ライフサイエンスコーパス: alpha-bungarotoxin

1 reduce the initial rate of binding for 125I-alpha-bungarotoxin.

2 irreversible acetylcholine receptor blocker alpha-bungarotoxin.

3 ungarotoxin and were blocked using unlabeled alpha-bungarotoxin.

4 d to neurofilaments, as well as with labeled alpha-bungarotoxin.

5 lization of the flexible tip of finger II in alpha-bungarotoxin.

6 along the muscle fibers, as demonstrated by alpha-bungarotoxin.

7 oth mouse strains were found to bind [(125)I]alpha-bungarotoxin.

8 ly permeable to calcium, and avid binders of alpha-bungarotoxin.

9 between K(+) and Na(+), and were blocked by alpha-bungarotoxin.

10 hich was blocked by the selective antagonist alpha-bungarotoxin.

11 mitter release and are sensitive to block by alpha-bungarotoxin.

12 current in the cells that can be blocked by alpha-bungarotoxin.

13 cetylcholine receptors, which are blocked by alpha-bungarotoxin.

14 a-2 subunit, and a fluorescent derivative of alpha-bungarotoxin.

15 rythroidine, or the alpha7 nAChR antagonist, alpha-bungarotoxin.

16 y binding of the alpha7-selective antagonist alpha-bungarotoxin.

17 umber of lower-affinity sites insensitive to alpha-bungarotoxin.

18 ine binding sites sensitive to inhibition by alpha-bungarotoxin.

19 re, PM IP3Rs were modulated by extracellular alpha-bungarotoxin.

20 ours after daily intramuscular injections of alpha-bungarotoxin.

21 ethyl-4-azidobenzoimidate derivative of 125I-alpha-bungarotoxin.

22 mol)>DHbetaE (50% with 1000 nmol) but not by alpha-bungarotoxin (0% at 0.63 nmol).

23 0 microM), methyllycaconitine (1 microM) and alpha-bungarotoxin (1 microM) afforded no protection whe

24 eptors containing alpha3beta4 subunits, then alpha-bungarotoxin (1 microm), an antagonist for nicotin

25 Perfusion of the ganglion with alpha-bungarotoxin (1 micrometer, which blocks alpha7 re

26 nAChR alpha 7 subunit-selective antagonists alpha-bungarotoxin (100 nM) and methyllycaconitine (10 n

27 ted by the alpha 7 nAChR-specific antagonist alpha-bungarotoxin (100 nM), but not by mecamylamine (50

28 ethyllycaconitine (1 nM) and irreversibly by alpha-bungarotoxin (100 nM), consistent with the express

29 Unlike [(125)I]alpha-bungarotoxin, [(125)I]alpha-conotoxin MI binding t

30 ary to use a combination of mecamylamine and alpha-bungarotoxin; (4) since mecamylamine and alpha-bun

31 r, the peptide does not block the binding of alpha-bungarotoxin, a competitive nAChR antagonist.

32 plex formed between this cognate peptide and alpha-bungarotoxin, a long alpha-neurotoxin.

33 oreactivity colocalized with the staining of alpha-bungarotoxin, a marker of the NMJ.

34 as altered or eliminated, or when transgenic alpha-bungarotoxin, a nicotinic acetylcholine receptor a

35 confocal microscopy and flow cytometry using alpha-bungarotoxin, a specific antagonist.

36 alpha-Bungarotoxin affinity purification or immunoprecip

37 lso reveals distinctive spectral changes for alpha-bungarotoxin, agonists, and alkaloid antagonists.

38 ]A85380; beta2-containing sites), and (125)I-alpha-bungarotoxin (alpha 7-containing sites) binding in

39 AChR subtype that is functionally blocked by alpha-bungarotoxin (alpha Bgt) and contains the alpha7 s

40 c acetylcholine receptors (nAChRs) that bind alpha-bungarotoxin (alpha Bgt) were studied on isolated

41 Using [(125)I] alpha-bungarotoxin (alpha-BGT) autoradiography, alpha7 e

42 e of the alpha7 subtype of nAChR with either alpha-bungarotoxin (alpha-BGT) or methyllycaconitine (ML

43 onoclonal antibody (mAb35), which recognizes alpha-bungarotoxin (alpha-Bgt)-insensitive nAChRs, and a

44 ting neurotransmitter release and in binding alpha-bungarotoxin (alpha-BGT).

45 ss of AChRs that binds the snake venom toxin alpha-bungarotoxin (alpha-Bgt-AChRs) has been shown to m

46 e and are in a position to contribute to the alpha-bungarotoxin (alpha-Bgtx) binding site, little is

47 choline receptor (AChR) that are involved in alpha-bungarotoxin (alpha-Bgtx) binding.

48 alpha-bungarotoxin (alpha-BgTx) selectively blocked the

49 r (nAChR) family have demonstrated that this alpha-bungarotoxin (alpha-BgTx)-binding neuronal recepto

50 alpha-Bungarotoxin (alpha-bgtx)-binding proteins, includ

51 rent carried by nAChRs that are sensitive to alpha-bungarotoxin (alpha-BgTx).

52 s with anti-somatostatin, we determined that alpha-bungarotoxin (alpha-btx) at 12.5 microg/day rescue

53 The hippocampus is a major target of alpha-bungarotoxin (alpha-BTX) binding.

54 alpha-Bungarotoxin (alpha-Btx) binds to the five agonist

55 the competition of cyclic imines with biotin-alpha-bungarotoxin (alpha-BTX) for binding to these prot

56 ibenamine or phentolamine) or ACh (atropine, alpha-bungarotoxin (alpha-BTX) or scopolamine) blocks or

57 anethiosulfonate) show a decreased number of alpha-bungarotoxin (alpha-btx) sites.

58 crophages were challenged with nicotine plus alpha-bungarotoxin (alpha-BTX), secretion of IL-6 and TN

59 nerve-myotube co-cultures were blocked with alpha-bungarotoxin (alpha-BTX).

60 tic transmission is blocked by curare and by alpha-bungarotoxin (alpha-BTX).

61 tor (nAChR)-blocking agents [e.g., curare or alpha-bungarotoxin (alpha-BTX)] prevents the death of MN

62 The fast component was blocked by 50 nM alpha-bungarotoxin (alpha-BuTx), which binds alpha7-subu

63 ne receptor (NnAChR) currents insensitive to alpha-bungarotoxin (alpha-BuTX-ICs) in cultured rat cort

64 the addition of subtype-specific inhibitors, alpha-bungarotoxin (alpha7 nAChR) and kappa-bungarotoxin

65 In contrast to alpha-bungarotoxin, alphaA-EIVA is inactive at alpha7-co

66 (125)I-alpha-bungarotoxin (alphaBGT) binding at the oocyte surf

67 Immunohistochemistry and in situ alpha-bungarotoxin (alphaBGT) binding showed that alpha7

68 s two major nAChR types: those recognized by alpha-bungarotoxin (alphaBgt), nearly all of which conta

69 us AC block, both the rapidly desensitizing, alpha-bungarotoxin (alphaBgt)-sensitive alpha7-AChRs and

70 desensitization and is reversibly blocked by alpha-bungarotoxin (alphaBgt).

71 otinic alpha7 receptor-selective antagonists alpha-bungarotoxin (alphaBgTx) and methyllycaconitine.

72 d the molecular determinants responsible for alpha-bungarotoxin (alphaBgtx) binding to nicotinic acet

73 ension that confers high-affinity binding of alpha-bungarotoxin (alphaBgTx) was established (alphaBgT

74 mum mecamylamine but was resistant to 100 nm alpha-bungarotoxin (alphaBgTx).

75 In chicks, nicotinic antagonists such as alpha-bungarotoxin (alphaBT) can prevent normal cell dea

76 ot observed for the AChR in complex with two alpha-bungarotoxin (alphaBTX) molecules.

77 s were pretreated with the alpha7 antagonist alpha-bungarotoxin (alphaBTX) or transfected with anti-a

78 ine receptor, is thought to be the principal alpha-bungarotoxin (alphaBTX)-binding protein in mammali

79 s partially blocked in wild-type cultures by alpha-bungarotoxin, an antagonist of the alpha7 nAChR su

80 e on fibronectin expression was abolished by alpha-bungarotoxin, an inhibitor of alpha7 nicotinic ace

81 (IC(50) > 10 microM) interacted with (125)I-alpha-bungarotoxin and (-)-[(3)H]nicotine binding sites,

82 of the stoichiometric complex formed between alpha-bungarotoxin and a recombinantly expressed 19-mer

83 g acetylcholine receptors (AChRs) with TRITC-alpha-bungarotoxin and AChE by indirect immunofluorescen

84 suggest that C-terminal cationic residues of alpha-bungarotoxin and alpha-cobratoxin contribute signi

85 The alpha9alpha10 nAChR antagonists, alpha-bungarotoxin and alpha-conotoxin RgIA, blocked eff

86 ha7 nAChR antagonists methyllycaconitine and alpha-bungarotoxin and by a desensitizing concentration

87 whose binding to the receptor is blocked by alpha-bungarotoxin and by carbamylcholine.

88 blocked by TTX but were blocked partially by alpha-bungarotoxin and completely by D-tubocurarine.

89 indicate that nicotinic receptors that bind alpha-bungarotoxin and contain alpha7 subunits require a

90 erve extracts identified receptors that bind alpha-bungarotoxin and contain alpha7 subunits.

91 tors in the nervous system is one that binds alpha-bungarotoxin and contains the alpha7 gene product.

92 e agonist (epibatidine) and two antagonists (alpha-bungarotoxin and d-tubocurarine).

93 cle contains high affinity binding sites for alpha-bungarotoxin and for autoimmune antibodies in sera

94 was blocked by the alpha7nAChR antagonists, alpha-bungarotoxin and mecamylamine, and by specific siR

95 cervical ganglionic cells was attenuated by alpha-bungarotoxin and methyllycaconitine but not by dih

96 response, but unlike the neuronal receptor, alpha-bungarotoxin and methyllycaconitine not only faile

97 The faster component was blocked by alpha-bungarotoxin and methyllycaconitine, suggesting th

98 luorescent competitive assays involving ImI, alpha-bungarotoxin and nicotine using MDM and the murine

99 red by labelling of intact cells with (125)I-alpha-bungarotoxin and precipitation with an epsilon-sub

100 ffinities and irreversibility of binding for alpha-bungarotoxin and similar snake alpha-neurotoxins a

101 from P1 on using Alexa Fluor 488 conjugated alpha-bungarotoxin and SK2 immunohistochemistry.

102 eforms at -60 mV, were blocked reversibly by alpha-bungarotoxin and strychnine and are most likely me

103 ), Lys(38), Val(39), Val(40), and Pro(69) in alpha-bungarotoxin and Tyr(189), Tyr(190), Thr(191), Cys

104 ors on myotubes were identified with labeled alpha-bungarotoxin and were blocked using unlabeled alph

105 roM in the absence of agonist or presence of alpha-bungarotoxin and with a K(eq) value of 30 microM i

106 gand binding studies ([(3)H]cytisine, (125)I-alpha-bungarotoxin, and (125)I-alpha-conotoxin MII) sugg

107 d nicotinic antagonists, methyllycaconitine, alpha-bungarotoxin, and alpha-cobratoxin, markedly restr

108 currents, which were blocked irreversibly by alpha-bungarotoxin, and with slowly desensitizing curren

109 EPSPs were blocked by methyllycaconitine and alpha-bungarotoxin, antagonists that are selective for n

110 pha-bungarotoxin; (4) since mecamylamine and alpha-bungarotoxin are known to block nicotinic receptor

111 microplate wells and the use of biotinylated-alpha-bungarotoxin as tracer.

112 of the alpha7 receptor-selective antagonist alpha-bungarotoxin as well as hippocampal auditory gatin

113 ha9-nAChR antagonists methyllycaconitine and alpha-bungarotoxin, as well as by small interfering RNA

114 ne receptors (AChRs) were determined by 125I alpha-bungarotoxin assay; and the level of expression of

115 position 178 yields a large blue shift with alpha-bungarotoxin association, whereas the agonists and

116 ine receptor (nAChR) alpha1 subunit bound to alpha-bungarotoxin at 1.94 A resolution.

117 llular domain of the alpha7 receptor, places alpha-bungarotoxin at the peripheral surface of the inte

118 the homologous nicotinic ACh receptors bind alpha-bungarotoxin at their ACh binding sites.

119 pha7 mRNA and protein, as measured by (125)I alpha-Bungarotoxin autoradiography.

120 7-199, which are part of overlapping ACh and alpha-bungarotoxin (Bgt) binding sites on AChRs, were as

121 wild-type subunits prevents the formation of alpha-bungarotoxin (Bgt) binding sites.

122 or AP-7; ACh, nicotine or muscarine; ACh and alpha-bungarotoxin (Bgt) or methyllycaconitine (MLA); an

123 Evidence is presented that alpha-bungarotoxin (Bgt)-binding nicotinic receptors fou

124 roteins demonstrate saturable, high-affinity alpha-bungarotoxin (Bgtx) binding with an apparent equil

125 histidine tag was added to the N-terminus of alpha-bungarotoxin (Bgtx) recombinantly expressed in E.

126 ments show that acetylcholine, nicotine, and alpha-bungarotoxin bind to ct-AChBP with high affinity,

127 at of the wild type as measured by iodinated alpha-bungarotoxin binding ([(125)I]-alpha-BgTx).

128 or mutant AChR subunits, we show, using 125I-alpha-bungarotoxin binding and immunofluorescence to mea

129 Using alpha-bungarotoxin binding and quantitative PCR and PCR

130 Data from (125)I-alpha-bungarotoxin binding assays indicate that cocaine

131 is characterized by a dense, diffuse band of alpha-bungarotoxin binding at the CA3/CA1 border in the

132 no significant differences in tectal [(125)I]alpha-bungarotoxin binding between tadpoles and adults.

133 dition, brain region specific differences in alpha-bungarotoxin binding between the mouse strains C3H

134 of the optic nerve decreased tectal [(125)I]alpha-bungarotoxin binding by 33+/-10%, but 6-month lesi

135 alpha-Bungarotoxin binding had little effect on the fric

136 Variations in alpha-bungarotoxin binding have been shown to correlate

137 At postnatal day 14, levels of [125I]alpha-bungarotoxin binding in layer IV were very low in

138 Accordingly, we examined alpha-bungarotoxin binding in mouse somatosensory cortex

139 nositol anchorage sequence conferred surface alpha-bungarotoxin binding in oocytes.

140 In addition, (125)I-epibatidine and [(125)I]alpha-bungarotoxin binding in the brains of alpha 5-defi

141 ed in significantly higher (14 +/- 3%) [125I]alpha-bungarotoxin binding in the contralateral vs. the

142 haracteristics of [(3)H]cytisine and [(125)I]alpha-bungarotoxin binding in the frog brain were simila

143 n contrast, there was no difference in [125I]alpha-bungarotoxin binding in the left and right cortice

144 hrna7 genotype and individual differences in alpha-bungarotoxin binding levels in adult brain might b

145 onfirmed the linkage of Chrna7 genotype with alpha-bungarotoxin binding levels in hippocampus, striat

146 dence that this subunit is a component of an alpha-bungarotoxin binding nicotinic acetylcholine recep

147 owing vibrissa plucking, the levels of [125I]alpha-bungarotoxin binding on postnatal day 6 were signi

148 After introduction of an alpha-bungarotoxin binding site near the pore, PM IP3Rs

149 delta-containing GABA(A)Rs, we inserted the alpha-bungarotoxin binding site tag in the alpha(4), bet

150 he plasma membrane of alpha2delta-2 using an alpha-bungarotoxin binding site-tagged alpha2delta-2 sub

151 In addition, alpha-bungarotoxin binding sites (indicating nicotinic r

152 ChR that can assemble to form (125)I-labeled alpha-bungarotoxin binding sites expressed on the cell s

153 Mab 131 blocked one of the two alpha-bungarotoxin binding sites on the fetal AChR, and

154 [3H]Cytisine and 125I-alpha-bungarotoxin binding sites were eliminated by beta

155 In contrast, (125)I-alpha-bungarotoxin binding sites were not altered after

156 reased the number of surface Alexa Fluor 488 alpha-bungarotoxin binding sites.

157 a specific activity of 3.9 micromol of 125I-alpha-bungarotoxin binding sites/g of protein.

158 sequence, containing residues important for alpha-bungarotoxin binding to alpha1, confers functional

159 by competition against the initial rate 125I-alpha-bungarotoxin binding to BC3H-1 cells.

160 ed by their competition against 125I-labeled alpha-bungarotoxin binding to homomeric receptors contai

161 density in area CA1 and is characterized by alpha-bungarotoxin binding to numerous Nissl-stained str

162 Our findings argue that alpha-bungarotoxin binding to the pharmatope, inserted a

163 urotoxins competitively inhibit biotinylated-alpha-bungarotoxin binding to Torpedo-nicotinic acetylch

164 C50,dTC) causing half-maximal retardation of alpha-bungarotoxin binding were determined on complexes

165 forebrain or in muscarinic M(2) receptor or alpha-bungarotoxin binding within the cortex.

166 in Xenopus oocytes was measured by [(125)I]-alpha-bungarotoxin binding, and ACh receptor function wa

167 of nAChR currents, autoradiography of [125I]-alpha-bungarotoxin binding, and in situ hybridization re

168 otype is linked to individual differences in alpha-bungarotoxin binding, but not alpha7 RNA levels, s

169 Typically, the number of AChRs, measured by alpha-bungarotoxin binding, is reduced to 10-30% of norm

170 whole cell patch clamp recording and surface alpha-bungarotoxin binding.

171 nd there was a comparable increase in (125)I-alpha-bungarotoxin binding.

172 mpetition against the initial rate of (125)I-alpha-bungarotoxin binding.

173 mpetition against the initial rate of (125)I-alpha-bungarotoxin binding.

174 competition against the initial rate of 125I-alpha-bungarotoxin binding.

175 act receptor measured by competition against alpha-bungarotoxin binding.

176 ing for acetylcholine esterase or conjugated alpha-bungarotoxin binding.

177 na7 genotype is associated with the level of alpha-bungarotoxin binding.

178 ptor synthesis, cell-surface trafficking, or alpha-bungarotoxin binding.

179 arbamoylcholine and nicotine) or antagonist (alpha-bungarotoxin) binding.

180 However, while alpha7 is found in purified alpha-bungarotoxin-binding complexes from rat brain or P

181 promote or inhibit cell-surface delivery of alpha-bungarotoxin-binding nAChRs (BgtRs) composed of al

182 stion whether alpha7 forms a homo-oligomeric alpha-bungarotoxin-binding nicotinic receptor in the mam

183 port the current working hypothesis that the alpha-bungarotoxin-binding nicotinic receptor is a homo-

184 ystem of Drosophila melanogaster contains an alpha-bungarotoxin-binding protein with the properties e

185 these antibodies in Western blot analyses of alpha-bungarotoxin-binding proteins purified from rat br

186 additional processing to produce functional, alpha-bungarotoxin-binding receptors with two alpha7 con

187 By using live imaging, with an alpha-bungarotoxin-binding site (BBS) and fluorophore-li

188 conformation coincides with the formation of alpha-bungarotoxin-binding sites and intrasubunit disulf

189 alpha-Conotoxin ImI and alpha-bungarotoxin-binding sites have been well characte

190 made electrically silent by tetrodotoxin and alpha-bungarotoxin block were frequently displaced by re

191 ist of alpha7-containing receptors, mimicked alpha-bungarotoxin blockade.

192 alpha-Bungarotoxin blocked both, consistent with the pre

193 y was determined by quantitating fluorescent alpha-bungarotoxin bound to each subunit on Western blot

194 with higher affinity compared to the resting/alpha-bungarotoxin-bound AChR, (e) binds to the Torpedo

195 ilizes a fluorescein-conjugated polypeptide, alpha-bungarotoxin (BTX) and a 13 amino acid BTX-binding

196 We studied [(125)I]alpha-bungarotoxin (btx) binding to alpha7 nicotinic ace

197 The polypeptide snake toxin alpha-bungarotoxin (BTX) has been used in hundreds of st

198 rafficking with subunits tagged with a 13-aa alpha-bungarotoxin (BTX)-binding site (BBS).

199 ovement was blocked by pre-administration of alpha-bungarotoxin but not di-hydro-beta-erythroidine.

200 ocked by intracerebroventricular infusion of alpha-bungarotoxin, but not by mecamylamine or dihydro-b

201 after contact and were blocked by curare and alpha-bungarotoxin, but not by TTX and Cd(2+), suggestin

202 t was blocked by an alpha7 nAChR antagonist (alpha-bungarotoxin), by alpha7 nAChR short interfering R

203 ) nicotinic acetylcholine receptor inhibitor alpha-bungarotoxin can block nicotine-induced calpain ph

204 ed by voltage-clamp analysis and/or by [125I]alpha-bungarotoxin competition binding assays the intera

205 c 13-residue peptide in a tight complex with alpha-bungarotoxin conforms to the beta hairpin structur

206 rsible block of acetylcholine receptors with alpha-bungarotoxin decreases acetylcholine receptor numb

207 ly related to the alpha-neurotoxins, such as alpha-bungarotoxin derived from the same snake, which ar

208 ing site, along with a lack of inhibition by alpha-bungarotoxin directed to the alpha subunit correla

209 in myotomes by labeling them with rhodamine-alpha-bungarotoxin followed by confocal microscopy and i

210 The peptide competes with alpha-bungarotoxin for binding at the alpha/delta and al

211 Azemiopsin efficiently competed with alpha-bungarotoxin for binding to Torpedo nicotinic acet

212 r nAChRs, but not by a selective antagonist, alpha-bungarotoxin, for alpha7-nAChRs.

213 blocked by dihydro-beta-erythroidine whereas alpha-bungarotoxin had no effect on response amplitude t

214 fter the site for the competitive antagonist alpha-bungarotoxin has formed and delta subunits have as

215 senger RNA and as components of 125I-labeled alpha-bungarotoxin (I-Bgt)-binding nAChR ( approximately

216 lts indicate that [(3)H]cytisine and [(125)I]alpha-bungarotoxin identify distinct nAChR subtypes in t

217 In alpha-bungarotoxin-immobilized tadpoles, intracellular r

218 ed age-related decreases in the postterminal alpha-bungarotoxin immunostained area, as well as the re

219 e that desensitizes slowly and is blocked by alpha-bungarotoxin in a rapidly reversible manner.

220 Specific binding of [(125)I]alpha-bungarotoxin in adults was present only at interme

221 r binding and autoradiography using [(125)I] alpha-bungarotoxin in the DLPFC.

222 ed the binding of [(3)H]cytisine and [(125)I]alpha-bungarotoxin in the laminated tectum.

223 injection of the nicotinic receptor blocker alpha-bungarotoxin increased BBB permeability in brain-i

224 ing receptors by perfusing the ganglion with alpha-bungarotoxin induced failures in synaptic transmis

225 ith slowly desensitizing currents, which are alpha-bungarotoxin-insensitive currents.

226 rotoxin-sensitive, alpha 7-type currents and alpha-bungarotoxin-insensitive, alpha 4 beta 2-type curr

227 st desensitizing (alpha 7-type) currents and alpha-bungarotoxin-insensitive, slowly desensitizing (al

228 ys(38), Val(39), and Val(40) in finger II of alpha-bungarotoxin interface with Phe(186), Tyr(187), Gl

229 The disulfide-rich core of alpha-bungarotoxin is suggested to be tilted in the dire

230 tion, it formed a high affinity complex with alpha-bungarotoxin (k(D) 0.2 nm) but showed relatively l

231 accompanied by some dramatic changes in the alpha-bungarotoxin-labeled ACh post-synaptic receptor el

232 The distribution of [(125)I]alpha-bungarotoxin labeling closely resembled the DBA/2

233 observed linkage between Chrna7 genotype and alpha-bungarotoxin levels may be due to genetic influenc

234 Vertebrate alpha-bungarotoxin-like molecules of the Ly-6 superfamil

235 tional rearrangements in flexible regions of alpha-bungarotoxin, mainly loops I, II, and the C-termin

236 effect of Abeta was found to be sensitive to alpha-bungarotoxin, mecamylamine, and dihydro-beta-eryth

237 beta19'Lys(BODIPYFL) receptors labeled with alpha-bungarotoxin monoconjugated with Alexa488 (alphaBt

238 ee, their equilibrium binding affinities for alpha-bungarotoxin, nicotine, and acetylcholine, combine

239 ked by TTX, voltage-gated sodium blocker, or alpha-bungarotoxin, nicotinic acetylcholine receptor ant

240 underlies the robust axotomy-like effects of alpha-bungarotoxin on motoneuron excitability, and the l

241 were studied in cell monolayers treated with alpha-bungarotoxin or antisense oligonucleotides and in

242 Antagonists of nicotinic receptors, such as alpha-bungarotoxin or mecamylamine, only partially rever

243 n channels, and then were tested with either alpha-bungarotoxin or methyllycaconitine, which are sele

244 These effects were not seen when alpha-bungarotoxin or PNU-282987 were administered to sp

245 her the alpha7 nicotinic receptor antagonist alpha-bungarotoxin or the alpha4beta2 nicotinic receptor

246 nicotinic acetylcholine receptor antagonist, alpha-bungarotoxin, or the alpha4beta2 nicotinic acetylc

247 the blockade of acetylcholine receptors with alpha-bungarotoxin over the same time interval produced

248 However, the distribution of the [(125)I]alpha-bungarotoxin-positive hippocampal interneurons was

249 DBA/2 mice had increased numbers of [(125)I]alpha-bungarotoxin-positive neurons in stratum lacunosum

250 xation was blocked by methyllycaconitine and alpha-bungarotoxin (preferential alpha7-nAChR antagonist

251 ic stages are those having high affinity for alpha-bungarotoxin rather than epibatidine.

252 icotinic acetylcholine receptor subtype, the alpha-bungarotoxin receptor (alpha Bgt), in the CN.

253 Neuronal alpha-bungarotoxin receptors (BgtRs) are nicotinic recep

254 We have characterized the alpha-bungarotoxin receptors (BgtRs) found on the cell s

255 Functional alpha-bungarotoxin receptors are expressed if the membra

256 trated in the postsynaptic membrane, whereas alpha-bungarotoxin receptors composed of alpha 7 subunit

257 ion partially reduced cytisine-resistant and alpha-bungarotoxin-resistant sites with lower and higher

258 The binding of radiolabeled alpha-bungarotoxin revealed a few thousand binding sites

259 dynamic studies indicated that alpha-Ctx or alpha-bungarotoxin seem to interact with GABAAR in a way

260 Inhibition of 383C binding by alpha-bungarotoxin selectively directed to the alpha sub

261 XB-mediated rescue through the activation of alpha-bungarotoxin-sensitive (presumably alpha7) nicotin

262 n of TNF synthesis is dependent on nicotinic alpha-bungarotoxin-sensitive acetylcholine receptors on

263 sensitive alpha9alpha10 nAChRs compared with alpha-bungarotoxin-sensitive alpha7 receptors.

264 displayed a 260-fold higher selectivity for alpha-bungarotoxin-sensitive alpha9alpha10 nAChRs compar

265 FP+ Kenyon cells, fast EPSCs are mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine rec

266 which the primary postsynaptic receptors are alpha-bungarotoxin-sensitive nicotinic acetylcholine rec

267 ppocampal interneurons that are mediated via alpha-bungarotoxin-sensitive nicotinic acetylcholine rec

268 Among neuronal non-alpha-bungarotoxin-sensitive receptors, alpha-conotoxin

269 currents were evoked by acetylcholine (ACh): alpha-bungarotoxin-sensitive, alpha 7-type currents and

270 ACh evoked two types of currents, alpha-bungarotoxin-sensitive, fast desensitizing (alpha

271 otoxin binding to alpha1, confers functional alpha-bungarotoxin sensitivity when strategically placed

272 n in zebrafish can be achieved with tethered alpha-bungarotoxin, silencing synaptic transmission with

273 t rabbits and monkeys and were visualized by alpha-bungarotoxin staining and three-dimensional recons

274 membrane of cells lacking ric-3, but surface alpha-bungarotoxin staining was only observed in cells c

275 visualization with immunohistochemistry and alpha-bungarotoxin staining.

276 A comparison of the free and bound alpha-bungarotoxin structures reveals significant confor

277 rt a new, higher resolution NMR structure of alpha-bungarotoxin that defines the structure-determinin

278 Expressing alpha-bungarotoxin that is tethered to the membrane by a

279 The mammalian prototoxin lynx1 shares with alpha-bungarotoxin the ability to bind and modulate nico

280 alpha-Bungarotoxin, the classic nicotinic antagonist, ha

281 Tx ImII was not able to block the binding of alpha-bungarotoxin to alpha7 nAChRs.

282 The binding of [125I]alpha-bungarotoxin to brain sections also was decreased

283 We used alpha-bungarotoxin to compare neuromuscular junction (NM

284 We have used fluorescently labeled alpha-bungarotoxin to image alpha7-containing receptors

285 In the nAChR equilibrated with alpha-bungarotoxin to stabilize the nAChR in a closed st

286 Assessment of hippocampal alpha-bungarotoxin to visualize nicotinic alpha7 recepto

287 e (3-fold) in the nicotinic receptor binding alpha-bungarotoxin (to the alpha7 subunit) which reached

288 We used [3H]epibatidine and 125I-alpha-bungarotoxin, together with subunit-specific monoc

289 ive sensitivity to inhibition by cytisine or alpha-bungarotoxin was used to evaluate pharmacological

290 s in the presence of either acetylcholine or alpha-bungarotoxin was used to test for the functional a

291 mer can bind other alpha-neurotoxins besides alpha-bungarotoxin, we designed a two-dimensional (1)H-(

292 ding and relabeling with different colors of alpha-bungarotoxin, we selectively labeled adjacent pool

293 ace complexes that neither function nor bind alpha-bungarotoxin when expressed in tsA201 cells.

294 re activated by acetylcholine and blocked by alpha-bungarotoxin when expressed in Xenopus laevis oocy

295 d with the selective alpha7-nAChR antagonist alpha-bungarotoxin, whereas other selective antagonists

296 beled nicotinic receptor antagonist [(125)I]-alpha-bungarotoxin, which binds to alpha7 subunit contai

297 which could be abolished by mecamylamine and alpha-bungarotoxin with different efficacies, suggesting

298 which could be abolished by mecamylamine and alpha-bungarotoxin with different efficacies, suggesting

299 ene product, rapidly desensitizes, and binds alpha-bungarotoxin with great affinity.

300 hRs) share many structural features and bind alpha-bungarotoxin with high affinity, several important