ライフサイエンスコーパス: alpha5 integrin

1 gingivalis invasion of cells is mediated by alpha5 integrin.

2 lls were more resistant to the inhibition of alpha5 integrin.

3 by supporting Akt-dependent upregulation of alpha5 integrin.

4 ally altered in the genes for fibronectin or alpha5 integrin.

5 ization identifies this second protein to be alpha5-integrin.

6 ntegrins, particularly those associated with alpha5 integrins.Activation of beta1 by antibody 8A2 als

7 Myoblasts ectopically expressing alpha5 integrin (alpha5 myoblasts) move normally when no

8 f constitutively active or dominant negative alpha5 integrin also resulted in alterations in the numb

9 tern blots revealed significant induction of alpha5 integrin and Fn expression by HEp-2 cells in resp

10 1 receptor I and antibodies directed against alpha5 integrin and Fn, indicating that increased invasi

11 pends on TGF-beta1 up-regulation of both the alpha5 integrin and Fn.

12 ; an increase in the pool of ubiquitinylated alpha5 integrin and its lysosome-dependent degradation;

13 Depletion of Mad1 impairs secretion of alpha5 integrin and results in defects in cellular attac

14 d with gene and surface expression levels of alpha5 integrin and urokinase plasminogen activator rece

15 , we show that EWS/FLI-induced repression of alpha5 integrin and zyxin expression promotes tumor prog

16 ggesting a functional link between sEGFR and alpha5-integrin and a role of the calf-1 domain in cell

17 /ARNO signaling is required for recycling of alpha5-integrin and R-Ras to the plasma membrane.

18 We have analyzed embryos lacking alpha4- or alpha5-integrins and show here that these integrins cont

19 ntibodies to human beta4, beta1, alpha6, and alpha5 integrins; and sera from patients with pemphigus

20 We find that alpha4 and alpha5 integrins are present in late-stage NB tumors and

21 pression and reduced Twist1-induced integrin alpha5, integrin beta1 and MMP9 expression.

22 ), similar to removal of the endothelium and alpha5 integrin blockade, inhibited the vasoconstriction

23 Our findings also show that alpha5 integrin, but not uPAR, was positively correlated

24 egulation and mislocalization of alpha3- and alpha5-integrins by immunohistochemistry but, surprising

25 adhesion to FN was blocked with mAbs against alpha5 integrin chain and with RGD-containing peptides.

26 Surprisingly, a chimeric alpha5 integrin containing the beta-propeller domain fro

27 a novel form of muscle dystrophy in mice is alpha5-integrin-dependent.

28 Knockdown of alpha5 integrin did not affect Akt activation, but inhib

29 s conditional knockout of another RCP cargo, alpha5 integrin, does not suppress pancreatic cancer met

30 ce with reduced expression of the alpha3 and alpha5 integrins exhibit a defect in paired-pulse facili

31 Knockdown of alpha5 integrin expression using small interfering RNA d

32 ammary epithelial cells (MECs) by increasing alpha5 integrin expression.

33 ts revealed an association of high levels of alpha5-integrin expression with decreased survival.

34 Concordantly, the alpha5 integrin fibronectin receptor, but not alpha2 or

35 pression was associated with upregulation of alpha5 integrin (fibronectin receptor component), the an

36 ese subpopulations of cells are dependent on alpha5 integrin function for their survival.

37 to GRGDNP (2.1 mM) was inhibited by blocking alpha5 integrin function, and was intensified by blockin

38 gressive phenotype in brain tumors, and high alpha5 integrin gene expression was associated with decr

39 The mutated human alpha5 integrin gene was transfected into CHO B2 cells,

40 ons of null mutations in alpha3, alpha4, and alpha5 integrin genes.

41 Both alpha(v) and alpha5 integrins have widespread expression in adult bra

42 ntial targets of the inhibitor, did not have alpha5 integrin immunoreactivity in inflamed airways.

43 In inflamed airways, alpha5 integrin immunoreactivity was present on lymphati

44 ing proliferation, ectopic expression of the alpha5 integrin in cultures of primary quail myoblasts p

45 ntegrin alpha5-floxed mouse line and ablated alpha5 integrin in endothelial cells.

46 The absence of alpha5-integrin in the various tissues of the alpha5-nul

47 ibition resulting from ectopic expression of alpha5 integrin is due to induction of autocrine negativ

48 coding just two of these proteins, zyxin and alpha5 integrin, is sufficient to restore cell adhesion

49 To study the functions of alpha5 integrin later in mouse embryogenesis and during

50 ta1 integrin because blockade of fibronectin-alpha5 integrin ligation attenuated this response.

51 The fact that some, although few, alpha5-integrin-negative vessels existed in alpha5-null

52 P-2 expressed on cancer cells interacts with alpha5 integrin on endothelial cells to mediate vascular

53 rs, expressed on cancer cells interacts with alpha5 integrin on endothelial cells to mediate vascular

54 ctivator nutlin-3a, the protective effect of alpha5 integrin on p53 activation and cell survival was

55 -7 breast cancer cells do not express either alpha5 integrin or type II TGF-beta receptor and hence a

56 nd surface protein expression for alpha1 and alpha5 integrin (P < 0.01) but not alpha3 integrin subun

57 Here we show that alpha5 integrin regulates spine morphogenesis and synaps

58 26-amino acid peptide in the calf domain of alpha5-integrin (residues 710-735) is 35% identical in s

59 rase cDNA into cells stably transfected with alpha5 integrin resulted in basal promoter activities 5-

60 y terminus of sEGFR and the calf-1 domain of alpha5-integrin share a region of sequence identity, whi

61 vessels, but not all, stained positively for alpha5-integrin, showing that they were host derived.

62 alpha5 integrin signaling regulates spine morphogenesis

63 ed with increased proteasomal degradation of alpha5 integrin subunit (ITGA5) and reduced activation o

64 s study, we show that high expression of the alpha5 integrin subunit compromises temozolomide-induced

65 Ectopic expression of the alpha5 integrin subunit in cancer cells with little or n

66 We found that depletion of the alpha5 integrin subunit increased p53 activity and temoz

67 grin in which the cytoplasmic portion of the alpha5 integrin subunit is replaced by the cytoplasmic p

68 tin in parallel to downregulating alphav and alpha5 integrin subunit levels.

69 ubunit but also an intense expression of the alpha5 integrin subunit particularly in the endothelial

70 p53 background, nutlin-3a downregulated the alpha5 integrin subunit, thereby increasing the cytotoxi

71 expression of pVHL induced expression of the alpha5 integrin subunit.

72 A monoclonal blocking antibody to the alpha5-integrin subunit (FN receptor) significantly inhi

73 IGF-I treatment caused a 73% reduction in alpha5-integrin subunit protein and a 25% increase in al

74 nectin and enhanced expression of alphav and alpha5 integrin subunits together with increased cell mi

75 alpha(v) or beta1, but not beta3, beta5, or alpha5, integrin subunits block Ad infection and viral e

76 t alpha1, alpha2, alpha6, and beta1, but not alpha5, integrin subunits reduced invasion of a reconsti

77 dentified indirect recruitment of GFP-tagged alpha5 integrin to an 11-mer peptide.

78 ized to linear, punctate structures, and the alpha5 integrin to some focal complexes and/or vesicle-l

79 osphorylation regulated vesicular traffic of alpha5-integrin to the cell surface and cell attachment

80 ting C/EBPbeta expression to directly induce alpha5 integrin transcription.

81 nd in vivo by preventing C/EBPbeta-dependent alpha5 integrin transcription.

82 f 29 gene transcripts, including the loss of alpha5-integrin transcripts.

83 inhibition of Akt phosphorylation prevented alpha5 integrin upregulation elicited by survivin overex

84 as inhibited; in parallel, the expression of alpha5 integrin was enhanced, and that of alpha6 integri

85 dhesion to fibronectin, and up-regulation of alpha5 integrin were also dependent on ADAM10 but not AD

86 ) cells-wild-type, heterozygous, or null for alpha5-integrin-were injected ectopically into syngeneic