ライフサイエンスコーパス: alphaherpesvirus

1 aricella-zoster virus (VZV) is a neurotropic alphaherpesvirus.

2 been seen with any other previously examined alphaherpesvirus.

3 n Marek's disease virus (MDV), a tumorigenic alphaherpesvirus.

4 is the first reported Bcl-2 homologue in an alphaherpesvirus.

5 the gD gene, MDV is an intermediate type of alphaherpesvirus.

6 a-zoster virus (VZV) are conserved among all alphaherpesvirus.

7 ssociated, and exclusively human neurotropic alphaherpesvirus.

8 the host immune responses to closely related alphaherpesviruses.

9 protein, referred to as VP26 (UL35) in other alphaherpesviruses.

10 ent proteins and is highly conserved in most alphaherpesviruses.

11 nteraction that is, so far, unique among the alphaherpesviruses.

12 tegument proteins and is conserved among the alphaherpesviruses.

13 ional analysis of this unique class of avian alphaherpesviruses.

14 volutionarily in HSV-1 and other neurotropic alphaherpesviruses.

15 n 1) have been shown to mediate the entry of alphaherpesviruses.

16 on the anti-chemokine strategies encoded by alphaherpesviruses.

17 ting that the interaction is conserved among alphaherpesviruses.

18 verall genome organization characteristic of alphaherpesviruses.

19 rences from their structural counterparts in alphaherpesviruses.

20 otein B revealed that LETV clusters with the alphaherpesviruses.

21 stics and also features in common with other alphaherpesviruses.

22 oded by the UL49 gene is conserved among the alphaherpesviruses.

23 gs revealed that Y480 was conserved only for alphaherpesviruses.

24 UL49 homologs are conserved among alphaherpesviruses.

25 The Us9 gene is conserved among most alphaherpesviruses.

26 and may not apply to VP22 homologs of other alphaherpesviruses.

27 lycoprotein K (gK), which is conserved among alphaherpesviruses.

28 residues that are highly conserved among the alphaherpesviruses.

29 ino terminus of gK, which is conserved among alphaherpesviruses.

30 serve similar conserved functions for other alphaherpesviruses.

31 embrane protein UL20 are conserved among all alphaherpesviruses.

32 e for the largest herpesvirus subfamily, the alphaherpesviruses.

33 T cell reactivity to the noncausative human alphaherpesvirus (alphaHHV) is commonly detected in the

34 Other alphaherpesviruses also express ICP0-related RING finger

35 elated RING finger proteins encoded by other alphaherpesviruses also induce colocalizing, conjugated

36 ent structural similarities between KSHV and alphaherpesvirus, an ORF19 monomer in KSHV, in contrast

37 ice with another picornavirus, as well as an alphaherpesvirus and a rhabdovirus.

38 ly 4 (IE4) protein, which is conserved among alphaherpesvirus and has transactivation activity in tra

39 la-zoster virus (VZV) is a human neurotropic alphaherpesvirus and the etiological agent of varicella

40 virus (PRV) Us3 gene is conserved among the alphaherpesviruses and encodes a serine/threonine protei

41 by ICP0-related proteins expressed by other alphaherpesviruses and even by a combination of the unre

42 21 is a conserved protein in the tegument of alphaherpesviruses and has multiple important albeit poo

43 Homologs of U(L)3.5 are present in some alphaherpesviruses and have 20 to 30% overall amino acid

44 similar to that which has been proposed for alphaherpesviruses and involve envelopment of tegumented

45 abies virus (PRV) is conserved among diverse alphaherpesviruses and therefore is predicted to be impo

46 are conserved with the ICP4 analogs of other alphaherpesviruses and were also predicted to be exposed

47 Infection with gammaherpesviruses, alphaherpesviruses, and betacoronaviruses can result in

48 ns, gE, gI, and Us9, have been implicated in alphaherpesvirus anterograde spread in several animal mo

49 of viral intracellular transport.IMPORTANCE Alphaherpesviruses are among the very few viruses that a

50 gI, respectively), Us9 and its homologue in alphaherpesviruses are necessary for the viral anterogra

51 Alphaherpesviruses are parasites of the peripheral nervo

52 ve produced contradictory conclusions on how alphaherpesviruses are transported from neuron cell bodi

53 S6) and variable (US4 and US5) among primate alphaherpesviruses, as well as from two noncoding interg

54 Herpes simplex virus (HSV) and other alphaherpesviruses assemble enveloped virions in the tra

55 hin members of one of the three subfamilies (alphaherpesviruses, betaherpesviruses, or gammaherpesvir

56 Like other alphaherpesviruses, BHV-1 establishes latency in sensory

57 omer in KSHV, in contrast to a UL25 dimer in alphaherpesviruses, binds each penton subunit, an observ

58 gument proteins is highly similar to that in alphaherpesvirus but completely different from that in b

59 vertex, a pattern highly similar to that in alphaherpesvirus but completely different from that in b

60 irus (EBV) differs not only from that of the alphaherpesviruses but also from that of the gamma-2 her

61 o that of HSV-1 and other neurotropic animal alphaherpesviruses but differs from that reported for VZ

62 between scaffolding proteins found in other alphaherpesviruses but not in members of the beta- or ga

63 The Us2 gene is conserved among alphaherpesviruses, but its function is not known.

64 syn loci.IMPORTANCE UL21 is conserved among alphaherpesviruses, but its role is poorly understood.

65 , was shown not to be conserved in the other alphaherpesviruses by bioinformatics analysis.

66 Using pseudorabies virus (PRV), an alphaherpesvirus capable of transneuronal spread in neur

67 How alphaherpesvirus capsids acquire tegument proteins remai

68 Upon entering a cell, alphaherpesvirus capsids are transported toward the minu

69 ll structural similarities of RRV capsids to alphaherpesvirus capsids suggest a common assembly and m

70 "naked" and membrane-associated cytoplasmic alphaherpesvirus capsids.

71 -mediated trafficking of naked and enveloped alphaherpesvirus capsids.

72 Varicella-zoster virus (VZV), a neurotropic alphaherpesvirus, causes childhood chickenpox (varicella

73 Marek's disease virus (MDV), a lymphotropic alphaherpesvirus, causes Marek's disease (MD) in chicken

74 Pseudorabies virus (PRV), a broad host range alphaherpesvirus, causes violent pruritus in many differ

75 nal half of UL37 from pseudorabies virus, an alphaherpesvirus closely related to herpes simplex virus

76 functionally characterize intraocular human alphaherpesvirus cross-reactive T cells.

77 Attenuated alphaherpesvirus derivatives have been used extensively

78 tant for identifying novel targets to reduce alphaherpesvirus disease.

79 As with other alphaherpesviruses, efficient EHV-1 entry was dependent

80 om the study of several LAT mutants of other alphaherpesviruses encoding miRNAs from their LAT region

81 A related alphaherpesvirus, encoding gE and gI homologs, is called

82 y analysis to determine if these two diverse alphaherpesviruses engage similar or different cellular

83 en though these cells do not express a known alphaherpesvirus entry receptor.

84 eins function with the previously identified alphaherpesvirus entry receptors nectin-1 and CD155 but

85 he murine cDNA in hamster cells resistant to alphaherpesvirus entry, the cells became susceptible to

86 The alphaherpesvirus envelope protein Us9 is a type II viral

87 -type mice, CCL3(-/-) mice infected with the alphaherpesvirus equine herpesvirus 1 (EHV-1) displayed

88 Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficientl

89 ntified as a cellular entry receptor for the alphaherpesvirus equine herpesvirus type 1 (EHV-1).

90 een identified in the genomes of three other alphaherpesviruses: equine herpesvirus 1 (EHV-1), varice

91 Many alphaherpesviruses establish a latent infection in the p

92 These data identify an alphaherpesvirus evasion strategy from NK cells and poin

93 Two models describing how alphaherpesviruses exit neurons differ with respect to w

94 Alphaherpesviruses express a heterodimeric glycoprotein,

95 us type 1 (EHV1), a well-known member of the alphaherpesvirus family, was used to infect equine respi

96 of ICP0 are encoded by other members of the alphaherpesvirus family.

97 s 1 (SaHV-1) genome, a primate member of the alphaherpesvirus family.

98 beta-sheet domain, which is conserved among alphaherpesviruses, functions in HSV-1 entry into neuron

99 Alphaherpesvirus gC proteins are type 1 membrane protein

100 cell fusion along with gL, gB, and, in most alphaherpesviruses, gD.

101 ing both murine nectin-1alpha and one of the alphaherpesvirus gDs were resistant to entry of HSV-1, i

102 In contrast to other alphaherpesviruses, gE is essential for VZV replication.

103 ng frames within the unique short segment of alphaherpesvirus genomes participate in egress and cell-

104 lacked an endocytosis motif, while all other alphaherpesvirus gH homologues contained a potential mot

105 One new finding was that unlike the other alphaherpesvirus gI homologs, a fraction of pulse-labele

106 In alphaherpesviruses, glycoprotein B (gB), gD, gH, and gL

107 Glycoprotein G (gG) of alphaherpesviruses has been described to function as a v

108 Marek's disease virus, an avian alphaherpesvirus, has been used as an excellent model to

109 t functions that may have some redundancy in alphaherpesviruses have been concentrated in fewer prote

110 These results indicate that these alphaherpesviruses have differing preferences for entry

111 ated receptor in the respiratory epithelium, alphaherpesviruses have generated a strategy to efficien

112 The alphaherpesviruses have long been considered vectors for

113 e important to the ability of the prototypic alphaherpesvirus herpes simplex virus 1 (HSV-1) to enter

114 MDV1 is colinear with the prototypic alphaherpesvirus herpes simplex virus type 1 (HSV-1) wit

115 productive replication of the representative alphaherpesvirus herpes simplex virus type 1, the repres

116 in family used as a cellular receptor by the alphaherpesviruses herpes simplex virus (HSV), pseudorab

117 ression of immediate-early (IE) genes of the alphaherpesviruses herpes simplex virus type 1 (HSV-1) a

118 pression of the immediate-early genes of the alphaherpesviruses herpes simplex virus type 1 and varic

119 Studies of UL37 homologs from two alphaherpesviruses, herpes simplex virus 1 (HSV-1) and p

120 ously demonstrated that gB homologs from two alphaherpesviruses, herpes simplex virus 1 (HSV-1) and s

121 anglia latently infected with two pathogenic alphaherpesviruses, herpes simplex virus 1 (HSV-1) and v

122 th the previously described B-capsids of the alphaherpesviruses, herpes simplex virus type 1 (HSV-1)

123 The distribution of the neurotropic alphaherpesviruses-herpes simplex virus type 1 (HSV-1) a

124 By swapping the entry glycoproteins of two alphaherpesviruses (HSV-1 and SaHV-1), we previously dem

125 these two regions were conserved among other alphaherpesvirus ICP0 homologs.

126 lar to those in HSV-1 are conserved in other alphaherpesviruses, (iii) CTCF binds to these motifs on

127 mportant for full virulence potential of the alphaherpesviruses in both natural and laboratory hosts.

128 estimated 99 putative proteins and resembles alphaherpesviruses in genomic organization and gene cont

129 n comparisons of the pathogenicity of simian alphaherpesviruses in mice, two isolates of the baboon v

130 The alphaherpesviruses include several important human patho

131 family was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HS

132 and those induced by other, closely related alphaherpesviruses, including HSV-1 and -2.

133 The various alphaherpesviruses, including Marek's disease virus (MDV

134 Alphaherpesviruses, including pseudorabies virus (PRV),

135 During infection of the nervous system, alphaherpesviruses-including pseudorabies virus (PRV)-us

136 well understood, although analyses of other alphaherpesviruses indicate a role for chromatin in viru

137 During the course of a productive infection, alphaherpesviruses induce certain events which occur dur

138 Transport of capsids in cells is critical to alphaherpesvirus infection and pathogenesis; however, vi

139 To date, the polarity of alphaherpesvirus infection in the respiratory epithelium

140 An essential process for alphaherpesvirus infection is spread from axons of perip

141 Alphaherpesvirus infection of the mammalian nervous syst

142 motility and morphology are disrupted during alphaherpesvirus infection, which aids viral replication

143 ional response of the mammalian CNS to acute alphaherpesvirus infection.

144 A clinical hallmark of human alphaherpesvirus infections is peripheral pain or itchin

145 ble for long-distance, directional spread of alphaherpesvirus infections via axons of infected neuron

146 in the host's innate defence against primary alphaherpesvirus infections.

147 f the craniofacial nervous system and latent alphaherpesvirus infections.

148 The structure--the first for any alphaherpesvirus inner tegument protein--reveals an elon

149 The neurotropic alphaherpesviruses invade and spread in the nervous syst

150 ycle of herpes simplex virus (HSV) and other alphaherpesviruses is the capacity to reactivate from la

151 A defining characteristic of alphaherpesviruses is the establishment of lifelong late

152 la-zoster virus (VZV), a double-stranded DNA alphaherpesvirus, is associated with seasonal outbreaks

153 seudorabies virus (PRV), a swine neurotropic alphaherpesvirus, is known to invade the central nervous

154 Marek's disease virus (MDV), an alphaherpesvirus, is the causative agent of a lethal dis

155 VZV IE62, which is well conserved within the alphaherpesviruses, is needed for trans-activation media

156 he first time these have been reported in an alphaherpesvirus), (iv) a sizeable region of the genome

157 M complex is more striking than that of most alphaherpesviruses lacking the same complex but resemble

158 Yet alphaherpesvirus latency in TSG has not been well charac

159 iated transcript (LAT) gene is a hallmark of alphaherpesvirus latency, and yet its control and functi

160 xon terminus) is a critical component of the alphaherpesvirus life cycle.

161 n binding protein (OBP) proteins and have an alphaherpesvirus-like dyad symmetry Ori-Lyt domain.

162 t proteins from pseudorabies virus (PRV), an alphaherpesvirus, localize to mitochondria and affect mi

163 this protease is still unclear, but for the alphaherpesvirus Marek's disease virus, its USP is invol

164 erative disease of chickens, is caused by an alphaherpesvirus, Marek's disease virus (MDV).

165 's disease (MD) in chickens is caused by the alphaherpesvirus MD virus (MDV) and is characterized by

166 Alphaherpesvirus-mediated membrane fusion is a complex a

167 reater understanding of mechanisms governing alphaherpesvirus membrane fusion is expected to inform t

168 The role of alphaherpesvirus membrane protein internalization during

169 uenced, demonstrating that this virus was an alphaherpesvirus most closely related to the gallid herp

170 Herpes simplex virus (HSV) and other alphaherpesviruses must move from sites of latency in ga

171 in-2 to test the effects on entry of various alphaherpesviruses, nectin-nectin interactions, and inte

172 Mammalian alphaherpesviruses normally establish latent infections

173 if Marek's disease virus (MDV), an oncogenic alphaherpesvirus of chickens, encodes miRNAs, we isolate

174 imian varicella virus (SVV) is a neurotropic alphaherpesvirus of monkeys that is a model for varicell

175 virus (PRV), a neurotropic, broad-host-range alphaherpesvirus of swine.

176 HCMV; it has no activity against other CMVs, alphaherpesviruses, or unrelated viruses.

177 -6A and -6B), HHV-7 encodes a homolog of the alphaherpesvirus origin binding protein (OBP), which bin

178 humans and animals is frequently exposed to alphaherpesviruses, originating from either external exp

179 ng reports regarding the importance of gK to alphaherpesvirus pathogenesis and details important stru

180 hat altered mitochondrial transport enhances alphaherpesvirus pathogenesis and infection.

181 Neurotropism is a defining characteristic of alphaherpesvirus pathogenicity.

182 UL20, which are highly conserved across all alphaherpesviruses, play important roles in the regulati

183 to captive primates, who reciprocally harbor alphaherpesviruses poised for zoonotic transmission to h

184 uitinase-encoding domain was dispensable for alphaherpesvirus propagation, but the rate of propagatio

185 rst report to describe the prenylation of an alphaherpesvirus protein.

186 The alphaherpesvirus PrV is known for its neuroinvasion, whe

187 ut not all, membrane proteins encoded by the alphaherpesvirus pseudorabies virus (PRV) are internaliz

188 The alphaherpesvirus pseudorabies virus (PrV) establishes la

189 When the swine alphaherpesvirus pseudorabies virus (PRV) infects the ra

190 extend these studies, we compared gH of the alphaherpesvirus pseudorabies virus (PrV) with gH of the

191 , was found to be a receptor for the porcine alphaherpesvirus pseudorabies virus (PRV).

192 f HSV type 1 (HSV-1), HSV-2, and the related alphaherpesvirus pseudorabies virus (PRV).

193 Using an infectious clone of the alphaherpesvirus pseudorabies virus, we have made a coll

194 e, we report that the gD glycoprotein of the alphaherpesviruses pseudorabies virus (PRV) and herpes s

195 contrast to a similar mutant of the related alphaherpesvirus, pseudorabies virus, and suggests that

196 and differences between HSV1 and the related alphaherpesvirus, pseudorabies virus, in which the homol

197 Like other alphaherpesviruses, pseudorabies virus (PrV) exhibits re

198 Alphaherpesvirus reactivation from thoracic sympathetic

199 s most similar to one of three related human alphaherpesvirus receptors, the one designated HveB and

200 Pseudorabies virus (PRV), an alphaherpesvirus related to herpes simplex virus type 1

201 Pseudorabies virus (PRV) is an alphaherpesvirus related to the human pathogens herpes s

202 Following reactivation from latency, alphaherpesviruses replicate in sensory neurons and asse

203 Thus, alphaherpesviruses repurpose the axonal transport and so

204 virus (VZV), a ubiquitous human neurotropic alphaherpesvirus, requires coordinated binding of multip

205 sequence of bovine herpesvirus 5 (BHV-5), an alphaherpesvirus responsible for fatal meningoencephalit

206 Varicella-zoster virus (VZV), an alphaherpesvirus restricted to humans, infects different

207 eral deletions in regions conserved in other alphaherpesviruses resulted in impaired activation and v

208 varicella-zoster virus (VZV), a neurotropic alphaherpesvirus, results in varicella.

209 ons of the gK primary sequences specified by alphaherpesviruses revealed the presence of a cysteine-r

210 Alignment of UL37 homologs encoded by alphaherpesviruses revealed the presence of highly conse

211 t E454 is invariant in a number of different alphaherpesvirus scaffold proteins.

212 The Us9 gene is highly conserved among the alphaherpesviruses sequenced to date, yet its function r

213 No recombinant alphaherpesvirus serine kinase has been biologically act

214 t UL37 tyrosine residues conserved among all alphaherpesviruses serve critical roles in cytoplasmic v

215 The Vhs homologues of alphaherpesviruses share sequence similarities with a fa

216 Moreover, it identifies the alphaherpesvirus-specific Us3 kinase as an mTORC1 activa

217 Alphaherpesviruses spread rapidly through dermal tissues

218 ort to determine the function of a conserved alphaherpesvirus structural protein called Us2, we scree

219 Characteristic of members of the alphaherpesvirus subfamily, VZV is neurotropic and estab

220 highly conserved among other members of the alphaherpesvirus subfamily.

221 ), which is conserved in most viruses of the alphaherpesvirus subfamily.

222 Like HSV-1, SaHV-1 belongs to the alphaherpesvirus subfamily.

223 lated simian simplexviruses belonging to the alphaherpesvirus subfamily.

224 After replicating in epithelial cells, alphaherpesviruses such as pseudorabies virus (PRV) inva

225 is especially important in the neuroinvasive alphaherpesviruses, such as human herpes simplex virus 1

226 ORTANCE Herpes simplex virus (HSV) and other alphaherpesviruses, such as varicella-zoster virus, depe

227 by sequence alignment to be conserved among alphaherpesviruses, suggesting a functional role.

228 The alphaherpesvirus tegument protein VP22 has been characte

229 protein kinase found in the short region of alphaherpesviruses, termed US3 in herpes simplex virus t

230 Varicella-zoster virus (VZV) is the alphaherpesvirus that causes chicken pox (varicella) and

231 aricella zoster virus (VZV) is a neurotropic alphaherpesvirus that causes chickenpox during primary i

232 Marek's disease virus (MDV) is an alphaherpesvirus that causes deadly T-cell lymphomas in

233 virus (MDV) is a highly contagious oncogenic alphaherpesvirus that causes disease that is both a canc

234 ine herpesvirus 5 (BHV-5) is a neurovirulent alphaherpesvirus that causes fatal encephalitis in calve

235 disease virus (MDV) is an acute transforming alphaherpesvirus that causes T-cell lymphomas in chicken

236 Varicella-zoster virus (VZV) is an alphaherpesvirus that causes two diseases, chickenpox an

237 Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and herpes zoster

238 Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella upon primary infe

239 Varicella-zoster virus (VZV) is a human alphaherpesvirus that infects sensory ganglia and reacti

240 Varicella-zoster virus (VZV) is an alphaherpesvirus that infects skin, lymphocytes, and sen

241 Varicella-zoster virus (VZV) is a human alphaherpesvirus that is highly cell associated in cell

242 Varicella-zoster virus (VZV) is an alphaherpesvirus that is restricted to humans.

243 Varicella-zoster virus (VZV) is an alphaherpesvirus that is the causative agent of chickenp

244 report that varicella-zoster virus (VZV), an alphaherpesvirus that is the causative agent of varicell

245 opithecine herpesvirus 1) is the only deadly alphaherpesvirus that is zoonotically transmissible from

246 represent a phylogenetically unique clade of alphaherpesviruses that are distinct from the Marek's di

247 cella-zoster virus (VZV) are closely related alphaherpesviruses that cause varicella (chickenpox) in

248 K) is a conserved virion glycoprotein of all alphaherpesviruses that is not found in other herpesviru

249 out a possible pathogenic branch of cetacean alphaherpesviruses that might be responsible for some fa

250 In alphaherpesviruses, the alpha-subunit (VP19c in HSV) has

251 Although gE is well conserved among alphaherpesviruses, the amino terminus of VZV gE is uniq

252 For most alphaherpesviruses, the minimal set of viral proteins re

253 ecificities as entry receptors for mammalian alphaherpesviruses through interaction with viral glycop

254 rate specificity for thymidine alone, unlike alphaherpesvirus thymidine kinases (TKs).

255 This transit in axons is essential for alphaherpesviruses to establish latency in ganglia and t

256 r viral replication and, in the case of many alphaherpesviruses, transmission into the nervous system

257 lex-binding region to be ORF32, a homolog of alphaherpesvirus UL17.

258 rther localize ORF19 and ORF32 proteins (the alphaherpesvirus UL25 and UL17 homologs in KSHV, respect

259 y regarding the location and conformation of alphaherpesvirus UL25 protein inside the virion.

260 ding the virion location and conformation of alphaherpesvirus UL25 protein.

261 es have shown that the bovine herpesvirus 1 (alphaherpesvirus) UL26.5 homolog will functionally subst

262 MDV glycoprotein C (gC) is encoded by the alphaherpesvirus UL44 homolog and is essential for the h

263 The alphaherpesvirus UL51 (pUL51) protein has been reported

264 The alphaherpesvirus UL51 protein is a tegument component th

265 Alphaherpesviruses, unlike beta- and gammaherpesviruses,

266 Us3 function and defines a new role for this alphaherpesvirus Us3 kinase in regulating MAPK activatio

267 ed that while HDAC2 is a conserved target of alphaherpesvirus US3 kinases, the functional significanc

268 The alphaherpesvirus Us4 gene encodes glycoprotein G (gG), w

269 method for studying neuron-to-cell spread of alphaherpesviruses using a compartmented culture system.

270 ve epitopes and TCRs may be useful for multi-alphaherpesvirus vaccine design and adoptive cellular th

271 Like all alphaherpesviruses, varicella-zoster virus (VZV) infecti

272 These alphaherpesvirus vCKBPs represent a novel family of prot

273 Additional evidence is provided that alphaherpesvirus virion host shutoff proteins are member

274 functional and structural similarities with alphaherpesvirus VP22, underscoring the evolutionary imp

275 sis of this minireview is that the ancestral alphaherpesvirus VZV coevolved in simians, apes, and hom

276 critical role in the virulence of the human alphaherpesviruses VZV and HSV-1 for human skin.

277 virus (VZV) is an extremely cell-associated alphaherpesvirus; VZV infection is spread almost exclusi

278 ino acids within the scaffolding proteins of alphaherpesviruses were mutated, and the properties of t

279 ly conserved in the UL25 homologues of other alphaherpesviruses, were found to be critical for stable

280 x virus type 1 (HSV-1) are distantly related alphaherpesviruses whose natural hosts are pigs and huma

281 Varicella-zoster virus (VZV) is an alphaherpesvirus with the characteristic neurotropism of

282 s 1, bovine herpesvirus 1 and 5, and related alphaherpesviruses with no sequence similarity to chemok