ライフサイエンスコーパス: alpha-helix

1 ng with Glu-126 within its carboxyl-terminal alpha helix.

2 is remodeling is triggered by a single Rpn12 alpha helix.

3 BH3 motif, which folds upon binding into an alpha helix.

4 n SMRT comprising a GSI motif followed by an alpha helix.

5 s and trimers, potentially via a coiled-coil alpha-helix.

6 main, a middle region, and a long C-terminal alpha-helix.

7 king pin mechanism involving the amphipathic alpha-helix.

8 ain proteins are inhibited by the inhibitory alpha-helix.

9 induces the N-terminal loop to fold into an alpha-helix.

10 , with high intrinsic potential to fold into alpha-helix.

11 Lys substitution destabilizes its N-terminal alpha-helix.

12 lel beta-sheet stabilized by a crossing-over alpha-helix.

13 the AXXXG motif on the opposite face of the alpha-helix.

14 amma-peptides to structurally mimic a native alpha-helix.

15 nomer interactions mediated by an N-terminal alpha-helix.

16 reas in the GRK1 peptide complex it forms an alpha-helix.

17 the same hydrophobic projecting hot spots of alpha-helix.

18 spots at positions i, i + 3, and i + 7 of an alpha-helix.

19 , a number of extended loops and a prominent alpha-helix.

20 mutants lacking the beta-hairpin and/or the alpha-helix.

21 of arginine residues located within the ZnF alpha-helix.

22 f such bifurcated H bonds in a transmembrane alpha-helix.

23 ic substitutions only along one face of this alpha-helix.

24 iparallel beta-sheet wrapped around a 5-turn alpha-helix.

25 hods, finding that human calcitonin forms an alpha-helix.

26 hydrophobic face of the amphipathic protein alpha-helix.

27 flexible center to an end-to-end K2hPg-bound alpha-helix.

28 form supramolecular nanofibers consisting of alpha-helix.

29 tional change by a C-terminal domain-derived alpha-helix.

30 ed by an intrinsic N-terminal autoinhibitory alpha-helix.

31 1-9), followed by the N-terminal portion of alpha-helix 1 (residues Cys-11, Glu-12, Val-13, Lys-15,

32 t two residues near the N-terminal region of alpha-helix 1 in GPPrP might mediate its susceptibility

33 epends on these amino acids, which reside on alpha-helix 1 of the CtrA receiver domain, and on cdG bi

34 cond thiol of C(15)SQC(18)H, indicating that alpha helix-1 is required for positioning the first cyst

35 s (2-3-fold), providing further evidence for alpha helix-1 positioning the first cysteine.

36 cyts c with deletions of single residues in alpha helix-1, which mimic bacterial cyt c, are poorly m

37 ognize simply the CXXCH motif, not requiring alpha helix-1.

38 The alpha-helix 2 of PrP contains a string of four threonine

39 alpha-helix 3 and the loop between beta2 and alpha-helix 2.

40 ed by rpb1-G730D, a substitution within Rpb1 alpha-helix 21 (alpha21).

41 lobular domain affecting interaction between alpha-helix 3 and the loop between beta2 and alpha-helix

42 central beta-sheet is highly structured and alpha-helix 3, which is partially formed, packs against

43 motions drive Switch-I region motions, while alpha-helix-3L7 motions control both.

44 uence with a predicted propensity to form an alpha-helix(583-591), one side of which consists of thre

45 amino acid substitutions in a putative Gln3 alpha-helix(656-666), which are required for a two-hybri

46 tational analysis suggest that transmembrane alpha-helix 7 affects the oligomerization interface.

47 Introduction of point mutations into alpha-helix 7 at ORF57 aa 280 to 299, a region highly co

48 Here, we identify a structural element, alpha-helix-7, in human Argonaute2 (Ago2) that is requir

49 area on RTA and makes primary contacts with alpha-helix A (residues 18-32), alpha-helix F (182-194),

50 shoe-shaped substrate pocket, formed from an alpha-helix, a 310 helix, and a recently evolved tri-pro

51 8)Q results in a Mg(2+)-complexed end-to-end alpha-helix, accompanied by attenuation of NMDAR inhibit

52 rotein bind membrane and form an amphipathic alpha-helix (AH).

53 nt mutation in the signal peptide breaks the alpha helix allowing co-translational cleavage.

54 ophobic N terminus that is a curved extended alpha-helix, alpha1, in X-ray crystal structures.

55 raction is mainly mediated by an amphipathic alpha-helix (alpha2), which undergoes a substantial conf

56 Our data show that the two A3H alpha-helixes alpha3 and alpha4 represent the Vif-bindin

57 is a flexible loop, followed by a C-terminal alpha-helix (alpha5).

58 own that Fic enzymes are autoinhibited by an alpha-helix (alphainh) that partly obstructs the active

59 to interact with RAG2 depends on a predicted alpha-helix (amino acids 997-1008) near the RAG1 C termi

60 ds, a linker loop domain with an amphipathic alpha-helix and a C-terminal mitochondrial carrier domai

61 pha-helix as the fragment wedges between the alpha-helix and a loop homologous to the main immunogeni

62 minal domain, which undergoes beta-strand-to-alpha-helix and alpha-helix-to-beta-strand transitions d

63 es with structural changes in the C-terminal alpha-helix and an increase in the distance between the

64 ally folded at pH 4.3 with approximately 35% alpha-helix and are unusually resistant to proteolysis.

65 The alpha-helix and beta-sheet contents decreased, while agg

66 sis revealed that, as temperature increased, alpha-helix and beta-sheet decreased, but aggregated bet

67 otion is concentrated in regions between the alpha-helix and beta-sheet domains.

68 like a polycrystalline material in which the alpha-helix and beta-sheet regions of the protein are si

69 ely selected amino acid residues fall on the alpha-helix and beta-sheets of the peptide-binding domai

70 Effective strategies for mimicking alpha-helix and beta-strand epitopes have been developed

71 -546/Glu-547 lie near the predicted 997-1008 alpha-helix and components of the active site, raising t

72 dent mechanism that involves the dpBMAL1 TAD alpha-helix and dpCLK W328 and a TAD-independent mechani

73 ort loop (Asn-Gln-Gly-Glu-Pro) instead of an alpha-helix and forms hydrogen bonds with Gln-281.

74 charide heparin derivative (dp8) bind to the alpha-helix and in the loops between the beta2 and beta3

75 mance index showed positive correlation with alpha-helix and negative with intermolecular+antiparalle

76 The alpha-helix and random coil contents of the 600 MPa trea

77 OH decreased the beta-turn and increased the alpha-helix and random coil.

78 air of helices is composed of the N-terminal alpha-helix and the C-terminal helix, showing structural

79 ence (named PMasseq) contains an amphipathic alpha-helix and the FWC signature, which is palmitoylate

80 han a smaller subdomain comprised of a short alpha-helix and three-stranded beta-sheet.

81 n placed close to the putative transmembrane alpha-helix and to the active-site entrance; an FAD isoa

82 43 kDa) and secondary structure (beta-sheet, alpha-helix and unordered structure) were analyzed.

83 ated by the folding of residues 3-11 into an alpha-helix, and mediated by membrane water or by previo

84 kinase activity, including the alphaB helix, alphaD helix, and the P-loop.

85 ructured in the monomeric state but forms an alpha-helix approximately 70 residues long in the self-a

86 about a proline "hinge" residue in a stator alpha-helix are directly responsible for generating the

87 ts of the secondary structure, including the alpha-helix, are conserved, but the salt bridge between

88 a-strand conformation, instead of forming an alpha-helix as observed in the previously solved structu

89 s site causes a conformational change of the alpha-helix as the fragment wedges between the alpha-hel

90 tructure leading to a loss of the N-terminal alpha-helix associated with decreased kappa-opioid recep

91 tion of cysteine at the amino terminus of an alpha-helix, associated with activity in thioredoxins, i

92 them based on the calculated free energy of alpha-helix association.

93 II), and inserted across the membrane as an alpha-helix at low pH (State III).

94 The stability of Trp-cage's alpha-helix at low temperatures suggests a possible evol

95 provide evidence for a partially disordered alpha-helix backbone that participates in hydrogen bondi

96 Such alpha-helix barrels engineered from peptides could find

97 he M87T mutation causes a major shift of the alpha-helix bearing the mutated residue, significantly w

98 roteins of increasing structural complexity (alpha-helix, beta-hairpin, alpha-helix bundle, and alpha

99 s higher accuracy, with a blind three-state (alpha-helix, beta-strand and coil) secondary structure p

100 ese findings may support the changing of the alpha-helix/beta-pleated sheets ratio in protein structu

101 tructural flexibility of the TMD in terms of alpha-helix/beta-sheet transitions in model membranes (m

102 This alpha-helix binds to the cytosolic face of the plasma me

103 Here we bridge two 3-alpha-helix bundle proteins with two radically different

104 The-fold consists of a four-alpha-helix bundle with structural similarity to the hig

105 with engineered variants of protein G (GA, 3-alpha-helix bundle).

106 tural complexity (alpha-helix, beta-hairpin, alpha-helix bundle, and alpha/beta-protein).

107 In contrast, mutants lacking the TAD alpha-helix but retaining the most distal C-terminal res

108 , each with a single predicted transmembrane alpha-helix, but their orientation and topography are un

109 , we disrupted the hydrophobic moment of the alpha-helix by replacing Phe(604), Ile(608), or Ile(612)

110 g sites in K2hPg Further, the adoption of an alpha-helix by VKK38 upon binding to K2hPg sterically op

111 In this dimer, the active position of alpha-helix C in the kinase N lobe is stabilized, which

112 all structure of StnA can be described as an alpha-helix cap domain on top of a common alpha/beta hyd

113 rus 5 into the density, it is shown that the alpha-helix close to the RNA became flexible when RNA wa

114 y to mammalian deubiquitinases with a unique alpha-helix close to the substrate-binding pocket.

115 fect the surface-exposed residues of the K10 alpha helix coiled-coil and caused localized disorganiza

116 ther to partially stabilize a short internal alpha-helix comprising L(M) residues 43-46.

117 After a rigid docking of NCC in an alpha-helix conformation, molecular dynamics (MD) and me

118 coil-beta motif forms a short membrane-bound alpha-helix connected by a disordered loop to the TM dom

119 a three-stranded beta-sheet and a C-terminal alpha-helix constrained by two disulfide bonds.

120 terminal domain and an incipient amphipathic alpha-helix contained within it.

121 The beginning of the C-terminal alpha-helix contains a strictly conserved and fully trim

122 alpha-helix --> beta-sheet, with increase in alpha-helix content during the lag phase followed by inc

123 inal to C-terminal interactions with greater alpha-helix content for the 20-29 fragment, with hydroph

124 phipathic CPPs correlates with their adopted alpha-helix content in membranes rather than their helic

125 A residual alpha-helix content in the central part of the peptide (

126 profiles were obtained as a function of the alpha-helix content of different segments of the 17-mer

127 he same kind of changes i.e. decrease in the alpha-helix content with a simultaneous increase in the

128 howed that while HHP treatment decreased the alpha-helix content, free sulfhydryl content, and Rg, it

129 f the secondary structure from beta-sheet to alpha-helix could be monitored at a time resolution of 1

130 EGF-D harboring a mutation in the N-terminal alpha-helix, D103A, exhibited enhanced potency for activ

131 2 regulates circadian repression through TAD alpha-helix-dependent and -independent mechanisms.

132 ochondrial outer membrane via its N-terminal alpha helix domain and hosts a redox-active [2Fe-2S] clu

133 Using the same 12-aa beta-strand-hinge-alpha-helix domain, superantigens engage both B7-2 and C

134 FTIR analysis indicated that PPO is an alpha-helix dominating enzyme.

135 on of 8 cysteine residues, important for its alpha-helixes enriched structure.

136 Side chains in the M1 alpha-helix experience extraordinarily large energy diff

137 ontacts with alpha-helix A (residues 18-32), alpha-helix F (182-194), as well as the F-G loop.

138 PGL-1 DD has a novel 13 alpha-helix fold that creates a positively charged chann

139 types of charged amino-acid residue pairs on alpha-helix folding.

140 The CTD is comprised of an alpha helix followed by an acidic region (AR) and a C-te

141 of CPT enzymes that form part of the second alpha-helix, for determining substrate and product speci

142 nine R210 on the adjacent subunit's backbone alpha-helix form salt bridges in hexamers and pentamers.

143 A is engaged on cellulose, as models predict alpha-helix formation and decreased cellulose interactio

144 ch that they favor helix formation) speed up alpha-helix formation by up to 50% and slow down the unf

145 The structure reveals how alpha-helix formation directly within the peptidyltransf

146 ons, and on the other hand, they can promote alpha-helix formation in certain peptides.

147 A underwent coupled folding and binding with alpha-helix formation upon interaction with RCD1, wherea

148 was resistant to conformational collapse or alpha-helix formation upon the addition of the osmolyte

149 ight coupling between membrane partitioning, alpha-helix formation, and electrostatic repulsions betw

150 ng a pathogenic, expanded Gln length and N17 alpha-helix formation.

151 n by formation of a glycine zipper involving alpha helix formed by amino acid residues 263-294.

152 ed monomer is mainly disordered with a short alpha-helix formed at the central hydrophobic core regio

153 face on Nsp9 is located in the two predicted alpha-helixes formed by 48 residues at the C-terminal en

154 ractions with the enzyme allow it to form an alpha-helix from residues 31-49.

155 nd suggest that the formation of an extended alpha-helix from the disordered carboxy-terminal region

156 Importantly, the N-terminal part of this alpha-helix, from Phe(93) to Thr(98), is required for bi

157 e that: (1) Glu-25 is more frequently in the alpha helix group in the phosphorylated state with the a

158 ed changes in structure from random coil --> alpha-helix --> beta-sheet, with increase in alpha-helix

159 spots at positions i, i + 3, and i + 7 of an alpha-helix had few orientations when interacting with t

160 ta-sheets+antiparallel beta sheets and lower alpha-helix had greater gluten strength.

161 ositioning of the RNMT lobe and the adjacent alpha-helix hinge, resulting in optimal positioning of h

162 These included alpha-helix II and hairpin turns between beta-strands be

163 Mutation of two basic residues in HTLV-2 MA alpha-helix II, previously implicated in BLV gRNA packag

164 a conformational rearrangement involving the alpha-helix III of LC3, especially in the three basic re

165 nt of mAb 10B9 was found to form a very rare alpha helix in its third CDR of the H chain.

166 The K259A mutation, mapping to an alpha helix in the predicted structure of 2C(ATPase), re

167 The zeta-protein is bound via its N-terminal alpha-helix in a catalytic interface in the F1 domain.

168 The role of the outermost transmembrane alpha-helix in both the maturation and function of the p

169 als that fibrillar exon1 has a partly mobile alpha-helix in its aggregation-accelerating N terminus,

170 Surprisingly, the corresponding part of the alpha-helix in mature VEGF-C did not influence binding t

171 nto membranes and forms a transmembrane (TM) alpha-helix in response to slight acidity, and has shown

172 stigated a deletion mutant lacking only this alpha-helix in stable cell lines and Xenopus laevis phot

173 tructures of these three factors revealed an alpha-helix in the C-terminal inhibitory domain that pac

174 ybrid analysis to identify a surface-exposed alpha-helix in the C-terminal mannosyltransferase domain

175 the canonical cleavage site form an extended alpha-helix in the ER membrane, which covers the cleavag

176 a 60:40 ratio of double- and single-stranded alpha-helix in the highly rigid hydrogel of native agaro

177 how that pore loop residues form a canonical alpha-helix in the monomer early in biogenesis and that

178 onclusion, we have identified an amphipathic alpha-helix in the NCX1 large intracellular loop that co

179 We detected a short alpha-helix in the soluble structure that comprised thre

180 rminal tail binds to membranes as a parallel alpha helix, induces bilayer thinning, and increases acy

181 to reveal that SpoVM's atypical amphipathic alpha-helix inserts deeply into the membrane and interac

182 beta-sheet, and insertion of the N-terminal alpha-helix into the heterodimer interface, leading to e

183 close proximity to one another only when the alpha helix is intact.

184 The alpha-helix is a ubiquitous secondary structural element

185 are high, the N-terminus of the amphipathic alpha-helix is bound to a cleft in the regulatory domain

186 sidues Arg-47, Arg-50) in the repeat 1 front alpha-helix is crucial for KCNQ2/3 but not Nav1.2 bindin

187 drop, the cleft closes, and the amphipathic alpha-helix is released to bind to the carrier domain vi

188 to this region, suggesting that folding into alpha-helix is required for chaperone-like activity unde

189 onserved tryptophan (W972) in the C-terminal alpha-helix is widely accepted as essential for E2 recru

190 icit and macromolecular crowding induce high alpha-helix levels in vitro, suggesting that prevalent c

191 from a beta-amino acid, to participate in an alpha-helix-like secondary structure.

192 Y from Bacillus subtilis revealing a 10-turn alpha-helix linking otherwise discrete GAF and wHTH doma

193 VRAASEFA320 that composes the first C-linker alpha-helix located just below the pore is a crucial det

194 petition for binding with coactivators on an alpha-helix located within the transactivation domain (T

195 nterface between the outermost transmembrane alpha-helix, M4, and the adjacent transmembrane alpha-he

196 erved MGF motif and the presence of a fourth alpha-helix make TDP2 UBA distinct from other known UBAs

197 Each alpha helix makes hydrogen-bond (H-bond) contacts with u

198 alpha-Helix mediated PPIs may be amenable to modulation

199 esign and experimental characterization of a alpha-helix-mediated homodimer with C2 symmetry based on

200 scaffold led to the selective disruption of alpha-helix-mediated PPIs.

201 Selective inhibition of alpha-helix-mediated protein-protein interactions (PPIs)

202 this class, which emerged from screening an alpha-helix mimetic library, stimulate the immune respon

203 sis of trispyrimidonamides as a new class of alpha-helix mimetics is reported.

204 gn of novel, low-molecular-weight, synthetic alpha-helix mimetics that recognize helical c-Myc in its

205 onalized alpha/beta/gamma-peptides assume an alpha-helix-mimicking 12,13-helix conformation in soluti

206 (93)CGPAI(97) portion of a predicted central alpha-helix most drastically suppressed the inhibitory a

207 This is the first single alpha-helix motif identified in viral proteins.

208 osome) but share the presence of the class A alpha-helix motif.

209 ta-stranded barrel pore, with its N-terminal alpha-helix (N-alpha) bound to its interior.

210 o the three conserved regions of the CTD: an alpha helix, needed for the structural integrity of the

211 (SNAREDelta60) suggested that an 'accessory' alpha-helix of Complexin-I inhibits release by inserting

212 The C-terminal alpha-helix of CXCL14 had neither antimicrobial nor chem

213 e, formed by contacts between the C-terminal alpha-helix of eL19 and 18S rRNA in concert with additio

214 inst GFP, ubiquitin, an OVA peptide, and the alpha-helix of influenza hemagglutinin's stem; the last

215 tagenesis to demonstrate that the N-terminal alpha-helix of mature VEGF-D (Phe(93)-Arg(108)) is criti

216 The C-terminal alpha-helix of NPY, which is formed in a membrane enviro

217 derable repositioning of the very C-terminal alpha-helix of pUL50 upon pUL53 binding.

218 e-exposed and is located near the N-terminal alpha-helix of the extracellular domain.

219 Hyp(10) disrupts only a small region of the alpha-helix of the Mn(2+).peptide complex, which display

220 Pseudomonas aeruginosa, including a charged alpha-helix on the globular domains of the ZapA tetramer

221 t there were changes in both pore length and alpha-helix organization near the cytoplasmic vestibule

222 We further probe the net collagen alpha-helix pitch angle within the gel mixtures using wh

223 ing pockets, the beta-hairpin pocket and the alpha-helix pocket.

224 ding has previously been employed to measure alpha-helix propensities among proteinogenic alpha-amino

225 This system allows the measurement of alpha-helix propensities for d-alpha-amino acid residues

226 was surrounded by IDRs, individual intrinsic alpha-helix propensities varied as shown by CD spectrosc

227 oil protein content along with a decrease in alpha-helix protein.

228 on and bishistidine ligation in a range of 4-alpha-helix proteins.

229 longer ranging effects, stabilizing a short alpha-helix quite distant from the mutation sites, but a

230 The peptide alpha-helix represents a common structural motif that me

231 in the beta6-alpha5 loop and the C-terminal alpha helix (residue 330).

232 interacting with a highly conserved central alpha helix-rich domain.

233 e availability of apoAI or other amphipathic alpha-helix-rich apoproteins relieves the burden of exce

234 (amino acids [aa] 1 to 152) and a structured alpha-helix-rich C-terminal domain (aa 153 to 455).

235 residues, which facilitate the formation of alpha-helix-rich oligomers, which further undergo struct

236 ent work suggests it also occurs normally in alpha-helix-rich tetramers and related multimers.

237 , but recent work suggests it also occurs in alpha-helix-rich tetramers.

238 and primarily disordered except for a single alpha-helix (SAH) at the N terminus and a short nascent

239 ddition to Survivin and Borealin, the single alpha-helix (SAH) domain of INCENP supports CPC localiza

240 d coil but a approximately 32-nm-long single alpha-helix (SAH) domain.

241 on measurements show a significant degree of alpha-helix sampling in the protein regions encompassing

242 sidues ("alpha/beta-peptides") can mimic the alpha-helix secondary structure, and that properly desig

243 rface receptors, a single transmembrane (TM) alpha-helix separates ecto- and cytosolic domains.

244 ion of the native peptide, by addition of an alpha-helix stabilising sequence and histidine residues,

245 contains a hydrocarbon cross-link to enhance alpha-helix stability.

246 tions of Ca(2+)-free (apo) CaM (reduction in alpha-helix structure by 13% (CD) and 15% (2D)).

247 tergent micelles, which results in a gain of alpha-helix structure in its N-terminal lipid-binding do

248 More precisely, we observe that the single alpha-helix structure is more stable in the phospholipid

249 aggregates, which retain a large content of alpha-helix structures.

250 mimetics was designed to target the central alpha-helix subdomain of Abeta (Abeta13-26).

251 ynuclein mutants with a disrupted N-terminal alpha-helix (T6K and A30P) had little effect under ident

252 beta-barrel domain and a long, mildly kinked alpha-helix tail.

253 nomers while the C-terminal section forms an alpha helix that directly blocks IL-17RA from binding to

254 n folds in the virion into a single extended alpha helix that wraps around the DNA.

255 of fructose 1,6-bisphosphate destabilizes an alpha-helix that bridges the allosteric and active site

256 sues and was found to form a well structured alpha-helix that closely resembles the juxtamembrane hel

257 ility occurs at the N-terminus and the first alpha-helix that connects the HlyIIC domain to the HlyII

258 lved at 2.7 A resolution reveals an extended alpha-helix that contributes to an intermolecular four-h

259 as a partly unwound helix, forms a complete alpha-helix that displaces the amino (N)-terminal helix

260 rich loop that binds the major groove and an alpha-helix that interacts with a downstream minor groov

261 between the two protomers is mediated by an alpha-helix that interacts with the ATP-binding site at

262 ment of MOAG-4 forms a transiently populated alpha-helix that interacts with the negatively charged C

263 g the NTD onto the AraC backbone revealed an alpha-helix that likely serves as the primary determinan

264 pressor ETV6 (or TEL) is autoinhibited by an alpha-helix that sterically blocks its DNA-binding ETS d

265 or TEL) is auto-inhibited ~50-fold due to an alpha-helix that sterically blocks its ETS domain bindin

266 hat the amphipathic nature of the C-terminal alpha-helix (Thr(603)-Thr(613)) was important for foldin

267 winged helix-turn-helix (wHTH) motifs use an alpha helix to read the base sequence in the major groov

268 m-loop target RNA and extends a newly-formed alpha helix to the distal loop where it forms protein in

269 mechanical pulling force can facilitate the alpha-helix to beta-sheet (alpha-to-beta) transition by

270 A shift from alpha-helix to beta-sheet conformation of proteins indic

271 ons promote the pentapeptides transform from alpha-helix to beta-sheet conformation.

272 Rather, these oligomers undergo an alpha-helix to beta-sheet conversion catalyzed by lipid

273 affects protein conformation, by causing an alpha-helix to beta-structures transition in both protei

274 ion of Glu(615) at the end of the C-terminal alpha-helix to Lys reduced surface expression of SERT-E6

275 The asymmetry caused the terminal alpha-helix to thermodynamically uncouple from the rest

276 e hexon and penton are mediated by a drastic alpha-helix-to-beta-strand structural transition.

277 ich undergoes beta-strand-to-alpha-helix and alpha-helix-to-beta-strand transitions during catalysis,

278 The functionally relevant random-coil-alpha-helix transition associated with Ca(2+) uptake tha

279 ng lipid conditions or rigidification of the alphaS helix triggers an increase in small unilamellar v

280 ecule was found to contain a large amount of alpha-helix/unordered structures and many signatures of

281 e produced a synthetic PA mutant in which an alpha helix was crosslinked into the alpha clamp to bloc

282 hat the amphipathic nature of the C-terminal alpha-helix was dispensable to endoplasmic reticulum exp

283 dominated in the coacervate state, although alpha-helix was predominant after subsequent cross-linki

284 ctures (e.g. the order of propensity to form alpha-helix was: PST-297S approximately PST-287K > PST-W

285 that a JMJD6 peptide (Lys84-Asn96) adapts an alpha-helix when bound to the ET domain.

286 in changes to the p-loop, alphaC helix, and alphaD helix when compared to the staurosporine-bound st

287 up to 50% and slow down the unfolding of the alpha-helix, whereas salt bridges with an unfavorable ge

288 ctroscopy showed that LsbB has an N-terminal alpha-helix, whereas the C-terminal of the molecule rema

289 m FPP to GPP, until replacement of the final alpha-helix, whereupon cyclopropanation and branching ac

290 nected to its cytotoxic domain by a flexible alpha-helix, which allows it to adopt two distinct confo

291 sized that this segment forms an amphipathic alpha-helix whose properties facilitate Cys-739 palmitoy

292 structure of the allosteric site revealed an alpha-helix with a loop connecting a coil fragment.

293 ularly flexible between the first and second alpha-helix with the first helical part exhibiting sligh

294 p f3's peroxidase activity, and extended the alpha-helix with the former peroxidatic cysteine residue

295 ic motif of the I-II linker forms a straight alpha-helix, with the positive charges facing the lipid

296 event adoption of the metal ion-induced full alpha-helix, with unknown functional consequences.

297 osition 175, which is part of an amphipathic alpha-helix within the C-terminal region of GobX.

298 surface of a series of residues on a stable alpha-helix within the motif with high potential as a pr

299 We propose that a predicted alpha-helix within this domain orienting parallel to the

300 Furthermore, the incipient alpha-helix (within the purified soluble C terminus) par