ライフサイエンスコーパス: alpha-chain

1 ion of CD25, the high affinity IL-2 receptor alpha chain.

2 arding the role of the similarly polymorphic alpha chain.

3 is a preferred cleavage site in the protein alpha chain.

4 rains share a lacto-N-neotetraose (nLc4) LOS alpha chain.

5 rminant in the optimal expression of the TCR-alpha chain.

6 -3, both of which are thought to bind to HGF alpha chain.

7 nsthyretin, serum amyloid A4, and fibrinogen alpha chain.

8 oded portions of CDR3 of the T cell receptor alpha chain.

9 xpression correlating with mRNA level of its alpha-chain.

10 promoted by, expression of an endogenous TCR alpha-chain.

11 ition, with little contribution from the TCR alpha-chain.

12 f Il4ra, the gene encoding the IL-4 receptor alpha-chain.

13 nition with no contribution from the HLA-DP2 alpha-chain.

14 )14J(alpha)18) T cell antigen receptor (TCR) alpha-chain.

15 ed by a self-peptide derived from the HLA-DR alpha-chain.

16 proximately 38% of BMCPs expressed the IL-3R alpha-chain.

17 r upregulate expression of the IL-7 receptor alpha-chain.

18 ouse recognize a peptide from the H/K-ATPase alpha-chain.

19 pecific receptor chain (TSLPR) and the IL-7R alpha-chain.

20 ferences are seen in the lacto-N-neotetraose alpha-chain.

21 of which is similar to that of the human Hp2 alpha-chain.

22 xis in mice expressing the human FcepsilonRI alpha-chain.

23 3epsilondelta ECDs to sit underneath the TCR alpha-chain.

24 reased expression of Stat6 and IL-4 receptor alpha-chain.

25 lding is intermolecular shearing of collagen alpha-chains.

26 ein (CCP) domain 1/CCP2 and CCP8 of the C4BP alpha-chains.

27 R Vbeta5.1 chains coupled with different TCR alpha-chains.

28 d by the ability to coexpress additional TCR alpha-chains.

29 ributes significantly, in particular, in the alpha-chains.

30 n the collagen domain of COL4A2 (collagen IV alpha chain 2) in a family displaying porencephaly with

31 includes Il2ra (for interleukin 2 receptor, alpha chain), a gene that is known to be associated with

32 Variants of fibrinogen A alpha-chain (AFib) cause the most common type of heredit

33 ained peptide sequences from type I collagen alpha chain, albumin, and LDL receptor-related protein.

34 red to consist of three genetically distinct alpha chains (alpha1, alpha2, and alpha3).

35 entification of three novel long collagen VI alpha chains, alpha4, alpha5, and alpha6, led to the que

36 Previous reports of fibrinogen A alpha-chain amyloidosis have been in isolated kindreds,

37 d and myeloid fates, expressed IL-6 receptor-alpha chain and responded to IL-6 by phosphorylation of

38 olutionary conservation of the invariant TCR-alpha chain and restricting molecule MR1, this populatio

39 e binds to the subunit centers of both nAChR alpha chains and one of the GLIC chains, in a site that

40 ing protein) is a polymer of seven identical alpha chains and one unique beta chain synthesized in li

41 Namely, the iT(reg) TCR alpha-chain and beta-chain are overlaid with the alpha-c

42 QA1 and DQB1 genes into two groups where any alpha-chain and beta-chain belonging to the same group a

43 a-chain and beta-chain are overlaid with the alpha-chain and beta-chain of MHC class II, respectively

44 Previous work has shown that both alpha-chain and beta-chain phosphorylations of CD11a/CD1

45 s encoding the T cell antigen receptor (TCR) alpha-chain and delta-chain (Tcra-Tcrd) undergoes recomb

46 MHC class II molecules are composed of one alpha-chain and one beta-chain whose membrane distal int

47 on CD8(+) T cell responses, mAbs to the TCR alpha-chain and T cells expressing two TCR species were

48 ma subunits were situated underneath the TCR alpha-chain and TCR beta-chain, respectively.

49 onsisting of the extracellular IL-2 receptor alpha-chain and the cytoplasmic ADAM15 domain were IL-2-

50 Three alpha-chain and three beta-chain public TCR sequences we

51 Both TCR alpha-chains and TCR beta-chains made contact with the C

52 ammed death-1 (PD-1) and CD25 (IL-2 receptor alpha chain), and led to antigen-specific tumor cell kil

53 Further, CD25, an IL-2R alpha chain, and lytic granules of NK cells in social mi

54 uFeHis evolution is faster for beta than for alpha chains, and pump-probe rR spectroscopy in solution

55 determining region 3 (CDR3) sequences on the alpha-chain, and displayed restricted V-beta use.

56 and soluble forms of CD25, the IL-2 receptor alpha-chain, and quenching T-cell-derived IL-2.

57 lymphotoxin beta receptor or the lymphotoxin alpha-chain, and there was minimal overlap between the s

58 eactive major basic protein, Siglec F, IL-5R alpha-chain, and transcripts encoding mouse eosinophil p

59 kinase CbetaII (PKCbetaII), GM-CSF receptor alpha-chain, and two actin-associated proteins, paxilin

60 loss-of-function studies, anti-IL-7 receptor alpha-chain (anti-IL-7Ralpha) antibody or its isotype co

61 h AD is available for the anti-IL-4 receptor alpha-chain antibody dupilumab, but a number of studies

62 , a monoclonal antibody to the IL-5 receptor alpha-chain, are comparatively limited, especially for b

63 o californica acetylcholine receptor (TAChR) alpha-chain as a neo-self Ag.

64 xpressing the Torpedo acetylcholine receptor alpha-chain as a neo-self-Ag exhibit a reduced frequency

65 of exogenous TCR-beta chains, but not of TCR-alpha chains, assembly and functional cell surface expre

66 thesized and secreted as a 290-kDa mutant C7 alpha chain at levels similar to wild type C7.

67 ed, mycolyl lipid-reactive (GEM) TCRs had an alpha-chain bearing the variable (V) region TRAV1-2 rear

68 well as an unconventional GA-binding protein alpha chain binding motif.

69 ith the associated peptide in favor of MHCII alpha-chain binding.

70 For the TCR alpha chain, both complete ER import and subunit assembl

71 en structure that has a nearly identical TCR alpha chain but a different beta chain, highlighting the

72 us, several other isotypes that use the same alpha chain but have beta chains encoded by other genes.

73 nartuzumab acts specifically by blocking HGF alpha-chain (but not beta-chain) binding to MET.

74 invariant Valpha14-Jalpha18 T cell receptor-alpha chain, but is rescued by overexpression of a rec-V

75 triple helical and NC1 domain of individual alpha-chains, but in vivo evidence is lacking.

76 Here we show that the human FcepsilonRI alpha-chain can efficiently reach the cell surface by it

77 beta2 (CD18) integrins with alpha-chains CD11a, -b, -c, and -d are important adhesio

78 n primary patient samples, the IL-3 receptor alpha chain CD123 was highly expressed on leukemia-initi

79 The interleukin-3 receptor alpha chain (CD123) has been identified as a potential i

80 ansient down-regulation of the IL-7 receptor alpha chain (CD127) in both CD4(+) and CD8(+) T cells.

81 cells to recycle IL-7 is dependent on IL-7R alpha-chain (CD127) and endocytosis, consistent with a m

82 erized by a high expression of IL-2 receptor alpha chain (CD25) and of forkhead box P3 (FOXP3), the l

83 2 (IL-2) signaling through the IL-2 receptor alpha chain (CD25) facilitates HIV replication in vitro

84 xpression of the high affinity IL-2 receptor alpha chain (CD25) on virus-specific CD4 T cells, which

85 itions predominant (GARP), the IL-2 receptor alpha chain (CD25), and programmed cell death 1 ligand 1

86 ) T cells express the interleukin 2 receptor alpha-chain (CD25) at lower levels.

87 lls (Tregs) constitutively express the IL-2R alpha-chain (CD25) on their surface.

88 cells (hDCs) produce IL-2 and express IL-2R alpha-chain (CD25), but the role of IL-2 in DC functions

89 mes damaged by apoptosis and glycoprotein Ib alpha chain (CD42b) shedding.

90 sregulation, including soluble IL-2 receptor alpha chain, CD45RO(+)CD4(+) effector T cells, and autoa

91 d the sigma-moiety is a triatomic alpha-beta-alpha chain composed of C, Si, or Ge atoms.

92 I, whereas rs7192 was predicted to influence alpha-chain conformation.

93 We found that the nLc4 alpha chain conforms at least four different antigens.

94 We found that folding of the TCR alpha chain constant domain Calpha is dependent on alpha

95 ion with MR1, whereas the invariant MAIT TCR alpha chain controlled specificity through a small numbe

96 wide frequency range (<0.00001-1.62%) of TCR alpha-chains corresponding to GAD65-specific T cells.

97 novel structural details with respect to the alpha chain cross-linking compared with earlier efforts.

98 ffness, compared with a 2.5-fold increase by alpha-chain cross-linking alone (gammaQ398N/Q399N/K406R)

99 involvement were completely absent, and only alpha-chain cross-linking occurred.

100 osslinking sites, but not in clots that lack alpha-chain crosslinking sites.

101 ntion of RBCs in clots is mediated by fibrin alpha-chain crosslinking.

102 colony-stimulating factor (GM-CSF) receptor alpha-chain (CSF2RA) deficiency is a rare, life-threaten

103 h IL-10 deficiency and 1 patient with IL-10R alpha chain deficiency and proved to be an effective the

104 po-form and in complex with human K10 and Fg alpha-chain-derived peptides, respectively.

105 e lacking ST2 (ST2(-/-)), the IL-33 receptor alpha-chain, developed attenuated AIA and reduced expres

106 Mice lacking ST2, the IL-33 receptor alpha-chain, developed attenuated collagen-induced arthr

107 position of group 14 atoms in the alpha-beta-alpha chain dictates whether electronic communication be

108 sidue present in the cytoplasmic tail of the alpha chain, DMalpha.

109 s had higher expression of the IL-2 receptor alpha chain, DN Ikaros-transduced cells achieved their c

110 ha1(VI), alpha2(VI), and alpha3(VI) collagen alpha chains encoded by the COL6A1, COL6A2, and COL6A3 g

111 cific, clonally diverse VB19 T cells express alpha-chains encoded by multiple AV genes with different

112 ult from a genetic deficiency of the GM-CSFR alpha chain, encoded in the X-chromosome pseudoautosomal

113 aining (pseudo)halide functionalities at the alpha-chain end but, depending on the termination mechan

114 ossessing a pentavalent arsenic acid (As(V)) alpha-chain end was transformed into trivalent As(III) p

115 in surface expression of IFN-gamma receptor alpha-chain even in the absence of IFN-alpha/beta signal

116 in LOS with a complete lacto-N-neotetraosyl alpha-chain even though previous reports suggested that

117 urther investigate this we evaluated laminin alpha-chain expression in the cerebral cortex and eye of

118 The C-terminal portion of the fibrin alpha chain extends into the alphaC region (210-610).

119 trally above CD1b, whereby the conserved TCR alpha-chain extensively contacts CD1b and GMM.

120 2, as well as to other epitopes of the TAChR alpha-chain extracellular domain, was maintained in old

121 ild-type mice versus those deficient in FcRn alpha-chain, FcgammaIIb, and FcgammaRI/FcgammaRIII, foll

122 ts resulted from heme distortion and, in the alpha chain, Fe-His bond tilting.

123 , the MAIT-TCR contacts are dominated by the alpha-chain, focused on the MR1 alpha2 helix.

124 hat the ability of AHSP to stabilize nascent alpha chain folding intermediates prior to hemin reducti

125 ry complexes of 1:1:1 stoichiometry with all alpha chain fragments.

126 ls are identified by their expression of the alpha-chain from the integrin alpha(E)(CD103)beta(7), an

127 use high-affinity binding resides in the HGF alpha-chain, full-length mutants maintained normal Met b

128 e localization of proximal constraint in the alpha chains, geminate recombination was found to be equ

129 n deficiency [via knockout of the fibrinogen alpha chain gene (Fbg(-/-))] affected APAP-induced liver

130 e soluble form of the interleukin-7 receptor alpha chain gene (sIL7R) produced by alternative splicin

131 n accumulation of unresolved T cell receptor alpha-chain gene (Tcra) breaks.

132 Mutations in the fibrinogen A alpha-chain gene are the most common cause of hereditary

133 , we show that the conserved T cell receptor alpha-chain generates insulin autoantibodies when transg

134 The TCR delta- and alpha-chain genes lie in a single complex locus, the TCR

135 d the disruption of endogenous TCR beta- and alpha-chain genes.

136 The alpha3(VI) collagen alpha chain has much larger N- and C-globular domains th

137 Laminin alpha chains have unique spatiotemporal expression patte

138 s contain a mixture of functionally distinct alpha-chain hemoglobin isoforms that are predicted to ha

139 s suggested that the presence of an extended alpha-chain hinders C3 PEA substitution of Hep II.

140 In alpha chains, however, the respective lysine and glutami

141 ing aptamers against Interleukin 10 receptor alpha chain (IL-10RA) and experimentally confirmed our p

142 Polymorphisms in the interleukin-4 receptor alpha chain (IL-4R alpha) have been linked to asthma inc

143 and vascular endothelial (VE) IL-4 receptor alpha chain (IL-4Ralpha) signaling in histamine-abelson

144 ing on their expression of the IL-4 receptor alpha chain (IL-4Ralpha/CD124).

145 ceptor (IL-5R), composed of a ligand binding alpha chain (IL-5Ralpha), and a common beta chain, betac

146 cell-specific deletion of the IL-6 receptor alpha chain (IL-6Ralpha) results in impaired Th1 and Th1

147 he gene expression of interleukin-7 receptor alpha chain (IL-7Ralpha) and postulated to be critical i

148 the expression of the interleukin-7 receptor alpha chain (IL-7Ralpha) in T cells, whereas it is dispe

149 Interleukin-7 receptor alpha chain (IL-7Ralpha) is induced upon T cell positive

150 levels of CD127, the interleukin 7 receptor alpha chain (IL-7Ralpha).

151 MEF cells from mice deficient in the IL-18R alpha-chain (IL-18Ralpha) compared with wild type MEF.

152 the Il4ra locus, which encodes IL-4 receptor alpha-chain (IL-4Ralpha), was essential for inducing and

153 Using their IL-6 receptor alpha-chain (IL-6Ralpha), Sirpalpha(+) DCs trans-present

154 p1 repressed expression of the IL-7 receptor alpha-chain (IL-7Ralpha) by antagonizing Foxo1 and negat

155 in a severe defect in interleukin 7 receptor alpha-chain (IL-7Ralpha) expression associated with its

156 naive and memory T cells, and IL-7 receptor alpha-chain (IL-7Ralpha) expression is dynamically regul

157 iral and bacterial infections, IL-7 receptor alpha-chain (IL-7Ralpha) is expressed on a subset of eff

158 expressing high and low levels of the IL-7R alpha-chain (IL-7Ralpha) that is essential for memory T

159 LCs) that express the interleukin 7 receptor alpha-chain (IL-7Ralpha).

160 ene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conversion of induced

161 in-of-function mutation in the IL-4 receptor alpha chain (Il4raF709) and wild-type (WT) control anima

162 in-of-function mutation in the IL-4 receptor alpha chain (Il4raF709) were orally sensitized with food

163 sion of the genes encoding the IL-6 receptor alpha-chain (Il6ra) and the IL-6 signal transducer gp130

164 the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significant risk factor for mult

165 ghting the likely dominance of the conserved alpha chain in MR1-antigen recognition.

166 e C-terminal vSAG segment binds to the MHCII alpha-chain in a conformation-sensitive manner, the memb

167 alanine to threonine at position 118 of the alpha-chain in the CDR3 region of the TCR improved its f

168 r the 3-hydroxylation of the A3 site of both alpha-chains in bone but not in tendon.

169 However, the importance of these alpha-chains in disease pathogenesis and the paired TCRb

170 ked disturbance in the deposition of laminin alpha-chains including alpha1, alpha2, alpha4, and alpha

171 The band intensity of beta-chain and alpha-chains increased as the extraction temperature inc

172 CD4 T cells that express CD25 (IL-2 receptor alpha-chain) increases with age on subsets of both CD31(

173 ated cross-linking of IgE-loaded FcepsilonRI alpha-chains induces cell activation via immunoreceptor

174 Daclizumab (Dac), an Ab against the IL-2R alpha-chain, inhibits brain inflammation in patients wit

175 ller T (NKT) cells with an invariant (i) TCR alpha chain (iNKT cells) recognize glycolipids from B. b

176 natural killer T cells with an invariant TCR alpha-chain (iNKT cells) are a conserved population of T

177 In a cis heterodimer, the alpha-chain interacts with the beta-chain coded by the s

178 e complement control protein-6 domain of the alpha-chain is necessary for the tolerogenic activity of

179 led to the fixation of the Hps with a longer alpha-chain is not known.

180 bsets bearing alphabeta TCRs using invariant alpha-chains is indicative of unique and important funct

181 high-affinity interleukin-2 (IL-2) receptor alpha chain, is rapidly upregulated by antigen-specific

182 of Fg (FgalphaCC; amino acids 392-644 in Fg alpha chain; isothermal titration calorimetry, K(D) = 0.

183 an invariant alpha-chain variable region 14-alpha-chain joining region 18 (V(alpha)14J(alpha)18) T c

184 IgG that bound the internal nLc3 alpha chain killed both L3,7 and L2,4 strains, whereas I

185 Serum soluble IL-2 receptor alpha chain levels and in vitro immunoglobulin productio

186 -phosphatase 1 and interferon-gamma receptor alpha-chain levels in activated CD4(+) T cells in the ly

187 rall architecture similar to that of laminin alpha chain LN domains but includes significant differen

188 g, we showed that the A allele alters IL-23R alpha-chain mRNA splicing and favors exon 9 skipping by

189 with disruptions in Muc1 and T-cell receptor alpha chain (Muc/TCR double knockout mice).

190 We found that the three alpha-chain mutations (alpha+53G, alpha+53R, or alphaY22

191 t/Jalpha-segment, but no conservation of the alpha-chain N region and no conservation of the Vbeta-ch

192 blood GAD65-specific CD4(+) T cells, and TCR alpha-chain next-generation sequencing to bulk memory CD

193 s: a structure-based design study on the TCR alpha chain (nine mutations) and an in vitro selection s

194 In the alpha chain nuFeHis dropped sharply at 20 mus, the final

195 tion mutations in COL13A1, which encodes the alpha chain of an atypical non-fibrillar collagen with a

196 We previously showed that the alpha chain of fibrinogen is a preferred substrate of mM

197 It has been proposed that mutations in the alpha chain of HexA can impair folding, enzyme assembly,

198 ions in the gene encoding the ligand-binding alpha chain of the GM-CSF receptor.

199 the homodimeric transmembrane dimer from the alpha chain of the integrin alpha(IIb)beta(3).

200 ined the turnover of a model PM protein, the alpha chain of the interleukin-2 receptor (Tac).

201 CD25, the alpha chain of the interleukin-2 receptor, is expressed

202 CD123, the transmembrane alpha chain of the interleukin-3 receptor, is expressed

203 IT TCR-MR1 docking that was dominated by the alpha chain of the MAIT TCR.

204 lation of a gene encoding an inactive mutant alpha chain of the Vibrio harveyi enzyme.

205 563)-Lys(539), and Gln(563)-Lys(601)) on the alpha chains of fibrin were newly identified.

206 These crosslinks involve both the gamma and alpha chains of fibrin.

207 e 1 modifies a single proline residue in the alpha chains of type I, II, and III collagens to (3S)-hy

208 Here we show that the extracellular (alpha) chain of LRP1 mediates TGFbeta-induced enhancemen

209 In contrast, incubation with the monomeric alpha-chain of C4BP was less effective.

210 encies of both T cells that express only the alpha-chain of CD8 and double-negative T cells.

211 m of hybrid cytokine containing IL-7 and the alpha-chain of HGF (HGFalpha) (hrIL-7/HGFalpha).

212 presence of a transdimer formed between the alpha-chain of HLA-DQ2 (DQA1*05:01) and the beta-chain o

213 RB(high) T cells from mice deficient for the alpha-chain of IL-27 receptor failed to induce colitis i

214 associated with diminished expression of the alpha-chain of IL-33 receptor on choriodecidual B cells

215 Because conservation of the TCR alpha-chain of invariant T cells is much higher than the

216 hese results support the hypothesis that the alpha-chain of MSPalphabeta mediates RON dimerization.

217 TCR, allowing for an interaction between the alpha-chain of TCR and MHC.

218 buted to autoantibodies directed against the alpha-chain of the high-affinity IgE receptor (Fcepsilon

219 The gene encoding the alpha-chain of the IL-2 receptor, IL2RA, harbors alleles

220 ells as well as the proper expression of the alpha-chain of the IL-7 receptor (CD127) and Ebf1.

221 s specific for the autoallergen Hom s 2, the alpha-chain of the nascent polypeptide-associated comple

222 While the alpha-chain of the NKTcr is invariant, the beta-chain is

223 M2) activation of macrophages driven via the alpha-chain of the receptor for interleukin 4 (IL-4Ralph

224 hich a large number of the T(EM) express the alpha-chain of VLA-2, CD49b.

225 n, type IV collagen contained macromolecular alpha-chains of 225 and 250 kDa.

226 domain (CY) sequences of the ligand-binding alpha-chains of gamma-chain-associated receptors.

227 Electrophoretic study revealed that alpha-chains of gelatin in films became lowered with inc

228 allosteric effectors and isolated beta- and alpha-chains of hemoglobin, it appears that NO reacts wi

229 tendon and bone, but absent in skin in both alpha-chains of the wild type animals.

230 rally accepted that LH2 modifies procollagen alpha chains on the endoplasmic reticulum before the for

231 vs low expression of the AI4 clonotypic TCR alpha-chain on developing thymocytes in B6.H2g7 and NOD

232 ugh downregulation of the IFN-gamma receptor alpha-chain on macrophages and dendritic cells.

233 ata suggest a likely binding site of the HGF alpha-chain on MET, which when dimerized leads to MET si

234 ssion of CD25 (interleukin-2 [IL-2] receptor alpha chain) on Ad5-elicited CD4 T cells, and administra

235 ased on the disruption of the endogenous TCR alpha chain only, followed by the transfer of genes enco

236 teracts with these two sites within the same alpha chain or whether it cross-links a site from each a

237 Deletion of ST2, the IL-33 receptor alpha chain, or treatment with a soluble IL-33 decoy rec

238 st, private TCRs, each comprising a distinct alpha chain paired with the same public beta chain, inte

239 et complementation is shorter in the ClfB.Fg alpha-chain peptide complex.

240 shown to be tolerant to p146-162, the TAChR alpha-chain peptide that dominated young nontransgenic T

241 was implemented to characterize cross-linked alpha chain peptides originating from native fibrin.

242 ingle, unique TCR-beta chain and diverse TCR-alpha chains, pinpointing malignant transformation to a

243 elected hemoglobin mutants, we show that the alpha chain possesses two electron transfer pathways, si

244 detected T cells with highly stereotyped TCR alpha-chains present among genetically unrelated patient

245 The migration of collagen type I alpha chains produced by these fibroblasts was mildly de

246 the extracellular domains of the functional alpha chain protein.

247 Once the FcepsilonRI alpha-chain reached the cell surface by itself, it forme

248 s express an invariant T-cell receptor (TCR) alpha chain rearrangement (Valpha14 Jalpha18 in mice; Va

249 are innate-like T cells with a conserved TCR alpha-chain recognizing bacterial metabolites presented

250 In this study, we use a coarse-grained C(alpha)-chain representation and Langevin dynamics to stu

251 ls that express an invariant T-cell receptor alpha-chain restricted by the nonclassical MHC class I m

252 absence of the gammaC-dodecapeptide and the alpha-chain RGD sequences suggests that the alphaIIbbeta

253 of the active enzyme to cleave the collagen alpha chains sequentially, at Gly(775)-Leu(776) in colla

254 mbrane ER retention signals, the FcepsilonRI alpha-chain signal peptide contains a negative regulator

255 Circulating IL-7 and soluble IL-7 receptor alpha-chain (soluble CD127) concentrations were measured

256 llows: HbA (the major adult Hb isoform, with alpha-chain subunits encoded by the alpha(A)-globin gene

257 e) and HbD (the minor adult Hb isoform, with alpha-chain subunits encoded by the alpha(D)-globin gene

258 to mice deficient in the alpha1(VI) collagen alpha chain, suggesting that the cleavage product of the

259 of a primary insulin peptide by a conserved alpha chain T cell receptor.

260 te expression of the T-cell antigen receptor alpha chain (TCR-alpha) in developing thymocytes.

261 he gene encoding the T cell antigen receptor alpha-chain (Tcra) and had a profound, intrinsic block i

262 ch then rearrange the locus encoding the TCR alpha-chain (Tcra).

263 The T-cell antigen receptor (TCR) alpha-chain (TCRalpha) is a type I integral membrane pro

264 cells expressing 'invariant' T cell receptor alpha-chains (TCRalpha chains) containing variable (V) a

265 l C-terminal segment of the insulin receptor alpha-chain (termed alphaCT).

266 inding and IgG that bound the truncated nLc3 alpha chain that lacks this Gal residue.

267 would result in synthesis of polylactosamine alpha chains that could be sialylated.

268 mas, we identified key residues on the MHCII alpha-chain that are differentially recognized by the CD

269 e employed next-generation sequencing of TCR alpha-chains that contain the TRAV1-2 gene segment to id

270 show that Hp of cow (Bos taurus) contains an alpha-chain, the structure of which is similar to that o

271 uccessive saccharide deletions from the nLc4 alpha chain to characterize further the binding and bact

272 assign cross-linked peptide pairs of fibrin alpha chains to the monoisotopic masses relying on accur

273 kine trans-presented with the IL-15 receptor alpha-chain to the shared IL-2/IL-15Rbeta and common gam

274 rtically to DP in the TM1237 region with the alpha chain toward the extracellular (EC) region and the

275 etry, and in vivo by using human FcepsilonRI alpha-chain transgenic mice in a functional passive cuta

276 s express an invariant T cell receptor (TCR) alpha-chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12

277 press a semi-invariant T cell receptor (TCR) alpha-chain, TRAV1-2-TRAJ33, and are activated by vitami

278 nvariant owing to their mostly invariant TCR alpha-chain usage (Valpha14-Jalpha18 in mice, Valpha24-J

279 ing, we systematically studied the impact of alpha-chain usage in the formation of T cell memory and

280 her than the beta-chain, and because the TCR alpha-chain V gene segment TRAV1-2 is used by two of the

281 eir use of the T cell antigen receptor (TCR) alpha-chain variable region (Valpha) and beta-chain vari

282 racterized by the expression of an invariant alpha-chain variable region 14-alpha-chain joining regio

283 We report here a new hemoglobin alpha chain variant in a female patient with mild anemia

284 This reporter gene was excised during TCR alpha-chain VJ-recombination, and the retained H2BeGFP s

285 f both regulators, further degradation of C3 alpha' chain was observed.

286 uction of insulin autoantibodies by TRAV5D-4 alpha-chains was abrogated by the mutation of insulin pe

287 oresis after data collection, two species of alpha chain were present, indicating that some proteolys

288 ents within the niche and found that laminin alpha chains were expressed by nonstem tumor cells and t

289 Furthermore, increased levels of IL-5R alpha-chain were expressed by B-1a B cells in SMGs and N

290 tion, single amino acid variants of the CDR3 alpha-chain were generated.

291 control protein (CCP) domains 8 and 2 of the alpha-chain were responsible for the strong, hydrophobic

292 on in 3-hydroxylation of the A3 site in both alpha-chains, whereas type I collagen extracted from ten

293 ntation that prevents interaction of the TCR-alpha chain with the MHC class II beta chain helix.

294 itro, the P30W AHSP variant bound oxygenated alpha chains with 30-fold increased affinity.

295 antigen, coprecipitation of the FcepsilonRI alpha-chain with the gamma-chain and beta-chain was mark

296 y studying retrogenic mouse lines expressing alpha-chains with different Valpha TRAV genes.

297 expressing BV1 or BV13 TCRs, associated with alpha-chains with highly diverse VJ usage, CDR3 amino ac

298 genic NOD strains expressing Valpha TRAV5D-4 alpha-chains with many different complementarity determi

299 P was found to lower nuFeHis selectively for alpha chains within the R state, and a binding site in t

300 Polylactosamine alpha chains would enhance virulence, and their sialylat