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1 PNMT inhibitory potency and affinity for the alpha2-adrenoceptor.
2 s inhibitors of PNMT and for affinity at the alpha2-adrenoceptor.
3 nd to be antagonists/inverse agonists of the alpha2-adrenoceptor.
4 mpounds also exhibit strong affinity for the alpha2-adrenoceptor.
5 is reduction is evident for both alpha1- and alpha2-adrenoceptors.
6 ne, consistent with an action at presynaptic alpha2-adrenoceptors.
7 urnover, by negative feedback regulation via alpha2-adrenoceptors.
8 with conflicting functional activity at the alpha2-adrenoceptor, a G-protein-coupled receptor with r
9 ly isolated LC neurons to examine opioid and alpha2-adrenoceptor action on potassium and calcium curr
11 responsible for PNMT inhibitory activity and alpha2-adrenoceptor affinity were investigated by evalua
14 ase (PNMT, EC 2.1.1.28), with respect to its alpha2-adrenoceptor affinity, than is 3-methyl-1,2,3, 4-
15 d in the PNMT active site and possess little alpha2-adrenoceptor affinity, thereby conferring good se
17 (10 micro M), and occluded partially by the alpha2 adrenoceptor agonist UK14,304 (10 micro M) as wel
18 low-dose dexmedetomidine, a highly selective alpha2 adrenoceptor agonist, could safely decrease the i
19 ee of EPSC depression was also seen with the alpha2-adrenoceptor agonist clonidine (5 microM), and th
20 We showed previously that injection of the alpha2-adrenoceptor agonist clonidine at the site of per
21 mplitude of potassium current induced by the alpha2-adrenoceptor agonist UK14304 was not significantl
22 .573) and a three-parameter equation for the alpha2-adrenoceptor (alpha2 pKi = 0.599pi - 0.0542MR - 0
26 rough the actions of noradrenaline at spinal alpha2 -adrenoceptors, although serotonin, acting on fac
27 s or i.c.v. pretreatment with yohimbine, the alpha2-adrenoceptor and 5-HT1A receptor antagonist, bloc
28 e similar at the PNMT active site and at the alpha2-adrenoceptor and that the electrostatic interacti
29 decreases in MAP and HR possibly via central alpha2-adrenoceptor and/or 5-HT1A receptors and not thro
30 mediate inhibition of transmitter release by alpha2-adrenoceptors and represent important regulators
31 e LC was studied because elevated amounts of alpha2-adrenoceptors and tyrosine hydroxylase have been
32 ttenuated partially by pretreatment with the alpha2 adrenoceptor antagonist yohimbine (10 micro M), a
36 blocked by intrathecal administration of the alpha2-adrenoceptor antagonist idazoxan and intra-LC co-
38 ipants were administered hydrocortisone, the alpha2-adrenoceptor antagonist yohimbine, or both before
39 e shown that local infusions of NE or of the alpha2-adrenoceptor antagonist, atipamezole, in the mous
40 suggested that (11)C-yohimbine, a selective alpha2-adrenoceptor antagonist, is an appropriate ligand
45 female rats with estrogen for 2 days reduces alpha2-adrenoceptor binding density by 25%, increases G
48 re, the compounds exert their effects at the alpha2-adrenoceptor both in vitro in human prefrontal co
49 s and is quite selective for PNMT versus the alpha2-adrenoceptor, but 24 is less potent than the corr
51 e results suggest that estrogen may decrease alpha2-adrenoceptor expression in the frontal cortex of
56 l periaqueductal gray is mediated in part by alpha2-adrenoceptors in the spinal cord dorsal horn.
58 nd Galphai as mediators of the PTX-sensitive alpha2-adrenoceptor-mediated inhibition of N-type Ca2+ c
59 ayed by endogenous G-protein subunits in the alpha2-adrenoceptor-mediated inhibition of N-type Ca2+ c
60 d behavioral actions mediated by alpha1- and alpha2-adrenoceptors on neurons in the nucleus raphe mag
61 sser extent the glycine site) or stimulating alpha2-adrenoceptors, profoundly increases AADC activity
65 ir sedative/hypnotic properties although the alpha2 adrenoceptor subtype responsible for these anesth
68 agonist, is an appropriate ligand for PET of alpha2 adrenoceptors that passes readily from blood to b
70 ty and 2) the coupling of both mu-opioid and alpha2-adrenoceptors to calcium channels seems to be mor
74 he specificity of (11)C-ORM-13070 binding to alpha2 adrenoceptors was demonstrated in rats pretreated
75 nucleus and reducing the affinity toward the alpha2-adrenoceptor was observed with this 3, 7-disubsti
76 antidepressant-free suicides, the number of alpha2-adrenoceptors was significantly higher in tempora
77 THIQ reduced the binding affinity toward the alpha2-adrenoceptor, we investigated the combination of
78 ted suicides, significantly lower numbers of alpha2-adrenoceptors were found in occipital cortex and
81 immunoreactivity and radioligand binding to alpha2-adrenoceptors were significantly lower (approxima
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