ライフサイエンスコーパス: alpha-ketoglutarate dehydrogenase

1 ion and inhibition of the Krebs cycle enzyme alpha-ketoglutarate dehydrogenase.

2 CA cycle enzymes, pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase.

3 piration: the bc1 center and, more recently, alpha-ketoglutarate dehydrogenase.

4 A cycle enzymes isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase.

5 fects on intact mitochondria by inactivating alpha-ketoglutarate dehydrogenase.

6 LSG184 is devoid of alpha-ketoglutarate dehydrogenase activity, indicating t

7 hough Nitrosomonas europaea lacks measurable alpha-ketoglutarate dehydrogenase activity, the recent c

8 Despite the absence of alpha-ketoglutarate dehydrogenase activity, whole cells

9 Here we show that the alpha-ketoglutarate dehydrogenase (alpha-KGDH) complex i

10 and, between phosphotransacetylase (PTA) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) for their

11 and organization of the multienzyme complex alpha-ketoglutarate dehydrogenase (alpha-KGDH).

12 ansferase, and the E2 and E3 subunits of the alpha-ketoglutarate dehydrogenase (alphaKGDH) complex as

13 , we found an increase in phosphorylation of alpha-ketoglutarate dehydrogenase (alphaKGDH) in female

14 chondrial LipDH is part of the mitochondrial alpha-ketoglutarate dehydrogenase and branched chain alp

15 acid cofactor of pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase and other mitochondria

16 citrate dehydrogenase mutants, diminished in alpha-ketoglutarate dehydrogenase and succinyl-CoA ligas

17 ributions of regulation of the activities of alpha-ketoglutarate dehydrogenase and the aspartate-glut

18 ltiple proteins, including the E2 subunit of alpha-ketoglutarate dehydrogenase and the glutathione S-

19 complexes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and branched-chain ke

20 ve E2 subunits of pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, and Gcv3, the H prote

21 se components of the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and glycine reductase

22 se components of the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and glycine reductase

23 cardiac sarcoplasmic reticulum Ca2+-ATPase, alpha-ketoglutarate dehydrogenase, and the mitochondrial

24 lines in mitochondrial function and identify alpha-ketoglutarate dehydrogenase as a likely site of fr

25 id is a coenzyme for pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, branched chain-ketoac

26 ltienzyme complexes: pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, branched-chain alpha-

27 Glutathionylation of alpha-ketoglutarate dehydrogenase can therefore be viewe

28 %), isocitrate dehydrogenase (-27%), and the alpha-ketoglutarate dehydrogenase complex (-57%).

29 hydrolipoamide dehydrogenase subunits of the alpha-ketoglutarate dehydrogenase complex (alphaKGDH), a

30 succinyltransferase, the E2 component of the alpha-ketoglutarate dehydrogenase complex (KDC).

31 m for 24 h, resulted in a pronounced loss of alpha-ketoglutarate dehydrogenase complex (KGDHC) activi

32 The activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC) declin

33 The mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is def

34 Brain metabolism and the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a mit

35 The activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), an ar

36 The activity of alpha-ketoglutarate dehydrogenase complex (KGDHC), an im

37 activity of a key mitochondrial enzyme, the alpha-ketoglutarate dehydrogenase complex (KGDHC), decli

38 a striking reduction in the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC).

39 Purified alpha-ketoglutarate dehydrogenase complex also is inacti

40 Lipoamide dehydrogenase, a component of the alpha-ketoglutarate dehydrogenase complex and two other

41 sferase to supply alpha-ketoglutarate to the alpha-ketoglutarate dehydrogenase complex and would, in

42 oxymethyl transferase, and components of the alpha-ketoglutarate dehydrogenase complex in conjunction

43 Zn(2+) inhibition of alpha-ketoglutarate dehydrogenase complex required enzym

44 Purified pig heart alpha-ketoglutarate dehydrogenase complex was strongly i

45 drogenase complex (OGHDC) (also known as the alpha-ketoglutarate dehydrogenase complex) is a rate-lim

46 d its target DLST-the E2 subcomponent of the alpha-ketoglutarate dehydrogenase complex, a rate-contro

47 ion of ThPP levels causes dysfunction of the alpha-ketoglutarate dehydrogenase complex, which explain

48 ced CoA to the reduction of NAD(+) using the alpha-ketoglutarate dehydrogenase complex.

49 This was attributed to inhibition of the alpha-ketoglutarate dehydrogenase complex.

50 notransferase, alanine aminotransferase, and alpha-ketoglutarate dehydrogenase complex.

51 respiration by reversible inhibition of the alpha-ketoglutarate dehydrogenase complex.

52 oteins, we demonstrate that the pyruvate and alpha-ketoglutarate dehydrogenase complexes directly cat

53 osttranslational lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes, resulting i

54 component of the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes.

55 ymes of central metabolism, the pyruvate and alpha-ketoglutarate dehydrogenase complexes.

56 d restored full activity to the pyruvate and alpha-ketoglutarate dehydrogenase complexes.

57 complex I during ischemia and complex IV and alpha-ketoglutarate dehydrogenase during reperfusion.

58 uld potentially compensate for inhibition of alpha-ketoglutarate dehydrogenase during symbiotic nitro

59 Using a purified alpha-ketoglutarate dehydrogenase from pig hearts, the e

60 ken to identify the site and consequences of alpha-ketoglutarate dehydrogenase glutathionylation.

61 zobium japonicum sucA mutant that is missing alpha-ketoglutarate dehydrogenase is able to grow on mal

62 alpha-Ketoglutarate dehydrogenase is highly susceptible

63 It was determined that inactivation of alpha-ketoglutarate dehydrogenase is responsible, in lar

64 xylic acid cycle, but we recently found that alpha-ketoglutarate dehydrogenase (KDH) activity is lack

65 d lipoamide dehydrogenase (E3) components of alpha-ketoglutarate dehydrogenase (KDH).

66 ed chain amino acid dehydrogenase (BCDH) and alpha-ketoglutarate dehydrogenase (KDH).

67 e activities of specific Krebs cycle enzymes alpha-ketoglutarate dehydrogenase (KGDH) and succinate d

68 fects on the tricarboxylic acid cycle enzyme alpha-ketoglutarate dehydrogenase (KGDH) which provides

69 lexes, such as pyruvate dehydrogenase (PDH), alpha-ketoglutarate dehydrogenase (KGDH), and the glycin

70 plexes and Krebs cycle enzymes revealed that alpha-ketoglutarate dehydrogenase (KGDH), succinate dehy

71 ich inhibit pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (KGDH), we hypothesize

72 rts its effects on respiration by inhibiting alpha-ketoglutarate dehydrogenase (KGDH).

73 Isolated mitochondrial alpha-ketoglutarate dehydrogenase (KGDHC) and pyruvate d

74 n of hypoxic/anaerobic genes was elevated in alpha-ketoglutarate dehydrogenase mutants, whereas expre

75 ial chaperones and assists in the folding of alpha-ketoglutarate dehydrogenase (OGDH), a rate-limitin

76 by using a coupled enzyme system with either alpha-ketoglutarate dehydrogenase or pyruvate dehydrogen

77 d) in association with peptides derived from alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrog

78 utamine synthetase, glutamate dehydrogenase, alpha-ketoglutarate dehydrogenase, phosphate-activated g

79 Glutathionylation of alpha-ketoglutarate dehydrogenase protected lipoic acid

80 l aspartate aminotransferase followed by the alpha-ketoglutarate dehydrogenase reaction.

81 zymes of the tricarboxylic acid (TCA) cycle, alpha-ketoglutarate dehydrogenase (sucAB) and succinyl c

82 lot analysis revealed that the E2 subunit of alpha-ketoglutarate dehydrogenase was reversibly glutath

83 The sucA gene, encoding the E1 component of alpha-ketoglutarate dehydrogenase, was cloned from Brady