ライフサイエンスコーパス: alpha3 integrin

1 ce was associated with altered expression of alpha3-integrin.

2 f K562 cells transfected with various mutant alpha3 integrins.

3 Molecular interactions between alpha3 integrin and 1 were characterized by using a seri

4 ociations between CD9 and CD151, and between alpha3 integrin and other proteins.

5 nes involved in metastasis showed that CD44, alpha3 integrin, and caveolin were down-regulated in the

6 ormal levels of nephrin, synaptopodin, ZO-1, alpha3 integrin, and GBM laminins.

7 on of focal adhesion proteins FAK, paxillin, alpha3-integrin, and a higher-molecular-weight form of b

8 ificantly inhibited by a function-perturbing alpha3 integrin antibody.

9 n molecules, including fibronectin, integrin alpha3, integrin beta1, integrin beta3, and cadherin 6.

10 ass spectroscopy and immunoblotting [laminin alpha3, integrin beta2, beta-actin, alpha-actinin, super

11 pithelial cells reconstituted with wild type alpha3 integrin, but not a mutant alpha3 unable to bind

12 cal integrin residues, a region of the human alpha3 integrin chain predicted to be involved in substr

13 hibited increased cell surface levels of the alpha3-integrin chain.

14 However, in cultures from alpha3 integrin-deficient mice, alpha6 beta1 mediates re

15 l kinase-Hippo suppressor pathway identified alpha3 integrin-deficient prostate cancers as potential

16 typic reversion was accompanied by decreased alpha3 integrin expression and reduced proliferation.

17 ell surface, which results in an increase in alpha3 integrin expression via activation of initiation

18 ied by altered actin organization, increased alpha3 integrin expression, and spreading cell morpholog

19 e with lung epithelial cell-specific loss of alpha3 integrin expression.

20 Mice with genetically reduced expression of alpha3 integrin fail to maintain long-term potentiation

21 Furthermore, the targeted mutation of the alpha3 integrin gene results in abnormal layering of the

22 A mutation was targeted to the murine alpha3 integrin gene.

23 ithin the primary tumor mediated by CD44 and alpha3 integrins hinders metastasis and that shedding is

24 Expression of either alpha6 or alpha3 integrin in alpha6 integrin knockdown cells resto

25 CKS, while at the membrane, colocalizes with alpha3-integrin in a peripheral adhesive zone of the gro

26 Expression of human alpha3 integrin increased the infectivity of virus for C

27 ly, phosphorylation at those sites regulates alpha3 integrin levels, which is critical for the timely

28 Examination of the actin cytoskeleton of alpha3 integrin mutant cortical cells reveals aberrant a

29 neurons as well as the deep layer neurons of alpha3 integrin mutant mice expressing EGFP were misplac

30 The preplate develops normally in alpha3 integrin mutant mice.

31 We show that alpha3 integrin mutation disrupts distinct aspects of ne

32 Using alpha3 integrin null eggs, we found that the alpha3beta1

33 whereas COX-2 inhibition was not observed in alpha3 integrin-null endothelial cells, indicating that

34 Consistent with these findings, the ECM of alpha3 integrin-null keratinocytes, which also migrated

35 an efficient in vivo targeting agent against alpha3 integrin of MDA-MB-231 breast tumor xenograft imp

36 tometry, the binding affinity (K(d)) of 1 to alpha3 integrin on MDA-MB-231 breast cancer cells was de

37 ith their primary counterparts, and blocking alpha3 integrin or CD44 function inhibited attachment an

38 rt that epithelial cell-specific deletion of alpha3 integrin prevents EMT in mice, thereby protecting

39 d in cells attached to laminin-5 through the alpha3 integrin receptor.

40 Because we detected reelin, alpha3-integrin receptor subunits, and disabled-1 immuno

41 ed by extensive colocalization of MARCKS and alpha3-integrin, resistance to eicosanoid-triggered deta

42 Because the global genetic ablation of alpha3-integrin results in an early lethal phenotype, we

43 e relationship between the expression of the alpha3 integrin subunit and c-myc is mimicked by other c

44 arkedly down-regulated the expression of the alpha3 integrin subunit at both the transcript and prote

45 Evidence is now presented that alpha2 and alpha3 integrin subunit levels are also reduced in cells

46 Thus, the down-regulation of the alpha3 integrin subunit may contribute to the enhanced t

47 Cross-linking of an anti-alpha3 integrin subunit monoclonal antibody also induced

48 cNAc-beta(1-->4) linkage on N-glycans of the alpha3 integrin subunit.

49 lpha1 and alpha5 integrin (P < 0.01) but not alpha3 integrin subunit.

50 interact with the cytoplasmic domain of the alpha3 integrin, to stabilize focal adhesions and activa

51 Studies with human alpha3 integrin-transfected Chinese hamster ovary cells

52 de 1 (LXY1) with high binding specificity to alpha3 integrin was identified.

53 cated in EMT; we found that in primary AECs, alpha3 integrin was required for beta-catenin phosphoryl

54 cells expressing alpha6beta4 but lacking the alpha3 integrin were insensitive to Ln-332 and HSC-CM pr

55 However, alpha3-integrins were relocalized into a granular patter