ライフサイエンスコーパス: alpha-receptor

1 A(3) is about equipotent to TxA(2) at the TP alpha receptor.

2 ownstream to the tumor necrosis factor (TNF) alpha receptor.

3 r trimerization of the tumor necrosis factor alpha receptor.

4 recruitment and activation by the human IFN-alpha receptor.

5 vation of the platelet-derived growth factor-alpha receptor.

6 quirement for pre-complexation to a specific alpha-receptor.

7 s is a consequence of the activation of PPAR-alpha receptors.

8 ically act on 5-HT3, cholecystokinin, or TNF-alpha receptors.

9 gnaling from the IL-12/IL-23, IL-22, and IFN-alpha receptors.

10 CD47 to macrophage signal regulatory protein alpha receptors.

11 eak inducer of apoptosis (TWEAK) but not TNF-alpha receptors.

12 -agonist that has full efficacy at all brain alpha-receptors.

13 on, we introduced a deficiency of interferon alpha receptor 1 (Ifnar1) into B6.Aec1Aec2 mice, which a

14 Like TLR3(-/-) mice, IFN-alpha receptor 1 (IFNAR1)(-/-) mice exhibited reduced tu

15 = 0.009), and soluble tumor necrosis factor alpha receptor 1 (P = 0.007) than did no weight-loss tre

16 uble A8 indicated specific cleavage of a TNF-alpha receptor 1 (p55 TNF-R1) but not a TNF-R2 peptide.

17 and the 55-kDa soluble tumor necrosis factor-alpha receptor 1 (sTNF-R1).

18 d nearly completely in tumor necrosis factor alpha receptor 1 (TNF-R1) knockout mice.

19 alizing antibodies against TNF-alpha and TNF-alpha receptor 1 (TNF-R1), suggesting that TNF-alpha pla

20 dent manner following the stimulation of TNF-alpha receptor 1 (TNF-R1).

21 ransgenic AD mice (3xTg-AD) lacking both TNF-alpha receptor 1 (TNF-RI) and 2 (TNF-RII), 3xTg-ADxTNF-R

22 The examination of IFN-alpha receptor 1 and 2 (IFNAR1 and IFNAR2) levels reveal

23 pared with the well-characterized type 1 IFN-alpha receptor 1 and 2 in mediating innate immune and au

24 Tumor necrosis factor-alpha receptor 1 and Fas recruit overlapping signaling p

25 ng cancer by enhancing tumor necrosis factor-alpha receptor 1 and nuclear factor-kappaB activation an

26 ent correlation was found between plasma TNF-alpha receptor 1 and SHBG levels in obese patients.

27 or necrosis factor alpha (TNF-alpha) and TNF-alpha receptor 1 block rSV5DeltaSH-induced apoptosis, su

28 Changes in soluble tumor necrosis factor alpha receptor 1 but not in C-reactive protein or interl

29 sTNF-alpha) promotes the shedding of the TNF-alpha receptor 1 ectodomain via increased mitochondrial

30 Moreover, blockade of IFN-alpha receptor 1 in NOD mice by a neutralizing antibody

31 hesion molecule 1, and tumor necrosis factor alpha receptor 1 in stored baseline blood samples.

32 ing monoclonal antibody directed against TNF-alpha receptor 1 inhibited FHA-associated apoptosis by 4

33 een baseline VCAM-1 or tumor necrosis factor alpha receptor 1 levels and risk of any of the DR end po

34 is essential for tumor necrosis factor (TNF) alpha receptor 1 regulation of intestinal epithelial cel

35 Tumor necrosis factor-alpha receptor 1 signaling is vital for blood-brain barr

36 nsaminase, and soluble tumor necrosis factor alpha receptor 1 were lower after treatment with UDCA th

37 osomal degradation of the IFNAR1 (interferon alpha receptor 1) subunit of the type I interferon (IFN)

38 Moreover, TNF-alpha receptor 1, an important membrane death receptor t

39 tibodies to Fas, tumor necrosis factor (TNF)-alpha receptor 1, or TNF-related apoptosis-inducing liga

40 eria toxin receptor (DTR) transgenic and IFN-alpha receptor 1-deficient mice, as well as purified pri

41 otein-1 but did not affect expression of TNF-alpha receptor 1.

42 y and reparative process, mainly through TNF-alpha receptor 1.

43 control livers, expression of IFN-beta, IFN-alpha receptor 1/2, Jak1, and Tyk2 remained unchanged in

44 centrations of soluble tumor necrosis factor alpha receptors 1 and 2 (sTNF-R1, sTNF-R2), interleukin

45 Activated tumor necrosis factor alpha (TNF-alpha) receptor 1 (TNFR1) recruits TNFR1-associated deat

46 ctivator of tumor necrosis factor alpha (TNF-alpha) receptor 1 (TNFR1) signaling, inducing both chemo

47 proteinase-2 (MMP-2), MMP-13, and interferon alpha-receptors 1 and 2.

48 asma levels of soluble tumor necrosis factor-alpha receptor-1 (sTNFR-1) and brain natriuretic peptide

49 tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor-1 (TNF-alphaR1), TNF-alphaR2, and interle

50 comitantly, the proinflammatory receptor TNF-alpha receptor-1 (TNFR1) was shed from the endothelial s

51 o the death domains of tumor necrosis factor-alpha receptor-1 and Fas/Apo-I.

52 electively down-regulated the functional IFN-alpha receptor-1 chain of type I, but not type II (IFN-g

53 of tumor necrosis factor (TNF)-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatou

54 Down-regulation of IFN-alpha receptor-1 resulted in defective JAK-STAT signalin

55 glial cells, whereas immunostaining for TNF-alpha receptor-1 was mainly positive in the retinal gang

56 Both protein and mRNA of TNF-alpha or TNF-alpha receptor-1 were predominantly localized to the inn

57 howed that mRNA signals for TNF-alpha or TNF-alpha receptor-1 were similarly more intense in glaucoma

58 ession and localization of TNF-alpha and TNF-alpha receptor-1 were studied in retina sections from 20

59 eutralizing Ab or to an inhibitor of the TNF-alpha receptor-1, increases proliferative potential, del

60 tile, 2.18; P = .005), tumor necrosis factor-alpha receptor 2 (odds ratio, 1.78; P = .04), and interl

61 ukin 6 (IL-6), soluble tumor necrosis factor alpha receptor 2 (sTNF-R2), E-selectin, soluble intercel

62 tween interleukin 6 or tumor necrosis factor alpha receptor 2 and risk in the NHS/NHS II.

63 seline levels of tumor necrosis factor (TNF)-alpha receptor 2, interleukin (IL)-6, and C-reactive pro

64 ty C-reactive protein, tumor necrosis factor-alpha receptor 2, interleukin-6, and soluble vascular ce

65 ty C-reactive protein, tumor necrosis factor-alpha receptor 2, interleukin-6, and white blood cell co

66 P), interleukin 6, and tumor necrosis factor alpha receptor 2-and risk of invasive epithelial ovarian

67 tation of the RACK-1 binding site in the IFN-alpha receptor 2/beta subunit of the type I IFN receptor

68 a multiprotein complex that includes the IFN-alpha receptor 2/beta-chain of the receptor, STAT1, Janu

69 ers, including soluble tumor necrosis factor-alpha receptor-2 (P<0.001), interleukin-6 (P=0.04), and

70 type peroxisome proliferator-activated (PPAR-alpha) receptors; (2) shifted nicotine self-administrati

71 Tumor necrosis factor alpha receptor 3 interacting protein 1 (Traf3ip1), also

72 By sorting for the PDGF-alpha receptor, a marker of paraxial mesoderm, and for t

73 gh affinity interaction between IL-2 and its alpha receptor, a moderately entropically favorable low

74 TNFR2-/- epidermis, suggesting that the TNF-alpha receptors act independently via different AP-1 com

75 predict that when EGFR is activated with TGF-alpha, receptor activation is biased toward the cell sur

76 ll-interfering RNA significantly reduced TNF-alpha, receptor activator for nuclear factor kB ligand,

77 .v. treatment prevented the elevation of TNF-alpha, receptor activator of NF-kappaB, and other inflam

78 autoubiquitination of tumor necrosis factor (alpha) receptor adaptor protein 6 (TRAF6), a protein inv

79 dy, the authors hypothesized that either the alpha-receptor agonist phenylephrine or the nitric oxide

80 o generate point mutations in the human PDGF alpha receptor (alphaPDGFR) cDNA, which resulted in sing

81 at the platelet-derived growth factor (PDGF)-alpha receptor (alphaPDGFR) is required for experimental

82 ndicated that platelet-derived growth factor alpha receptor (alphaPDGFR) plays an important role in a

83 of the platelet-derived growth factor (PDGF) alpha receptor (alphaPDGFR).

84 e binds to the same site that binds the IL-2 alpha receptor and buries into a groove not seen in the

85 volved the recruitment of PKCbeta to the IFN-alpha receptor and interaction with protein tyrosine pho

86 ed IFN-alpha receptor expression, though IFN-alpha receptor and NKP30 expression was closely associat

87 his report we show, using mice lacking PGF(2)alpha receptor and pregnant rats, that PGF(2)alpha is re

88 ated following stimulation of the interferon-alpha receptor and the TCR in T cells by two different e

89 tabilize a similar complex of the interferon-alpha receptor and TYK2.

90 erleukins, leptin, and tumor necrosis factor-alpha receptors and their downstream molecular adaptors

91 ions of haematopoietic cells on MSCs via TNF-alpha receptors and then activating NF-kappaB signaling

92 ng antibodies, soluble tumor necrosis factor-alpha receptors, and hemin by abolishing both sEng and s

93 lated in response to LPS challenge in an IFN-alpha receptor- and IFN regulatory factor (Irf)9-depende

94 aracterizing pharmaceutical agents including alpha receptor antagonists as medical expulsive agents.

95 to monotherapy with antimuscarinic agents or alpha-receptor antagonists.

96 ressin antagonists and tumor necrosis factor-alpha receptor antibody are in phase II and III clinical

97 CV replicon expression, whereas the anti-IFN-alpha receptor antibody could partially block IRF-7-medi

98 e blockade of IFN-alpha receptor by anti-IFN-alpha receptor antibody on the replicon cells increased

99 e p55 TNF-alpha receptor whereas the p75 TNF-alpha receptor appeared to augment this response.

100 deficiency of NO synthesis and (2) both TNF-alpha receptors are necessary for TNF-alpha's prothrombo

101 Prostaglandin F(2 alpha) (PGF(2 alpha)) receptors are G-protein-coupled receptors consis

102 s work identifies PDGF signaling through the alpha receptor as an important event downstream of Sry i

103 ghts the role of Netrin-1 and a specific TNF-alpha receptor as candidate targets to prevent or treat

104 e p55 (p55 TNFR-/-) or p75 (p75 TNFR-/-) TNF-alpha receptors as donors in well-defined bone marrow tr

105 wn to act both as a ligand by binding to TNF-alpha receptors, as well as a receptor that transmits ou

106 he abundance of tyrosine-phosphorylated PDGF alpha receptors; as a result, STAT5 does not become acti

107 nt-negative mutants of tumor necrosis factor-alpha receptor-associated factor (TRAF) 6, TRAF2, and NF

108 tion-dependent manner: tumor necrosis factor-alpha receptor-associated factor 2 (TRAF2) and C-termina

109 The TNF-alpha receptor-associated factor 2 (TRAF2) and its downs

110 -containing adaptor protein, Tollip, and TNF-alpha receptor-associated factor 6 expression.

111 iated kinase 4 and 1, but independent of TNF-alpha receptor-associated factor 6.

112 or the MyD88-dependent ubiquitination of TNF-alpha receptor-associated factor 6; activation of TGF-be

113 Tumor necrosis factor alpha (TNF-alpha) receptor-associated factor 2 (TRAF2) regulates ac

114 tors, including beta-alpha-gamma/delta-alpha-alpha receptors at lower levels of gamma2/delta expressi

115 otein kinase A with KT5720, but not with the alpha receptor blockers prazosin (alpha1) and/or yohimbi

116 In addition, the blockade of IFN-alpha receptor by anti-IFN-alpha receptor antibody on th

117 Inhibition of the stromal cell-derived 1 alpha receptor (C-X-C receptor type 4 or CXCR4) using AM

118 results show for the first time that the IFN-alpha receptor can crosscommunicate with ErbB3.

119 Ligation of the tumor necrosis factor alpha receptor CD120a initiates responses as diverse as

120 The TNF-alpha receptor, CD120a, has recently been shown to be lo

121 specificity of action is conferred by their alpha receptor chains, IL-2Ralpha and IL-15Ralpha.

122 Ciliary Neurotrophic Factor (CNTF), and its alpha receptor (CNTF-Ralpha).

123 The ciliary neurotrophic factor alpha-receptor (CNTFRalpha) is required for motoneuron s

124 Although CNTF alpha-receptor (CNTFRalpha) mRNA and protein are localiz

125 have found that TAK1 is recruited to the TNF-alpha receptor complex in a RIP-dependent manner followi

126 as the forced recruitment of NEMO to the TNF-alpha receptor complex is insufficient for TNF-alpha-ind

127 can activate STAT4 by recruitment to the IFN-alpha receptor complex specifically via the carboxy-term

128 is to specifically recruit MEKK3 to the TNF-alpha receptor complex, whereas the forced recruitment o

129 domains of either of the subunits of the IFN-alpha receptor complex.

130 NF-alpha monoclonal antibody (MAb) and a TNF-alpha receptor construct (p75-Fc) were compared with tha

131 ody to platelet-derived growth factor (PDGF) alpha receptors coprecipitated STAT5 from extracts of un

132 d to interact with the tumor necrosis factor alpha receptor [corrected].We have identified a locus co

133 es, opioid-mediated down-regulation of MIP-1 alpha receptors could be blocked by the general PKC inhi

134 ly affect FE, nor does FE depend on Fas, TNF-alpha receptor, cytotoxic T-lymphocyte antigen-4, IL-2,

135 Conversely, IFN-alpha receptor-deficient AGMs (Ifnalphar1(-/-)), had sig

136 ferential effects were not observed when TNF-alpha receptor-deficient mice were infected.

137 Using TNF-alpha receptor-deficient mice, we identify TNF-alpha sig

138 ockout mice with either single or double TNF-alpha receptor deletion.

139 The recovery may reflect alpha-receptor desensitization.

140 Serum TNF-alpha receptors did not differ between unused (4.3+/-0.8

141 ed progesterone, glucocorticoid, or estrogen alpha receptors did not translocate FLAG-beta-catenin to

142 e cytokine subunit p28 and the non-signaling alpha-receptor EBI3.

143 erved in mice also lacking both types of TNF-alpha receptors, excluding excess TNF-alpha production a

144 cells lacking the p55 (but not the p75) TNF-alpha receptor exhibited decreased proliferation and pro

145 dipose TNF-alpha mRNA when compared with TNF-alpha receptor-expressing ob/ob mice.

146 TNF-alpha receptor expression and function, along with combi

147 pendency of DCs and Ly6C(+) monocytes on IFN-alpha receptor expression for EmGFP/IL-15 upregulation a

148 efect was not attributable to diminished IFN-alpha receptor expression, though IFN-alpha receptor and

149 e response of the alveolar epithelium to TNF-alpha receptor family signaling.

150 eptor, a member of the tumor necrosis factor alpha receptor family.

151 the effects of etanercept, a soluble p75 TNF alpha receptor-Fc fusion protein, in 2 patients with HID

152 r a soluble tumor necrosis factor alpha (TNF-alpha) receptor/Fc construct (TNFR-Fc, etanercept).

153 ls that express the NG2 proteoglycan and the alpha receptor for PDGF (NG2 cells, polydendrocytes) mak

154 such as the use of a nonstandard sushi-type alpha receptors for IL-2 and IL-15 in assembling quatern

155 tingly, prostate cancer cells expressing the alpha-receptor for platelet-derived growth factor (PDGFR

156 t, and that these events are mediated by the alpha-receptor for platelet-derived growth factor (PDGFR

157 Inhibition of tumor necrosis factor alpha receptor function by use of neutralizing monoclona

158 llebrand factor nor platelet glycoprotein Ib-alpha receptor (GPIb-alpha) is required for RBCs to adhe

159 inflammation (soluble tumor necrosis factor alpha receptor I [sTNF-RI], interleukin 6 [IL-6], and hi

160 etion of TNF-alpha and the expression of TNF-alpha receptor I in HM.

161 interleukin (IL)-8 and tumor necrosis factor-alpha receptor I, were significantly elevated in the cas

162 or-necrosis factor (TNF)-alpha; soluble TNF- alpha receptor I; and C-reactive protein (CRP) were meas

163 sis factor alpha (TNF-alpha) and soluble TNF-alpha receptors I and II; interleukin 1 beta (IL-1 beta)

164 ds to 2 distinct cell-surface receptors: TNF-alpha receptor-I (TNFR-I: p55) and TNF-alpha receptor-II

165 cytes deficient in the interferon-alpha (IFN-alpha) receptor IFN-alphaR showed reduced expression of

166 (NK) cells from mice lacking the type I IFN-alpha receptor (Ifnar(-/-)) or STAT1 (which signals down

167 er, in both CD4 competent, wild-type and IFN-alpha receptor (IFNAR) KO mice, Pneumocystis infection l

168 s an important inhibitory role in interferon-alpha receptor (IFNAR) signaling in mice.

169 ties through an evolutionarily conserved IFN-alpha receptor (IFNAR), consisting of IFNAR1 and IFNAR2.

170 amazonensisinfectivity in an IFN1-alpha receptor (IFNAR)-dependent manner.

171 increasedL.amazonensisinfectivity in an IFN1-alpha receptor (IFNAR)-dependent manner.

172 by the signaling via a single receptor, IFN-alpha receptor (IFNAR).

173 tion factor signaling through the interferon-alpha receptor (Ifnar1), resulting in the antigen-indepe

174 n (B = 0.27, p < .05), tumor necrosis factor alpha receptor II (B = 0.07, p < .01), and intercellular

175 d decreased HLA-DR and Tumor necrosis factor-alpha receptor II (CD120b) expression compared with cont

176 s included solubilized tumor necrosis factor-alpha receptor II (sTNF-alphaRII), vascular cell adhesio

177 erleukin-6 (IL-6), and tumor necrosis factor-alpha receptor II (TNF-alpha RII) in the atorvastatin gr

178 TNF-alpha receptor II (TNF-RII) was localized in the cytopla

179 10 [IL-10]), placental (TNF-alpha, IL-6, TNF-alpha receptor II [RII], and IL-1beta), and cord (IL-1be

180 TSD had higher average tumor necrosis factor alpha receptor II levels (B = 0.05, p < .05).

181 C-reactive protein and tumor necrosis factor alpha receptor II) and endothelial function (intercellul

182 n the AHEI and soluble tumor necrosis factor-alpha receptor II, interleukin-6, soluble intercellular

183 rotein, interleukin-6, tumor necrosis factor-alpha receptor II, pro-brain natriuretic peptide (pro-BN

184 V and caspase 8, and >80% expressed the TNF-alpha receptor II, while Fas, TNFR-I, and CD27 expressio

185 e precursor, as well as sequestration of TNF-alpha receptors II and I, is performed by the zinc-depen

186 : TNF-alpha receptor-I (TNFR-I: p55) and TNF-alpha receptor-II (TNFR-II: p75).

187 of the unliganded form of the interleukin-7 alpha receptor (IL-7Ralpha) extracellular domain (ECD) a

188 ct via the non-signaling membrane-bound IL-6 alpha-receptor (IL-6R) as an agonistic cytokine but also

189 lex, the viral cytokine can engage the human alpha-receptor (IL-6Ralpha) to form a hexameric vIL-6/IL

190 ignaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling re

191 ical studies of interleukin-7 (IL-7) and its alpha-receptor (IL-7Ralpha) and comparisons with other g

192 raction between interleukin-7 (IL-7) and its alpha-receptor, IL-7Ralpha, plays fundamental roles in t

193 ransduction pathways generating from the TNF-alpha receptor in cardiomyocytes and leading preferentia

194 th receptor Fas or the tumor necrosis factor alpha receptor in peripheral T cells.

195 To evaluate the role played by each TNF-alpha receptor in the pathogenesis of this syndrome, mic

196 ions, estradiol up-regulates the level of ER-alpha receptors in keratinocytes and induces keratinocyt

197 scence was performed to localize PAF and TNF-alpha receptors in those cells.

198 ion to canonical beta-alpha-gamma/delta-beta-alpha receptors, including beta-alpha-gamma/delta-alpha-

199 rotective, whereas signaling through the TNF-alpha receptor increases the severity of 1918 virus infe

200 We find that, in addition to the "alpha-receptor-independent" tetrameric vIL-6/gp130 compl

201 jected into lean mice lacking individual TNF-alpha receptors indicated that TNF-alpha autoamplificati

202 exercise with microspheres before and after alpha-receptor inhibition (phentolamine) and then NPY Y1

203 sin, rauwolscine) or combined (phentolamine) alpha-receptor inhibition.

204 pathways, such as hypoxia-inducing factor-1-alpha, receptor-interacting protein 1, and apoptosis-ind

205 ibitory effects of roscovitine on STAT5/PDGF alpha receptor interaction, STAT5 activity, and cell sur

206 necrosis factor-alpha, tumor necrosis factor-alpha receptor, interleukin-6 receptor, or L-selectin.

207 licit a calcium flux, failed to induce MIP-1 alpha receptors internalization, and mediated a less pot

208 examined the paradoxical hypothesis that the alpha-receptor inverse agonist doxazosin might produce b

209 e studies thus provide insights into the TNF-alpha receptors involved in mediating and modulating the

210 The level of interferon alpha receptor is also reduced, albeit less drastically

211 The interferon alpha receptor is composed of two subunits: IFNaR1 and I

212 The TNF-alpha receptor is demonstrated to signal through IkappaB

213 Comparing CD4 T cell-depleted IFN-alpha receptor knockout (KO) mice to wild-type mice, we

214 Tumour necrosis factor-alpha receptor knockout (KO) mice, including TNFR1KO, TN

215 pression of both genes was not seen in PGF(2)alpha receptor knockout mice.

216 uggest that inhibition of the T cell p55 TNF-alpha receptor may provide an additional useful therapeu

217 f NO synthesis and selective blockade of TNF-alpha receptors may provide unique therapeutic approache

218 These findings suggest that alpha receptors mediate the effect of TH on the timing o

219 showed that tumor necrosis factor-alpha (TNF-alpha) receptors mediated cytoprotective signaling again

220 Furthermore, TNF-alpha receptor mutants lacking a functional death domain

221 uced NK cell activity and not to altered IFN-alpha receptor, NKP30, NKP44, NKP46, or NKG2D expression

222 erations are mediated through an endothelial alpha-receptor-NOS-signalling pathway.

223 receptor, Stat4 activation by the human IFN-alpha receptor occurs through indirect recruitment by in

224 s infection, but the broad expression of IFN-alpha receptors often leads to adverse reactions in many

225 e, a process that required expression of IFN-alpha receptor on the T cells and IL-15 in the host.

226 icant reduction in surface expression of TNF-alpha receptors on Fancc(-/-) HSC/P.

227 of TNF-alpha, which, acting through the TNF-alpha receptor p55, augments macrophage colony-stimulati

228 ng a probe to platelet-derived growth factor-alpha receptor (PDGF alpha R), an OPC-expressed mRNA.

229 of the mouse platelet-derived growth factor alpha receptor (PDGFalphaR) is fused to the cytosolic do

230 we show that platelet-derived growth factor-alpha receptor (PDGFR-alpha) is specifically phosphoryla

231 ects are mediated through activation of PDGF-alpha receptors (PDGFR-alpha) on perivascular astrocytes

232 Platelet-derived growth factor alpha receptor (PDGFRA)/NG2-expressing glia are distribu

233 brain express platelet-derived growth factor alpha-receptors (PDGFRA), as they do in more caudal regi

234 utside of the PDGF family activated the PDGF alpha receptor (PDGFRalpha) and promoted disease progres

235 disease, the platelet-derived growth factor alpha receptor (PDGFRalpha) is dramatically more capable

236 locked PDGF-dependent activation of the PDGF alpha receptor (PDGFRalpha).

237 The platelet-derived growth factor alpha-receptor (PDGFRalpha) plays a vital role in the de

238 It may be that cardiac alpha receptors play a primary role in elevating HR and

239 Therefore, we evaluated the role that PPAR-alpha receptors play in the heart.

240 alpha (TNF-alpha), acting via the type 1 TNF-alpha receptor, promotes fibrin deposition, while gamma

241 eukin-6 must first complex with its specific alpha-receptor (Ralpha) in order to bind and activate gp

242 s contain one of five chimeric retinoic acid alpha-receptor (RAR alpha) genes (X-RAR alpha) created b

243 ption factors CCAAT/enhancer binding protein-alpha, receptor retinoid X receptor-alpha, and peroxisom

244 olabeling for androgen (AR) and estrogen (ER alpha) receptors revealed no colocalization of hcrt/orx

245 a converting enzyme (TACE) prevented the TNF-alpha receptor shedding response, which suggests that ex

246 Ob/ob male but not female mice lacking TNF-alpha receptors showed significantly lower levels of adi

247 These data demonstrate that IFN-alpha receptor signaling in nonhematopoietic cells is im

248 cytosis activity, indicating that intact TNF-alpha receptor signaling is critical for microglial-medi

249 TNF-alpha receptor signaling regulates epithelial cell secre

250 To dissect TNF-alpha receptor signaling requirements in AD, we generate

251 (IFNAR1*557Gluext*46), which encodes the IFN-alpha receptor signaling subunit.

252 body response requires B cell-autonomous IFN-alpha receptor signaling, it is independent of B cell-in

253 The role of TNF-alpha receptor subtypes in mediating glutamate receptor

254 RY produced "classic" inverse agonism at all alpha receptor subtypes; thus, a neutral efficacy was no

255 nities comparable to that of the IL-15-IL-15 alpha receptor subunit (IL-15Ralpha) interaction.

256 to construct IL-2 mutants that bind the IL-2 alpha receptor subunit (IL-2Ralpha, CD25) with affinitie

257 indicate that reduced expression of the RXR-alpha receptor subunit may represent a mechanism for res

258 of the cytokine subunit p19 and the soluble alpha receptor subunit p40, binds to a receptor complex

259 in that it does not require the nonsignaling alpha-receptor subunit for the formation of gp130-based

260 IL-12 and IL-23 share p40 as an alpha-receptor subunit, yet show only 15% sequence homol

261 -fold differing affinities for their private alpha receptor subunits.

262 Inhibition of TGF-alpha receptor suppressed the G1-induced increase in GLT

263 The TNF-alpha receptor system is expressed in the cornea, and NF

264 Phosphorylation of the TNF-alpha receptor TNF-R1 has been shown to differentially r

265 t not by the antibody against the type I TNF-alpha receptor (TNF-RI).

266 Cs with the antibody against the type II TNF-alpha receptor (TNF-RII), but not by the antibody agains

267 are primarily mediated through the major TNF-alpha receptor, TNF-R1, which is constitutively expresse

268 lacking either of the tumor necrosis factor-alpha receptor (TNFR) genes were also studied; the induc

269 in a subset of peripheral glia, and the TNF-alpha receptor (TNFR), Wengen, is expressed in motoneuro

270 mpared delivery of the tumor necrosis factor alpha receptor (TNFR)-immunoglobulin G1 (IgG1) Fc fusion

271 cluding the tumor necrosis factor alpha (TNF-alpha) receptor (TNFR), Fas, and death domain receptors

272 The tumor necrosis factor alpha receptor (TNFR1) activates downstream effectors th

273 e of functional type I tumor necrosis factor alpha receptor (TNFR1) and interferon gamma.

274 Activation of the p55 TNF-alpha receptor (TNFR1) with an agonist antibody is suffi

275 Little is known about the role of TNF-alpha receptors (TNFR1/p55 and TNFR2/p75) in angiogenic

276 b/ob mice, p55 and p75 tumor necrosis factor-alpha receptors (TNFRs) act cooperatively to induce PAI-

277 seases; however, the precise role of the TNF-alpha receptors (TNFRs) has not been well defined using

278 t in TTP and either or both of the known TNF-alpha receptors (TNFRs), type 1 (TNFR1) and type 2 (TNFR

279 ce deficient in TNFR-I, TNFR-II, or both TNF-alpha receptors (TNFRs), we determined that AQARSAASKVKV

280 we observed increased expression of the TNF-alpha receptor Tnfrsf1b and Netrin-1.

281 s, including the redistribution of the SDF-1 alpha receptor, to the basal surface and leading edge of

282 ceptor complex composed of an IL-15-specific alpha receptor, together with beta and gammac receptors

283 s of type 1 tumor necrosis factor alpha (TNF-alpha) receptor transcription in gastrointestinal cells

284 hain of the tumor necrosis factor alpha (TNF-alpha) receptor transcripts with IFN-gamma activation.

285 ptosis, because macrophages deficient in IFN-alpha receptor type I (IFNAR1) are highly resistant to n

286 ith adenoviral vector expressing soluble TNF-alpha receptor type I attenuated both MMP-2 and MMP-9 ac

287 , resistin and soluble tumor necrosis factor alpha receptor type II) in peripheral blood were measure

288 of soluble tumor necrosis factor alpha (TNF-alpha) receptors types 1 and 2 (sTNF-R1 and sTNF-R2), C-

289 T or platelet-derived growth factor receptor alpha receptor tyrosine kinase genes.

290 studies demonstrate that activation of PPAR-alpha receptors using a selective PPAR-alpha ligand resu

291 th factor, soluble p75 tumor necrosis factor alpha receptor, vascular cell adhesion molecule 1, and m

292 Consistent with this observation, the IFN-alpha receptor was essential for the ability of MNV to c

293 The expression of TNF-alpha receptors was confirmed by RT-PCR.

294 Surface expression of TNF-alpha receptors was unchanged in LN-56 compared to LNCaP

295 rotoxin (CIRL or latrophilin) and neurexin 1 alpha receptors were found to be functionally present.

296 otein, fibrinogen, and tumor necrosis factor-alpha receptors were not related to the risk.

297 th sexes, whereas high levels of soluble TNF-alpha receptors were significant only among women.

298 genetically deficient in the p55 and p75 TNF-alpha receptors were used to study the roles of these re

299 ssues was mediated primarily via the p55 TNF-alpha receptor whereas the p75 TNF-alpha receptor appear

300 of the cytokine growth factor, IL-6, and its alpha receptor, would elicit growth of injured spinal co