ライフサイエンスコーパス: already

1 This synucleinopathy was fully developed already 10 days after fibril injection, accompanied by p

2 fective population sizes (N e) than foragers already 20 k years ago, well before the Neolithic revolu

3 n tetrapod phylogeny is controversial, as it already acquired the specialized morphology that charact

4 s avoid seeding highly ranked nodes that are already activated by diffusion active between stages.

5 Africa and Asia rather than settlement by an already admixed population.

6 (CD63 expression 79% vs 32%, P<.05) and LAR already after 1 week (DeltaFEV1 26% vs 13%, P<.05).

7 .03) to the same extent as antigen avoidance already after 8 weeks.

8 origin and in large synapses, is upregulated already after a few hours of sleep deprivation and shows

9 other markers, plasmatic villin 1 decreased already after a short (3 hours) treatment with necrostat

10 gender inequities; a looming increase in the already alarming shortfall in health-care professionals;

11 Such changes are already altering the composition of ecological communiti

12 the vasculature, GSCs, and GECs, using drugs already approved by the FDA, can reduce both tumor size

13 olic pathway that can be targeted by new and already approved drugs to treat fragile X patients.

14 iral activity in the nonhuman primate models already approved for another indication or for which the

15 I discuss biologic agents already approved for the management of allergic and resp

16 degrees, including fungal chitosan, which is already approved for use in wines, is an efficient appro

17 Because suberoylanilide hydroxamic acid is already approved to treat cutaneous T-cell lymphoma, it

18 might act within the same pathways of genes already associated with central hypomyelination.

19 ations triggered by water scarcity, which is already associated with the large and rapidly growing po

20 c-wave amplitude in the CLN5 deficient mice already at 1 month of age, indicative of pathological ev

21 terns in children with allergy were observed already at 1 month of age, when the IgA antibodies are p

22 However, the BMI curves begun to diverge already at 17.8 years before expected symptom onset.

23 , which predicted overall and renal survival already at 3 months after the start of therapy.

24 Already at 6 weeks of age, expression of hepatic Dpp4 wa

25 will focus on those that hold promise or are already at an advanced stage of testing (OsPSTOL1, AVP1,

26 sess whether the trajectory to asthma begins already at birth and whether epigenetic mechanisms, spec

27 the mouse with a robust connection observed already at birth.

28 hysiological capacity, and consequently, are already at extinction risk under projected acceleration

29 CT scan is present or when the subjects are already at high risk.

30 However, some patients are already at low risk after baseline colonoscopy and the v

31 s especially relevant among children who are already at risk for diabetic nephropathy.

32 s show that the smoothness assumption breaks already at scales smaller than a tenth of the system siz

33 Already at steady-state conditions, tau-tg mice exhibit

34 ed IL-8 release in the lung epithelial cells already at subtoxic concentrations (1-10 mug/mL) but not

35 2 resulted in altered gene expression levels already at the haemangioblast stage, with transcription

36 , and predicting the long-term graft outcome already at the progenitor stage remains a challenge.

37 rp increase in sensitivity is likely present already at the second addition at room temperature.

38 Already at the second stage, the visual area V2, the com

39 of patients with elevated IOP (91%) had this already at the start of the uveitis.

40 r motivational effect on performance in ADHD already at this relatively young age.

41 of evolution when the translation system had already attained high fidelity, the correspondence betwe

42 Methods for quantifying cell numbers are already available (e.g., fluorescence in situ hybridizat

43 ization of widespread gain signals affecting already available cognitive processes underlies the matu

44 ming you have the phone and the software are already available).

45 Although much evidence is already available, much remains unknown.

46 sive anatomical and gene expression datasets already available.

47 summer temperatures in the northern GBR may already be constraining coral growth and reef resilience

48 , the tuning parameters of these neurons may already be established at the onset of visual experience

49 ampaigns necessarily vaccinate those who may already be immune.

50 supplied by Pockwock Lake that was found to already be operating at the upper limit of the recommend

51 dence was found that alveolar collapse might already be present in an early stage when there is only

52 ion abnormalities and airway remodelling can already be seen early in life and can increase in magnit

53 otion sickness suggest that we may, in fact, already be targeting the peripheral EVS.

54 hardware system with only 88 memristors can already be used for tasks, such as handwritten digit rec

55 While a large number of miRNAs have already been annotated, there may well be large numbers

56 hat other subunits of the AMPA receptor have already been associated with neurodevelopmental disorder

57 ng embryonic development and in addition has already been demonstrated in cancer cells.

58 pha/beta mediated nuclear import pathway has already been described for beta-DG, the intracellular tr

59 or the synthesis of deoxypolypropionates has already been described.

60 ng the design of PSMA radioligands that have already been developed?

61 Although the alpha-alkylation of ketones has already been established, the analogous reaction using a

62 hene originated from the Pauli blocking have already been exploited for mode-locking device applicati

63 he genome sequences of eight aspergilli have already been explored to investigate aspects of fungal b

64 ation and properties of linear ratchets have already been extensively explored.

65 Twenty-seven genes have already been linked to primary lymphedema, either isolat

66 e the potential to replace neurons that have already been lost and thereby to restore visual function

67 sition of the western boundary currents have already been observed, and the consequences of such chan

68 cations, and the first clinical studies have already been performed in the setting of hematological m

69 tions of randomisation and intervention have already been reported.

70 IsoMut has already been successfully applied in multiple recent stu

71 f anti-HIV-1 antibodies; a strategy that has already been successfully applied to other IgG-based the

72 Indeed, HSA has already been successfully used for the delivery of small

73 Inhibitors to FLT3 have already been tested in clinical trials, however, drug re

74 The NCI SEER and Alliance data have already been thoroughly vetted.

75 sult in imprisonment for someone who had not already been to prison or who was not on parole.

76 rsity of Maine Climate Change Institute, has already been used to shed light on our flawed understand

77 As I review here, this approach has already been used to test ideas of patterning, different

78 interaction between phages and bacteria has already been well described, it only recently emerged th

79 notype, with massive immune cell infiltrates already before birth.

80 cipants with high-density EEG, we show that, already before the presentation of a critical word, cont

81 s established early during leaf development, already before the typical pavement cell shapes emerge,

82 s heralds a revolution in diagnosis, and has already begun to inform increasingly targeted and indivi

83 Importantly, these connections are already being exploited to treat patients with dozens of

84 reas, in which endothelial autophagy flux is already blocked.

85 were diploidized with ancestral tetraploidy already blurred.

86 MCC components, but cannot reactivate APC/C already bound to MCC.

87 on with chemical and genetic approaches, has already brought to our current understanding of the ribo

88 ies can neutralize free virus and kill cells already carrying the virus.

89 ATION: These experiments show that cytokines already clinically used in other conditions offer the pr

90 l at water resource recovery facilities that already combust anaerobic digester biogas for energy sin

91 n about the response to DSBs once cells have already committed to mitosis.

92 spite the addition of a new primer set to an already complex assay, no significant increase in assay

93 haea, indicating that the archaeal host cell already contained many key components that govern eukary

94 st that the transcriptome of precursor cells already contains the genes necessary for cellular differ

95 Psychologists already contribute to individual-level behavior-change c

96 stallographic data for molecular replacement already converges in 1,000-10,000 diffraction patterns,

97 er plasma technology can be successful in an already crowded arena.

98 f LoxP recombination in mice that inherit an already deleted LoxP allele in trans A similar phenomeno

99 epigenetic mechanisms in childhood asthma is already demonstrable at birth.

100 her number of RTIs in the first year of life already demonstrate an aberrant microbial developmental

101 Ice-free cryopreservation (IFC) already demonstrated matrix structure preservation combi

102 Several clinical trials have already demonstrated that combinations of nonchemotherap

103 tified eight mutations that do not match the already described mutations influencing the host range.

104 tion in organ-transplant recipients who have already developed posttransplant skin cancer has not bee

105 antiparkinsonian benefit in patients who had already developed side effects from their long-term use

106 sion (569 newly diagnosed and 1,103 patients already diagnosed with arterial hypertension) were inclu

107 triking phenotypes: anthocyanin accumulation already displayed 4 weeks after inoculation and shoot bi

108 no longer shielded by host membranes and are already displaying ubiquitin, suggesting that LUBAC ampl

109 bearing animals enhance metastatic growth of already disseminated tumour cells.

110 re resistant species like S. siderea are not already dominant.

111 tantial evidence for extensive Cu metallurgy already during these early cultures.

112 y to undergo large conformational changes is already encoded by passive mechanics of the individual e

113 s that the first animal, the Urmetazoan, was already endowed with neurosecretory cells that probably

114 , and several MNP-based anti-infectives have already entered phase 1, 2, and 3 clinical trials, with

115 cing area of translational research that has already entered the clinic.

116 the newly developed coating was compared to already established coatings based on different polymers

117 st to the relative directing group abilities already established for the six-membered ring system (NH

118 57 (likely) pathogenic variants in 50 genes already established in neurodevelopmental disorders (46

119 otides in wild-type animals with GN reversed already established proteinuria, diminished tissue infla

120 with their emergence from a viral population already established there, perhaps from early disease.

121 azil, South Africa, and Thailand, which have already established viral load programmes.

122 deterioration of sleep physiology, which is already evident at the stage of mild cognitive impairmen

123 This early pattern of Abeta accumulation is already evident in individuals with normal Abeta42 in th

124 y derived from bacterial precursors that had already evolved a wide range of cytoskeletal functions.

125 Droplet microfluidics has already evolved into a complex field.

126 notion being that the enzymes involved have already evolved towards optimal performance.

127 Israel has already exceeded the developed regions' Sustainable Deve

128 sive galaxies were extremely compact and had already exhausted their fuel for star formation.

129 nosed in the chronic phase of Chagas disease already exhibit heart involvement, and there is no vacci

130 origin, as the earliest recognized examples already exhibit many of the specializations present in m

131 This shows that sophisticated eyes already existed at the beginning of the fossil record of

132 ulations have shown the ability to reproduce already existing 'experimental models', which in turn, h

133 rbate low soil water availability in regions already expected to suffer from negative direct impacts

134 an acidification on an upwelling system that already experiences inherently low pH conditions, the Ca

135 mately 20 Hz with surface electromyogram (as already extensively reported) but also with contraction

136 Established home monitoring technology is already facilitating early detection and improved visual

137 Already films with 60 microm-thick scattering layer feat

138 isomal matrix proteins is that it can accept already folded proteins as substrates.

139 th de novo tumour formation and expansion of already formed tumours in mice.

140 esis that forest loss is most detrimental in already fragmented landscapes.

141 ing that mutation drives GC content lower in already GC-poor regions, and using our precise context-d

142 Here, we used AML cells that already had low PU.1 levels and further inhibited PU.1 u

143 Despite the impact it has already had on the fields of cardiac arrhythmias and who

144 uters, with the "big data" revolution having already happened in genomics and environment, and eventu

145 how that stage I lung adenocarcinoma lesions already harbor significantly altered T cell and NK cell

146 We review how molecular profiling already has led to an evolution in the classification of

147 While many species already have a well-defined and characterized miRNAome,

148 diagnosis, patients with Parkinson's disease already have a wide range of motor and non-motor feature

149 iverging land plants do not form lignin, but already have elements of its biosynthetic machinery.

150 CRISPR-Cas9 is already having a substantial effect on cardiovascular ba

151 version for poliovirus types 1, 2, and 3 was already high for the three IPV-Al vaccines after two vac

152 ntexts where overall testing and linkage are already high.

153 escent T cells after vaccination, which were already higher than those of young adults before vaccina

154 eported pyrazolo[5,1-c][1,2,4]benzotriazine, already identified as selective GABAA receptor subtype l

155 Targeted metabolomics methods have already identified new molecular markers and metabolomic

156 the impact of the highly significant factors already identified.

157 ailable data from several human pilot trials already identify target strategies that may maximize ant

158 es in a critical foundation species may have already impacted the intertidal community.

159 Because CMV already impacts on T-cell memory at a young age, we stud

160 ograde shear stress further deteriorates the already impaired endothelial function with attendant end

161 ied potentially pathogenic variants in genes already implicated in diverse language-related syndromes

162 in the field of quantum technologies and has already improved sensing capabilities in areas ranging f

163 Already in 1954 Gordon Allport stated that stereotypes m

164 Female-biased genes already in an active chromatin state in male liver gener

165 ystem of firms and showed that the system is already in an unstable monopoly state in which growth of

166 e some large European metropolitan areas are already in breach of EU safety limits for NO2, this phen

167 an that of many neurologic pharmacotherapies already in clinical use.

168 Thus, drugs and therapeutics already in development for targeting these retinopathies

169 ented independently of continuous magnitudes already in infancy, but is nonetheless more deeply conne

170 al compounds with low-risk profiles that are already in routine clinical use for other clinical indic

171 As NSAIDs are already in routine use in gynecological treatment regime

172 associated with multicellular systems arise already in small networks [1, 2].

173 mains debated whether such modulation occurs already in subcortical auditory structures.

174 hile its theoretical concept was established already in the 1950s and its contribution is commonly me

175 P < .001), over acute time-points, apparent already in the early febrile phase (1.29 vs 1.75; P = .0

176 cialized behavioral competences, originating already in the early postnatal phase.

177 ould select double mutants lacking the T-DNA already in the first offspring generation.

178 es likely catalysed many different reactions already in the last universal common ancestor.

179 could impair the intestinal mucosal barrier already in the seronegative phase of acute HIV infection

180 we demonstrate that two cardiotonic steroids already in use in humans, digoxin and digitoxin, are pot

181 that dyW-/- mice exhibit a myogenesis defect already in utero.

182 ory for GWAS data and summary statistics and already includes published data and results from several

183 When commenced in already insulin autoantibody(+) NOD mice, continuous BAF

184 beetle from regions of the world that it has already invaded.

185 d sizes evaluated were within the parameters already investigated within the clinic for DC Bead.

186 randomized clinical trials to update what is already known about specific treatments in cardiovascula

187 C-C to a C-O bond formation, contrary to the already known alkylations of such ambident nucleophiles,

188 We also discuss in the context of what is already known and newly defined signaling pathways that

189 ndependently discovered that FtsZ, a protein already known as a key player in bacterial cytokinesis,

190 irmed that the isolated FaEO consists in the already known isoform and that it is the most characteri

191 e survival of A. baumannii in NHS, including already known serum resistance factors, and many novel g

192 These include genes already known to mediate EGFR inhibitor resistance as we

193 Some of these problems were already known to the authors of the minimizers technique

194 , leaves of da1-1 and bb/eod1-2 mutants were already larger than the isogenic Col-0 wild type, but th

195 stimulus during subsequent re-learning, and already late during initial acquisition.

196 ively employed in drug discovery, and it has already led to the discovery of two FDA-approved (antivi

197 With three biosimilars already licensed and numerous development programs under

198 des, primarily in deeper beds where light is already limiting.

199 Consequently, geographic diversity-already low in 1985-remained unchanged through 2014.

200 beta1-beta2 hairpin, previously shown to be already lowly populated in the urea-denatured state.

201 ited fluorescence microscopy techniques have already made a substantial imprint in the biological sci

202 hea, and chlamydia, for which the USPSTF has already made specific recommendations.

203 ulations is still in early stages, there are already many examples of novel and African ancestry-spec

204 prove health outcomes in individuals who are already marginalised.

205 For AE = Ba and Sr, the materials are already marginally metallic at P = 1 atm and the combina

206 that corneal epithelial super enhancers are already marked as potential regulatory domains in embryo

207 Our data suggest that mutated desmin already markedly impedes myocyte structure and function

208 s were measured in adult MVMs, most of which already meet RDAs.

209 the ensemble level, where local elements are already merged into global representations.

210 ites of a bladder cancer patient (i.e. cells already migrated outside primary tumor).

211 (mAbs) targeting Notch protein activity have already moved into clinical trials.

212 that precise fine-tuning of conduction along already-myelinated axons may also be mediated by alterat

213 t they predicted an event that they actually already observed are also more likely to report holding

214 ls in T cell-specific A20-deficient mice was already observed in CD4(+) single-positive CD25(+) GITR(

215 al pathways of viral evolution, beyond those already observed in natural infections, and may help pre

216 t that the majority of infections had likely already occurred when the investigation began and that e

217 le under conditions where loss of health has already occurred, and in doing so tissue homeostasis can

218 graft rejection after significant injury has already occurred, fail to detect chronic subclinical inf

219 that Lep-MAP3 obtains very good performance already on 5x sequencing coverage and outperforms the fa

220 ple where roots act as the "sampler' and are already onsite.

221 demic strained health systems in west Africa already overburdened with other diseases, including mala

222 with FMD undergo intracranial imaging if not already performed.

223 population aged under 65 years, and were not already planning to administer the high-dose influenza v

224 imilar, indicating that the genetic loci are already poised to transcribe these novel RNAs.

225 tion with others early: Infants and toddlers already possess basic skills to help others and share re

226 at types of defense mechanisms a plant would already possess to defend against a potential pathogen t

227 sregulated in IDC and that these changes are already present at the DCIS stage.

228 lso binds with, and regulates, K(+) channels already present at the plasma membrane to affect K(+) up

229 ll and in the ASCVD cohort, such a trend was already present before publication of the guideline.

230 gle viral variants from minority populations already present before therapy initiation.

231 Liver cirrhosis was already present in 62 patients at first presentation.

232 e show that structure-independent processes, already present in bulk systems and demonstrably differe

233 dies suggest that homologous peroxidases are already present in mycetozoan eukaryotes such as Dictyos

234 how SWCNTs interact with chemicals that are already present in our aquatic environments, which is es

235 dial asynchrony required for EBW to occur is already present in some areas during SR.

236 revealed that an ancestral PIF-like gene was already present in streptophyte algae, i.e., before the

237 the identity and organization of structures already present in the environment.

238 state-dependent changes in neuronal activity already present in the MTL.

239 iously described limits and in some cases is already present in the optic lobe neurons of T. brassica

240 ate whether the contemporary HG strategy was already present in the Upper Paleolithic, we used comple

241 rimarily rooted in the short-range CDW order already present in zero field, not in the field-induced

242 ntial of PrP(C) deletion given that patients already present symptoms at the time of diagnosis.

243 temporal cortex, this proto-organization was already present, prior to the emergence of category sele

244 Already prior to TLR- or Ag-specific stimulation, CXCL4-

245 tures associated with twitching: Two TFP can already produce movements reminiscent of recently observ

246 nance spectroscopy has found widespread use, already profiling over 400,000 blood samples.

247 This unique observational sample has already provided concrete measurements on the coalescenc

248 Most of the new clones, all already provided with a genetic and sanitary certificati

249 Disparity selectivity has already reached a matured level before the monocular dep

250 ols represents an important reality that has already reached an evident degree of maturity, although

251 ring proton pump inhibitor treatment, or had already received more than one dose of acid suppression

252 e often referred for (18)F-FDG imaging while already receiving antibiotic treatment.

253 The relevance of these issues was already recognized in the 1970s when the need for specia

254 Such approaches have already refined our understanding of the alloimmune resp

255 d point, as higher concentrations are likely already regulated.

256 that altered neural processing of reward is already related to increased cortisol output and depress

257 lectrophiles-that substantially enhances the already remarkable utility of cross-coupling processes.

258 r mango volatile compounds, 10 of which were already reported as being potential key flavour compound

259 R 100-120 min (R(2) = 0.94), with 80-100 min already representing a reasonable compromise between dur

260 An overnight acquisition is already required to reach a quadrupole mass filter-like

261 MDR-TB was due to the recent transmission of already-resistant M. tuberculosis strains rather than re

262 all therapy cycles, whereas 40% of patients already responded after a single cycle.

263 ve SC neurons receive and find that they are already selective as a result of precisely converging in

264 y, the unloaded shortening velocity (V0 ) is already set at the end of latency relaxation (LR), appro

265 the actin filament under zero load, V0 ) is already set at the end of the latency relaxation (LR) pr

266 ggests that increasing typhoon frequency has already shifted ecosystem structure and function (declin

267 dog skulls show unique (neomorphic) features already shortly after birth, and these features persist

268 However, human fetuses already show considerable asymmetries in arm movements b

269 tnatal day 180 (P180), FF and S NMJs of SOD1 already showed, respectively, lower and higher quantal c

270 eral wild relatives of tetraploid wheat have already shown a significant drought tolerance.

271 We found that as already shown for oAbeta, also oTau can bind to amyloid

272 Creating an Area II-deleted state within already specified Neurog3-expressing endocrine progenito

273 cillus subtilis, on the fate of pristine and already sulfidized Ag-NPs.

274 hese aspects include information on the time already survived by the patient and the patient's surviv

275 sensitive cash transfers was poor households already targeted by countries' established poverty-reduc

276 Having already the data acquired (1D/2D NMR and RDCs), the proc

277 rtain parts of the DMN in preclinical AD and already then affect brain connectivity.

278 Given that already there are rapid declines of many populations of

279 f southern California, and sensitive habitat already threatened by eustatic sea level rise.

280 Rotary has already transitioned its grants program to include 6 are

281 bsence of myocardial dysfunction (2D) if not already tried; 5) in patients with cardiac arrest, we re

282 gies, and for enhancing adaptive capacity to already unavoidable climate change.

283 hat COR15A starts to fold into alpha-helices already under mild dehydration conditions (97% relative

284 uently acquired expression changes in miRNAs already undergoing dynamic expression modulation during

285 ogy in addition to genomics studies that are already underway.

286 he general genetic genealogy community, have already used DNA Compass, demonstrating its utility.

287 ombining an enzyme analysis method, which is already used in clinical practice, with electrochemical

288 These antioxidant drugs are already used in humans for other therapeutic indications

289 inhibitors of infection, including compounds already used in humans.

290 ch allows us to leverage existing approaches already used in k-mer analysis to identify enriched moti

291 and transcervical Foley catheterisation-are already used in low-resource settings.

292 nvironmental exposure chambers are currently already used in phase 2, 3, and even 4 trials.

293 Many respondents indicated that they were already using ATS, or believed that ATS were already via

294 s have limited cerebellar resources that are already utilized for single tasks and, for dual tasks, c

295 ies with specificity for many other antigens already validated as targets for IgG suggest a wide pote

296 These results extend the scope of the already very versatile Suzuki-Miyaura reaction toward th

297 already using ATS, or believed that ATS were already viable approaches, for toxicological assessment

298 Already, we demonstrate their existence in six separate

299 Hence, PPI networks are already well investigated by current aligners, so to gai

300 of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and