex in norma

77 48R) inhibited the complex formation between alpha-actinin-4 and CLP36.

78 eling by metabotropic signaling and identify alpha-actinin-4 as a critical effector of structural pla

79 Our study identified alpha-actinin-4 as a novel NHERF1 interaction partner an

80 ed a tension-sensitive upstream regulator of alpha-actinin-4 as synaptopodin.

81 FSGS3/CD2AP colocalizes with E-cadherin and alpha-actinin-4 at the apical junction in polarized Madi

82 Degradation of the podocyte-specific protein alpha-actinin-4 by the UPS depended on oxidative modific

83 Genetic alterations of alpha-actinin-4 can cause podocyte injury through multip

84 and coimmunoprecipitation studies showed the alpha-actinin-4 carboxyl-terminal region specifically in

85 Knockdown of alpha-actinin-4 decreased total junctional actin and inh

86 Knockdown of synaptopodin and alpha-actinin-4 decreases the strength of cell-cell adhe

87 Here we show that alpha-actinin-4 deficiency occurs in multiple human prim

88 docytes and provide an explanation as to how alpha-actinin-4 deficiency or mutations found in human p

89 ltured podocytes, treatment with C3a reduced alpha-actinin-4 expression and promoted ILK-dependent nu

90 podocyte loss and changes in ILK, Snail, and alpha-actinin-4 expression.

91 ence supporting mechanisms involving loss-of-alpha-actinin-4 function in human glomerular diseases re

92 Although a mechanism involving gain-of-alpha-actinin-4 function was well described and is respo

93 siRNA-mediated depletion of alpha-actinin-4 in human podocytes resulted in a marked

94 This function of alpha-actinin-4 in spine dynamics was underscored by gai

95 and found that silencing of either EWI-2 or alpha-actinin-4 increased cell infectivity.

96 Here alpha-actinin-4 induced spine head enlargement, a morpho

97 The NHERF1/alpha-actinin-4 interaction increased alpha-actinin-4 ub

98 Additionally, two FSGS-associated alpha-actinin-4 mutations (R310Q and Q348R) inhibited th

99 nteraction with spinophilin, but not through alpha-actinin-4 or Arp3.

100 These findings demonstrate that alpha-actinin-4 plays an important role in coupling acti

101 alpha-Actinin-4 specifically localized to sites of actin

102 al change requiring the C-terminal domain of alpha-actinin-4 that binds to CaMKII, an interaction we

103 A point mutation at lysine 255 in human alpha-actinin-4 to glutamate increases the binding affin

104 NHERF1/alpha-actinin-4 interaction increased alpha-actinin-4 ubiquitination and decreased its express

105 alpha-Actinin-4, an actin cross-linking protein, was ide

106 d by NHERF3 and another ligand such as NHE3, alpha-actinin-4, and PKCalpha, promoting formation of NH

107 including those of podocin, nephrin, neph1, alpha-actinin-4, and vimentin.

108 the gene encoding the actin-binding protein alpha-actinin-4, are a cause of familial FSGS.

109 TN4 gene, encoding the actin-binding protein alpha-actinin-4, are a rare cause of autosomal dominant

110 fy a Ca(2+)-sensitive actin-binding protein, alpha-actinin-4, as a novel group 1 mGluR-interacting pa

111 alpha-actinin-4-CLP36 complex, like loss of alpha-actinin-4, markedly reduced the level of CLP36 in

112 al podocyte proteins including synaptopodin, alpha-actinin-4, nephrin, JAM4, and beta-catenin.

113 epletion prevents junctional accumulation of alpha-actinin-4, vinculin, and actin.

114 Our studies reveal a critical role of the alpha-actinin-4-CLP36 complex in podocytes and provide a

115 tion of the CLP36 level or disruption of the alpha-actinin-4-CLP36 complex significantly inhibited Rh

116 Inhibition of the alpha-actinin-4-CLP36 complex, like loss of alpha-actini

117 Intercellular tension also induces alpha-actinin-4-dependent recruitment of vinculin to the

118 n of Snail and downregulation of nephrin and alpha-actinin-4.

119 n vitro, including diminished proteolysis of alpha-actinin-4.

120 etained a global linear staining pattern for alpha-actinin-4.

121 brane of infected cells and association with alpha-actinin-4.

122 the in vitro actin assembly assay identified alpha-actinin-4/focal segmental glomerulosclerosis 1 (FS

123 g interactions between the EF-hand domain of alpha-actinin (Act-EF34) and peptides derived from palla

124 Alpha actinins (ACTNs) are known for their ability to mo

125 alpha-Actinins (ACTNs) are a family of proteins cross-li

126 rphology, and expressed the MEC markers SMA, alpha-actinin, adenylate cyclase II, and vimentin.

127 By mutating or titrating actin cross-linkers alpha-actinin Ain1 and fimbrin Fim1 in live cells, we re

128 alpha-Actinin ain1 deletion cells form a normal contract

129 The T. vaginalis alpha-actinin amino acid sequence and the sequences of t

130 ailed to detect any of the epitopes or other alpha-actinin amino acid sequences.

131 organized accumulation of actin, myosin, and alpha-actinin and a complete loss of myofibrillar organi

132 otion, PLM synaptogenesis was independent of alpha-actinin and ENA-VASP, both of which bind to the N-

133 alpha-Actinin and Ena/VASP proteins bind to the stress f

134 radation of key sarcomeric proteins, such as alpha-actinin and filamin C, and is essential for mainte

135 al substrates, including the z-disc proteins alpha-actinin and filamin C.

136 -132 markedly attenuated degradation of both alpha-actinin and filamin C.

137 integrin, other cytoplasmic proteins such as alpha-actinin and filamin can directly interfere with ta

138 molecular understanding of the mechanisms of alpha-actinin and filamin catch-bonding behavior.

139 g, we successfully predicted which mammalian alpha-actinin and filamin paralogs would be mechanoaccum

140 in II motors and actin cross-linkers such as alpha-actinin and filamin, accumulate in response to int

141 anism of actin association in both wild-type alpha-actinin and in the K225E mutant.

142 y regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FA

143 ghly seropositive in response to trichomonad alpha-actinin and its truncated protein (ACT-P2) (positi

144 IP6K1 physiologically associates with alpha-actinin and localizes to focal adhesions.

145 ative mislocalization of the Z-disk proteins alpha-Actinin and muscle LIM protein 84B.

146 Furthermore, alpha-actinin and myosin minifilaments turned over signi

147 ely controlled by zyxin and binding partners alpha-actinin and p130Cas, but not vasodilator-stimulate

148 The interaction between alpha-actinin and palladin, two actin-cross-linking prot

149 ge-independent growth, co-precipitation with alpha-actinin and production of localized and disseminat

150 tes of Cas and two other adhesion molecules, alpha-actinin and talin, were also significantly slower

151 A single interaction of alpha-actinin and titin turns out to be surprisingly wea

152 ing specificity between the scaffold protein alpha-actinin and various ligands, which appears to requ

153 s of local stress fiber damage, whereas both alpha-actinin and VASP independently contribute to limit

154 recruitment of the actin regulatory proteins alpha-actinin and VASP to compromised stress fiber zones

155 t forms filaments with desmin and also binds alpha-actinin and vinculin.

156 a scaffold protein (actin), a cross-linker (alpha-actinin), and a motor (myosin).

157 proteins), adherens junctions (VE-cadherin, alpha-Actinin), and the basement membrane (Collagen IV),

158 s via its C-terminal SH3 domains in an ATN-1(alpha-actinin)- and ALP-1(ALP/Enigma)-dependent manner,

159 roteins alpha-smooth muscle actin, vimentin, alpha-actinin, and adenylyl cyclase II.

160 Here, we show that non-muscle myosin II, alpha-actinin, and filamin accumulate to mechanically st

161 ents separated by the actin bundling protein alpha-actinin, and is mechanically coupled to noncontrac

162 e and mutant ZASP interact with alpha-actin, alpha-actinin, and myotilin.

163 d by overexpression of the actin crosslinker alpha-actinin, and rheology measurements reveal that cha

164 on simulations with the K237E mutant chicken alpha-actinin--and evaluate the mechanism of alpha-actin

165 adin also serves as a molecular scaffold for alpha-actinin, another key actin crosslinker.

166 Immunofluorescence staining with the anti-alpha-actinin antibody (a z-line marker) showed that nea

167 ArgBP2gamma binding to alpha-actinin appears to underlie its ability to localiz

168 alpha-Actinins are actin-binding proteins that can be br

169 Although alpha-actinins are better known to cross-link actin fila

170 e sites, such as actin-titin cross-links via alpha-actinin, are sufficient to maintain Z-disk stabili

171 These findings identify epitopes of alpha-actinin as candidate serodiagnostic targets and su

172 in vitro experiments of motility assays with alpha-actinins as molecular force sensors.

173 afish embryos results in the accumulation of alpha-actinin associated with severely impaired contract

174 filaments and the muscle-specific isoform of alpha-actinin at the PM of differentiated myotubes.

175 anization, changing spacing and alignment of alpha-actinin bands due to increase in proteolytic activ

176 increases, myosin band spacing decreases and alpha-actinin bands form.

177 ical binding site residues are similar to an alpha-actinin binding motif previously suggested for the

178 We map a small alpha-actinin binding region in ArgBP2 (residues 192-228

179 alpha-actinin--and evaluate the mechanism of alpha-actinin binding to actin.

180 presented here was to evaluate the impact of alpha-actinin binding to ICAM-2 on the phenotype of NB t

181 f pancreatic cancer, does not interfere with alpha-actinin binding.

182 Furthermore, mutations inhibiting the alpha-actinin-binding activity abolished the ability of

183 lls expressing ICAM-2 variants with modified alpha-actinin-binding domains differed from cells expres

184 en expressed variants of ICAM-2 with mutated alpha-actinin-binding domains, and compared the impact o

185 We show that the actin-binding protein alpha-actinin binds to the C-terminal surface targeting

186 The calmodulin-like domain of alpha-actinin binds to the Z-repeats of titin.

187 The ubiquitously expressed family of alpha-actinins bridges actin filaments to stabilize adhe

188 ting in the formation of distinct fascin- or alpha-actinin-bundled domains.

189 n was soluble and interacted with sarcomeric alpha-actinin by coimmunoprecipitation, while alpha-syne

190 Regulation of alpha-actinin by IP6K1 requires its kinase activity.

191 icant reduction of cardiac myocyte proteins (alpha-actinin, cardiac myosin-binding protein C, and car

192 Knockdown of alpha-actinin causes aberrant rigidity sensing, loss of

193 We show that ALP-1 and alpha-actinin colocalize at dense bodies where actin fil

194 we show in an in vitro assay that talin and alpha-actinin compete for binding to beta3 integrins, bu

195 It has been shown that alpha-actinin competes with talin for binding to the cyt

196 to the actin cytoskeleton by talin, and then alpha-actinin competes with talin to bind beta3 integrin

197 epletion of CLP36 or disruption of the CLP36-alpha-actinin complex in breast cancer cells substantial

198 Our data suggest that the EWI-2-alpha-actinin complex is involved in the regulation of t

199 (actin, tropomyosin, troponins) and Z-band (alpha-actinin) components and promotes their degradation

200 g activity with robust expression of cardiac alpha-actinin, connexin 43, myosin light chain 2a, alpha

201 dies and robust expression of cardiac Mef2c, alpha-actinin, connexin43, MLC2a, and troponin I.

202 n adapter protein, ArgBP2, is a component of alpha-actinin containing stress fibers and inhibits migr

203 yosin network consisting of actin filaments, alpha-actinin cross-linking proteins, and non-muscle myo

204 of reconstituted actin networks formed with alpha-actinin crosslinks.

205 The data suggest the presence of alpha-actinin-dependent and alpha-actinin-independent me

206 Consistently, we find opposite effects of alpha-actinin depletion and expression of mutants on sub

207 Surprisingly, only one-fourth of alpha-actinin dimers were bound to two actin filaments.

208 t fascin domains are densely packed, whereas alpha-actinin domains consist of widely spaced parallel

209 two actin cross-linking proteins, fascin and alpha-actinin, during the first steps of structure assem

210 that depletion of the focal adhesion protein alpha-actinin enhances force generation in initial adhes

211 Finally, alpha-actinin enters NAs periodically and in clusters th

212 says, and the range of levels of identity of alpha-actinin epitopes with HuACTN1 was 0% to 50%.

213 Comparison of the T. vaginalis alpha-actinin epitopes with proteins in data banks, such

214 f actin cytoskeleton, bundle-like sarcomeric alpha-actinin expression, higher pacing beat rate at low

215 ed by disrupting nonfocal adhesion proteins (alpha-actinin, F-actin, and myosin II) and subcellular o

216 s initial adhesion and force generation) and alpha-actinin for integrin binding.

217 Expression of an alpha-actinin fragment containing the integrin binding d

218 We demonstrate that calmodulin displaces alpha-actinin from their shared binding site on alpha11.

219 Disruption of alpha-actinin function by dominant-negative or small hai

220 e, which contains orthologoues of each human alpha-actinin gene, including duplicated copies of actn3

221 carrying a deletion of the single C. elegans alpha-actinin gene.

222 lamin that shares actin-binding domains with alpha-actinin had a strong inhibitory effect on PC2(iv)

223 adjacent sarcomeres that are cross-linked by alpha-actinin homodimers.

224 ling activity and is more dynamic than human alpha-actinin HsACTN4.

225 Our results suggest that alpha-actinin impairs integrin signaling by both undermi

226 nor component of the Z-disc (about 1 per 400 alpha-actinin) important for myofibrillar development an

227 These results may shed light on the role of alpha-actinin in cellular mechanotransduction and focal

228 We expressed the two isoforms of human alpha-actinin in murine fibroblasts that express human e

229 Palladin coexists with alpha-actinin in stress fibers and focal adhesions and b

230 loss of densin results in reduced levels of alpha-actinin in the brain and selective reduction in th

231 nsport was seen for alpha6beta1-integrin and alpha-actinin in U2OS.

232 alpha-actinins in particular are the major actin crossli

233 The actin-bundling protein alpha-actinin increased PC2(iv) channel function in the

234 the presence of alpha-actinin-dependent and alpha-actinin-independent mechanisms, and indicate that

235 king model for NA assembly whereby transient alpha-actinin-integrin complexes help nucleate NAs withi

236 Here we directly observe that fascin and alpha-actinin intrinsically segregate to discrete bundle

237 The actin binding protein alpha-actinin is a major component of focal adhesions fo

238 alpha-Actinin is a promiscuous cross-linker, linking fil

239 alpha-Actinin is abundant by E19, suggesting that it is

240 alpha-Actinin is an actin cross-linker and may act as a

241 alpha-Actinin is an essential actin cross-linker involve

242 The interaction with alpha-actinin is blocked by CaMKII autophosphorylation a

243 indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediat

244 The cytoskeletal protein alpha-actinin is shared between these two force-producin

245 lates with force generation, suggesting that alpha-actinin is the main link transmitting force betwee

246 e of alpha actinin-1 (ACTN1), one of the two alpha actinin isoforms expressed in keratinocytes, in sk

247 ng four hydrophobic residues, common to many alpha-actinin ligands.

248 ises four to six layers of links, presumably alpha-actinin, linking antiparallel overlapping ends of

249 lex formation with the actin-binding protein alpha-actinin, linking membrane-bound CD13 to the cytosk

250 filaments within the Z-band is devoid of any alpha-actinin links and is likely to be the location of

251 When mixed, fascin and alpha-actinin mutually exclude each other by promoting t

252 taining protein (ZASP)/Cypher interacts with alpha-actinin, myotilin, and other Z-disc proteins via t

253 from women and men that were unreactive with alpha-actinin (negative control sera) failed to detect a

254 We propose that the reduced motility of alpha-actinin null is due to abnormal dense bodies that

255 and caveolin, Rab5a in early endosomes, and alpha-actinin, often in relationship to cortical actin.

256 tituted with zyxin variants that lack either alpha-actinin or Ena/VASP-binding capacity display compr

257 These results also suggest that the zyxin/alpha-actinin/p130Cas module may ensure that motile cell

258 udies also showed that composite networks of alpha-actinin/palladin/actin behave very similar to pure

259 beled CLANs and to ascertain the presence of alpha-actinin, PIP(2), and syndecan-4 within them.

260 on, we have demonstrated that the sarcomeric alpha-actinins play a role in the regulation of calcineu

261 alpha-Actinin plays a critical role in restoration of ac

262 Specifically, alpha-actinin plays distinct roles in regulating alphaII

263 Furthermore, we showed that alpha-actinin promote talin association with beta1-integ

264 Once adhesions have matured, alpha-actinin recruitment correlates with force generati

265 othelial ABPs, such as cortactin, myosin, or alpha-actinin, regulate leukocyte extravasation by contr

266 showed that the interplay between talin and alpha-actinin regulates signal transmission via controll

267 alpha-Actinin regulates the immune synapse formation and

268 In contrast, alpha-actinin remained nearly unchanged in both samples.

269 n elicit distinct responses, with myosin and alpha-actinin responding to dilation, and filamin mainly

270 The molecular conformation of alpha-actinin's actin-binding domain (ABD) regulates its

271 IP6K1 deletion disrupts alpha-actinin's intracellular localization and function.

272 activation trajectory is generated in which alpha-actinin's vinculin-binding site swings out of the

273 CHC in myotubes induced a loss of actin and alpha-actinin sarcomeric organization, whereas CHC deple

274 In intact cells, alpha-actinin selectively stabilizes CaMKII association

275 es pombe, in which the cross-linking protein alpha-actinin SpAin1 bundles the actin filament network.

276 actin filaments of mixed polarity like other alpha-actinins, SpAin1 has lower bundling activity and i

277 Cortexillins I-III are members of the alpha-actinin/spectrin subfamily of Dictyostelium calpon

278 We conclude that alpha-actinin stabilizes Ca(V)1.2 at the plasma membrane

279 ongly that a highly seropositive reaction to alpha-actinin suggests exposure to T. vaginalis.

280 A model, based on the structure of alpha-actinin, suggests that the EF domain modulates the

281 However, we found evidence that palladin and alpha-actinin synergistically modify network viscoelasti

282 binding of vinculin and, to a lesser extent, alpha-actinin, talin, and filamin, to phosphomimetic Cav

283 ere we show that the F-actin-binding protein alpha-actinin targets CaMKIIalpha to F-actin in cells by

284 just forces on matrices, unveiling a role of alpha-actinin that is different from its well-studied fu

285 oleus muscles exhibit normal localization of alpha-actinin, the nebulin M1M2M3 domain, Tmod3, and cyt

286 Force transmitted through alpha-actinin then triggers adhesion maturation.

287 tion of EWI-2 with the actin-binding protein alpha-actinin; this association was regulated by PIP2.

288 influencing phosphorylation of both FAK and alpha-actinin through its product 5-IP7.

289 data show that Ca(2+)-independent binding of alpha-actinin to CaMKII differentially modulates the pho

290 The binding of alpha-actinin to CaMKII is Ca(2+)-independent and activa

291 prominent actin-bundling proteins fascin and alpha-actinin to distinct networks is an intrinsic behav

292 ents interlace with perijunctional actin and alpha-actinin to form a continuous belt of muscle-like s

293 te a major mechanosensitive pathway in which alpha-actinin triggers adhesion maturation by linking in

294 Deletion of IP6K1 abolishes alpha-actinin tyrosine phosphorylation, which is known t

295 Filamin A, non-muscle myosin IIA, clathrin, alpha-actinin, vimentin, actin, caldesmon, myosin IC, an

296 Sarcomeric alpha-actinin was equally abundant in the EOMs at all st

297 n flow is correlated with a third component, alpha-actinin, which upon CRISPR knockout led to reduced

298 Specific 15-mer peptide epitopes of alpha-actinin with low to no identity with other protein

299 at Zasp52 is required for the association of alpha-actinin with the flight muscle Z-disc, and for nor

300 Our results suggest a model where multiple alpha-actinin/Z-repeat interactions cooperate to ensure