ライフサイエンスコーパス: alpha-difluoromethylornithine

1 treatment in cells grown in the presence of alpha-difluoromethylornithine.

2 s a more potent inhibitor of the enzyme than alpha-difluoromethylornithine.

3 ying exogenous putrescine in the presence of alpha-difluoromethylornithine.

4 , or by preventing putrescine formation with alpha-difluoromethylornithine.

5 TM activation is polyamine dependent because alpha-difluoromethylornithine, a specific inhibitor of O

6 Treatment with alpha-difluoromethylornithine, a specific ornithine deca

7 Furthermore, alpha-difluoromethylornithine, a suicide inhibitor of OD

8 The specific ODC inhibitor, alpha-difluoromethylornithine, abrogated all suppressive

9 In addition, in vivo inhibition of ODC with alpha-difluoromethylornithine also exacerbated the colit

10 Treatment of gerbils with either alpha-difluoromethylornithine, an inhibitor of ODC, or M

11 ; (ii) depletion of cellular polyamines with alpha-difluoromethylornithine, an inhibitor of ornithine

12 Treatment of ZD:Wt mice with alpha-difluoromethylornithine, an inhibitor of ornithine

13 alpha-Difluoromethylornithine, an irreversible inhibitor

14 Oral consumption of alpha-difluoromethylornithine, an irreversible specific

15 itor of cationic amino acid transport, or by alpha-difluoromethylornithine, an ornithine decarboxylas

16 utrescine was inhibited by the ODC inhibitor alpha-difluoromethylornithine, and L-proline generation

17 Inhibiting ODC activity with alpha-difluoromethylornithine delayed DCVC-induced cell

18 DL-alpha-Difluoromethylornithine (DFMO) causes polyamines o

19 roblastoma (NB) cells with the ODC inhibitor alpha-difluoromethylornithine (DFMO) depleted polyamine

20 Inhibition of polyamine biosynthesis with alpha-difluoromethylornithine (DFMO) has been shown to i

21 Depletion of cellular polyamines by DL-alpha-difluoromethylornithine (DFMO) induced levels of J

22 The Odc inhibitor alpha-difluoromethylornithine (DFMO) inhibited neuroblas

23 Alpha-difluoromethylornithine (DFMO) inhibits the proto-

24 L-Alpha-difluoromethylornithine (DFMO) is a chemopreventiv

25 ned treatment with the Odc suicide inhibitor alpha-difluoromethylornithine (DFMO) or Odc heterozygosi

26 We found that the inhibition of ODC by alpha-difluoromethylornithine (DFMO) resulted in a appro

27 tic action of the NO donor agents as well as alpha-difluoromethylornithine (DFMO), a known ODC inhibi

28 tment of ODC/Ras double transgenic mice with alpha-difluoromethylornithine (DFMO), a specific inhibit

29 When K14-MEK mice were given alpha-difluoromethylornithine (DFMO), a suicide inactiva

30 y to determine the chemopreventive effect of alpha-difluoromethylornithine (DFMO), an enzyme-activate

31 duced by zinc deficiency can be inhibited by alpha-difluoromethylornithine (DFMO), an enzyme-activate

32 n polyamine levels in COS-7 cells induced by alpha-difluoromethylornithine (DFMO), an inhibitor of or

33 were cultured in the presence or absence of alpha-difluoromethylornithine (DFMO), an inhibitor of th

34 We administered alpha-difluoromethylornithine (DFMO), an irreversible in

35 We administered alpha-difluoromethylornithine (DFMO), an irreversible in

36 The use of alpha-difluoromethylornithine (DFMO), an irreversible in

37 itor of cationic amino acid transport, or by alpha-difluoromethylornithine (DFMO), an ODC inhibitor.

38 , i.e. N1,N11-diethylnorspermine (DENSPM) or alpha-difluoromethylornithine (DFMO), have synergistic e

39 NO, like alpha-difluoromethylornithine (DFMO), interferes with ce

40 One of the currently used drugs, alpha-difluoromethylornithine (DFMO), is a suicide inhib

41 A specific inhibitor of the transgene, alpha-difluoromethylornithine (DFMO), reversibly blocked

42 n by TPA, the irreversible inhibitor of ODC, alpha-difluoromethylornithine (DFMO), was used.

43 t with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO).

44 ministration of the suicide inhibitor of ODC alpha-difluoromethylornithine (DFMO, 0.5% w/v) in the dr

45 s by inhibiting ornithine decarboxylase with alpha-difluoromethylornithine dramatically enhanced the

46 Treatment with the biosynthesis inhibitor alpha-difluoromethylornithine during tetracycline remova

47 Arginase inhibitor alpha-difluoromethylornithine enhanced NO production/dil

48 position to that observed for putrescine and alpha-difluoromethylornithine in previous T. brucei ODC

49 nhibiting ornithine decarboxylase (ODC) with alpha-difluoromethylornithine increased the levels of AT

50 Depletion of cellular polyamines by alpha-difluoromethylornithine induced levels of phosphor

51 Polyamine depletion with alpha-difluoromethylornithine inhibited the activities o

52 vation, the polyamine biosynthesis inhibitor alpha-difluoromethylornithine inhibits the ability of MT

53 either the ornithine decarboxylase inhibitor alpha-difluoromethylornithine or the S-adenosylmethionin

54 ol as well as those grown in the presence of alpha-difluoromethylornithine plus putrescine.

55 administration of the suicidal ODC inhibitor alpha-difluoromethylornithine reduced UVB-induced BCCs i

56 with the ornithine decarboxylase inhibitor L-alpha-difluoromethylornithine sensitized all of these le

57 nstream target of Akt, was also increased in alpha-difluoromethylornithine-treated cells, which was p

58 alpha-Difluoromethylornithine treatment of infected mice

59 The ODC inhibitor, alpha-difluoromethylornithine, was administered to H pyl

60 Treatment with the ODC enzyme inhibitor alpha-difluoromethylornithine, which results in regressi