ライフサイエンスコーパス: alpha-lipoic acid

1 in the two diabetic groups (with and without alpha-lipoic acid).

2 le vitamins biotin and pantothenic acid, and alpha-lipoic acid.

3 s produced by the oxidative stress scavenger alpha-lipoic acid.

4 inistration, a high-fat diet with or without alpha-lipoic acid (1.65 g/kg) was given to the mice and

5 s (4-benzoic acid) porphyrin (10 mg/kg), and alpha-lipoic acid (100 mg/kg).

6 decreased by preincubation with NAC (1 h) or alpha-lipoic acid (24 h) but not vitamin E.

7 receiving diets supplemented with or without alpha-lipoic acid (400 mg/kg) for 11 months of diabetes.

8 this deficit is dose-dependently reversed by alpha-lipoic acid, a change associated with an improveme

9 culture medium with 100, 200, or 500 microM alpha-lipoic acid, a metabolic antioxidant, after inocul

10 (R)-alpha-Lipoic acid, a mitochondrial coenzyme, is a powerf

11 melatonin, a naturally occurring indole, and alpha-lipoic acid, a naturally occurring dithiol, were a

12 To examine the effect of alpha-lipoic acid, a potent natural antioxidant, on athe

13 alpha-Lipoic acid, a thiol antioxidant, has been shown t

14 alpha-Lipoic acid administration for the entire duration

15 fold and 70%, respectively, in diabetes, and alpha-lipoic acid administration inhibited these increas

16 The effect of alpha-lipoic acid administration on retinal 8-hydroxy-2'

17 Alpha lipoic acid (ALA) and vitamin C (Vit-C) are very i

18 Treating A-T cells with the antioxidant, alpha lipoic acid (ALA), restored mitochondrial respirat

19 Male SD rats were pretreated with alpha-lipoic acid (ALA) and dihydrolipoic acid (DHLA) or

20 ts with a racemic mixture of the antioxidant alpha-lipoic acid (ALA) could improve glucose metabolism

21 alpha-lipoic acid (ALA) is a potent antioxidant that is

22 onditions at a much lower concentration than alpha-lipoic acid (ALA).

23 ination of mixed tocopherols (666 IU/d) plus alpha-lipoic acid (ALA; 600 mg/d) or matching placebos f

24 f several antioxidant agents (ascorbic acid, alpha-lipoic acid, alpha-tocopherol, Mn(III)-tetrakis(4-

25 mitochondria, lipoic acid synthase produces alpha-lipoic acid, an antioxidant and an essential cofac

26 dduct formation in human liver microsomes by alpha-lipoic acid, an inhibitor of NADPH: p450 reductase

27 entation with the mitochondrial antioxidants alpha-lipoic acid and coenzyme Q(10) also suppresses Bak

28 ut normalized by treatment with antioxidants alpha-lipoic acid and D-alpha-tocopherol and, surprising

29 l derivatives of potent antioxidant vitamin, alpha-lipoic acid, and related analogues were designed,

30 Alpha-lipoic acid appears to be effective as well.

31 Diabetic rats were treated with 0.5% alpha-lipoic acid as a diet supplement or with hydroxyet

32 Treating diabetic rats with alpha-lipoic acid but not HES-DFO partially improved sci

33 Remarkably, alpha-lipoic acid completely prevented the increase in p

34 systemic treatment with either HC-030031 or alpha-lipoic acid could completely prevent hypersensitiv

35 Treatment with 500 microM alpha-lipoic acid decreased by 50% both the number and s

36 tration of either insulin or the antioxidant alpha-lipoic acid decreased proteinuria and oxidative st

37 The presence of 100 or 200 microM alpha-lipoic acid did not influence rickettsial growth i

38 Since alpha-lipoic acid does not seem to exhibit direct antiri

39 Alpha-lipoic acid dose- and time-dependently prevented t

40 Pretreatment with R-alpha-lipoic acid effectively protected ARPE-19 cells fr

41 n of the cell culture medium with 100 microM alpha-lipoic acid for 72 h after infection prevented the

42 Alpha-lipoic acid had a biphasic effect: it dose-depende

43 Alpha-lipoic acid had no significant effect on either en

44 The metabolic thiol antioxidant alpha-lipoic acid has been suggested to be of therapeuti

45 nstrate that the long-term administration of alpha-lipoic acid has beneficial effects on the developm

46 supplements studied, N-acetyl-L-cysteine and alpha-lipoic acid hold the most promise.

47 rovide further evidence for the potential of alpha-lipoic acid in treatment of diseases related to ox

48 We report that the nutritional supplement alpha-lipoic acid inhibits cystine stone formation in th

49 Alpha-lipoic acid is a potent antioxidant that prevents

50 Our results suggest that dietary alpha-lipoic acid is a promising protective agent for re

51 r 0.2% (wt/vol) in drinking water], and/or R-alpha-lipoic acid (LA) [0.2% or 0.1% (wt/wt) in diet].

52 e shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects b

53 alpha-Lipoic acid (LA) has been found to attenuate diabe

54 alpha-Lipoic acid (LA) has been shown to improve memory

55 In diabetic patients, alpha-lipoic acid (LA) improves skeletal muscle glucose

56 d with the antioxidants vitamin E (VE) and R-alpha-lipoic acid (LA) in streptozotocin-induced diabeti

57 alpha-Lipoic acid (LA) is a cofactor for mitochondrial a

58 hombencephalic neurons and co-treatment with alpha-lipoic acid (LA) or one of several other antioxida

59 ed that 2 mo of dietary supplementation with alpha-lipoic acid (LA) prevented early glomerular injury

60 ects of administration of the antioxidant DL-alpha-lipoic acid (LA) to streptozotocin-injected diabet

61 We investigated the role of (R)-alpha-lipoic acid (LA) vs. glutathione and ascorbic acid

62 ate whether dietary supplementation with (R)-alpha-lipoic acid (LA) was effective at reducing oxidati

63 rter (hSMVT) has been suggested to transport alpha-lipoic acid (LA), a potent antioxidant and anti-in

64 or the mitochondrial antioxidant precursor R-alpha-lipoic acid (LA).

65 ranslocation, old rats were treated with (R)-alpha-lipoic acid (LA; 40 mg/kg i.p. up to 48 h), a disu

66 % (wt/vol) in the drinking water] and/or (R)-alpha-lipoic acid [LA, 0.5% (wt/wt) in the chow] improve

67 ants regulated Ang II receptors differently: alpha-Lipoic acid lowered Ang II binding after 24 h, and

68 e retina is impaired and may be corrected by alpha-lipoic acid (LPA), a drug that inhibits vascular h

69 tioxidants ascorbate, ascorbate 2-phosphate, alpha-lipoic acid, N-acetyl-L-cysteine and glutathione i

70 iabetic rats, treatment with the antioxidant alpha-lipoic acid normalized the amount of leukostasis b

71 e of this study was to examine the effect of alpha-lipoic acid on retinal capillary cell apoptosis an

72 ls was not improved by treatment with either alpha-lipoic acid or HES-DFO.

73 Application of the antioxidant alpha-lipoic acid potently prevents glucose-induced oxid

74 Treating diabetic rats with alpha-lipoic acid prevented the diabetes-induced increas

75 Alpha-lipoic acid prevented the reduction in SCG creatin

76 supplementation of old animals with 0.5% (R)-alpha-lipoic acid prior to cell isolation almost complet

77 he antioxidants epigallocatechin gallate and alpha-lipoic acid reduces polyglutamine aggregation.

78 ncubation with the AMPK activators AICAR and alpha-lipoic acid substantially prevented all of those c

79 nd their nondiabetic apoE(-/-) controls with alpha-lipoic acid supplement than in those without it.

80 Alpha-lipoic acid supplementation had no effect on gluco

81 alpha-Lipoic acid supplementation represents an achievab

82 Conversely, the antioxidant alpha-lipoic acid, that protected against the loss of gl

83 treatment regardless of the concentration of alpha-lipoic acid used.

84 Duration of diabetes was 1 month, and alpha-lipoic acid was administered intraperitoneally 5 t

85 These protective effects of alpha-lipoic acid were accompanied by a reduction of pla

86 of acrolein and the protective effects of R-alpha-lipoic acid were examined with a variety of previo

87 Dihydrolipoic acid (the reduced form of alpha-lipoic acid), which contains free sulfhydryl group

88 receptor binding in cell membranes, whereas alpha-lipoic acid, which does not contain free sulfhydry