ライフサイエンスコーパス: alpha2beta1 integrin

1 sm that differs from but synergizes with the alpha2beta1 integrin.

2 orylation events that are independent of the alpha2beta1 integrin.

3 in situ is the alpha1beta1 integrin, not the alpha2beta1 integrin.

4 ing of collagen to one of its receptors, the alpha2beta1 integrin.

5 e identified flavocetin-A as an inhibitor of alpha2beta1 integrin.

6 h calpain-1, and calpain enzymes can degrade alpha2beta1 integrin.

7 express elevated levels of MMP-1, AP-1, and alpha2beta1 integrin.

8 were largely nonfunctional in the absence of alpha2beta1 integrin.

9 stream of DDR1, whereas FAK is downstream of alpha2beta1 integrin.

10 L-7 increases their adhesion to collagen via alpha2beta1 integrin.

11 the functional endorepellin receptor is the alpha2beta1 integrin.

12 ir, fibroblasts first attach to collagen via alpha2beta1 integrin.

13 tivating antibodies against beta1, beta3, or alpha2beta1 integrins.

14 The alpha2beta1 integrin, a collagen receptor on platelets a

15 The alpha2beta1 integrin, a collagen/laminin receptor, is ex

16 The alpha2beta1 integrin, a collagen/laminin receptor, is ex

17 The alpha2beta1 integrin, a receptor for collagens, laminins

18 from several investigators suggest that the alpha2beta1 integrin, a receptor for collagens, laminins

19 Moreover we found that alpha2beta1 integrin acquired core3 O-glycans in cells e

20 n, and may be due to cellular differences in alpha2beta1-integrin activation/ligand affinity state.

21 oth signaling through IGF-IR and influencing alpha2beta1 integrin activity.

22 However, ligation of the alpha2beta1 integrin alone was insufficient to activate

23 1 integrin alone or both the alpha1beta1 and alpha2beta1 integrins, along with Chinese hamster ovary

24 Anti-alpha2beta1 integrin and anti-GP VI antibodies inhibited

25 The role of alpha2beta1 integrin and CD44/CSPG receptor binding on h

26 the signal requires two collagen receptors, alpha2beta1 integrin and discoidin domain receptor (DDR)

27 These results suggest that both alpha2beta1 integrin and GP VI are involved in inside-ou

28 l analyses proved that flavocetin-A binds to alpha2beta1 integrin and its alpha2A domain with high af

29 We also show that alpha2beta1 integrin and Src tyrosine kinase, which have

30 DDR-2 signaling was independent of the alpha2beta1 integrin and the interleukin-1-induced signa

31 ngiogenesis by simultaneously binding to the alpha2beta1 integrin and the vascular endothelial growth

32 own as a GPIb inhibitor, efficiently targets alpha2beta1 integrin and thus blocks collagen-induced pl

33 ntagonism, through concurrent binding to the alpha2beta1 integrin and vascular endothelial growth fac

34 onstrate that endorepellin requires both the alpha2beta1 integrin and VEGFR2 for its angiostatic acti

35 vokes a physical down-regulation of both the alpha2beta1 integrin and VEGFR2, with concurrent activat

36 major cell surface receptor for collagen I, alpha2beta1 integrin, and provide an initial investigati

37 the sequence GDE(A) recognized by the VLA-2 (alpha2beta1) integrin, and to test if VLA-2 is involved

38 lso induced CLANs, whereas adsorbed beta3 or alpha2beta1 integrin antibodies did not.

39 nt to C-68 was inhibited by EDTA and by anti-alpha2beta1 integrin antibodies.

40 ities on p176 that can be blocked by an anti-alpha2beta1 integrin antibody.

41 ion whereas no effect was observed with anti-alpha2beta1 integrin antibody.

42 telet spreading was markedly reduced by anti-alpha2beta1 integrin antibody.

43 Thus, our study identifies alpha2beta1 integrin as an important survival pathway in

44 Accordingly, C2C12 cells stably expressing alpha2beta1 integrin as the only collagen-binding integr

45 ent of C2C12-alpha2+myoblasts expressing the alpha2beta1 integrin as the sole collagen receptor.

46 collagen I was dependent on alpha1beta1 and alpha2beta1 integrins, as shown with function blocking a

47 that in squamous epithelial cells, collagen-alpha2beta1 integrin binding activates RhoA, slowing cel

48 evealed the presence of an Asp-Gly-Glu (DGE) alpha2beta1 integrin-binding motif in the N-terminal dom

49 ain, as bait for affinity purification of an alpha2beta1 integrin-binding toxin from the crude venom.

50 The alpha2beta1 integrin binds collagen in a Mg2+-dependent

51 In a search for an alpha2beta1 integrin-blocking component from the venom o

52 ngs suggest that the separation of GPIb- and alpha2beta1 integrin-blocking members within the C-type

53 Endothelial cells that express alpha2beta1 integrin but lack VEGFR2, do not respond to

54 cells genetically engineered to express the alpha2beta1 integrin, but not in cells either lacking th

55 tudies demonstrated that reexpression of the alpha2beta1 integrin by a poorly differentiated breast c

56 Ligation of the alpha2beta1 integrin by C1q contained in immune complexe

57 ely--alphaVbeta3 integrin by nearly 65%, and alpha2beta1 integrin by nearly 95%.

58 ported that the nonactivated conformation of alpha2beta1 integrin can also bind to large ligands, suc

59 Thus, the cooperation between IL-7R and alpha2beta1 integrin can represent an important pathogen

60 ) and collagen (via its interaction with the alpha2beta1 integrin), caused Vav to become phosphorylat

61 alpha2beta1 integrin, CD36, and GP VI have all been impl

62 ently reduced cell surface expression of the alpha2beta1 integrin collagen receptor and impaired sign

63 on lead to an accelerated down-regulation of alpha2beta1 integrin compared to the slow turnover of un

64 integrin, leading to decreased levels of the alpha2beta1 integrin complex, decreased activation of fo

65 esent in alpha2-MVBs, internalized clustered alpha2beta1 integrin coprecipitates with calpain-1, and

66 In addition, the impact of alpha2beta1 integrin-deficiency on the function of prima

67 The alpha2beta1 integrin-dependent difference in angiogenesi

68 In contrast, there was no alpha2beta1 integrin-dependent difference in the angioge

69 In this study, we show that decorin promotes alpha2beta1 integrin-dependent endothelial cell adhesion

70 ngs demonstrate that genetic deletion of the alpha2beta1 integrin does not significantly alter the ra

71 nvasion, restores cell surface expression of alpha2beta1 integrin, downstream FAK autophosphorylation

72 capillary morphogenesis requires endothelial alpha2beta1 integrin engagement of a single type I colla

73 on collagen stimulation or clustering of the alpha2beta1 integrin, even in the absence of increased l

74 ged with B16F10 melanoma cells, mice lacking alpha2beta1 integrin ex-pression exhibit increased tumor

75 response to Listeria monocytogenes required alpha2beta1 integrin expression by peritoneal mast cells

76 Peritoneal mast cells require alpha2beta1 integrin expression for activation in respon

77 en I binding, collagen I-driven motility, or alpha2beta1-integrin expression.

78 on formation and altered localization of the alpha2beta1 integrin from cell-cell to cell-matrix adhes

79 and clustering-specific pathway that diverts alpha2beta1 integrin from its normal endo/exocytic traff

80 S16, a potent and selective inhibitor of the alpha2beta1 integrin, from Echis multisquamatus venom.

81 nhanced the collagen-inhibitory effect of an alpha2beta1-integrin function-blocking antibody.

82 Thus, the alpha2beta1 integrin functionally inhibits breast tumor

83 The interaction between alpha2beta1 integrin (GPIa/IIa, VLA-2) and vascular coll

84 uction of MMP-1 occurs by signaling from the alpha2beta1 integrin in contact with dermal fibrillar ty

85 l and genetic evidence of a central role for alpha2beta1 integrin in experimental and developmental a

86 evious studies indicating high expression of alpha2beta1 integrin in normal breast epithelium and los

87 To define the role of the alpha2beta1 integrin in pathologic angiogenesis, we inve

88 protein (IAP/CD47) augments the function of alpha2beta1 integrin in smooth muscle cells (SMC), resul

89 In this study, we examined the role of alpha2beta1 integrin in Th17-mediated destructive arthri

90 These results suggest a role for the alpha2beta1 integrin in the control of homeostasis of im

91 Numerous data have implicated the alpha2beta1 integrin in various cell types as the primar

92 that suggests an antiangiogenic role for the alpha2beta1 integrin in vivo.

93 To define the role of the alpha2beta1 integrin in wound healing, wound repair was

94 r mechanisms that regulate expression of the alpha2beta1, integrin in cells with megakaryocytic diffe

95 ing autophagy through a VEGFR2-dependent but alpha2beta1 integrin-independent pathway.

96 ligand and molecular mechanisms by which the alpha2beta1 integrin induces activation and cytokine sec

97 protein separation protocols and tested for alpha2beta1 integrin-inhibiting capabilities by ELISA.

98 Engagement of the alpha2beta1 integrin initiated a HAEC response similar t

99 galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393

100 ely, these results suggest that endorepellin/alpha2beta1-integrin interaction and effects are specifi

101 Our results suggest that alpha2beta1 integrin interacts with two different ligand

102 The functional cooperation between IL-7R and alpha2beta1 integrin involves activation of the JAK/PI3K

103 The alpha2beta1 integrin is a major collagen receptor on pla

104 We now report that the alpha2beta1 integrin is a novel receptor for multiple co

105 s study indicates that the collagen receptor alpha2beta1 integrin is a regulator of cell fate in huma

106 The alpha2beta1 integrin is abundantly expressed by basal ke

107 e the first evidence, to our knowledge, that alpha2beta1 integrin is an important pathway in Th17 cel

108 gent-stable, physical association of IAP and alpha2beta1 integrin is detected by coimmunoprecipitatio

109 We further show that alpha2beta1 integrin is expressed on synovial Th17 cells

110 We found that alpha2beta1 integrin is expressed on synovial Th17 cells

111 This finding suggests that the alpha2beta1 integrin is not only important for innate im

112 a signaling pathway whereby occupancy of the alpha2beta1 integrin is required, but not sufficient, fo

113 -positive HCC cells displayed high levels of alpha2beta1 integrin (ITG) receptor, both in vitro and i

114 Blockade of alpha2beta1 integrin led to a decrease in the number of

115 reaggregation of cells plated on collagen I (alpha2beta1 integrin ligand).

116 We demonstrate that alpha2beta1 integrin-ligation negatively regulates expre

117 suggest that crosstalk between c-met and the alpha2beta1 integrin may contribute to mast-cell activat

118 We hypothesized that reexpression of the alpha2beta1 integrin may regulate expression of other ge

119 Moreover, flavocetin-A antagonized alpha2beta1 integrin-mediated adhesion and migration of

120 ng of human lung fibroblast cells through an alpha2beta1 integrin-mediated interaction as shown in ce

121 tocrine TNC increased BTIC growth through an alpha2beta1 integrin-mediated mechanism that elevated NO

122 Thus, IAP stimulates alpha2beta1 integrin-mediated SMC migration via Gi-media

123 platelet aggregation, was blocked by an anti-alpha2beta1 integrin monoclonal antibody (P1E6), demonst

124 e C-terminal domain V of perlecan) binds the alpha2beta1 integrin on endothelial cells and triggers a

125 are associated with expression levels of the alpha2beta1 integrin on the platelet surface.

126 ADAM9-S binds directly to alpha6beta4 and alpha2beta1 integrins on the surface of colon carcinoma

127 ss spectroscopy as the alpha2 subunit of the alpha2beta1 integrin, one of the major type I collagen-b

128 potentials based on engagement of either the alpha2beta1 integrin or CD44/CSPG.

129 olysis in the NOTCH pathway, or silencing of alpha2beta1 integrin or JAG1, reduced the proliferative

130 However, forced overexpression of alpha2beta1 integrin or MMP1 in smooth muscle cells expr

131 The addition of an antibody against alpha2beta1 integrin partially reversed the inhibitory e

132 Our findings reveal that the alpha2beta1 integrin plays an important role in angiogen

133 Activated and neutralized alpha2beta1 integrin polyclonal antibodies, interleukin-

134 We demonstrate that the alpha2beta1 integrin provides a costimulatory function r

135 We propose, therefore that alpha2beta1 integrin receptor levels in dermal fibroblas

136 The alpha2beta1 integrin receptor plays a key role in angiog

137 pecific interaction of endorepellin with the alpha2beta1 integrin receptor.

138 ycan perlecan, inhibits angiogenesis via the alpha2beta1-integrin receptor.

139 milarities in wound healing, deletion of the alpha2beta1 integrin resulted in a dramatic increase in

140 hesion to collagen mediated primarily by the alpha2beta1 integrin resulted in a strong dephosphorylat

141 requires Mg2+ and is exclusively mediated by alpha2beta1 integrin, resulted in partial activation of

142 We now show that reexpression of the alpha2beta1 integrin results in up-regulation of both th

143 The alpha2beta1 integrin specific triple helical peptide lig

144 ate that signaling via the collagen receptor alpha2beta1 integrin specifically inhibits AICD by inhib

145 t and either C1q or type I collagen bound to alpha2beta1 integrin stimulates PMC activation.

146 Here we have demonstrated that the alpha2beta1 integrin suppresses metastasis in a clinical

147 lycystin-1 forms multiprotein complexes with alpha2beta1-integrin, talin, vinculin, paxillin, p130cas

148 s NF-kappaB-dependent expression of MMP1 and alpha2beta1 integrin, that are required for smooth muscl

149 ypic changes elicited by reexpression of the alpha2beta1 integrin, the alpha6 or beta4 integrin subun

150 We have recently shown that alpha2beta1 integrin, the receptor of type I collagen, i

151 f two collagen receptors-the alpha1beta1 and alpha2beta1 integrins-through induction of mRNAs encodin

152 The interaction between endorepellin and alpha2beta1 integrin triggers a unique signaling pathway

153 In the current study, an alpha2beta1 integrin triple helical peptide ligand deriv

154 recognized the non-activated conformation of alpha2beta1 integrin under shear stress conditions effec

155 ain, the portion responsible for binding the alpha2beta1 integrin, was ineffective.

156 s, recognition sites for the alpha1beta1 and alpha2beta1 integrins were identified in the short arms

157 ation of p125(FAK) of C2C12 cells expressing alpha2beta1 integrin, whereas parental cells do not.

158 Transcription factor AP-1 and alpha2beta1 integrin, which are key regulators of MMP-1

159 new, potent viper venom-derived inhibitor of alpha2beta1 integrin, which does not belong to the disin

160 or effect on the function of alpha1beta1 and alpha2beta1 integrins, which have been reported to play

161 Moreover, blockade of alpha2beta1 integrin with a neutralizing mAb inhibited I

162 The combination of anti-alpha2beta1 integrin with anti-GP VI antibody completely

163 In contrast, clustering of alpha2beta1 integrin with antibodies or the human pathog

164 We propose that interaction of the alpha2beta1 integrin with dermal collagen mediates induc

165 lines and primary blasts, that engagement of alpha2beta1 integrin with its ligand collagen I (ColI),

166 Engagement of the alpha2beta1 integrin with monoclonal antibodies or with

167 Cross-linking of the alpha2beta1 integrin with stimulatory monoclonal antibod