ライフサイエンスコーパス: alpha-internexin

1 ransport is completely abolished by deleting alpha-internexin.

2 rom the periphery regulate the expression of alpha-internexin.

3 a series of type IV proteins beginning with alpha-internexin.

4 nerated transgenic mice that overexpress rat alpha-internexin.

5 onal specific intermediate filament protein, alpha-internexin.

6 transactivation and the network formation by alpha-internexin.

7 express the low molecular weight nIF protein alpha-internexin.

8 rotein that most closely resembles mammalian alpha-internexin.

9 ght nIF protein with even higher homology to alpha-internexin.

10 the cytoskeleton such as neurofilaments and alpha-internexin.

11 dies, we report here for the first time that alpha-internexin, a neuronal IF protein, is present with

12 Alpha-internexin, a neuronal intermediate filament prote

13 Alpha-internexin also coassembles with all three neurofi

14 A complex containing 80 kDa 4.1R, alpha-internexin and neurofilament L was immunoprecipita

15 mers, have supported a widely held view that alpha-internexin and neurofilament triplet form separate

16 g a NF-H-LacZ fusion protein in mice induces alpha-internexin and neurofilament triplet to aggregate

17 TxBP-1/alpha-internexin and Tax are expressed in the cytoplasm

18 Our data show that alpha-internexin and the neurofilament proteins are func

19 , the primary components of neuronal IFs are alpha-internexin and the neurofilament triplet proteins.

20 eriments that bacterially expressed forms of alpha-internexin and vimentin form heterodimer molecules

21 In contrast, the IFs peripherin and alpha-internexin are preferentially localized to the ONL

22 ng of the mRNA sequence encoding the chicken alpha-internexin (chkINA) protein from embryonic brains.

23 neuronal genes, including Robo1, N-MYC, and alpha-internexin, confirmed their strong expression in m

24 The proteins UCH-L1 and alpha-internexin could be independent prognostic biomark

25 gene of which is a homolog of the mammalian alpha-internexin, during retinal development in zebrafis

26 Alpha-internexin exhibits transport and turnover rates i

27 erentially localized to the ONLo at P0, with alpha-internexin expressed by a restricted subset of OSN

28 The total levels of alpha-internexin expressed in the hemizygous and homozyg

29 As neurons mature, alpha-internexin expression declines, and expression of

30 Alpha-internexin expression was also examined after cent

31 nks, we have determined the axial lengths of alpha-internexin homodimer and alpha-internexin-vimentin

32 s, we demonstrated that zebrafish inaa is an alpha-internexin homolog that shares characteristics wit

33 After rubrospinal tractotomy, alpha-internexin immunoreactivity transiently increased

34 Alpha-internexin immunoreactivity was absent in the peri

35 eus was seen only in motoneurons that lacked alpha-internexin immunoreactivity, supporting the idea t

36 brospinal neurons, which constitutively show alpha-internexin immunoreactivity.

37 gene sequence and physiological function of alpha-internexin in avians.

38 ltin and XNIF paralleled the distribution of alpha-internexin in mammalian embryos.

39 To study the potential role of alpha-internexin in neurodegeneration, we have generated

40 The concurrent expression of UCH-L1 and alpha-internexin in pancreatic neuroendocrine tumors was

41 ontaining NFL, NFM, and NFH with and without alpha-internexin in quadruple- or quintuple-transfected

42 The discovery of alpha-internexin in the cytoplasmic inclusions implicate

43 teins, the 68-kDa NF-L and the 66-kDa NF-66 (alpha-internexin), in the rat CNS during development.

44 subunit (NFM), and the intermediate filament alpha-internexin (INT) at P4.

45 The results strongly support the view that alpha-internexin is a fourth subunit of neurofilaments i

46 alpha-Internexin is a member of the neuronal intermediat

47 t despite a postnatal decline in expression, alpha-internexin is as abundant as the triplet in the ad

48 alpha-Internexin is one of the neuronal intermediate fil

49 alpha-Internexin is the first neuronal intermediate fila

50 d with all three polymers - Arp2, tau and an alpha-internexin-like neurofilament.

51 highest sequence identity with gefiltin, an alpha-internexin-like nIF protein from the goldfish visu

52 Thus, we speculate that the persistence of alpha-internexin-like nIF proteins in the amphibian nerv

53 F triplet protein (NF-L), and two additional alpha-internexin-like proteins.

54 We show using a urea disassembly assay that alpha-internexin molecules are likely to be more stable

55 ta suggest that during neuronal development, alpha-internexin molecules are readily assimilated onto

56 hybridization studies showed an increase in alpha-internexin mRNA expression in the facial nucleus a

57 ibrium due to the increased stability of the alpha-internexin network.

58 F-H and also the more recently characterized alpha-internexin-NF66.

59 rain by genetically deleting three subunits (alpha-internexin, NFH and NFL) markedly depresses hippoc

60 The expression of alpha-internexin occurs in most neurons as they begin di

61 her neuronal intermediate filament proteins (alpha-internexin, peripherin) also accumulated in these

62 iplet proteins in mammals and suggested that alpha-internexin plays a key role in the neuronal cytosk

63 ere was a dramatic decrease in the number of alpha-internexin-positive cells.

64 Moreover, deleting alpha-internexin potentiates the effects of NF-M deletio

65 Previous studies found that expression of alpha-internexin precedes that of the NF triplet protein

66 Mutational analyses of the alpha-internexin promoter demonstrated that E1A-12-media

67 We examined alpha-internexin protein expression after three facial n

68 In contrast, alpha-internexin remained elevated 28 d after nerve rese

69 tides were identified as neurofilament L and alpha-internexin, respectively.

70 Overexpression of alpha-internexin resulted in the formation of cerebellar

71 The earlier peak expression of alpha-internexin than the triplet during brain developme

72 purified vimentin or the type IV IF protein alpha-internexin to form heterodimer coiled-coil molecul

73 ether with NF-H in mice dramatically reduces alpha-internexin transport and content in axons througho

74 We conclude that alpha-internexin upregulation in injured motoneurons sug

75 ilaments such as neurofilament medium chain, alpha-internexin, vimentin, and desmin are not able to b

76 al lengths of alpha-internexin homodimer and alpha-internexin-vimentin heterodimer molecules and thei

77 The concurrent expression of UCH-L1 and alpha-internexin was correlated with the prognosis in 2

78 rylated mid-Mr NF protein (NF-M/P + + +) and alpha-internexin were first detected at 15 weeks and hig

79 he domain corresponding to the rod region of alpha-internexin, which is essential for neurofilament a