ライフサイエンスコーパス: alpha-tropomyosin

1 residue mutations in TPM1, the gene encoding alpha-tropomyosin.

2 ssociation with decreased phosphorylation of alpha-tropomyosin.

3 ur through direct interaction with actin and alpha-tropomyosin.

4 ene identified in these analyses encodes for alpha-tropomyosin.

5 leles of myosin heavy chain, troponin-T, and alpha-tropomyosin.

6 proteins, including myosin, alpha-actin, and alpha-tropomyosin.

7 nly: beta-actin increased 1.4-fold (P<0.05); alpha-tropomyosin, 1.3-fold (P<0.05); alpha1-actinin, 1.

8 myosin heavy chain, cardiac troponin T, and alpha-tropomyosin account for > 45% of familial hypertro

9 alpha-Tropomyosin (alpha-TM) has a conserved, charged As

10 c cardiomyopathy mutations A63V and E180G in alpha-tropomyosin (alpha-Tm) have been shown to cause sl

11 Alternative splicing of alpha-tropomyosin (alpha-TM) involves mutually exclusive

12 Mutations in striated muscle alpha-tropomyosin (alpha-TM), an essential thin filament

13 tion inTPM3, which encodes the slow skeletal alpha-tropomyosin (alphaTm), was linked to NM in a large

14 h them to smooth muscle-specific splicing of alpha-tropomyosin and also alpha-actinin.

15 tein levels of smooth muscle alpha-actin and alpha-tropomyosin and increased levels of macrophage mar

16 yocytes expressing green fluorescent protein-alpha-tropomyosin and microinjected with mAb17 revealed

17 s with multiple transcripts, skeletal muscle alpha-tropomyosin and one for a repetitive sequence, sho

18 isting of the first 19 residues of rat short alpha-tropomyosin and the last 18 residues of the GCN4 l

19 t depression in levels of phosphorylation of alpha-tropomyosin and troponin I in fiber bundles from t

20 ts with mutations in troponin T, troponin I, alpha-tropomyosin, and actin do not invariably present w

21 s of cardiac troponin T, cardiac troponin I, alpha-tropomyosin, and cardiac actin was performed using

22 Two distinct point mutations within alpha-tropomyosin are associated with the development of

23 nd that both short nonmuscle and long muscle alpha-tropomyosins bind there as well, though with diffe

24 sense mutations in cardiac troponin T (TnT), alpha-tropomyosin, C-protein, or cardiac myosin heavy ch

25 Missense mutations in alpha-tropomyosin can cause familial hypertrophic cardio

26 rt that purified RNA from the 3'UTR of human alpha-tropomyosin can inhibit in vitro translation in a

27 Here, a rat fast alpha-tropomyosin cDNA with the Met8Arg mutation was exp

28 cardiac function or structure, whereas total alpha-tropomyosin deficiency is incompatible with life.

29 Striated and smooth muscle alpha-tropomyosins differ by the regions encoded by exon

30 nts that activate the weak 3' splice site of alpha-tropomyosin exon 2 as well as a variety of heterol

31 in family, 9G8, can activate the splicing of alpha-tropomyosin exon 2.

32 mapped the functional domains encoded by the alpha-tropomyosin exon 9a (striated muscle-specific) and

33 In alpha-tropomyosin, exon 6a or 6b is not specific to any

34 opomyosin (TM9a) and TM2 (TM9d), a nonmuscle alpha-tropomyosin expressed in many cells.

35 ta-tropomyosin expression is down-regulated, alpha-tropomyosin expression is increased.

36 sin heavy chain, troponin T, troponin I, and alpha-tropomyosin for disease-causing mutations.

37 We have used the rat alpha-tropomyosin gene as a model system of tissue-speci

38 (FHC) caused by an Asp175Asn mutation in the alpha-tropomyosin gene in affected subjects from three u

39 3' untranslated region riboregulator of the alpha-tropomyosin gene is not needed for the inhibition

40 Exon 3 of the alpha-tropomyosin gene is specifically repressed in smoo

41 Nucleotide residue 579 in the alpha-tropomyosin gene may have increased susceptibility

42 lotypes of three kindreds with FHC due to an alpha-tropomyosin gene mutation, Asp175Asn, were analyze

43 We conclude that haploinsufficiency of the alpha-tropomyosin gene produces little or no change in c

44 We created a mouse that lacks a functional alpha-tropomyosin gene using gene targeting in embryonic

45 the 3' untranslated region (3'UTR) of human alpha-tropomyosin has tumor-suppressor properties in viv

46 high percentage of beta-tropomyosin replaces alpha-tropomyosin in the hearts of transgenic mice, the

47 Recombinant TM5a, a short non-muscle alpha-tropomyosin, inhibited depolymerization.

48 The inclusion of exons 2 and 3 of alpha-tropomyosin is governed through tissue-specific al

49 Exon 3 of alpha-tropomyosin is specifically inhibited in smooth mu

50 N-acetylated striated muscle TM (stTM), long alpha-tropomyosin isoforms with the same N-terminal sequ

51 l model peptides with sequences of alternate alpha-tropomyosin isoforms, and a troponin T fragment th

52 working heart preparations) of heterozygous alpha-tropomyosin knockout and wild-type mice were indis

53 Heterozygous alpha-tropomyosin knockout mice have approximately 50% a

54 Homozygous alpha-tropomyosin "knockout" mice die between embryonic

55 mice have approximately 50% as much cardiac alpha-tropomyosin mRNA as wild-type littermates but simi

56 brillar tropomyosin despite the reduction in alpha-tropomyosin mRNA.

57 between embryonic day 9.5 and 13.5 and lack alpha-tropomyosin mRNA.

58 Analysis of striated muscle alpha-tropomyosin mutants in which internal sequence has

59 in hypertrophic cardiomyopathy caused by the alpha-tropomyosin mutation Asp175Asn.

60 ses of hypertrophic cardiomyopathy caused by alpha-tropomyosin mutations have been hampered by the ra

61 mutations, 6 had troponin I mutations, 3 had alpha-tropomyosin mutations, and 1 had an actin mutation

62 expression of SMC-related genes alpha-actin, alpha-tropomyosin, myosin heavy chain, and calponin H1 d

63 was studied by deletion from skeletal muscle alpha-tropomyosin of internal residues 49-167.

64 -terminal 31 residues of rat striated-muscle alpha-tropomyosin (preceded by a fragment of the GCN4 le

65 in mRNA as wild-type littermates but similar alpha-tropomyosin protein levels.

66 Nine recombinant chicken skeletal alpha-tropomyosin proteins were prepared, eight C-termin

67 an 81-residue N-terminal fragment of muscle alpha-tropomyosin reveals a parallel two-stranded alpha-

68 combinant human cardiac troponin (rhcTn) and alpha-tropomyosin (rhcTm) expressed in Escherichia coli.

69 model carrying the human Met9Arg mutation of alpha-tropomyosin slow (Tpm3).

70 human TPM3 gene encoding gamma-tropomyosin (alpha-tropomyosin-slow) expressed in slow skeletal muscl

71 from the ability of hC0C1f to bind actin and alpha-tropomyosin, suggesting that cleaved C0-C1f could

72 pon other defined regulatory elements in the alpha-tropomyosin test minigene.

73 ncoprotein E1A 3' splice site, IVS2 of human alpha-tropomyosin, the consensus polypyrimidine tract fo

74 issue-specific splicing, represses exon 3 of alpha-tropomyosin through distant pyrimidine-rich tracts

75 g of the mutually exclusive exons 2 and 3 of alpha-tropomyosin (TM) involves repression of exon 3 in

76 Cardiac alpha-tropomyosin (Tm) single-site mutations D175N and E

77 We investigated the functional impact of alpha-tropomyosin (Tm) substituted with one (D137L) or t

78 s cardiomyopathic mutations in human cardiac alpha-tropomyosin (Tm), a method of depletion/reconstitu

79 the cardiac contractile apparatus, including alpha-tropomyosin (Tm).

80 proteins, including four point mutations in alpha-tropomyosin (Tm).

81 sted from non-transgenic mice that expressed alpha-tropomyosin (Tm).

82 an HCM mouse model with an E180G mutation in alpha-tropomyosin (Tm180) that demonstrates increased my

83 C-terminal, or both ends of striated muscle alpha-tropomyosin (TM9a) and TM2 (TM9d), a nonmuscle alp

84 he 34 C-terminal residues of striated muscle alpha-tropomyosin, TM9a(251-284).

85 Exon 3 of the rat alpha-tropomyosin (Tpm1) gene is repressed in smooth mus

86 a Spanish-American family caused by a novel alpha-tropomyosin (TPM1) mutation and examine the pathog

87 D230N missense mutation in the gene encoding alpha-tropomyosin (TPM1) was identified.

88 ); S179F of troponin T (TNNT2); and D175N of alpha-tropomyosin (TPM1).

89 le-specific exon (SK) of human slow skeletal alpha-tropomyosin, TPM3, and stimulates inclusion of the

90 Tnnt2, together with alpha-tropomyosin (Tpma) and cardiac troponins C and I (

91 A series of rat alpha-tropomyosin variants was expressed in Escherichia

92 ago, mutations in cardiac troponin (Tn)T and alpha-tropomyosin were linked to familial hypertrophic c