ライフサイエンスコーパス: alphav integrin

1 inal GvHD that can be inhibited by targeting alphav integrin.

2 cyte migration was dependent on endoglin and alphaV integrin.

3 doglin and reduced endoglin interaction with alphaV integrin.

4 asts that selectively initiate expression of alphaV integrin.

5 rophages through interaction with macrophage alphav integrin.

6 over-representation of peptides that target alphav integrins.

7 iac fibrosis via a mechanism that depends on alphav integrins.

8 ting that 17E6 is an allosteric inhibitor of alphaV integrins.

9 f Th17 cells is also critically dependent on alphav integrins.

10 an SCC line with retroviral vectors encoding alphav integrins.

11 sing levels of EBP50 and SAP97 compared with alphav integrin, a protein expressed at constant adult l

12 se virus (FMDV) have been shown to use three alphav integrins, alphavbeta1, alphavbeta3, and alphavbe

13 lphav integrin subunit, eliminating all five alphav integrins, although causing lethality, allows con

14 ocused primarily on the formation of the PLP-alphav integrin-AMPA receptor complex in vivo and whethe

15 in wild-type cerebellum, PLP associates with alphav integrin and the calcium-impermeable GluR2 subuni

16 t mediation of virus entry by a co-receptor (alphaV integrins and HVEM) has been determined for both

17 al a novel tumor suppressor-like function of alphav integrins and provide a genetically tractable mou

18 s activated at the DC/CD4+ T cell synapse by alphav integrins and that this activation is required fo

19 vailability of beta1 and alpha4, alpha5, and alphaV integrins and the presence of collagenase activit

20 g membrane translocation or stabilization of alphaV-integrin and FAK activation.

21 which is similar to the N-terminal domain of alphaV integrin, and that the C-terminal half contains f

22 the cell surface molecules alpha6-integrin, alphav-integrin, and the c-kit receptor.

23 er evaluation of the mechanisms of action of alphav-integrin antagonists in anti-angiogenic therapeut

24 assays with inhibitory anti-alpha5 and anti-alphav integrin antibodies showed that both subunits con

25 Binding of alphav integrins appeared to have more influence than di

26 , our data indicate that (i) alpha5beta1 and alphav integrins are essential for cell-cell fusion and

27 Here, we show that alpha5beta1 and alphav integrins are essential for cell-cell fusion and

28 Here, we show that alpha5beta1 and alphav integrins are essential for hMPV infectivity and

29 Various beta1 integrins and alphav integrins are present on mouse eggs.

30 Therefore, neither alpha5 nor alphav integrins are required in endothelial cells for i

31 RPTPalpha colocalizes with alphav-integrins at the leading edge during early spread

32 In addition, a small-molecule inhibitor of alphav integrins attenuates fibrosis, even when pre-esta

33 Like alphaV, integrin beta1b was expressed in DFCs, and beta1

34 g is important, combining defects in CAR and alphav integrin binding was essential to effectively red

35 pe cell interactions, lack CAR binding, lack alphav integrin binding, or lack both CAR and alphav int

36 lphav integrin binding, or lack both CAR and alphav integrin binding.

37 cin, two of these peptides-one containing an alphav integrin-binding Arg-Gly-Asp motif and the other

38 These data reveal a common alphaV integrin-binding theme for tropoelastin: alphaVbe

39 alphav integrin blockade also reduces TGFbeta activation

40 ons by LMP2A, and a neutralizing antibody to alphaV-integrin blocked migration, suggesting that the e

41 er, in the absence of endothelial alpha5 and alphav integrins, but not of either alone, there are ext

42 ple, adenoviruses are known to interact with alphaV integrins by virtue of a high-affinity arginine-g

43 cies, our results indicate that both CAR and alphav integrins can impact vector distribution in vivo.

44 The alphav-integrins, cell adhesion molecules that are highl

45 rported TSP-1 binding proteins, CS36 and the alphav integrin chain, or TSP-1-derived peptides CGRGDS

46 tion of these cells, suggesting that the PLP/alphav integrin complex was important for the AMPA-media

47 he generation of Th17 cells and suggest that alphav integrins could be therapeutic targets in autoimm

48 Inducible, endothelial cell-specific alphav integrin deletion similarly blunted inflammation

49 expression in human epithelial cells induces alphaV-integrin-dependent migration through a mechanism

50 Mouse embryos genetically null for all alphav integrins develop intracerebral hemorrhage owing

51 By contrast, mice lacking both alpha5 and alphav integrins developed interrupted aortic arches, la

52 the AMPA receptor, but in mice lacking PLP, alphav integrin did not associate with GluR2.

53 Here, we show that these alphav integrins differentially contribute to sustained

54 Thus, function of beta3 or alphav integrins does not seem to be involved in compens

55 technology to study the in vivo functions of alphav integrins during epithelial cell proliferation an

56 rly spreading, and coimmunoprecipitates with alphav-integrins during spreading on fibronectin and vit

57 After the RGD motif-induced targeting on alphav integrins expressed near tumor tissue, iRGD encou

58 opment, and also reveal a novel function for alphav integrins expressed on axons in the postnatal cen

59 tion/internalization and transduction of CAR/alphav integrin-expressing cells.

60 ions as a ligand for binding alpha4beta1 and alphaV integrin-expressing cells.

61 terfere with neovascularization, we targeted alphav integrin-expressing endothelial cells, which bloc

62 Strategies to interfere with alphav integrin expression and/or function may therefore

63 d ERK2 knockdown potentiated the decrease in alphaV integrin expression associated with toxicity.

64 dditionally, enhanced neovascularization and alphav integrin expression correlated with GvHD severity

65 We show that genetic ablation of alphav integrin expression in basal epithelial cells of

66 ications such as visualizing and quantifying alphav-integrin expression by PET.

67 phav-integrin; however, the overall level of alphav-integrin expression was not altered by Ras or Raf

68 ing for alpha6-integrin, and negative or low alphav-integrin expression, and resulted in a 166-fold e

69 ction-blocking monoclonal antibody (mAb) nor alphav integrin function-blocking mAb inhibited sperm bi

70 Here we show that codeletion of the p53 and alphav integrin genes in mouse stratified epithelia indu

71 -mutant embryos deficient in both alpha5 and alphav integrin genes.

72 alphav integrins have been identified as coreceptors for

73 CAR and alphav integrins have been identified as the primary cel

74 alphav integrins have been implicated in many developmen

75 The RGD-binding alpha5 and alphav integrins have been shown to be key regulators of

76 Although alphav integrins have been shown to play critical roles

77 ed on the cell surface as a heterodimer with alphav-integrin; however, the overall level of alphav-in

78 inhibited by a neutralizing antibody against alphav integrin in a dose-dependent manner.

79 Conditional deletion of alphav integrin in both central nervous system glia and

80 ve been used to examine the roles of CAR and alphav integrin in determining the tropism of Ad vectors

81 GFRbeta promoter-driven Cre system to delete alphav integrins in activated fibroblasts identified the

82 s necessitate reevaluation of the primacy of alphav integrins in many functions including vascular de

83 Here we describe a role for alphav integrins in regulating Toll-like receptor (TLR)

84 These data suggest a novel role for alphav integrins in the association between cerebral mic

85 Thus, the present study suggests a role for alphaV integrins in the mechanotransduction of pressure

86 etheless, in embryos lacking both alpha5 and alphav integrins in their endothelial cells, initial vas

87 ssing Ad35 knobs, which enter cells by a CAR/alphav integrin-independent pathway, fiber shaft length

88 uggest that MKK3, rather than MKK6, mediates alphav integrin-induced p38 MAPK activation.

89 Rho-associated protein kinase inhibitor, and alphav integrin inhibitor all attenuated mechanical stre

90 cardiac PDGFRbeta(+) cells, suggesting that alphav integrin inhibitors may be effective for the trea

91 hat down-regulating or functionally blocking alphav integrins inhibits endogenous p38 mitogen-activat

92 Disruption of both CAR and alphav integrin interactions may be critical for effecti

93 Mice in which alphav integrin is depleted in PDGFRbeta(+) cells are pr

94 tion in the absence of PLP and GluR2 or when alphav integrin levels were reduced.

95 In the present study, we found that alphav integrin ligation activated small GTPase Rac1 pre

96 ISS-ODN also enhanced surface expression of alphav integrins, making them significantly more suscept

97 in endoglin immunoprecipitates, and enhanced alphaV integrin-mediated activation of TGF-beta.

98 CAR- and alphav integrin-mediated infections are influenced by ot

99 AMPA stimulated alphav integrin-mediated OPC migration by increasing bot

100 ion, but only dominant negative MKK3 blocked alphav integrin-mediated p38 MAPK activation and uPA up-

101 tially, and dominant negative Rac1 inhibited alphav integrin-mediated p38 MAPK activation.

102 only MAPK-activated protein kinase 2 affects alphav integrin-mediated uPA up-regulation significantly

103 ream signaling molecules of p38 MAPK mediate alphav integrin-mediated uPA up-regulation.

104 ing the myelin proteolipid protein (PLP) and alphav integrin modulated the AMPA-stimulated migration,

105 at intetumumab (CNTO 95), a fully human anti-alphav integrin monoclonal antibody, is a radiosensitize

106 e found that renal fibroblasts express three alphav integrins, namely alphavbeta1, alphavbeta3, and a

107 We therefore proceeded to test whether alphav integrins' natural ligands fibronectin and vitron

108 These data suggest a mechanism whereby alphav integrins normally suppress epithelial cell proli

109 Further analysis indicated that alphav integrins on DCs activated latent TGF-beta during

110 llectively, these data provide evidence that alphav integrins on embryonic central nervous system neu

111 that lack alpha5, alphav or both alpha5 and alphav integrins on their vSMCs, using the SM22alpha-Cre

112 These findings suggest that soluble alphav integrins or antagonists of these coreceptors cou

113 A second shRNA to either alphav-integrin or beta3-integrin, but not to another al

114 e AMPA receptor subunits themselves with the alphav integrin/PLP complex.

115 Thus, after AMPA receptor stimulation, an alphav integrin/PLP/neurotransmitter receptor protein co

116 endoglin in focal complexes, an increase in alphaV integrins present in endoglin immunoprecipitates,

117 t the effects of LMP2A on membrane-localized alphaV-integrin promoted migration.

118 Primarily alphav integrin receptors mediated this down-regulation

119 lacking the arginine-glycine-aspartate (RGD) alphaV integrin recognition site from its penton base, w

120 Adenovirus (Ad) endocytosis via alphav integrins requires activation of the lipid kinase

121 blocking monoclonal antibodies revealed that alphaV integrin(s) and integrin alphaVbeta5 specifically

122 Furthermore, inhibiting alphav integrins (S247), but not alpha5 (ATN-161), in at

123 The generation of soluble alphav integrins should also permit further detailed kin

124 Mouse embryos genetically null for the alphav integrin subunit develop intracerebral hemorrhage

125 Immunofluorescence colocalized OVS with the alphav integrin subunit which, along with CD9, resides p

126 Surprisingly, ablation of the gene for the alphav integrin subunit, eliminating all five alphav int

127 Binding of either beta3 or alphaV integrin subunits increased MMP-1/10 secretion in

128 The ability of chimeric alpha5/alphav integrin subunits, in association with the beta1

129 f short interfering RNAs targeting beta1 and alphav integrin subunits, we downregulate all integrin r

130 the beta3 and the complementary alphaIIb and alphav integrin subunits.

131 To specify which alphav integrins the virus utilizes, we tested MAbs spec

132 formed B lymphoblastoid cell lines expressed alphav integrins, the adenovirus internalization recepto

133 Ad receptor and undergo internalization via alphav integrins, this mutant does not escape from the e

134 facilitates viral internalization by binding alphav integrins through an RGD motif.

135 y studies demonstrated colocalization of the alphaV integrin to FAPs.

136 further show that prostate cancer cells use alphav integrin to migrate efficiently and directionally

137 of conserved clearance mechanisms employing alphav integrins upstream of tyrosine kinases and Rho GT

138 Furthermore, pharmacologic inhibition of alphav integrins using cyclic RGD peptides blocked TGF-b

139 Synovial tissue expression of alphav integrins was determined by immunohistochemistry.

140 Interestingly, alphaV-integrin was greatly increased in membrane-enrich

141 tic cells, further studies demonstrated that alphav integrins were required for the next step in infe

142 re, we report on the roles of the alpha5 and alphav integrins, which are the major endothelial fibron

143 -MB-231 breast cancer cells whereas engaging alphav integrins with vitronectin activates p38 MAPK and