ライフサイエンスコーパス: alpha-dystrobrevin

1 to the other known dystrobrevin (now termed alpha-dystrobrevin).

2 rs distinct properties of association on the alpha-dystrobrevins.

3 of two key DGC signaling-related molecules: alpha-dystrobrevin 1 (global MIFs) and syntrophin beta1

4 predominate in skeletal muscle: full-length alpha-dystrobrevin-1 (84 kD), and COOH-terminal truncate

5 Thus, the distinct distributions of alpha-dystrobrevin-1 and -2 can be partly explained by s

6 a selective reduction in the localization of alpha-dystrobrevin-1 and -2, alpha- and beta1-syntrophin

7 lycan restores the sarcolemmal expression of alpha-dystrobrevin-1 and -2, and beta1- and beta2-syntro

8 )-AR signalosome by the C-terminal domain of alpha-dystrobrevin-1 and not the closely related splice

9 pha-dystrobrevin-2 binds dystrophin, whereas alpha-dystrobrevin-1 binds both dystrophin and utrophin.

10 alpha-Dystrobrevin-1 is associated with Dp71, utrophin,

11 By contrast, alpha-dystrobrevin-1 is found in perivascular astrocytes

12 In contrast, alpha-dystrobrevin-1 is more highly restricted to the sy

13 In contrast, alpha-dystrobrevin-1 remained synaptically localized in

14 of dyb-1(lf) were partially rescued by mouse alpha-dystrobrevin-1.

15 revin-1 (84 kD), and COOH-terminal truncated alpha-dystrobrevin-2 (65 kD).

16 ecipitation of in vitro-translated proteins, alpha-dystrobrevin-2 binds dystrophin, whereas alpha-dys

17 ng isoform-specific antibodies, we find that alpha-dystrobrevin-2 is localized on the sarcolemma and

18 alpha-Dystrobrevin-2 preferentially copurifies with dyst

19 alpha-Dystrobrevin-2 was lost from the nonsynaptic sarco

20 dence of myopathy, despite reduced levels of alpha-dystrobrevin-2.

21 1 and not the closely related splice variant alpha-dystrobrevin-2.

22 tal protein, physically interacts with DYB-1/alpha-dystrobrevin (a component of the dystrophin comple

23 Mice rendered null for alpha-dystrobrevin, a component of the dystrophin comple

24 neuromuscular junctions of mice deficient in alpha-dystrobrevin, a component of the dystrophin glycop

25 In mice that lacked alpha-dystrobrevin, a component of the dystrophin-glycop

26 strophin-associated protein complex (DPC) is alpha-dystrobrevin, a dystrophin-related and -associated

27 We show here that alpha-dystrobrevin (alpha-DB), a protein contributing to

28 e, we show that a cytoplasmic DGC component, alpha-dystrobrevin (alpha-DB), is dispensable for format

29 d 75 kDa isoforms of tyrosine phosphorylated alpha-dystrobrevin (alpha-dbn) 1 (which are required for

30 d neuromuscular junctions and interacts with alpha-dystrobrevin and that the level of alpha-catulin i

31 in-associated proteins, the sarcoglycans and alpha-dystrobrevin, are critical for both cardiac and sk

32 of the postsynaptic membrane, and establish alpha-dystrobrevin as a key control point for regulation

33 DAMAGE associates directly with alpha-dystrobrevin, as shown by yeast two-hybrid, and co

34 Thus, like alpha-dystrobrevin, beta-dystrobrevin is likely to assoc

35 recipitation is dependent on the presence of alpha-dystrobrevin but not beta-dystrobrevin.

36 In the present study, we have cloned a novel alpha-dystrobrevin cDNA encoding a protein (referred to

37 alpha-Dystrobrevin (DB), a cytoplasmic component of the

38 hat the level of alpha-catulin is reduced in alpha-dystrobrevin-deficient mouse muscle.

39 alterations in mouse skeletal muscle lacking alpha-dystrobrevin (Dtna(-/-)), we identified a highly s

40 Alternative splicing of the alpha-dystrobrevin gene generates multiple isoforms whic

41 alysis and biochemical binding studies, that alpha-dystrobrevin in fact contains two independent synt

42 ding beta-dystroglycan, alpha-syntrophin and alpha-dystrobrevin in mdx muscle.

43 The precise role of alpha-dystrobrevin in skeletal muscle has not yet been d

44 In skeletal muscle, alpha-dystrobrevin is a component of the dystrophin-asso

45 Alpha-dystrobrevin is a dystrophin-related protein expre

46 alpha-Dystrobrevin is both a dystrophin homologue and a

47 at the interaction between alpha-catulin and alpha-dystrobrevin is evolutionarily conserved in C. ele

48 eas synaptic AChEs are more stable, and that alpha-dystrobrevin is important for controlling the dens

49 at alternatively spliced variants of the new alpha-dystrobrevin isoform, alpha-DB2b, are differential

50 ntial expression of exons 12 and 13 in other alpha-dystrobrevin isoforms in skeletal muscle and heart

51 ion similar to that previously described for alpha-dystrobrevin isoforms.

52 Thus, alpha-dystrobrevin may serve a signaling function that i

53 ; however, the physiological function of the alpha-dystrobrevins remains unknown.

54 To study alpha-dystrobrevin's function in skeletal muscle, we use

55 ated within an alternatively spliced exon of alpha-dystrobrevin, termed the variable region-3 (vr3) s

56 A positive interaction between DMN and alpha-dystrobrevin was confirmed with an in vitro coimmu