ライフサイエンスコーパス: alpha6beta4 integrin

1 and fail to show extensive association with (alpha6beta4 integrin.

2 egrin and the AG86 peptide that binds to the alpha6beta4 integrin.

3 ld-type keratinocytes Rac1 is complexed with alpha6beta4 integrin.

4 d-type, but not a cytoplasmic tail-truncated alpha6beta4 integrin.

5 tein laminin 5 (LM-5) and frequently express alpha6beta4 integrin.

6 tumorigenesis is dependent on laminin 5 and alpha6beta4 integrin.

7 n the activation of this lipid kinase by the alpha6beta4 integrin.

8 termediates in the activation of PI3K by the alpha6beta4 integrin.

9 on the organization of endogenous BP230 and alpha6beta4 integrin.

10 processes that depend on the ligation of the alpha6beta4 integrin.

11 dhere to laminin 5 (LM5) via alpha3beta1 and alpha6beta4 integrins.

12 alpha6beta4 integrin, a component of hemidesmosomes, als

13 have examined intracellular signaling by the alpha6beta4 integrin, a laminin receptor expressed in ba

14 Recently, expression of alpha6beta4 integrin, a transmembrane protein of the epi

15 The alpha6beta4 integrin-a laminin-5 receptor-mediates assem

16 s are stretched or hypo-osmotically shocked, alpha6beta4 integrin accumulates at cell edges, whereas

17 332 matrix organization is determined by the alpha6beta4 integrin/actin cytoskeleton via Rac1/cofilin

18 estigated the signaling pathway by which the alpha6beta4 integrin activates PI3K.

19 mily members are likely to have key roles in alpha6beta4 integrin activation by receptor tyrosine kin

20 its C2 region, Sdc1 forms a complex with the alpha6beta4 integrin along with the receptor tyrosine ki

21 at PCSCs are regulated by a pathway in which alpha6beta4 integrin amplifies signaling through ErbB2 a

22 Together with its alpha6 partner, alpha6beta4 integrin anchors epithelial cells to the bas

23 a4 and F-actin is supported by the fact that alpha6beta4 integrin and actin were released from clone

24 d lamellae, a striking colocalization of the alpha6beta4 integrin and F-actin was seen.

25 in motile cells Col XVII recruits BPAG1e to alpha6beta4 integrin and is necessary for activation of

26 uring wound healing and tumorigenesis on the alpha6beta4 integrin and its association with receptor t

27 cellular matrix (ECM), signaling through the alpha6beta4 integrin and Sgk1 (serum and glucocorticoid-

28 ior work has shown that HER2 associates with alpha6beta4 integrin and syndecan-1 (Sdc1), in which Sdc

29 is promoted by expression of alpha3beta1 and alpha6beta4 integrins and by palmitoylation of the CD9 a

30 interacts directly with both alpha3beta1 and alpha6beta4 integrins and with other tetraspanins, there

31 contrast, EGFR associates with Sdc4 and the alpha6beta4 integrin, and EGFR-dependent motility depend

32 g antibody perturbed signals mediated by the alpha6beta4 integrin, and the beta1-blocking antibody pe

33 51 also supports protein kinase C (PKC)alpha-alpha6beta4 integrin association and PKC-dependent beta4

34 Upon ligand binding, the alpha6beta4 integrin becomes phosphorylated on tyrosine

35 cells, we reveal distinct functions for the alpha6beta4 integrin, beta1 integrins, and an E3 laminin

36 nce of screening EB-PA patients not only for alpha6beta4 integrin but also for plectin deficiency.

37 We find that alpha6beta4 integrin chains localize to the plasma membr

38 n basement membrane ligands, prevents normal alpha6beta4 integrin clustering into hemidesmosomes.

39 A novel role for PI3K in alpha6beta4 integrin clustering is proposed.

40 ciated with an epithelial phenotype, such as alpha6beta4 integrin, collagen XVII, E-cadherin, and des

41 (BPAG2), the alpha6 and beta4 chains of the alpha6beta4 integrin complex, and the beta3 chain of lam

42 XVII mediates the association of BPAG1e and alpha6beta4 integrin containing the truncated beta4 subu

43 These results suggest that expression of the alpha6beta4 integrin contributes to some but not all of

44 correlated with decreased expression of the alpha6beta4 integrin, decreased formation of hemidesmoso

45 ntegrin association was required for stable, alpha6beta4 integrin-dependent cell attachment on lamini

46 Ln-332 is the ligand of alpha3beta1 and alpha6beta4 integrins, differently expressed on the HCC

47 alpha6beta4 integrin does not mediate tumor survival thr

48 ethylase inhibitors suppressed expression in alpha6beta4 integrin-expressing cells.

49 alpha5beta1 and alpha6beta4 integrin expression levels were quantified o

50 press keratin 15 and lie in a region of high alpha6beta4 integrin expression.

51 ion of a signaling pathway that releases the alpha6beta4 integrin from these stable adhesion complexe

52 Together, these results indicate that the alpha6beta4 integrin functions in carcinoma migration on

53 The alpha6beta4 integrin has been widely implicated in carci

54 Functional studies on the alpha6beta4 integrin have focused primarily on its role

55 4 genes, encoding the hemidesmosomal protein alpha6beta4-integrin, have been involved in the pathogen

56 BP180 is a novel transmembrane ligand of the alpha6beta4 integrin heterodimer.

57 H-Ras, transcriptionally active E2F, and the alpha6beta4 integrin in a common pathway that culminates

58 this study, we examined the function of the alpha6beta4 integrin in clone A cells, a colon carcinoma

59 urrent study, we show that expression of the alpha6beta4 integrin in MDA-MB-435 breast carcinoma cell

60 ons emphasize the critical importance of the alpha6beta4 integrin in providing stability to the assoc

61 Taken together, these data implicate the alpha6beta4 integrin in tumor formation by regulating tu

62 control cell line, revealing a role for the alpha6beta4 integrin in tumor formation.

63 utes to the tumor-promoting functions of the alpha6beta4 integrin in vivo.

64 Expression of the alpha6beta4 integrin increases the invasive potential of

65 In contrast, we demonstrate here that the alpha6beta4 integrin induces apoptosis in carcinoma cell

66 A function-blocking mAb specific for the alpha6beta4 integrin inhibited clone A migration on lami

67 kdown keratinocytes exhibit a loss in BPAG1e-alpha6beta4 integrin interaction, a reduction in lamelli

68 The alpha6beta4 integrin is a laminin 332 (LN332) receptor c

69 Our data indicate that the alpha6beta4 integrin is a master regulator of transcript

70 In advanced breast carcinomas, the alpha6beta4 integrin is associated with a migratory and

71 Expression of the alpha6beta4 integrin is associated with poor patient pro

72 The alpha6beta4 integrin is known to associate with receptor

73 unofluorescence microscopy revealed that the alpha6beta4 integrin is localized as discrete clusters i

74 alpha6beta4 integrin is localized on the basal surface i

75 431 chemotaxis ( approximately 1 ng/ml), the alpha6beta4 integrin is mobilized from hemidesmosomes as

76 nes encoding the subunit polypeptides of the alpha6beta4 integrin (ITGA6 and ITGB4, respectively) hav

77 port that adhesion-independent clustering of alpha6beta4 integrin, known to be important in mediating

78 ivo environment, decreased expression of the alpha6beta4 integrin led to enhanced apoptosis as determ

79 Specifically, alpha6beta4 integrin localizes to large lamellipodial ex

80 We demonstrate that alpha6beta4 integrin mediates pancreatic epithelial cell

81 nction-blocking antibodies, we show that the alpha6beta4 integrin participates in EGF-stimulated chem

82 heir malignant potential as evidenced by the alpha6beta4 integrin/phosphatidylinositol 3-kinase/Akt/m

83 Within each hemidesmosome, alpha6beta4 integrin plays a crucial role in hemidesmoso

84 progression and they have revealed that the alpha6beta4 integrin plays a multifaceted role in regula

85 HD components include the alpha6beta4 integrin, plectin, and BPAGs (bullous pemphi

86 In summary, we find that the alpha6beta4 integrin potentiates autotaxin expression th

87 In mouse primary hepatocytes, inhibition of alpha6beta4 integrin prevented activation of JNK and sup

88 The alpha6beta4 integrin promotes carcinoma in-vasion by its

89 hese studies define a mechanism by which the alpha6beta4 integrin promotes carcinoma invasion and inv

90 We demonstrate that the alpha6beta4 integrin promotes carcinoma invasion through

91 Specifically, we show that the alpha6beta4 integrin promotes the survival of p53-defici

92 The alpha6beta4 integrin protects adherent epithelial and ca

93 -3 protein binding, and intriguingly, 14-3-3/alpha6beta4 integrin protein interaction is required for

94 ous basement membrane through autocrine LM-5-alpha6beta4 integrin-RAC-NFkappaB signaling.

95 chronophin (CIN)) downstream of signaling by alpha6beta4 integrin/Rac1 in human keratinocytes.

96 nin-5, acting through its alpha3beta1 and/or alpha6beta4 integrin receptors, in UB branching during n

97 odeling and outline its role with respect to alpha6beta4 integrin recycling.

98 The alpha6beta4 integrin (referred to as "beta4" integrin) i

99 Whether alpha6beta4 integrin regulates migration remains controv

100 ovide novel mechanistic insight into how the alpha6beta4 integrin selectively activates the Src famil

101 Unexpectedly, mice deficient in alpha6beta4 integrin signaling or Sgk1 exhibit hypermyel

102 332 tracks, a process that is dependent upon alpha6beta4 integrin signaling to Rac1 and the actin-sev

103 Thus, we propose a novel mechanism in which alpha6beta4 integrin signaling via Rac1, 14-3-3 proteins

104 n-mediated adhesion via alpha3beta1, but not alpha6beta4 integrin, supports cell survival through EGF

105 e beta4 integrin subunit, a component of the alpha6beta4 integrin that is known to enhance carcinoma

106 on in lipid rafts is necessary to couple the alpha6beta4 integrin to a palmitoylated SFK and promote

107 y, Y1494 is essential for the ability of the alpha6beta4 integrin to promote carcinoma invasion.

108 major regulatory site for signaling from the alpha6beta4 integrin to promote tumor development and pr

109 utation of Y1494 inhibits the ability of the alpha6beta4 integrin to support anchorage-independent gr

110 These findings suggest that the coupling of alpha6beta4 integrin to the control of cell cycle progre

111 The syndecans remain anchored to the alpha6beta4 integrin via its cytoplasmic domain, but the

112 To identify genes regulated by the alpha6beta4 integrin, we compared gene expression profil

113 pression of these genes in cells lacking the alpha6beta4 integrin, whereas demethylase inhibitors sup

114 The alpha6beta4 integrin, which is also associated with a po

115 Engagement of LN332 or clustering of the alpha6beta4 integrin with integrin-specific antibodies c

116 The interaction of the alpha6beta4 integrin with the syndecans appears critical