ライフサイエンスコーパス: alphavirus

1 ist for human use against CHIKV or any other alphavirus.

2 ains, SD1 and SD2, are derived from the same alphavirus.

3 izing antibodies in mice to their respective alphavirus.

4 loser together than Semliki Forest virus, an alphavirus.

5 Chikungunya virus is a positive-stranded RNA alphavirus.

6 al with inhibitory activity against multiple alphaviruses.

7 tly neutralizing antibodies against multiple alphaviruses.

8 t this new knowledge can be applied to other alphaviruses.

9 producing fusion-competent mature spikes on alphaviruses.

10 y no approved drugs to treat infections with alphaviruses.

11 is a representative member of the New World alphaviruses.

12 nezuelan equine encephalitis virus and other alphaviruses.

13 eins had only been found in flaviviruses and alphaviruses.

14 ated groups: the Old World and the New World alphaviruses.

15 is a representative member of the New World alphaviruses.

16 te SLEV E from trimers of related flavi- and alphaviruses.

17 pplied for vaccine development against other alphaviruses.

18 tecture found previously in flaviviruses and alphaviruses.

19 d in mice infected with 3 flaviviruses and 2 alphaviruses.

20 EEV) is one of the most pathogenic New World alphaviruses.

21 L402 in cdE2 as important for the budding of alphaviruses.

22 ural proteins that is different from that of alphaviruses.

23 ainst CHIKV and other reemerging arthrogenic alphaviruses.

24 s well as during infections with three other alphaviruses.

25 ion which characterizes Ross River and other alphaviruses.

26 plex and belongs to the New World cluster of alphaviruses.

27 role for Ifitm3 in controlling infection of alphaviruses.

28 nown about the antiviral effect of IFITM3 on alphaviruses.

29 Ifitm3 in restricting infection of multiple alphaviruses.

30 applied to other encephalitogenic New World alphaviruses.

31 enuation of other encephalitogenic New World alphaviruses.

32 on by chikungunya, Mayaro, and O'nyong'nyong alphaviruses.

33 Here, the alphavirus -1 PRF signals were characterized, revealing

34 CHIKV is the most important alphavirus affecting humans, resulting in a chronic arth

35 markably, 5-NT also inhibits infection by an alphavirus and a coronavirus.

36 virus (CHIKV) is a re-emerging vector-borne alphavirus and is transmitted to humans by Aedes mosquit

37 de in understanding the overall structure of alphavirus and VEEV virions, and glycoprotein spikes in

38 ses and applied our method to 11 recombinant alphaviruses and 4 recombinant flaviviruses hybridized t

39 a wide range of enveloped viruses, including alphaviruses and a baculovirus.

40 that replication of Old World and New World alphaviruses and a bunyavirus was reduced in mature comp

41 ad-spectrum antiviral activity against other alphaviruses and CHIKV isolates but also exhibited limit

42 a common ancestor and divergent evolution of alphaviruses and flaviviruses from a common ancestor.

43 Most alphaviruses and many other arboviruses are mosquito-bor

44 cal development as inhibitors of neurotropic alphaviruses and, potentially, of other RNA viruses.

45 d to early endosomes containing internalized alphavirus, and depletion of TSPAN9 inhibited virus fusi

46 ovides an important advance in understanding alphavirus, and probably other virus, encephalitis.

47 virus (CHIKV) is a re-emerging vector-borne alphavirus, and there is no approved effective antiviral

48 ility to viral infection using flaviviruses, alphaviruses, and bunyaviruses as examples of emerging p

49 y extended to other viruses, including ZIKV, alphaviruses, and herpesviruses.

50 Alphaviruses are a group of human and animal pathogens w

51 Alphaviruses are a group of single-stranded RNA viruses

52 Alphaviruses are a reemerging viral cause of arthritogen

53 The Old World alphaviruses are emerging human pathogens with an abilit

54 Alphaviruses are enveloped positive-sense RNA viruses th

55 Alphaviruses are enveloped viruses with highly organized

56 The Old World alphaviruses are highly cytopathic and known to evade th

57 Arthritogenic alphaviruses are human pathogens maintained in nature th

58 Alphaviruses are important and widely distributed human

59 Mosquito-borne alphaviruses are important causes of epidemic encephalom

60 While a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases,

61 Nevertheless, most of the alphaviruses are known to induce a type I interferon (IF

62 Alphaviruses are known to interact with members of the C

63 Most alphaviruses are mosquito-borne and exhibit a broad host

64 Alphaviruses are mosquito-borne viruses that cause signi

65 We show that the genomic RNAs of alphaviruses are not universally 5' capped, with a signi

66 Alphaviruses are one of the most geographically widespre

67 Alphaviruses are serious, sometimes lethal human pathoge

68 Alphaviruses are small enveloped RNA viruses that includ

69 Alphaviruses are small enveloped RNA viruses that infect

70 Alphaviruses are small enveloped RNA viruses with highly

71 Alphaviruses are small enveloped viruses whose surface i

72 Alphaviruses are spread by mosquitoes and can cause seri

73 Virus encephalitis is a major disease, and alphaviruses, as highlighted by the recent epidemic of c

74 mbrane (PM), but the process and dynamics of alphavirus assembly and budding are poorly understood.

75 iously been shown to differ from that of the alphavirus assembly pathway, leads to an organization of

76 viously uncharacterized factor important for alphavirus assembly.

77 plex adenovirus, vesicular stomatitis virus, alphavirus-based chimeras, and measles vaccine Schwarz s

78 Alphaviruses bud from the plasma membrane (PM), but the

79 to the plasma membrane, which is the site of alphavirus budding.

80 were broadly cross-reactive against diverse alphaviruses but were nonneutralizing.

81 ine encephalitis virus (EEEV), two New World alphaviruses, can cause fatal encephalitis, and EEEV is

82 Thus, protease activity of the alphavirus capsid is a potential antialphaviral target t

83 IMPORTANCE The alphavirus capsid protease is an attractive antiviral th

84 The alphavirus capsid protein (CP) is a serine protease that

85 udies provide the first dynamic views of the alphavirus capsid protein in living cells and a system t

86 The similar domain structures of alphavirus capsid proteins suggest that this new knowled

87 Three related viruses belonging to the genus Alphavirus cause severe encephalitis in humans: Venezuel

88 virus (RRV), chikungunya virus, and related alphaviruses cause debilitating polyarthralgia and myalg

89 Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pai

90 The alphavirus chikungunya virus (CHIKV) has caused multiple

91 cells with 5-NT decreased the infectivity of alphavirus chikungunya virus and coronavirus mouse hepat

92 dengue virus and yellow fever virus and the alphavirus chikungunya virus, which are also (re)emergin

93 also responsible for recent outbreaks of the alphavirus chikungunya.

94 ice with two distantly related arthritogenic alphaviruses, chikungunya virus (CHIKV) and Ross River v

95 ng pathogenesis of two related arthritogenic alphaviruses, chikungunya virus and Ross River virus.

96 Like other alphaviruses, CHIKV displays broad tissue tropism, which

97 VSVDeltaG-alphavirus chimeras could have general applicability as

98 The genus Alphavirus consists of a group of enveloped, single-stra

99 Among infections due to all but 1 alphavirus, death was strongly associated with a suppres

100 The hallmark of alphavirus disease is crippling pain and inflammation of

101 The hallmark of alphavirus disease is crippling pain and joint arthritis

102 ector was investigated in a well-established alphavirus disease model.

103 there is no licensed specific treatment for alphavirus disease, and the increasing spread of infecti

104 Alphavirus dogma has long dictated the production of a d

105 peutics for infections cause by encephalitic alphaviruses due to an incomplete understanding of their

106 ture of the key contacts of DIII-stem in the alphavirus E1 homotrimer and describe a sensitive and qu

107 c CHIKV/SFV provide insights on the role the alphavirus E2 protein plays on pathogenesis.

108 unya viruses) and two New World encephalitic alphaviruses (eastern and Venezuelan equine encephalitis

109 tradeoffs, we developed the insect-specific alphavirus, Eilat virus (EILV), as a vaccine platform.

110 Here we describe a unique alphavirus, Eilat virus (EILV), isolated from a pool of

111 Recently, a new alphavirus, Eilat virus (EILV), was described, and in co

112 wever, in contrast to typical mosquito-borne alphaviruses, EILV could not infect mammalian or avian c

113 ange restriction of the first "mosquito-only alphavirus," EILV.

114 Susceptibility to alphavirus encephalomyelitis is dependent on a variety o

115 Neuronal cell death during fatal alphavirus encephalomyelitis is immune-mediated; however

116 Therefore, in fatal alphavirus encephalomyelitis, pathogenic Th17 cells ente

117 and its regulation for host survival during alphavirus encephalomyelitis.

118 gulation in determining host survival during alphavirus encephalomyelitis.

119 rt our hypothesis that peripherally injected alphaviruses enter the CNS by hematogenous seeding of th

120 to simulate mosquito infection and examined alphavirus entry in the CNS.

121 the host cell proteins that are involved in alphavirus entry.

122 Alphavirus envelope proteins, organized as trimers of E2

123 lar dynamics based on an atomic model of the alphavirus envelope with icosahedral symmetry.

124 Alphaviruses establish a persistent infection in arthrop

125 Together, our data indicate that alphaviruses extensively reorganize the cell surface and

126 road host range of pathogenic mosquito-borne alphaviruses, facilitate vaccine development, and inform

127 virus (WEEV) is an arbovirus from the genus Alphavirus, family Togaviridae, which circulates in Nort

128 lation of TF will aid current efforts in the alphavirus field searching for approaches to mitigate al

129 Sindbis virus (SINV) is a mosquito-borne alphavirus found in Eurasia, Africa, and Oceania.

130 sults suggest not only that packaging of the alphavirus genome is determined by the presence of packa

131 Alphavirus genome-based, self-replicating RNAs (replicon

132 However, bioinformatic analyses of alphavirus genomes suggested that a ribosomal frameshift

133 is one of the most pathogenic members of the Alphavirus genus in the Togaviridae family.

134 kungunya virus (CHIKV), which belongs to the Alphavirus genus, has a wide distribution in the Old Wor

135 Sindbis virus, a prototypic member of the Alphavirus genus, has been used to study the pathogenesi

136 a robust and comprehensive phylogeny of the Alphavirus genus, presenting a more complete evolutionar

137 Chikungunya alphavirus has caused large epidemics worldwide and lead

138 ent by the same subdomain derived from other alphaviruses has strong negative effects on infectious v

139 of the in vitro-synthesized RNA into cells, alphaviruses have become an attractive system for expres

140 hat affect the pathogenesis of arthritogenic alphaviruses have not been defined.

141 itory function of IRF-1 against infection of alphaviruses in cell culture, its role in vivo remains u

142 used to identify early entry sites of these alphaviruses in the CNS.

143 2 position 18, and this holds true for other alphaviruses in the Semliki Forest antigenic complex.

144 ezuelan equine encephalitis virus (VEEV), an alphavirus, in complex with two strongly neutralizing an

145 ane to capture Sindbis virus, a prototypical alphavirus, in its membrane-binding form at pH 6.4.

146 Arthritogenic alphaviruses including Ross River virus (RRV), Sindbis v

147 Arthritogenic alphaviruses, including Ross River virus (RRV), infect h

148 Neurotropic alphaviruses, including western, eastern, and Venezuelan

149 f producing proinflammatory mediators during alphavirus-induced arthralgia.

150 PPS is a promising new therapy for alphavirus-induced arthritis, acting to preserve the car

151 te for drug repurposing for the treatment of alphavirus-induced arthritis.

152 ent a safe and effective approach to prevent alphavirus-induced disease in humans.IMPORTANCE This wor

153 Here, using mouse models of alphavirus-induced musculoskeletal disease, we demonstra

154 y increase our understanding of the basis of alphavirus-induced pathology.

155 The enveloped alphaviruses infect cells via a low-pH-triggered membran

156 Alphaviruses infect host cells by utilizing the endocyti

157 (i) within the first 2 to 4 h postinfection, alphavirus-infected cells become unable to respond to IF

158 to show that complete degradation of Rpb1 in alphavirus-infected cells occurs within 6 h postinfectio

159 l analysis, we demonstrate greater levels of alphavirus infection and disease pathogenesis when Ifitm

160 understanding of host responses that control alphavirus infection and viral determinants that counter

161 The hallmark of alphavirus infection in vertebrates is the induction of

162 We showed that alphavirus infection induced the formation of patches an

163 rovide previously unidentified evidence that alphavirus infection induces bone loss and that OBs are

164 Together, our data support a model in which alphavirus infection induces reorganization of the PM an

165 Susceptibility to alphavirus infection is age dependent, and host maturati

166 Here, we show that alphavirus infection is increased in Ifitm3(-/-) and Ifi

167 additional 99 suspected or probable cases of alphavirus infection were detected during active surveil

168 were more susceptible than WT mice to lethal alphavirus infection with Venezuelan equine encephalitis

169 he cartilage matrix, which is damaged during alphavirus infection.

170 afe vaccines have been developed against any alphavirus infection.

171 thology and resolving inflammation following alphavirus infection.

172 OBs may therefore contribute to bone loss in alphavirus infection.

173 system to define detailed mechanisms during alphavirus infection.

174 le siRNA screen in the context of an in vivo alphavirus infection.

175 role of the host membrane protein TSPAN9 in alphavirus infection.

176 Mosquito-borne alphavirus infections are an important cause of encephal

177 re no licensed vaccines that protect against alphavirus infections.

178 s protection against two distinct species of alphavirus irrespective of the route of infection.

179 yelitis due to infection with mosquito-borne alphaviruses is an important cause of death and of long-

180 We conclude that entry of alphaviruses is by direct penetration of cell plasma mem

181 on as a public health threat, the biology of alphaviruses is insufficiently understood.

182 ) strain of Semliki Forest virus (SFV; genus Alphavirus) is avirulent in adult mice, while the L10 st

183 ungunya virus (CHIKV), an arthritis-inducing alphavirus, is the cause of a massive ongoing outbreak i

184 Chikungunya virus (CHIKV), an Old World alphavirus, is transmitted to humans by infected mosquit

185 Chikungunya virus--a mosquito-borne alphavirus--is endemic in Africa and south and southeast

186 critical but little understood steps in the alphavirus life cycle.

187 Like other arthritogenic alphaviruses, mechanisms of CHIKV pathogenesis are not w

188 eterodimers on the surface of the pathogenic alphavirus, mediate the low pH-triggered fusion of viral

189 The sequential steps in the alphavirus membrane fusion pathway have been postulated

190 n this study, we developed a new strategy of alphavirus modification aimed at making these viruses ca

191 SFV also serves as a model for studies of alphavirus molecular biology and host-pathogen interacti

192 ative regulator of IFN signaling, influences alphavirus neuroinvasion and pathogenesis.

193 ted that hypervariable domains (HVDs) of the alphavirus nsP3 protein interact with virus-specific hos

194 Our phylogeny suggests the origin of the alphaviruses occurred in the southern oceans and spread

195 CHIKV is a reemerging alphavirus of global significance with high potential to

196 ody therapeutic development against multiple alphaviruses of global concern.

197 the mosquito-borne virus clade of pathogenic alphaviruses, our findings have important evolutionary i

198 re formation is one of the driving forces of alphavirus particle assembly.

199 range of RNA viruses, such as flaviviruses, alphaviruses, picornaviruses, bunyaviruses, and coronavi

200 Cleavage of the alphavirus precursor glycoprotein p62 into the E2 and E3

201 Chikungunya virus (CHIKV) is an alphavirus prevalent in tropical regions.

202 In addition, alphaviruses provide well-studied experimental systems w

203 However, alphaviruses replicate efficiently in cells expressing I

204 Alphaviruses replicate exclusively in the cytoplasm, and

205 he accumulated knowledge of the mechanism of alphavirus replication and promoter structures, in parti

206 Our studies show that IRF-1 controlled alphavirus replication and swelling in joint-associated

207 been made in understanding the mechanism of alphavirus replication and virus-host interactions.

208 d a novel series of indole-2-carboxamides as alphavirus replication inhibitors, one of which conferre

209 rivatives as novel inhibitors of neurotropic alphavirus replication, using a cell-based phenotypic as

210 STAT innate immunity pathways in response to alphavirus replication.

211 ve microarray analysis of flies harboring an alphavirus replicon and control green fluorescent protei

212 Alphavirus replicons were evaluated as potential vaccine

213 Alphaviruses represent a diverse set of arboviruses, man

214 Alphaviruses represent a group of clinically relevant vi

215 Alphaviruses represent a highly important group of human

216 Alphaviruses represent a significant public health threa

217 Chikungunya virus (CHIKV) is an alphavirus responsible for causing epidemic outbreaks of

218 hikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for recent epidemic outbreaks of

219 Chikungunya virus (CHIKV), a re-emerging alphavirus responsible for several outbreaks worldwide i

220 s-like vesicles (VLVs) are generated when an alphavirus RNA replicon expresses the vesicular stomatit

221 led lentivirus virions and that incorporated alphavirus RNA.

222 n mice infected with a related arthritogenic alphavirus, Ross River virus, but not in mice infected w

223 Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and anim

224 is widely held that arboviruses such as the alphavirus Sindbis virus gain entry into cells by a proc

225 a host factor that promotes infection by the alphaviruses Sindbis virus (SINV), Semliki Forest virus

226 to 1,000-fold decrease in replication of the alphaviruses Sindbis virus and Venezuelan equine encepha

227 sion vectors for two Old World arthritogenic alphaviruses (Sindbis and Chikungunya viruses) and two N

228 ed flavivirus, West Nile virus (WNV), and an alphavirus, Sindbis virus (SINV).

229 The alphavirus small membrane proteins 6K and TF have been r

230 e made chimeric viruses in which E3 from one alphavirus species is replaced with E3 from another spec

231 rent vaccine strategies target only a single alphavirus species.

232 pecific FXR protein family and the Old World alphavirus-specific G3BP protein family.

233 ates formed by SINV nsP3 and other Old World alphavirus-specific nsP3s, VEEV nsP3 forms unique, large

234 s transcribed from a promoter located in the alphavirus-specific RNA replication intermediate and is

235 fting event occurs during translation of the alphavirus structural polyprotein.

236 ates seen after infection with arthritogenic alphaviruses such as chikungunya virus.

237 activity against other clinically important alphaviruses such as O'nyong-nyong virus and Sindbis vir

238 Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungu

239 Alphaviruses such as Semliki Forest virus (SFV) are enve

240 In contrast to CHIKV, other related alphaviruses, such as Venezuelan equine encephalitis vir

241 ery low overall similarity between different alphaviruses, suggesting the possibility of its function

242 ected with the mutant virus suggest that the alphavirus TF protein is important for passage through t

243 litis virus (VEEV) is an emerging pathogenic alphavirus that can cause significant disease in humans.

244 hikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes a chronic debilitating polyarthra

245 Chikungunya virus (CHIKV) is a reemerging alphavirus that causes a debilitating arthritic disease

246 kungunya virus (CHIKV) is an arthropod-borne alphavirus that causes acute and chronic arthritis.

247 Chikungunya virus (CHIKV) is a reemerging alphavirus that causes acute febrile illness and severe

248 unya virus (CHIKV) is a mosquito-transmitted alphavirus that causes acute fever and acute and chronic

249 Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthra

250 Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic ar

251 virus (CHIKV) is a reemerging mosquito-borne alphavirus that causes debilitating arthralgia in humans

252 unya virus (CHIKV) is a mosquito-transmitted alphavirus that causes debilitating musculoskeletal pain

253 (CHIKV) is a reemerging mosquito-transmitted alphavirus that causes epidemics of debilitating polyart

254 hikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes major epidemics of rash, fever, a

255 unya virus (CHIKV) is a mosquito-transmitted alphavirus that causes severe acute and chronic disease

256 Chikungunya virus (CHIKV) is an alphavirus that has emerged as a global health burden.

257 virus (CHIKV) is a mosquito-borne arthralgic alphavirus that has garnered international attention as

258 hikungunya virus (CHIKV) is a mosquito-borne alphavirus that has reemerged to cause profound epidemic

259 uelan equine encephalitis virus (VEEV) is an alphavirus that is prevalent in the Americas and that is

260 hikungunya virus (CHIKV) is a mosquito-borne alphavirus that is responsible for considerable epidemic

261 kungunya virus (CHIKV) is the mosquito-borne alphavirus that is the etiologic agent of massive outbre

262 Chikungunya virus (CHIKV) is a re-emerging Alphavirus that is transmitted to humans by Aedes mosqui

263 V) is one of a group of mosquito-transmitted alphaviruses that cause debilitating, and often chronic,

264 globally distributed group of arthritogenic alphaviruses that cause weeks to months of debilitating

265 Like many alphaviruses, the structural targets on CHIKV that elici

266 The ability of alphaviruses to induce bone pathologies remains poorly d

267 This ability of most alphaviruses to infect arthropods and vertebrates is ess

268 y was observed with related flaviviruses and alphaviruses, To evaluate diagnostic sensitivity and spe

269 equine encephalitis viruses (VEEV and WEEV; Alphavirus; Togaviridae) are mosquito-borne pathogens ca

270 nform potential strategies to reduce/prevent alphavirus transmission.

271 Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes that is known to ca

272 We show that pathogenic alphaviruses use secondary structural motifs within the

273 ese vectors have been derived from Old World alphaviruses using a second viral subgenomic promoter to

274 fitm3 against arthritogenic and encephalitic alphaviruses using cells and animals with a targeted gen

275 VEEV and related alphaviruses utilize programmed -1 ribosomal frameshifti

276 r the development of new rationally designed alphavirus vaccine candidates that combine efficient imm

277 to outbreaks, we designed and tested a novel alphavirus vaccine comprised of cationic lipid nucleic a

278 al utility of our LANAC formulation as a pan-alphavirus vaccine.

279 utility in the licensure of next-generation alphavirus vaccines and therapeutics for use in humans b

280 chimeras could have general applicability as alphavirus vaccines.

281 However, current alphavirus vectors expressing reporters of infection hav

282 Engineered alphavirus vectors expressing reporters of infection hav

283 multivalent vaccine against the encephalitic alphaviruses VEEV and EEEV, both of which can cause fata

284 The genome from the alphavirus Venezuelan equine encephalitis virus (VEE) wa

285 ong these viral threats are the encephalitic alphaviruses Venezuelan equine encephalitis virus (VEEV)

286 The alphaviruses Venezuelan equine encephalitis virus (VEEV)

287 examined the evolution process of one of the alphaviruses, Venezuelan equine encephalitis virus (VEEV

288 edical importance, compared with the related alphaviruses, very little is known about the structure o

289 One determinant of alphavirus virulence is nonstructural protein 3 (nsP3) t

290 of consensus clones as tools for studies of alphaviruses was demonstrated.

291 fectivity of Sindbis virus (SINV), the model alphavirus, was largely a function of the cell line prod

292 Using full-length sequences of all known alphaviruses, we produced a robust and comprehensive phy

293 Recently, the small 6K and TF proteins of alphaviruses were shown to contribute to virulence in vi

294 nse pathways primarily using the neurotropic alphavirus western equine encephalitis virus (WEEV).

295 ne encephalitis virus (VEEV) is a pathogenic alphavirus, which circulates in the Central, South, and

296 is divided into the Old World and New World alphaviruses, which demonstrate profound differences in

297 Neurotropic alphaviruses, which include western equine encephalitis

298 uelan equine encephalitis virus (VEEV) is an alphavirus with a wide distribution across the globe.

299 ts indicated that WEEV is a highly conserved alphavirus with only approximately 5% divergence in its

300 We developed alphaviruses with fluorescent protein tags on one of the