ライフサイエンスコーパス: alphavbeta5 integrin

1 uitment via Rac1 both require MFG-E8-ligated alphavbeta5 integrin.

2 sis independently of the OS binding receptor alphavbeta5 integrin.

3 irectly associates with the beta5 subunit of alphaVbeta5 integrin.

4 tors that mediate this uptake, they lack the alphavbeta5 integrin.

5 a by interacting with glomerular endothelial alphavbeta5 integrin.

6 sue and cell lines expressed alphavbeta3 and alphavbeta5 integrins.

7 rved with antibodies against alphaVbeta3 and alphaVbeta5 integrins.

8 ization studies suggest that alphaVbeta3 and alphaVbeta5 integrins also play roles in KSHV entry.

9 an sulfate proteoglycan-bound AAV-2 requires alphaVbeta5 integrin and activation of the small GTP-bin

10 etinal pigment epithelial (RPE) cells employ alphavbeta5 integrin and CD36 receptors to phagocytose p

11 ique profile of receptors, in particular the alphavbeta5 integrin and CD36.

12 Rac1 activation during phagocytosis requires alphavbeta5 integrin and its ligand milk fat globule EGF

13 a3, alpha5, beta1, alpha5beta1, alphavbeta3, alphavbeta5 integrins and CD36) and inhibitors of specif

14 Expression of alphavbeta3- or alphavbeta5-integrins and selectins is widespread on blo

15 s with soluble alpha3beta1, alphaVbeta3, and alphaVbeta5 integrins, and cumulative inhibition was obs

16 cRGD) with nanomolar activity as alphavbeta3/alphavbeta5 integrin antagonists.

17 These data indicate that alphavbeta3 or alphavbeta5 integrins are not essential for tumor growth

18 These data indicate that alphavbeta3 and alphavbeta5 integrins are not essential for vascular dev

19 alphavbeta3 or alphavbeta5 integrins are widely expressed on blood and

20 unction-blocking monoclonal antibody against alphavbeta5 integrin, as could differentiation in the wi

21 Stratified squamous epithelia express the alphavbeta5 integrin, but in squamous cell carcinomas (S

22 bona fide engulfment pathway in concert with alphavbeta5 integrin by regulating cytoskeletal assembla

23 ng endothelial cell monolayers via RhoA- and alphavbeta5 integrin-dependent mechanisms.

24 Daily alphavbeta5 integrin-dependent phagocytosis of spent pho

25 cid uptake through alphavbeta3 integrin- and alphavbeta5 integrin-dependent phosphorylation of Akt by

26 ntially express alphavbeta1, alphavbeta3 and alphavbeta5 integrins during differentiation in vitro.

27 e alpha1beta1, alpha2beta1, alphavbeta3, and alphavbeta5 integrins each support dermal microvascular

28 to loss of either the phagocytosis receptor alphavbeta5 integrin, expressed by the RPE but not by ph

29 phagocytosis was evaluated by knocking down alphavbeta5 integrin expression with siRNA against the h

30 asts as well as motility, matrix deposition, alphavbeta5 integrin expression, and radical oxygen spec

31 The alphavbeta5 integrin-FAK-mediated pathway regulates phag

32 Inhibition of alphavbeta3 or alphavbeta5 integrin function has been reported to suppr

33 Using its alphaVbeta5 integrin, HSG cells attached to BSP but not

34 The role of alphavbeta5 integrin in phagocytosis was evaluated by kn

35 used to determine levels of alphavbeta3 and alphavbeta5 integrins in TM tissue and cultures of norma

36 Cilengitide is a selective alphavbeta3 and alphavbeta5 integrin inhibitor.

37 The alphavbeta5 integrin is known to promote Ad cell entry.

38 ng and internalization studies indicate that alphaVbeta5 integrin is not a primary attachment recepto

39 3 integrin expression and signalling through alphavbeta5 integrin may be critical to continued differ

40 The alphavbeta5 integrin may have an important role in acute

41 In summary, our results indicate that alphaVbeta5 integrin-mediated endocytosis of AAV-2 occur

42 expression of mutant beta5 integrin, nor was alphavbeta5 integrin-mediated engulfment modulated by cl

43 h cell surface alpha3beta1, alphaVbeta3, and alphaVbeta5 integrin molecules and tyrosine kinase ephri

44 nd OPN knockdown inactivated alphavbeta3 and alphavbeta5 integrins, negligibly affecting their expres

45 We suggest that the alphavbeta5 integrin plays a critical role in the traffi

46 Here we determined that alphaVbeta5 integrin plays a part in efficient AAV infec

47 activated promptly after light onset via the alphavbeta5 integrin receptor and its ligand MFG-E8, thu

48 se results demonstrate an essential role for alphavbeta5 integrin receptors and their downstream sign

49 Cilengitide, an inhibitor of alphavbeta3 and alphavbeta5 integrin receptors, demonstrated minimal tox

50 ro through interactions with alphavbeta3 and alphavbeta5 integrin receptors.

51 broblast-to-CAF activation, which depends on alphavbeta5-integrin redistribution of pFAK-independent

52 Knockdown of alphavbeta5 integrin reduced phagocytosis by approximate

53 This study supports the idea that alphaVbeta5 integrin serves as a co-receptor for AAV-2 v

54 Genetically defined cells expressing alphaVbeta5 integrin showed increased susceptibility to

55 the retinal pigment epithelium (RPE) employs alphavbeta5 integrin to recognize spent photoreceptor ou

56 that bound to VN, competing with alphavbeta3/alphavbeta5 integrin/VN binding, thus promoting cell det

57 ics that selectively bind to alphavbeta3 and alphavbeta5 integrins were synthesized and covalently do

58 e two vitronectin receptors, alphavbeta3 and alphavbeta5 integrin, which have been shown to cooperate