ライフサイエンスコーパス: alpha2-macroglobulin

1 insulin) and inflammation (e.g., leptin and alpha2-macroglobulin).

2 coli protein RidA, and the mammalian protein alpha2-macroglobulin.

3 eins, acetylated low density lipoprotein and alpha2-macroglobulin.

4 rculation probably includes both albumin and alpha2-macroglobulin.

5 tate cancer cells by a proteinase inhibitor, alpha2-macroglobulin.

6 ibitors and cleave both antithrombin III and alpha2-macroglobulin.

7 induced by a chase with mouse laminin-1 and alpha2-macroglobulin.

8 an inhibitory concentration close to that of alpha2-macroglobulin.

9 the presence of eukaryotic proteins such as alpha2-macroglobulin.

10 ored using Pro-Phe-Arg-pNA, independently of alpha2-macroglobulin.

11 f the wound environment becomes complexed to alpha2-macroglobulin.

12 n (50%), ADAM9 (54%), vitronectin (54%), and alpha2-macroglobulin (55%), as well as some cell surface

13 tissue positively correlated with levels of alpha2-macroglobulin, a marker of epithelial leak, in lo

14 Alpha2-macroglobulin, a protease inhibitor secreted as p

15 alpha2-Macroglobulin (A2M) is a proteinase inhibitor fou

16 nitis (apolipoprotein A-2 [APOA2], 9.7-fold; alpha2-macroglobulin [A2M], 4.5-fold; apolipoprotein A-1

17 se and cleavage of the proteinase inhibitors alpha2-macroglobulin (alpha2-M) and alpha 1-proteinase i

18 ocorticoid-supplemented enhanceosome for the alpha2-macroglobulin (alpha2-M) gene and compare this wi

19 bin III (ATIII), heparin cofactor II (HCII), alpha2-macroglobulin (alpha2-M), protease nexin I, and p

20 cid sequences that were identical to that of alpha2 macroglobulin (alpha2M).

21 alpha2-Macroglobulin (alpha2M) activated with methylamin

22 purified from human plasma and identified as alpha2-macroglobulin (alpha2M) and pregnancy zone protei

23 s studies of the plasma proteinase inhibitor alpha2-macroglobulin (alpha2M) demonstrated that alpha2M

24 alpha2-Macroglobulin (alpha2M) functions as a major carr

25 alpha2-Macroglobulin (alpha2M) inhibits diverse extracel

26 alpha2-Macroglobulin (alpha2M) is a broad spectrum prote

27 hypochlorite-induced modifications of human alpha2-macroglobulin (alpha2M) markedly increase its cha

28 Ligation of the alpha2-macroglobulin (alpha2M) signaling receptor by rec

29 n the present study, we demonstrate that the alpha2-macroglobulin (alpha2M) signaling receptor is up-

30 Surprisingly, oxidation of native alpha2-macroglobulin (alpha2M) with 125 microM hypochlor

31 The carboxy terminus of alpha2-macroglobulin (alpha2M), a proteinase inhibitor r

32 related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a

33 creased amounts of the LRP ligand, activated alpha2-macroglobulin (alpha2M), at 4 degrees C.

34 ximately 700-kDa complex with the inhibitor, alpha2-macroglobulin (alpha2M), that retains activity ag

35 ich targets to early/recycling endosomes, or alpha2-macroglobulin (alpha2M), which targets to late en

36 ng receptor for many protein ligands, and of alpha2-macroglobulin (alpha2M)-proteinase complexes as o

37 is complexed to the blood transport protein, alpha2-macroglobulin (alpha2M).

38 lative of the human endopeptidase inhibitor, alpha2-macroglobulin (alpha2M).

39 Receptor-recognized forms of alpha2-macroglobulin (alpha2M*) bind to two classes of c

40 A previous study demonstrated that activated alpha2-macroglobulin (alpha2M*) binding to the low-densi

41 Ligation of cell surface GRP78 by activated alpha2-macroglobulin (alpha2M*) promotes cell proliferat

42 tivation in response to EI-tPA and activated alpha2-macroglobulin (alpha2M*) required the NMDA recept

43 Activated alpha2-macroglobulin (alpha2M*) signals predominantly th

44 activated forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M*) to cell surface-associat

45 recognized forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M*) to GRP78 on the cell sur

46 s apoE-containing lipoproteins and activated alpha2-macroglobulin (alpha2M*), promote neurite outgrow

47 n the CD91/LRP ligand, the activated form of alpha2-macroglobulin (alpha2M*).

48 of native, half-transformed, and transformed alpha2-macroglobulins (alpha2Ms) labeled with a monoclon

49 talloprotease as demonstrated by cleavage of alpha2-macroglobulin, although physiological substrates

50 ormed higher molecular weight complexes with alpha2-macroglobulin, an inhibitor of MMPs.

51 essing and had very low capacities to cleave alpha2-macroglobulin and a peptide substrate.

52 luid appeared to result from binding between alpha2-macroglobulin and activated MMP-1.

53 atic expression of the rat acute phase genes alpha2-macroglobulin and beta-fibrinogen.

54 blot analyses confirmed the upregulation of alpha2-macroglobulin and ceruloplasmin in the diabetic r

55 AST/ALT, whereas it significantly decreased alpha2-macroglobulin and complement C3, P < 0.05.

56 x3, gp130 still stimulates the expression of alpha2-macroglobulin and synergizes with IL-1 to up-regu

57 Other LRP1 ligands, including alpha2-macroglobulin and tissue-type plasminogen activat

58 The LRP1 agonists, alpha2-macroglobulin and tissue-type plasminogen activat

59 se gene, beta-fibrinogen, paralleled that of alpha2-macroglobulin and was significantly reduced follo

60 ration of one potential acute phase protein (alpha2 macroglobulin), and albumin concentration is inve

61 dulin) and of amyloid deposition (clusterin, alpha2-macroglobulin, and ADAM9).

62 Apolipoprotein E, alpha2-macroglobulin, and amyloid precursor protein (APP

63 LRP and its ligands apolipoprotein E, alpha2-macroglobulin, and beta-amyloid precursor protein

64 pression of 15 of 42 genes including MART-1, alpha2-macroglobulin, and CD59.

65 nts using fluorescently labeled transferrin, alpha2-macroglobulin, and cholera toxin B-subunit conjug

66 malities were found for C1-INH protein, C1q, alpha2-macroglobulin, antithrombin III, and angiotensin-

67 of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precurs

68 roteinases: alpha1-antiproteinase inhibitor, alpha2-macroglobulin, aprotinin, and soybean inhibitor,

69 din, although fucoidin was without effect on alpha2-macroglobulin binding or uptake.

70 protease inhibitor-binding protein-G-related alpha2-macroglobulin-binding (GRAB) protein, and the ant

71 Clusterin and alpha2-macroglobulin bound to PGPFs to significantly ame

72 ligation of murine macrophage receptors for alpha2-macroglobulin, bradykinin, epidermal growth facto

73 392) for a Ser increased the reactivity with alpha2-macroglobulin but not with casein or Cm-Tf.

74 Ldlr-/- mice, whereas the rate of removal of alpha2-macroglobulin by the LDLR-related protein, which

75 excess of unlabeled gp96 or the CD91 ligand alpha2-macroglobulin, by anti-CD91 Ab and by the specifi

76 sed genes) of acute-phase response proteins: alpha2-macroglobulin, ceruloplasmin, complement componen

77 patic expression of the rat acute phase gene alpha2-macroglobulin compared to both laparoscopic CLP u

78 relationships of CD109, a member of the the alpha2-macroglobulin/complement (AMCOM) gene family.

79 esents a novel and independent branch of the alpha2-macroglobulin/complement gene family (AMCOM) and

80 TGF-beta2.alpha2-macroglobulin complexes are more refractory to he

81 HGF increased alpha2-macroglobulin concentrations on postburn days 2,

82 nding studies with the LRP ligand, activated alpha2-macroglobulin, confirmed that LRP was present and

83 ion of lysosomal function, since the rate of alpha2-macroglobulin degradation was not affected by the

84 GRP78 also serves as the receptor for alpha2-macroglobulin-dependent signaling and for uptake

85 omplement 3 and pregnancy zone protein-like, alpha2-macroglobulin domain-containing 8).

86 nase inhibitor, alpha1-antichymotrypsin, and alpha2-macroglobulin function as critical antiapoptotic

87 Therefore, genetic variability in the alpha2-macroglobulin gene is a risk factor associated wi

88 ies have reported an association between the alpha2-macroglobulin gene on chromosome 12 and late-onse

89 aximal interleukin-6-inducible activation of alpha2-macroglobulin gene promoter.

90 The A/A genotype in exon 24 of the alpha2-macroglobulin gene was associated with neuropatho

91 ansmembrane conductance regulator and rodent alpha2-macroglobulin, growth hormone receptors, and insu

92 nstructions of an intermediate form of human alpha2-macroglobulin (half-transformed alpha2M) in which

93 6REs was confirmed by cross-competition with alpha2-macroglobulin IL-6RE and specific interactions wi

94 s was low compared with Stat3 binding to the alpha2-macroglobulin IL-6RE.

95 Levels of the proteinase inhibitor alpha2-macroglobulin in burn fluid and chronic ulcer wou

96 ns, of the blood biomarkers only decorin and alpha2-macroglobulin increased predictive value for futu

97 nd activated and receptor-recognized form of alpha2-macroglobulin-induced calcium signaling was aboli

98 [Cl-] in alpha2-macroglobulin-labeled endosomes, which enter a la

99 re (1.91) was found near D12S98 close to the alpha2-macroglobulin locus in the affected pairs in whic

100 Finally, we show TFPI inhibits 125I-alpha2-macroglobulin-methylamine binding to hepatoma cel

101 es 14 (MLS 2.16), 5 (MLS 2.00), 12, close to alpha2-macroglobulin (MLS 1.91), and 21, close to amyloi

102 alpha2-Macroglobulin null mice demonstrate increased res

103 omplement-like repeats, CR3 and CR8, from an alpha2-macroglobulin-proteinase ligand binding region of

104 the binding and inactivation of TGF-beta1 by alpha2-macroglobulin, rather than by modulation of growt

105 density lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP).

106 to the low-density receptor-related protein/alpha2-macroglobulin receptor (LRP/alpha2MR) is blocked

107 density lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP/alpha2MR) mediates th

108 0 microM), interaction between CR3 and human alpha2-macroglobulin receptor binding domain that involv

109 The alpha2-macroglobulin receptor LRP1 cycles with Glut4 and

110 Previously, CD91, the alpha2-macroglobulin receptor, was identified as the hea

111 y lipoprotein receptor-related protein (LRP)/alpha2-macroglobulin receptor-mediated endocytosis of 12

112 s exotoxin (PE) binds the heavy chain of the alpha2-macroglobulin receptor/low density lipoprotein re

113 type plasminogen activator (uPA) through the alpha2-macroglobulin receptor/low density lipoprotein-re

114 otein family, which includes C3, C4, C5, and alpha2-macroglobulin, shows that SpC3 is the first diver

115 including leupeptin, aprotinin, serpins, and alpha2-macroglobulin, suggesting the presence of non-can

116 he activated and receptor-recognized form of alpha2-macroglobulin to macrophages was greatly reduced,

117 alized acetylated low density lipoprotein or alpha2-macroglobulin was degraded and released from cell

118 n treatment of DCs with mannan or LRP ligand alpha2-macroglobulin, we observed only a minor decrease

119 ll antigen MART-1 and the protease inhibitor alpha2-macroglobulin were detected in the melanocyte cel

120 tic trypsin inhibitor, antithrombin III, and alpha2-macroglobulin, whereas active tetramers are resis

121 y IL-2 showed specific binding to a protein, alpha2-macroglobulin, which may be the reason that IL-2

122 repeat, of RAP inhibited the interaction of alpha2-macroglobulin with LRP.