ライフサイエンスコーパス: alpha-helices

1 f a beta sheet flanked with two antiparallel alpha helices.

2 row distance distributions along and between alpha helices.

3 proteins with curved beta sheets topped with alpha helices.

4 en antiparallel beta strands stacked between alpha helices.

5 iparallel beta-sandwich wrapped in two short alpha helices.

6 ng the membrane domain of the enzyme via two alpha-helices.

7 ygens and amide H(+)s four residues apart in alpha-helices.

8 beta-strands and random coil with two small alpha-helices.

9 llel homodimers formed by transmembrane (TM) alpha-helices.

10 nique beta-sandwich fold with short terminal alpha-helices.

11 ule scaffold that captures the topography of alpha-helices.

12 llel beta-strands along with two surrounding alpha-helices.

13 S domains, each comprising six transmembrane alpha-helices.

14 in (LBD), which consists predominantly of 11 alpha-helices.

15 residues stemming from the beta-strands and alpha-helices.

16 the binding domain entrance, flanked by two alpha-helices.

17 rrangements of four N-terminal transmembrane alpha-helices.

18 nded antiparallel beta sheet and a few short alpha-helices.

19 ng of three gatekeeping residues and several alpha-helices.

20 that porate cellular membranes by the use of alpha-helices.

21 the channel is closed by dense packing of 12 alpha-helices.

22 lel beta-sheet buttressed on one side by two alpha-helices.

23 r space and is likely to be composed of four alpha-helices.

24 y of inhibitory peptides to make amphipathic alpha-helices.

25 P) reveals a novel all-helix fold with seven alpha-helices.

26 proteolytically stable structural mimics of alpha-helices.

27 -sheets and a corresponding reduction of the alpha-helices.

28 cross-linkers to be the best at stabilizing alpha-helices.

29 nterdigitated knob-socket motifs between two alpha-helices.

30 tructure, formed of 12 beta-strands and nine alpha-helices.

31 ficient folding and perfect pairing of their alpha-helices.

32 n of hydrophobic and hydrophilic residues in alpha-helices.

33 t rather two closely associated antiparallel alpha-helices.

34 ed of 25 repeats capped by N- and C-terminal alpha-helices.

35 rbcS) or only the surface-exposed algal SSU alpha-helices.

36 actions of macrodipoles between neighbouring alpha-helices.

37 n, resulting in a total of six transmembrane alpha-helices.

38 e of HIV gp41 and represents a bundle of six alpha-helices.

39 ized side chains in the first turn of the M2 alpha-helices.

40 ers exhibit three highly conserved predicted alpha-helices.

41 etylcholine receptor formed by transmembrane alpha-helices.

42 s to a group of charged, E(R/K)-rich, single alpha-helices.

43 a central mixed beta-sandwich surrounded by alpha-helices.

44 transmembrane-spanning and five cytoplasmic alpha-helices.

45 of detergent molecules between transmembrane alpha-helices.

46 esis studies suggest that at least predicted alpha-helices 2 and 3 are required for Aar activity.

47 of the proximal Tyr-263, which also links TM alpha-helices 2 and 3 via a hydrogen bond, alter proton

48 results, the N-terminal domain contains four alpha-helices, 20 to 30 amino acids long.

49 ic intermediates is structure and packing of alpha-helices 3 and 7 and the degree of structure in bet

50 we propose a dimerization interface between alpha-helices 4 and 5 and the loop between beta2 and bet

51 ndicate structural flexibility is induced in alpha-helices 4 and 5, suggesting this region contribute

52 that restrains conformational flexibility in alpha-helices 4 and 5.

53 erine 145, tyrosine 178, and cysteine 189 on alpha-helices 6, 7, and 8, respectively, within zeta-iso

54 arious activities (AAA) domain, specifically alpha-helices 7 and 9, as relevant contact sites.

55 on for this function was mapped carefully to alpha-helices 7 to 9.

56 hange at the interface between the region of alpha-helices A/A' and the meander loop of the enzyme, w

57 tates involves movement of the even-numbered alpha-helices across the surfaces of the odd-numbered al

58 We found that these alpha-helices act as a transient intermediate to beta-sh

59 beta-strands (beta1-beta4) connected by four alpha-helices (alpha1-alpha4).

60 del is that activated Bak and Bax insert two alpha-helices, alpha5 and alpha6, as a hairpin across th

61 pectroscopy, that COR15A starts to fold into alpha-helices already under mild dehydration conditions

62 in fold containing three orthogonally packed alpha helices and a 310 helix, FF6 contains an additiona

63 domain and extensive nucleotide contacts via alpha helices and a C-terminal loop.

64 Here we show that alpha helices and beta strands differ significantly in t

65 red structures composed of domains formed by alpha helices and beta strands.

66 ions play a role in capping the C-termini of alpha-helices and 310-helices.

67 amino-terminal domain (NTD) comprising seven alpha-helices and a beta-hairpin, a carboxy-terminal dom

68 onsisting of a central beta-sheet flanked by alpha-helices and a C-terminal beta-hairpin unique to TA

69 ure displays a novel fold comprised of seven alpha-helices and a highly curved three-stranded antipar

70 s a core scaffold composed of a layer of two alpha-helices and a layer of three-stranded antiparallel

71 s core region is composed almost entirely of alpha-helices and assembles into stable homodimers in so

72 helmingly a random coil, with the structured alpha-helices and beta-sheets being confined to the geno

73 The folds of alpha-helices and beta-sheets interacted together to for

74 25 nm, and the energy difference between the alpha-helices and beta-sheets is 4.9 kcal/mol per helica

75 act parallel and antiparallel arrangement of alpha-helices and beta-strands, enumerated all possible

76 rization interface, primarily contacting the alpha-helices and beta2-beta3 loops from each monomer.

77 ng proteins with a conserved fold made up of alpha-helices and can possess diverse properties.

78 HaSCP-2 composed of five alpha-helices and four stranded beta-sheets.

79 Many of them fold into membrane-bound alpha-helices and function by causing cell wall disrupti

80 he N-terminal domain of CdaS consists of two alpha-helices and is attached to the C-terminal catalyti

81 suggests that pATOM36 is composed largely of alpha-helices and its assembly into the outer membrane i

82 ighly stable central beta-sheet and flanking alpha-helices and loop regions are formed.

83 human TBC1D1 and TBC1D4 domains both have 16 alpha-helices and no beta-sheet elements.

84 The monomeric molecule consists of 10 alpha-helices and one short beta-hairpin, and, although

85 was found in a subset of buried positions in alpha-helices and pervasively in the underlying beta-str

86 A2 contains a bundle of alpha-helices and replaces one dimer of coat proteins at

87 re is assembled from amino acids in both the alpha-helices and ribbon element.

88 eavages were consistently observed for three alpha-helices and the adenosine binding regions for AK c

89 -defined secondary structures, in most cases alpha-helices and their orientation is given by a tilt a

90 common evolution from disordered monomers to alpha-helices and then to beta-sheets when the proteins

91 is formed by regular (i.e. beta-strands and alpha-helices) and non-periodic structural units such as

92 arboxy-terminal domain (CTD) comprising four alpha-helices, and a flexible linker with a 310-helix co

93 ts structure, comprising eight transmembrane alpha-helices, and catalytic site are distinct from thos

94 s protein contained three beta-sheets, seven alpha-helices, and coils.

95 omains share a six-stranded beta-sheet, five alpha-helices, and conserved motifs similar to those req

96 d by layered arrangements of beta-sheets and alpha-helices, and how these arrangements became globula

97 which are intermittently surrounded by four alpha-helices, and the C terminus, including the alpha5-

98 the ISRs reside in a cluster of five surface alpha-helices, and the carboxyl-terminal region (CTR), a

99 a model for the packing of these N-terminal alpha-helices, and this packing is different from severa

100 core structure composed of six antiparallel alpha-helices, and this structure is considered instrume

101 ructure with an alpha/beta topology in which alpha-helices are at the N- and C-terminal ends of the m

102 those of native Rubisco, suggesting that the alpha-helices are catalytically neutral.

103 e of a beta-sheet topped by two semiparallel alpha-helices are discussed in this review, highlighting

104 rns of biological significance, right-handed alpha-helices are perhaps the most abundant structural m

105 minal alpha-helices; when ATP is scarce, the alpha-helices are proposed to inhibit ATP hydrolysis by

106 of the binding cavities is restored if these alpha-helices are repositioned extrinsically, suggesting

107 In solution, alpha-helices are stabilized at the termini by a variety

108 peptides, giving new insight into how single alpha-helices are stabilized.

109 These regions, mainly composed of alpha-helices, are located on a surface opposite the DNA

110 and Der p 5, comprising three anti-parallel alpha-helices arranged in a helical bundle.

111 nds report on the hydration of transmembrane alpha-helices as concluded from vibrational coupling exp

112 have evolved to efficiently utilize protein alpha-helices as molecular electrets, the synthetic coun

113 ubulin secondary structure at the H8 and H10 alpha-helices as well as at the S9 beta-sheet, where alp

114 peptides incorporate into lipid bilayers as alpha-helices, as reflected in their circular dichroism

115 ctrostatic interactions that keep the portal alpha-helices at a constant separation.

116 sordered in water, but fold into amphipathic alpha-helices at high osmolyte concentrations in the pre

117 The triangular pyramid domain has three alpha-helices at its narrow end, which are connected to

118 the nuclear receptor PPARalpha (increase of alpha-helices at the expense of decreasing beta-sheets),

119 , consisting of a beta-roll, followed by two alpha-helices (B- and C-helices).

120 --may be regarded as non-peptide mimetics of alpha-helices because they are of comparable size and ha

121 hanges in skin protein secondary structures (alpha-helices, beta-sheet, random coils and turns), as e

122 into ideal protein structures consisting of alpha-helices, beta-strands and minimal loops.

123 ing peak areas associated with turns, bends, alpha-helices, beta-structures, and random coils for ina

124 affect T cell alloreactivity, whereas in the alpha helices, both compatible and noncompatible amino a

125 strands (MinD-binding regions) converted to alpha helices bound to MinD dimers.

126 , each consisting of 42 aa arranged in three alpha-helices, build an elongated superhelical structure

127 rable non-ideal features--for example kinked alpha-helices, bulged beta-strands, strained loops and b

128 are significantly more extended than linear alpha-helices but less extended than straight chains.

129 tutions at the carboxy termini can stabilize alpha-helices by reducing conformational entropy.

130 ices across the surfaces of the odd-numbered alpha-helices by rotation of the domains.

131 Two alpha-helices C-terminal to the core domain, but unique

132 This work demonstrates that all packing in alpha-helices can be simplified to repetitive patterns o

133 e that interfacial tertiary contacts between alpha-helices can regulate siRNA cytoplasmic delivery an

134 Conserved polar residues in the two alpha-helices closest to the c-ring probably line the pr

135 dues at the C-terminus form a bundle of five alpha-helices co-linear with the five-fold axis of symme

136 Subunit D (ScD) consists of a long pair of alpha-helices connected by a short helix ((79)IGYQVQE(85

137 The nascent chain forms two alpha-helices connected by an alpha-turn and a loop, ena

138 The homotrimer of parallel, coiled coil alpha-helices contains a His3-Cu(I) metal site where CO

139 C-terminal domain of ORF57, which is rich in alpha-helices, contributes to homodimerization of ORF57

140 ble beta-sheet structure with tightly packed alpha-helices decorating the exterior of the fibrils.

141 Each subunit is comprised of 18 alpha-helices designated "A-R" and an intracellular carb

142 rolysis by assuming an "up" state, where the alpha-helices, devoid of ATP, enter the alpha3beta3-cata

143 o the stable beta-sheet core, the peripheral alpha-helices display significant local fluctuations lea

144 n, peptides corresponding to two out of four alpha helices dominated the response in both vaccinees a

145 The folding of polypeptide side chains into alpha-helices dramatically enhances the polymerization r

146 Cappings play a central role stabilizing alpha-helices due to lack of intrahelical hydrogen bonds

147 ld symmetrical structure that comprises four alpha-helices enwrapping a pair of antiparallel beta-str

148 ures, we are able to show that whereas short alpha-helices exhibit two-state cooperativity, the type

149 eveal that the variance in structure maps to alpha-helices flanking the central beta-sheet and not to

150 erminal half to be comprised of two extended alpha-helices followed by a C-terminal region that is in

151 Two antiparallel alpha-helices form a coiled-coil domain linked by a larg

152 N-terminal domain of yeast Scc1 contains two alpha helices, forming a four-helix bundle with the coil

153 chimeric Arabidopsis SSUs containing the SSU alpha-helices from Chlamydomonas reinhardtii can form hy

154 short intracellular loop connecting membrane alpha-helices H and I (H-I loop), the AD, CBS1, and CBS2

155 Remarkably, the catalytic iron and alpha-helices harboring its ligands were displaced up to

156 The odd-numbered alpha-helices have an L-shape, with proline or serine re

157 The dynamics of peptide alpha-helices have been studied extensively for many yea

158 The amphipathic alpha-helices have relatively low stability, in the rang

159 are four-helix bundles with a core of three alpha-helices held together by a [4Fe-4S] cluster.

160 lity is highly restricted for amides in core alpha-helices (i.e., helices A-C and F), and a comparabl

161 insertion/deletions in loop regions between alpha-helices, (ii) extensions to the N and C termini, (

162 ligands through aspartates on transmembrane alpha-helices III (canonical Asp(3.32)) or V (non-canoni

163 a unique binding domain consisting of three alpha helices in addition to a typical GT-A-type glycosy

164 dly, we find that at low ionic strength, the alpha helices in H2A-H2B are frequently sampling partial

165 HP35 is a small peptide composed of three alpha helices in the folded configuration.

166 Here we show that alpha helices in the Linker2 (L2) region of rhesus TRIM5

167 or bind lipid surfaces via their amphipathic alpha-helices in a manner typical of apolipoproteins.

168 re packed against one another and flanked by alpha-helices in an alphabetabetaalpha arrangement remin

169 f the beta2AR, the S1P1, or the kappaOR form alpha-helices in crystal structures but lack significant

170 l divalent cations, which induces end-to-end alpha-helices in many conantokins.

171 932-967 form a coiled-coil of two monomeric alpha-helices in parallel orientation.

172 The isolated protein folds into amphipathic alpha-helices in response to increased crowding conditio

173 els are probably located in a bundle of four alpha-helices in the a-subunit that are tilted at approx

174 oned at key conserved sites within predicted alpha-helices in the C terminus.

175 hod is guided by correspondences between the alpha-helices in the density map and model, and does not

176 l of orientation in the cross-beta core, and alpha-helices in the disordered portions of the fibrils.

177 um, ATP and a magnesium ion are bound to the alpha-helices in the down state.

178 al helix-capping motifs (N-Cap) of different alpha-helices in the F-BAR domain, important for F-BAR h

179 the molecular arrangement of the N-terminal alpha-helices in the filament core, including a melted c

180 a are consistent with transient formation of alpha-helices in the first 100 N-terminal residues of th

181 that tBid is monomeric with six well defined alpha-helices in the micelles.

182 ive crystal structure reveals that loops and alpha-helices in the native state must undergo conformat

183 The high content of alpha-helices in Tra1 enabled tracing of the majority of

184 t a proline kink in M1 that separates pi and alpha helices, in both alpha (N217, V218 and P221) and n

185 polar residues provided by a bundle of four alpha-helices inclined at approximately 30 degrees to th

186 hat serves as a scaffold for the hydrophobic alpha-helices involved in pH-dependent pore formation.

187 The critical extension of the alpha-helices is 0.25 nm, and the energy difference betw

188 Formation of alpha-helices is a fundamental process in protein foldin

189 chains at the first turn of the pore-lining alpha-helices is a key determinant of the rate of ion pe

190 re also differs: A significant population of alpha-helices is found in chemically denatured configura

191 The flexibility of alpha-helices is important for membrane protein function

192 r of polyglutamine is very stable, dimers of alpha-helices lack the kinetic stability necessary to su

193 onclude that the structural integrity of the alpha-helices lining the central hole and this loop are

194 22Y substitution alters the positions of the alpha-helices lining the central hole of the PCNA ring,

195 ha-helix, M4, and the adjacent transmembrane alpha-helices, M1 and M3, retains the ability to flux ca

196 brane ion channel is lined by a ring of five alpha helices, M2 segments, one from each subunit.

197 ormation of a monomeric state, where its two alpha-helices, N-terminal heptad repeat (NHR) and C-term

198 the right-handed twist of the DNA, with the alpha helices occupying the major groove.

199 es the subnanometer image contrast such that alpha helices of individual proteins are resolved.

200 the development and validation of stabilized alpha helices of son of sevenless 1 (SAH-SOS1) as protot

201 se VirB homologs, and the transmembrane (TM) alpha helices of VirB10-like TraF form a 55-A-diameter r

202 experimental dimeric structures formed by TM alpha-helices of 21 single-pass membrane proteins (inclu

203 te detection of a single C=O stretch band of alpha-helices of CcO in H2O medium.

204 the mutation disrupts the N-terminus of the alpha-helices of dimeric beta-tropomyosin, a change pred

205 the high dimerization capacity of the third alpha-helices of endophilin A and leucine 215 substituti

206 d Gs involve the amino- and carboxy-terminal alpha-helices of Gs, with conformational changes propaga

207 dicating that the connector, which links the alpha-helices of HAMP domains, plays an important struct

208 Gd(DTPA-BMA)) indicated that the amphipathic alpha-helices of Hsp12 in SDS micelles lie on the membra

209 Here we identify residues in the alpha-helices of ParG that are critical for DNA segregat

210 udy with yeast two-hybrid suggests that most alpha-helices of R16/17, except for the R17 alpha1 helix

211 the third (M3) and fourth transmembrane (M4) alpha-helices of the alpha4 subunit.

212 l elements within the Linker2 region dock to alpha-helices of the coiled-coil domain, likely establis

213 lycan interacts with the loop connecting two alpha-helices of the F-box-combining site.

214 Solvent-exposed residues along the alpha-helices of the HLA-DP2 alpha- and beta-chains were

215 r pore-forming mechanism of action involving alpha-helices of the N-terminal domain, whereas structur

216 models of PrP(Sc) retain most of the native alpha-helices of the normal, noninfectious prion protein

217 ted bacterioruberin is bound parallel to the alpha-helices of the peptide backbone.

218 mino acid composition of two surface-exposed alpha-helices of the SSU: higher plant-like helices knoc

219 ylalanine (Phe) residue within the S2 and S3 alpha-helices of the voltage sensor domain (VSD) of Kv c

220 pha6' extending over the 2(nd) and the 3(rd) alpha-helices of Vta1NTD microtubule interacting and tra

221 nese domain, as well as on the transmembrane alpha-helices of YgaP.

222 Artificial mimicry of alpha-helices offers a basis for development of protein-

223 stranded, antiparallel beta-sheet flanked by alpha-helices on each side, representing a unique oligom

224 ptide complex, which displays cation-induced alpha-helices on each terminus of the peptide.

225 mposed of a sheet of eight strands with four alpha-helices on one side of the sheet.

226 The stalk extends via two parallel long alpha-helices, one in each of the related b and b' subun

227 ith two distinct domains dominated by either alpha helices or beta strands.

228 ted secondary structure, where it folds into alpha helices or unstructured loops.

229 ccur without a hydrophobic core, and without alpha-helices or beta-sheets.

230 ein complexes in the Protein Data Bank where alpha-helices or beta-strands form critical contacts.

231 probabilities between residues in contacting alpha-helices or strands.

232 t a structure consisting of two antiparallel alpha-helices, packed in an exceptionally tight hairpin

233 lly generated three-dimensional models of TM alpha-helices positioned in membranes; (iv) amino acid s

234 Included was the absence of two alpha-helices present in all other OmpR/PhoB response re

235 is that the stabilization of the individual alpha-helices provides an optimum stability and allows f

236 amolecular (native) beta-sheets (55.08%) and alpha-helices/random coils (30.51%), but upon heating fr

237 ) beta-sheets (60-80%) in gamma-livetin, and alpha-helices/random coils (60.59%) in alpha-livetin.

238 te, the beta-hairpin is unfolded whereas the alpha-helices remain predominantly formed.

239 Coiled-coil interactions, between or among alpha-helices, represent the most common tertiary and qu

240 inner and outer circles of N- and C-terminal alpha-helices, respectively.

241 Naturally-occurring single alpha-helices (SAHs), are rich in Arg (R), Glu (E) and L

242 The domains form two amphipathic alpha helices separated by a rigid kink, which prevents

243 ere it interacts with the juxtaposed ends of alpha-helices shaping the narrow membrane-spanning pore.

244 re and it consists of three partially folded alpha-helices spanning residues 7-38, 41-46, and 58-73.

245 The long N-terminal GrpE alpha-helices stabilize the linker of DnaK in the comple

246 loid-like architecture, in which amphipathic alpha helices stacked perpendicular to the fibril axis i

247 sensing and curvature-generating amphipathic alpha-helices, supports a hypothesis that connects helix

248 s reveal 12, mostly irregular, transmembrane alpha-helices surrounding a cavity with sugar- and H(+)-

249 flytrap (VFT) perception domains followed by alpha helices that extend into the cytoplasmic membrane.

250 tified a novel Pincer domain composed of two alpha helices that physically tethers the C-terminal dom

251 erminal domain formed from a cluster of four alpha-helices that appears to distinguish this protein f

252 B56gamma contains 18 alpha-helices that are organized into eight HEAT (Huntin

253 ces cerevisiae allowed identification of the alpha-helices that belong to the a subunit and revealed

254 ter sakazakii PriC forms a compact bundle of alpha-helices that brings together residues involved in

255 based macromolecule with spatially organized alpha-helices that can catalyse its own formation.

256 lia revealed a structure comprising the five alpha-helices that form the phospholipase catalytic modu

257 unique E2-binding domain that includes three alpha-helices that interact extensively with the "backsi

258 onally beneficial dynamic motion between the alpha-helices that is critical for the transmission of s

259 two structural repeats, coupled by flanking alpha-helices that project from the membrane.

260 ral motifs formed by two or more amphipathic alpha-helices that twist into a supercoil.

261 sin (PR), a protein with seven transmembrane alpha-helices that was found to assemble to hexamers in

262 The quality of the map allowed us to assign alpha-helices, the predominant secondary structure eleme

263 For alpha-helices, there is also a weak correlation in the H

264 e to reduce the kink in the pore-lining (S6) alpha-helices, thereby forming the helix bundle crossing

265 ed hydrophobicity to the hydrophobic half of alphaS helices, thereby stabilizing alphaS-membrane inte

266 nvolves allosteric realignment of C-terminal alpha-helices thus generating a binding surface for coac

267 the first and second putative transmembrane alpha-helices (TMalpha1 and TMalpha2).

268 ellular parts of cleft-forming transmembrane alpha-helices (TMHs) 5, 8, and 11.

269 dues introduced into different transmembrane alpha-helices (TMs).

270 a transition of ~20 residues from a pair of alpha-helices to a beta-hairpin and 3(10)-helix.

271 nalysis revealed the hydrophobic face of two alpha-helices to be critical for membranous localization

272 ransformations, for example from coiled-coil alpha-helices to beta-sheet strands.

273 es and undergo a dynamic transition from the alpha-helices to the beta-sheets, which marks the onset

274 ore pronounced tilt of the closed-channel M2 alpha-helices toward the pore's long axis narrows the pe

275 In the plastic regime, the three-stranded alpha-helices undergo a noncooperative phase transition

276 on liposome-reconstituted MscL transmembrane alpha-helices, using a 'virtual sorting' single-molecule

277 gement of basic residues and the amphipathic alpha-helices was substantially different between serogr

278 TOXCAT assay for interactions of isolated TM alpha-helices, we found that TM1, a Cx26 pore domain, ha

279 penetrating peptides (CPPs) form amphipathic alpha-helices when bound to lipid membranes.

280 an ATP molecule bound to its two C-terminal alpha-helices; when ATP is scarce, the alpha-helices are

281 ll fusion requires a parallel orientation of alpha-helices, whereas antiparallel oriented coiled-coil

282 encapsulated ferritin (EncFtn) has two main alpha helices, which assemble in a metal dependent manne

283 rophobic interactions among their N-terminal alpha-helices, which also anchor the pilin subunits in t

284 ups of an arginine-rich region spanning both alpha-helices, which lowers the configurational entropy;

285 bound InsP3 rotates 55 degrees closer to the alpha-helices, which provide most of the protein's inter

286 o a site at the opening of two transmembrane alpha-helices, which results in the scissile bond being

287 binding domains are composed of two extended alpha helices with no apparent surfaces for small-molecu

288 elices 6, 7, and 10 are separate amphipathic alpha-helices with a calculated periodicity of T = 3.34

289 sient increase in hydration of transmembrane alpha-helices with a t(1/2) = 60 mus, which tallies with

290 V POD is formed by one pair of long parallel alpha-helices with another pair in opposite orientation.

291 al barrels, that is, preassembled bundles of alpha-helices with central channels, can be used as buil

292 lical bundle systems consisting of synthetic alpha-helices with either the sequence Ac-(LSLLLSL)3-NH2

293 The SinR(74-111) chain forms two alpha-helices with the organisation of the dimer similar

294 -stranded parallel beta-sheet flanked by six alpha-helices with the putative catalytic triad, Asp-366

295 The tube is constructed of ten alpha-helices with their amino termini arrayed in a righ

296 They are analogous to alpha-helices, with axial aromatic stacking interactions

297 In the present study, we show that the alpha-helices within glucagon and GLP-1, but not GLP-2,

298 The two alpha-helices within the dimer together with the bound l

299 interpretation of the packing of individual alpha-helices within the fibers, and the construction of

300 Interactions between alpha-helices within the hydrophobic environment of lipi