ライフサイエンスコーパス: alpha-sarcin

1 r in vivo (no coentry of the ribonucleotoxin alpha-sarcin).

2 o the phosphodiester bond that is cleaved by alpha-sarcin.

3 tion to allow the co-entry of toxins such as alpha-sarcin.

4 zation step that allows coentry of the toxin alpha-sarcin.

5 y was determined by measuring the coentry of alpha-sarcin, a protein synthesis inhibitor.

6 because it is targeted by cytotoxins such as alpha-sarcin and ricin that completely abolish translati

7 rs and is specifically cleaved by the toxins alpha-sarcin and ricin.

8 e ribosome, and the target of the cytotoxins alpha-sarcin and ricin.

9 Ricin A-chin and alpha-sarcin are ribotoxins that inactivate eukaryotic r

10 of two ribotoxic enzymes, ricin A chain and alpha-sarcin, both of which catalyze sequence-specific R

11 ermeabilize canine A72 or mink lung cells to alpha-sarcin, but canine adenovirus type 1 particles per

12 The ribotoxin alpha-sarcin cleaves the large 23S ribosomal RNA (rRNA)

13 ing erythrocyte lysis in vitro and promoting alpha-sarcin coentry and intoxication of cells in cultur

14 Restrictocin, a member of the alpha-sarcin family of site-specific endoribonucleases,

15 nd related fungal endoribonucleases from the alpha-sarcin family site-specifically cleave the sarcin/

16 particles to MOLT-4 cells allowed coentry of alpha-sarcin, indicating viral entry.

17 purinates the adenosine at position 4324 and alpha-sarcin is a ribonuclease that cleaves the phosphod

18 Because the alpha-sarcin loop has been placed near the peptidyltrans

19 These results lead us to conclude that the alpha-sarcin loop is located at the base of the L1 proje

20 n that depurinates an adenine residue in the alpha-sarcin loop of 25S rRNA and inhibits translocation

21 The alpha-sarcin loop of large subunit rRNAs is one of the s

22 emoves an adenine residue from the conserved alpha-sarcin loop of the large rRNA, thereby preventing

23 n to be protected by A site tRNA, and in the alpha-sarcin loop, the site of interaction of elongation

24 that it is located in close proximity to the alpha-sarcin loop.

25 ity of ribosomal function to cleavage of the alpha-sarcin loop.

26 ribosomal subunit components neighboring the alpha-sarcin loop.

27 d a C --> U mutation at position 2666 in the alpha-sarcin loop.

28 pair supports the proposal that cleavage by alpha-sarcin occurs by a base flipping mechanism.

29 We studied the effect of alpha-sarcin on defined steps of translation by the bact

30 Translational inhibitors alpha-sarcin, ricin and auto-immune antibodies to GTPase

31 on, including the L11 binding domain and the alpha-sarcin-ricin loop (SRL).

32 onally-important rRNA regions, including the alpha-sarcin-ricin loop, have different relative positio

33 als a major change in the orientation of the alpha-sarcin-ricin loop.

34 inate a universally conserved adenine in the alpha-sarcin/ricin loop (SRL) and inhibit protein synthe

35 at the canonical RIP target site within the alpha-sarcin/ricin loop (SRL) of 28S rRNA.

36 ves a universally conserved adenine from the alpha-sarcin/ricin loop (SRL) of the 28S rRNA.

37 cific adenine base from the highly conserved alpha-sarcin/ricin loop (SRL) of the large ribosomal RNA

38 bosomes and depurinates the highly conserved alpha-sarcin/ricin loop (SRL) of the large subunit rRNA.

39 (RTA) binds to stalk P-proteins to reach the alpha-sarcin/ricin loop (SRL) where it cleaves a conserv

40 hibits protein synthesis by depurinating the alpha-sarcin/ricin loop (SRL).

41 o the ribosomal protein L3 to depurinate the alpha-sarcin/ricin loop and binding of PAP to L3 was cri

42 guanine residues from the highly conserved, alpha-sarcin/ricin loop in the large rRNA, resulting in

43 a specific adenine from the highly conserved alpha-sarcin/ricin loop in the large rRNA.

44 a specific adenine from the highly conserved alpha-sarcin/ricin loop in the large rRNA.

45 rotein that depurinates the highly conserved alpha-sarcin/ricin loop in the large rRNA.

46 eucaryotic 5 S ribosomal RNA (rRNA) and the alpha-sarcin/ricin loop of 23 S rRNA, organizes the stru

47 cific adenine base from the highly conserved alpha-sarcin/ricin loop of the large ribosomal RNA, ther

48 tein (RIP) that depurinates ribosomes at the alpha-sarcin/ricin loop of the large rRNA, resulting in

49 Stx1 and Stx2) share the same substrate, the alpha-sarcin/ricin loop, but differ in their specificiti

50 in the proportion of 28S rRNA intact at the alpha-sarcin/ricin loop.

51 ve center cleft in the binding of PAP to the alpha-sarcin/ricin stem loop of rRNA.

52 d both by lack of infectivity and by loss of alpha-sarcin toxicity in the presence of recoated partic

53 alpha-Sarcin-treated ribosomes showed no defects in mRNA

54 ion factor G (EF-G) was strongly impaired in alpha-sarcin-treated ribosomes.

55 at the time of exposure to ricin A chain or alpha-sarcin were able to initiate signal transduction f

56 stent with our hypothesis, ricin A chain and alpha-sarcin were strong agonists of SAPK/JNK1 and of it