ライフサイエンスコーパス: alpha-melanocyte-stimulating hormone

1 nine vasopressin, agouti-related protein and alpha-melanocyte stimulating hormone.

2 detectable levels of adrenocorticotropin or alpha-melanocyte-stimulating hormone.

3 examined how these responses are affected by alpha-melanocyte-stimulating hormone.

4 production but this response was reduced by alpha-melanocyte-stimulating hormone.

5 hat the levels were increased in response to alpha-melanocyte-stimulating hormone.

6 tions on stimulation with its natural ligand alpha-melanocyte-stimulating hormone.

7 abated the positive effects of [Nle, D-Phe]-alpha-melanocyte-stimulating hormone.

8 as glucagon and proopiomelanocortin-derived alpha-melanocyte-stimulating hormone.

9 We report that alpha-melanocyte-stimulating hormone (10-9 M) was effect

10 cy of (188)Re-(Arg(11))[Cys(3,4,10),d-Phe(7)]alpha-melanocyte-stimulating hormone(3-13) (CCMSH) in th

11 ,8 tetrahydrobiopterin resulting in a stable alpha-melanocyte stimulating hormone/6(R)-L-erythro 5,6,

12 ojic acid, and niacinamide) and stimulators (alpha-melanocyte-stimulating hormone, 8-methoxypsoralen,

13 e inhibitor of rac1 abrogated the ability of alpha-melanocyte stimulating hormone, a peptide hormone

14 One such factor is alpha-melanocyte-stimulating hormone, a potent anti-infl

15 vity of the melanotropin peptides alpha-MSH (alpha-melanocyte-stimulating hormone, Ac-Ser-Tyr-Met-Glu

16 sion this study provides further evidence of alpha-melanocyte stimulating hormone acting to "protect"

17 on is similar in these two species homologs (alpha-melanocyte-stimulating hormone = adrenocorticotrop

18 For this purpose antibodies against alpha-melanocyte stimulating hormone, adrenocorticotropi

19 When treated with a stable alpha-melanocyte-stimulating hormone agonist, mutant mic

20 effects of two melanocortin system ligands, alpha melanocyte stimulating hormone (alpha-MSH) and ago

21 Within the ARC, IRS-2 was co-localized with alpha melanocyte stimulating hormone (alpha-MSH) as well

22 under both direct and indirect regulation by alpha melanocyte-stimulating hormone (alpha-MSH)-synthes

23 alpha-Melanocyte stimulating hormone (alpha-MSH) analogs

24 The regulated release of anorexigenic alpha-melanocyte stimulating hormone (alpha-MSH) and ore

25 The peptides alpha-melanocyte stimulating hormone (alpha-MSH) and oxy

26 cotropic hormone (ACTH), beta-endorphin, and alpha-melanocyte stimulating hormone (alpha-MSH) are syn

27 Both forms act as competitive antagonists of alpha-melanocyte stimulating hormone (alpha-MSH) at mela

28 etermine whether the neuroprotective peptide alpha-melanocyte stimulating hormone (alpha-MSH) attenua

29 Alpha-melanocyte stimulating hormone (alpha-MSH) has pig

30 te nucleus (ARC), and on opioid peptides and alpha-melanocyte stimulating hormone (alpha-MSH) in the

31 ne-regulated transcript (CART) coexists with alpha-melanocyte stimulating hormone (alpha-MSH) in the

32 alpha-Melanocyte stimulating hormone (alpha-MSH) is a ne

33 The neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) is an i

34 opiomelanocortin (POMC)-derived neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) is know

35 Alpha-melanocyte stimulating hormone (alpha-MSH) is one

36 ed and compared with four other radiolabeled alpha-melanocyte stimulating hormone (alpha-MSH) peptide

37 rg-X-Asp-conjugated and X-Ala-Asp-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) peptide

38 of new (99m)Tc-labeled Arg-X-Asp-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) peptide

39 elanoma prevention based on using analogs of alpha-melanocyte stimulating hormone (alpha-MSH) that fu

40 The pro-opiomelanocortin product alpha-melanocyte stimulating hormone (alpha-MSH), an MC3

41 The concentration of PRL, alpha-melanocyte stimulating hormone (alpha-MSH), and lu

42 acrophage chemoattractant protein-1 (MCP-1), alpha-melanocyte stimulating hormone (alpha-MSH), and pe

43 -DOTA-ReCCMSH(Arg(11)), a cyclic analogue of alpha-melanocyte stimulating hormone (alpha-MSH), exhibi

44 ng factor (CRF) might be mediated via MC4-R. alpha-Melanocyte stimulating hormone (alpha-MSH), the MC

45 ncreasing the production of the MC4R ligand, alpha-melanocyte stimulating hormone (alpha-MSH), to reg

46 ach, MC4-R agonists, melanotan-II (MT-II) or alpha-melanocyte stimulating hormone (alpha-MSH), were u

47 y the ARC(POMC) neuron-derived MC4R agonist, alpha-melanocyte stimulating hormone (alpha-MSH).

48 ceptors are stimulated by the native ligand, alpha-melanocyte stimulating hormone (alpha-MSH).

49 d are stimulated by the melanocortin agonist alpha-melanocyte stimulating hormone (alpha-MSH).

50 or cells was blocked by co-administration of alpha-melanocyte stimulating hormone (alpha-MSH, 20 ng),

51 nal activity of leptin, the leptin receptor, alpha-melanocyte stimulating hormones (alpha-MSH) and th

52 whether the functional IL-1beta antagonist, alpha-melanocyte-stimulating hormone (alpha-MSH(1-13)),

53 odistribution, and clearance kinetics of the alpha-melanocyte-stimulating hormone (alpha-MSH) analog

54 Radiohalogenated alpha-melanocyte-stimulating hormone (alpha-MSH) analogs

55 We report in vitro and in vivo data of new alpha-melanocyte-stimulating hormone (alpha-MSH) analogu

56 de Y (NPY) and anorexigenic peptides such as alpha-melanocyte-stimulating hormone (alpha-MSH) and ano

57 ression, resulting in selective increases of alpha-melanocyte-stimulating hormone (alpha-Msh) and car

58 G protein-coupled receptor (GPCR) that binds alpha-melanocyte-stimulating hormone (alpha-MSH) and has

59 The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) and its

60 The melanocortin system, which includes alpha-melanocyte-stimulating hormone (alpha-MSH) and its

61 These proteins antagonize the effects of alpha-melanocyte-stimulating hormone (alpha-MSH) and oth

62 opposing effects of the anorexigenic agonist alpha-melanocyte-stimulating hormone (alpha-MSH) and the

63 MC4R responds to an agonist, alpha-melanocyte-stimulating hormone (alpha-MSH) and to

64 We have previously shown that alpha-melanocyte-stimulating hormone (alpha-MSH) can opp

65 food intake and PK2 increased the release of alpha-melanocyte-stimulating hormone (alpha-MSH) from ex

66 -clamp recordings revealed that both NPY and alpha-melanocyte-stimulating hormone (alpha-MSH) inhibit

67 alpha-Melanocyte-stimulating hormone (alpha-MSH) is a po

68 Alpha-melanocyte-stimulating hormone (alpha-MSH) is a tr

69 Alpha-melanocyte-stimulating hormone (alpha-MSH) is an a

70 state, the appetite-suppressing neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is redu

71 in (ACTH) of pars distalis corticotropes and alpha-melanocyte-stimulating hormone (alpha-MSH) of pars

72 This study aimed at revealing the role of alpha-melanocyte-stimulating hormone (alpha-MSH) on baso

73 esize melanocortin receptor agonists such as alpha-melanocyte-stimulating hormone (alpha-MSH) or anta

74 e of the radiolabeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone (alpha-MSH) peptide

75 termine whether (99m)Tc- and (111)In-labeled alpha-melanocyte-stimulating hormone (alpha-MSH) peptide

76 ating phage that displayed up to 5 copies of alpha-melanocyte-stimulating hormone (alpha-MSH) peptide

77 (POMC) neurons and the POMC-derived peptide alpha-melanocyte-stimulating hormone (alpha-MSH) promote

78 cortin type 1 receptor (MC1R), also known as alpha-melanocyte-stimulating hormone (alpha-MSH) recepto

79 The alpha-melanocyte-stimulating hormone (alpha-MSH) recepto

80 mentation (suntanning) requires induction of alpha-melanocyte-stimulating hormone (alpha-MSH) secreti

81 The pituitary peptide alpha-melanocyte-stimulating hormone (alpha-MSH) stimula

82 Activation of MC1R in melanocytes by alpha-melanocyte-stimulating hormone (alpha-MSH) stimula

83 Reduction in the activity of the alpha-melanocyte-stimulating hormone (alpha-MSH) system

84 nzyme prolylcarboxypeptidase (PRCP) degrades alpha-melanocyte-stimulating hormone (alpha-MSH) to an i

85 ow coat color by antagonizing the binding of alpha-melanocyte-stimulating hormone (alpha-MSH) to the

86 nucleus of the hypothalamus (PVN), to block alpha-melanocyte-stimulating hormone (alpha-MSH) type 3

87 for MC1R, inhibiting the alpha-melanocortin (alpha-melanocyte-stimulating hormone (alpha-MSH))-induce

88 for melanocortin 4 (MC-4) receptors such as alpha-melanocyte-stimulating hormone (alpha-MSH), a prod

89 volved in the regulation of feeding by using alpha-melanocyte-stimulating hormone (alpha-MSH), an end

90 ',N'''-tetraacetic acid), a cyclic analog of alpha-melanocyte-stimulating hormone (alpha-MSH), has th

91 amus and regulating release of products like alpha-melanocyte-stimulating hormone (alpha-MSH), neurop

92 NPY) are potent appetite stimulants, whereas alpha-melanocyte-stimulating hormone (alpha-MSH), neurot

93 s of either a melanocortin receptor agonist, alpha-melanocyte-stimulating hormone (alpha-MSH), or ant

94 a-MSH (NDP-MSH), a highly potent analogue of alpha-melanocyte-stimulating hormone (alpha-MSH), posses

95 dy was designed to examine the evidence that alpha-melanocyte-stimulating hormone (alpha-MSH), which

96 -amino group of Lys(10) of the cyclic lactam alpha-melanocyte-stimulating hormone (alpha-MSH)-derived

97 ability of the receptor to bind its ligand, alpha-melanocyte-stimulating hormone (alpha-MSH).

98 ased circulating and lesional skin levels of alpha-melanocyte-stimulating hormone (alpha-MSH).

99 f starting mPOMC was converted to des-acetyl alpha-melanocyte-stimulating hormone (alpha-MSH).

100 is approach, we produced biologically active alpha-melanocyte-stimulating hormone (alpha-MSH).

101 The anorexigenic neuromodulator alpha-melanocyte-stimulating hormone (alpha-MSH; referre

102 ere blocked by 2 different IL-1 antagonists, alpha melanocyte stimulating hormone (alphaMSH) and inte

103 esity resembling mice with reduced action of alpha melanocyte stimulating hormone (alphaMSH).

104 Physiologically activated by alpha-melanocyte stimulating hormone (alphaMSH), MC1R fu

105 wever, melanoma cells synthesize and release alpha-melanocyte stimulating hormone (alphaMSH, the liga

106 The behavior of these cells is influenced by alpha-melanocyte-stimulating hormone (alphaMSH) and mela

107 The POMC-derived peptide alpha-melanocyte-stimulating hormone (alphaMSH) is a mel

108 Interestingly, hypothalamic Pomc mRNA and alpha-melanocyte-stimulating hormone (alphaMSH) peptide

109 alpha-Melanocyte-stimulating hormone also increased the

110 ibits the rise in cAMP levels in response to alpha-melanocyte-stimulating hormone, an MC4R agonist, b

111 of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.

112 stitutions did not affect the ability of the alpha-melanocyte stimulating hormone analogue [Nle4,D-Ph

113 We evaluated the safety and efficacy of an alpha-melanocyte-stimulating hormone analogue, afamelano

114 The presence of alpha-melanocyte stimulating hormone and adrenocorticotr

115 nduce dendrite formation in B16F1 cells, and alpha-melanocyte stimulating hormone and ultraviolet lig

116 that rac1 mediates the well-known ability of alpha-melanocyte stimulating hormone and ultraviolet lig

117 We used known melanogenic stimulators (alpha-melanocyte-stimulating hormone and 3,4-dihydroxyph

118 alpha-Melanocyte-stimulating hormone and adrenocorticotr

119 in; the proopiomelanocortin-derived peptides alpha-melanocyte-stimulating hormone and beta-endorphin,

120 Both central alpha-melanocyte-stimulating hormone and corticotropin-r

121 n or contraction in melanocytes, mediated by alpha-melanocyte-stimulating hormone and melanin-concent

122 alpha, and of the anti-inflammatory peptides alpha-melanocyte-stimulating hormone and melanocyte-stim

123 marrow-derived macrophages, we observed that alpha-melanocyte-stimulating hormone and selective MC1-R

124 s spectra of the model peptides (bradykinin, alpha-melanocyte stimulating hormone, and melittin) chan

125 ro-opiomelanocortin (POMC)-derived peptides, alpha-melanocyte-stimulating hormone, and adrenocorticot

126 f dynorphin A-17, a decrease in the level of alpha-melanocyte-stimulating hormone, and an alteration

127 c gene encodes both the anorexigenic peptide alpha-melanocyte-stimulating hormone, and the opioid pep

128 dy was to investigate the mechanism by which alpha-melanocyte-stimulating hormone antagonizes proinfl

129 vasion and that the anti-invasive actions of alpha-melanocyte stimulating hormone are consistent with

130 tropic hormone, beta-lipotropic hormone, and alpha-melanocyte-stimulating hormone are also derived.

131 ls of stochastic carcinogenesis and identify alpha-melanocyte-stimulating hormone as a potential atte

132 Additionally, our results identify alpha-melanocyte-stimulating hormone as a potential medi

133 effects through the blockade of signaling by alpha-melanocyte-stimulating hormone at central nervous

134 Full-length alpha-melanocyte-stimulating hormone, at concentrations

135 Notably, the density of anorexigenic alpha-melanocyte-stimulating hormone axons was reduced i

136 loudman S-91 mouse melanoma cells respond to alpha-melanocyte-stimulating hormone) by demonstrating a

137 Recently, it has been shown that alpha-melanocyte stimulating hormone can directly activa

138 At concentrations in excess of 10-9 M alpha-melanocyte-stimulating hormone decreased nitric ox

139 to the cell surface, but it does not restore alpha-melanocyte-stimulating hormone-dependent cAMP sign

140 (99m)Tc(CO)3-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone derivative, betaAla

141 tide that inhibits the binding and action of alpha-melanocyte-stimulating hormone derived from proopi

142 alpha-melanocyte-stimulating hormone from arcuate POMC n

143 These data show that alpha-melanocyte-stimulating hormone has a pronounced ef

144 alpha-Melanocyte-stimulating hormone, however, decreased

145 eptides (dynorphin A-17, beta-endorphin, and alpha- melanocyte-stimulating hormone) involved in the c

146 its production by melanocytes in response to alpha-melanocyte-stimulating hormone is associated with

147 Alpha-melanocyte-stimulating hormone is produced by seve

148 Afamelanotide, an analogue of alpha-melanocyte-stimulating hormone, is known to induce

149 d integrin expression and ask to what extent alpha-melanocyte stimulating hormone might protect cells

150 ts of two intercellular signaling molecules, alpha-melanocyte stimulating hormone (MSH) and agouti si

151 or induces activation of regulatory T cells, alpha-melanocyte stimulating hormone (MSH) and transform

152 Pigmentation in mammals is stimulated by alpha-melanocyte stimulating hormone (MSH), which binds

153 on of two intercellular signaling molecules, alpha-melanocyte-stimulating hormone (MSH) and agouti si

154 which may mediate the hypophagic effects of alpha-melanocyte-stimulating hormone (MSH) in the rat.

155 sthetized rats, unilateral microinjection of alpha-melanocyte-stimulating hormone (MSH) into the medu

156 Alpha-Melanocyte-stimulating hormone (MSH) is a potent a

157 alpha-Melanocyte-stimulating hormone (MSH) utilizes cAMP

158 alpha-Melanocyte-stimulating hormone (MSH), a stimulus w

159 the complete loss of both [Nle(4)-d-Phe(7)]-alpha-melanocyte stimulating hormone (NDP-MSH) binding a

160 cture-activity studies of [Nle(4), D-Phe(7)]-alpha-melanocyte stimulating hormone (NDP-MSH) identifie

161 ic agouti-related protein (AGRP)/[Nle4,DPhe7]alpha-melanocyte stimulating hormone (NDP-MSH) ligands i

162 the protective effect of [Nle(4), D-Phe(7)]-alpha-melanocyte stimulating hormone (NDP-MSH), a potent

163 [Nle(4),d-Phe(7)]-alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) lab

164 d using assays for agonist, [Nle(4)-d-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) or

165 sm of human MC4R activation by [Nle4, d-Phe7]alpha-melanocyte-stimulating hormone (NDP-MSH), by first

166 ope of neuropeptide glutamic acid-isoleucine/alpha-melanocyte-stimulating hormone (NEI/alphaMSH) pept

167 f the (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptides.

168 d been grown in the presence of 10-11-10-9 M alpha-melanocyte-stimulating hormone prior to stimulatio

169 through actions on TRH neurons, addition of alpha-melanocyte-stimulating hormone produced a 3.5-fold

170 ion of the expression of proopiomelanocortin/alpha-melanocyte-stimulating hormone, provoked by C75 an

171 y pathologies concerning cells which express alpha-melanocyte-stimulating hormone receptors and utili

172 In contrast, alpha-melanocyte stimulating hormone reduced cell attach

173 s corticotropin-releasing factor, leptin and alpha-melanocyte stimulating hormone regulate cytokine b

174 These results suggest that alpha-melanocyte-stimulating hormone regulates nitric ox

175 othalamic explants but significantly reduced alpha melanocyte stimulating hormone release in vitro.

176 temperature just before light onset, whereas alpha-melanocyte stimulating hormone release, especially

177 selectively increases beta-endorphin but not alpha-melanocyte-stimulating hormone release in the hypo

178 or in mediating immunomodulatory actions of alpha-melanocyte-stimulating hormone remains to be seen.

179 rs with the melanocortin analog [Nle, D-Phe]-alpha-melanocyte-stimulating hormone (starting 3 or 6 hr

180 h as endothelin 1, hepatocyte growth factor, alpha-melanocyte stimulating hormone, stem cell factor,

181 Neuropeptide Y (NPY) inhibited and alpha-melanocyte-stimulating hormone stimulated ARC gluc

182 preputial glands of rodents is regulated by alpha-melanocyte stimulating hormone, the major agonist

183 ared with the regulation of melanogenesis by alpha-melanocyte-stimulating hormone through melanocorti

184 by Western immunoblotting and the ability of alpha-melanocyte stimulating hormone to oppose the actio

185 We have previously shown alpha-melanocyte stimulating hormone to protect melanocy

186 In mice and humans, binding of alpha-melanocyte--stimulating hormone to the melanocyte-

187 ction of NF-kappaB DNA binding activity with alpha-melanocyte-stimulating hormone was detected 2 h af

188 ease in cAMP in response to stimulation with alpha-melanocyte-stimulating hormone was measured in HEK

189 by elevating cyclic adenosine monophosphate, alpha-melanocyte-stimulating hormone was not found to ha

190 or and appear to be physiological targets of alpha-melanocyte-stimulating hormone, which inhibits foo

191 es, and tumorigenicity assays indicates that alpha-melanocyte-stimulating hormone, which is overprodu

192 y, which aims to maintain high urine output; alpha-melanocyte-stimulating hormone, with anti-inflamma

193 edulla and in a subset of cells coexpressing alpha-melanocyte-stimulating hormone within the pituitar