ライフサイエンスコーパス: alpha6 integrin

1 was associated with increased expression of alpha6 integrin.

2 ta-catenin, also inhibited the expression of alpha6 integrin.

3 immunoprecipitated together with laminin and alpha6 integrin.

4 ns are co-expressed at the cell surface with alpha6 integrin.

5 beta1 integrins, but not alpha4, alpha5, or alpha6 integrins.

6 ing a functional cross-talk between CD82 and alpha6 integrins.

7 esulted from less cell surface expression of alpha6 integrins.

8 -deficient skin adhered to laminin-5 through alpha6 integrins.

9 ranslated regions of proinvasive alphav- and alpha6-integrins.

10 selectively and specifically bound to human alpha6 integrin, a 120-kDa protein present in gingiva an

11 protein laminin through cooperation with the alpha6 integrin, a specific laminin receptor.

12 Cultured keratinocytes expressing alpha6 integrin, a transmembrane protein known to bind L

13 In addition, without alpha6 integrin, activation and expression of NFkappaB w

14 and expression of the cell surface molecules alpha6-integrin, alphav-integrin, and the c-kit receptor

15 ment membrane proteins and reduced levels of alpha6 integrin and FGF2.

16 They find that expression of alpha6 integrin and its splice variants differs between

17 show that IGF-1R activation is dependent on alpha6 integrin and that this transactivation requires S

18 6beta4, help contain retraction and both the alpha6 integrins and alpha3beta1 integrin contribute to

19 es suggest that HPV infection is mediated by alpha6-integrin and/or heparan-sulfonated receptors.

20 unction-perturbing anti-beta1 integrin, anti-alpha6 integrin, and anti-laminin antibodies respectivel

21 autoantibody, antibodies to human beta4 and alpha6 integrins, and sera from patients with BP showed

22 scattering properties, positive staining for alpha6-integrin, and negative or low alphav-integrin exp

23 y anti-beta1 integrin antibodies and by anti-alpha6 integrin antibodies.

24 so inhibited by anti-beta1 integrin and anti-alpha6 integrin antibodies.

25 on morphogenesis in vivo was seen with anti-alpha6 integrin antibody, suggesting that alpha6 is not

26 mouse testis cells with anti-beta1- or anti-alpha6-integrin antibody, but not anti-c-kit antibody, p

27 sal type II hemidesmosomes disappear and the alpha6 integrins appear evenly distributed over lamellae

28 e yeast two-hybrid assay, we have identified alpha6 integrin as a BP180-binding partner.

29 We identify alpha6-integrin as a mechanosensing integrin subunit tha

30 which proliferating keratinocytes expressing alpha6 integrin at the site of epithelial wounding might

31 tion of function-blocking antibodies against alpha6 integrin, beta1 integrin or the laminin-1/E8 doma

32 ificantly reduced the expression of integrin alpha6, integrin beta4, Fak, paxillin, Rac1/2/3, and ROC

33 (p<0.05), identifying this population as an alpha6 integrin bright subset.

34 phenotype of the MHC-I-Thy-1+c-kit- SSCs was alpha6-integrin+CD24+alphavintegrin-Sca-1-CD34-.

35 ogenitors: podocalyxin-like protein (PODXL), alpha6-integrin (CD49f), alpha4-integrin (CD49d), c-Met,

36 of the CD82-integrin alpha6 complex reduces alpha6 integrin cell surface expression.

37 causes an aberrant VE-cadherin, laminin and alpha6 integrin distribution in vessels, along with sign

38 xpression and changing pattern of alpha3 and alpha6 integrins during development of the mammalian inn

39 during gamete fusion; yet, eggs null for the alpha6 integrin exhibit normal fertilization.

40 model for examining the relationship between alpha6 integrin expression and cell differentiation, sin

41 First, reduction of alpha6 integrin expression does not halt mitotic divisio

42 n epidermis from several body sites, whereas alpha6 integrin expression is more uniform.

43 urface phenotype (low beta1 integrin and low alpha6 integrin expression) than label-retaining keratin

44 extravillous differentiation, with decreased alpha6 integrin expression, increased alpha1, and elevat

45 disrupted or unaffected by a perturbation of alpha6 integrin expression.

46 ugh its direct interactions with alphav- and alpha6-integrin expression.

47 Blocking of alpha6-integrin function by inhibitory antibody prevents

48 the first time, a homozygous mutation in the alpha6 integrin gene (ITGA6) in a family with three affe

49 tively selected using antibodies to CD34 and alpha6 integrin in combination with fluorescent activate

50 Knockdown of alpha6 integrin in keratinocytes not only results in mot

51 cess; 2) the decreased surface expression of alpha6 integrins in CD82-expressing cells is likely resp

52 s lung myofibroblasts express high levels of alpha6-integrin in vitro and in vivo.

53 Moreover, re-expression of alpha6 integrin increases beta4 integrin protein at the

54 e support for the possibility that BP180 and alpha6 integrin interaction is not only mediated by the

55 We conclude that alpha6 integrin is an essential upstream regulator of th

56 ay different roles during brain development: alpha6 integrin is essential for migration of tectal cel

57 We demonstrate that alpha6 integrin is likely to mediate the inductive effec

58 4 integrins are sensitive to Amino-Nogo, but alpha6 integrin is not.

59 These findings suggest that alpha6-integrin is a matrix stiffness-regulated mechanos

60 In studies with both alpha6 integrin knock-out mice lenses and primary lens c

61 ssion of either alpha6 or alpha3 integrin in alpha6 integrin knockdown cells restores alpha2 integrin

62 alpha2 integrin mRNA levels are decreased in alpha6 integrin knockdown cells, alpha3 and beta4 integr

63 ed on inhibition of fertilization by an anti-alpha6 integrin mAb (GoH3), suggest that the alpha6beta1

64 ation, indicating that redistribution of the alpha6 integrins may contribute to the protrusion of the

65 subsequently, results in the attenuation of alpha6 integrin-mediated cellular morphogenesis; and 3)

66 ken together, these data indicate that while alpha6 integrin-mediated interactions with laminin are r

67 on between specific domains of the BP180 and alpha6 integrin molecules is inhibited by a 14 mer pepti

68 n, CD34+ keratinocytes were found to express alpha6 integrin more intensely than CD34- cells (p<0.05)

69 Notably, the level of alpha6 integrins on the cell surface was down-regulated

70 The alpha6 integrins, particularly alpha6beta4, help contain

71 ession of several transcripts is expanded in alpha6 integrin-perturbed embryos (orthodenticle and eng

72 e late in neurulation, is abolished in these alpha6 integrin-perturbed embryos.

73 rmation, brachyury, is expressed normally in alpha6 integrin-perturbed embryos.

74 Finally, we show that in vivo, NLGN1 and alpha6 integrin preferentially colocalize in the mature

75 s recruited to and activated specifically in alpha6 integrin receptor signaling complexes in the lens

76 tment of cells with laminin, a substrate for alpha6 integrin receptors, provided minimal inhibition.

77 regulating stromelysin-1 expression, whereas alpha6 integrins regulate cell motility.

78 stinguished by their unique co-expression of alpha6 integrin, Sca1 and CD200 surface proteins.

79 Here we investigated whether alpha6 integrin signals upstream to this IGF-1R-mediated

80 ses and primary lens cell cultures following alpha6 integrin siRNA knockdown, we show that IGF-1R act

81 The alpha6 integrin subunit can be expressed as both alpha6b

82 I studied the expression pattern of the alpha6 integrin subunit during the early development of

83 s receptors for fertilin beta, since an anti-alpha6 integrin subunit monoclonal antibody, GoH3, has b

84 Inhibiting alpha3 but not alpha6 integrin subunit using blocking antibodies or sma

85 grin subunit, oral pemphigoid sera recognize alpha6 integrin subunit, and anti-epiligrin cicatricial

86 gs from cultured ovaries of mice lacking the alpha6 integrin subunit, we found that the fertilization

87 disintegrin loop of fertilin beta and by the alpha6 integrin subunit.

88 combination of antibodies against alpha3 and alpha6 integrin subunits inhibit endothelial cell attach

89 ching was observed only when both alpha3 and alpha6 integrin subunits were inhibited.

90 e normally basal immunostaining of beta1 and alpha6 integrin subunits, pY, and paxillin was lost or m

91 lpha3beta1 integrin but not to the alpha2 or alpha6 integrin subunits.

92 n subunit, and sera of OP patients recognize alpha6 integrin throughout the clinical course.

93 First, cAMP accelerates redistribution of alpha6-integrin to the periphery of the acinus and thus

94 At embryonic day (E)10.5 alpha6 integrin was expressed in the otic epithelium but

95 of alpha5 integrin was enhanced, and that of alpha6 integrin was inhibited.

96 In this region of the lens alpha6 integrin was uniquely localized along the cell-ce

97 trates, whereas mutant keratinocytes lacking alpha6 integrin were relatively resistant to infection v

98 Altered expression of alpha6 integrin, which forms a heterodimer with the beta

99 Along with binding to HSPGs, HPV16 binds to alpha6 integrins, which initiate further intracellular s

100 The association of alpha6 integrin with the Triton-insoluble cytoskeleton i