ライフサイエンスコーパス: already-known

1 stantial number of operons in the genome are already known.

2 e interaction sites for interaction partners already known.

3 through cGMP phosphodiesterase activation as already known.

4 rocess by linking new information to what is already known.

5 unction where sequence or fold similarity is already known.

6 wards Persei) where the electron fraction is already known.

7 emical and physical properties of structures already known.

8 rd cell ion channels and their regulation is already known.

9 tween the reticulocyte isoforms and the ones already known.

10 lies in which the actual molecular defect is already known.

11 , as well as the pseudouridine synthase, are already known.

12 egions, but this limits the study to what is already known.

13 negative inhibitor of the c-Myb protein was already known.

14 st data sets, for which expected results are already known.

15 ough the basic facts about the ribosome were already known 40 years ago, elucidating its atomic struc

16 ues in the homologs, are compared to what is already known about functionally important residues in t

17 In addition to organizing what is already known about human aggression, this review, using

18 Hopefully, what is already known about IFN will prompt further exploration

19 randomized clinical trials to update what is already known about specific treatments in cardiovascula

20 According to what is already known about the market demand for over-the-count

21 ained by adding neutral evolution to what is already known about the mutation process.

22 Our model is consistent with what is already known about the regulation of CDK and PP2A:B55de

23 ne defects, respectively, adding to what was already known about the validity of contrast enhanced sy

24 ved ncRNA genes in CLL, highlighting what is already known about their function, proposing a novel mo

25 C-C to a C-O bond formation, contrary to the already known alkylations of such ambident nucleophiles,

26 More than 60 DUBs are already known, although little is known about their biol

27 al-world graphs whose community structure is already known and find that the method detects this know

28 We also discuss in the context of what is already known and newly defined signaling pathways that

29 al added value of new research given what is already known, and to encourage those conducting researc

30 ndependently discovered that FtsZ, a protein already known as a key player in bacterial cytokinesis,

31 Already known as a receptor for endogenous molecules, CD

32 art of the 70 S ribosome, whose structure is already known at a better resolution.

33 Two sites appear as outstanding: One is the already known binding pocket of 2GBI, which is accessibl

34 stulated mechanism not only explains what is already known but also suggests that other products and

35 A plant peroxisomal CoA transporter is already known, but plant mitochondrial or chloroplastic

36 rting point, identify 59 RLPs, including the already known CLAVATA2 and TOO MANY MOUTHS genes.

37 gens is often constrained by the analysis of already known compounds, there is a need to identify new

38 family and adds specific prenylation to the already known determinants of Rab localization.

39 he extreme end of the phenotypic spectrum of already known disorders.

40 se in vitro data are taken together with the already known effects of cholesterol 5,6-secosterols on

41 ptidases that are simply species variants of already known enzymes from those that represent novel en

42 respectively); three of these compounds are already known experimentally to be ferromagnetic semicon

43 Cutaneous malignant melanoma (CMM), already known for its highly aggressive behavior and res

44 This family of molecules, already known for its key metabolic functions, has been

45 Already known for its role in nictitating membrane respo

46 o immune clearance in an ESBL E coli lineage already known for its virulence is an unsettling develop

47 We showed that in addition to the properties already known for LEDGINs, the binding of tBPQAs to the

48 Cyclodextrins are already known for their ability to encapsulate various d

49 f these new epitopes in the context of those already known for VACV in mice and humans revealed two i

50 In addition to confirming genes that were already known from mGWAS, we were able to identify and v

51 Here we consider broadly what is already known from non-NGS studies about thermal adaptat

52 inor events: wording in the report, findings already known from patient history or prior imaging or c

53 proved successful in both reconstructing the already known functional domains and in identifying the

54 are signaling centers, in addition to their already known functions in the mechanics of vertebral co

55 While four PIGs are identical to already known genes (pfeR, pvdS, tonB, and fumC, respect

56 Results obtained to date partly confirm already known genetic vulnerabilities, but also point to

57 IC in the wild-type strain, including three already known IC-repressed genes.

58 There are few methods already known in the literature to make these molecules;

59 ed regions in RecQL5 as KIX and SRI domains, already known in transcriptional regulators for Pol II.

60 utomatically discovered 28 TIs (some of them already known) in five different symmetry families.

61 acetyl-trytophan (IA-Trp) in addition to the already known indole-3-acetyl-aspartic acid (IA-Asp) and

62 irmed that the isolated FaEO consists in the already known isoform and that it is the most characteri

63 data demonstrate that, in addition to these already known mechanisms, MT1-MMP is regulated by O-glyc

64 dard invertebrate code as well as confirming already known metazoan deviations from it (ascidian, ver

65 Several major improvements of the already known methods to build up such chiral backbones

66 ds (+/-)-19, (+/-)-20, and (+/-)-21 and two (already-known) monosubstituted C1-symmetrical TBTQ analo

67 e extract the values of these exponents from already known numerical or theoretical results, and we n

68 ue cDNA fragments encode genes/ESTs that are already known, of which only two have been mapped to thi

69 3 years with particular reference to what is already known on this topic.

70 tes were insignificant, as the diagnosis was already known, or they were considered colonizers/contam

71 rug-associated hemostatic complications, the already known pathogenetic mechanisms involved, and the

72 terns cannot be represented or understood by already known patterns of sperms or other micro-swimmers

73 Together with already known phenolics, including caffeic acid, p-couma

74 activating gene 1 (RAG1), in addition to the already known phenotypes of SCID and Omenn syndrome (see

75 wing from the thoracic notum as well as the already known pleural elements of the arthropodan leg.

76 elation-based computation, based directly on already-known properties of V1 neurons, can account for

77 Similarly to the already known Q10 parameters for temperature, accelerati

78 ment and poor long-term outcome and confirms already known risk factors for poor prognosis.

79 independent ncRNA genes besides homologs of already known RNAs.

80 Among the already known RO membrane fouling mechanisms, a novel RO

81 Beyond the already known role of macrophages as pathogenic effector

82 e survival of A. baumannii in NHS, including already known serum resistance factors, and many novel g

83 This accomplishment, together with the already-known single-input gates (performing as YES and

84 ies of bR(570) and M(412), together with the already known spectroscopic properties of the different

85 se that COFS syndrome be included within the already known spectrum of NER disorders: XP, CS, and tri

86 oach can identify etiological links that are already known (such as between fetal hemoglobin and mala

87 It is based on the already known technique where sulfur is used as a natura

88 This is in contrast with already known techniques which rely on interactions with

89 ed to encode four of these enzymes and it is already known that one of these, LOX2, is dispensable fo

90 enes whose time of replication in S phase is already known, the presence of a cell in early or late S

91 If the tree topology is already known, then seven leaves suffice for identifiabi

92 While many of the loci involved are already known, these conditions remain incurable, and ge

93 sions, 8-oxoguanine and thymine glycol, were already known to activate repair in irradiated mammalian

94 gnificance level of 5 x 10(-8) including six already known to associate with VTE (ABO, F2, F5, F11, F

95 Many of these transcripts were already known to be abnormally expressed in neoplastic t

96 with MS and healthy control subjects and is already known to be associated with brain substructure v

97 ared only by the MDR and XDR genomes and not already known to be associated with drug resistance.

98 mmary and the expression levels of genes not already known to be associated with the pathway provide

99 ponse, measured in the mesoscopic regime, is already known to be conditioned or renormalized by therm

100 lates a number of genes in addition to those already known to be controlled by MarA.

101 Besides genes already known to be directly under the control of Spo0A-

102 38 "candidate EDA targets", 14 of which were already known to be expressed in hair follicles or epide

103 The data set also contained 2 genes already known to be expressed in the aorta, elastin at 5

104 Methylglyoxal is already known to be generated by carbohydrate and lipid

105 If so, then M(1)dG, already known to be highly mutagenic in human cells, als

106 g the Grainyhead factor Get1/Grhl3, which is already known to be important for epidermal barrier form

107 tein kinase intracellular signaling pathways already known to be important for neoplasia.

108 avioural differences within a population) is already known to be important in group interactions.

109 TRX2 is already known to be induced by oxidative stress dependen

110 AFI genes, gadA, gadX, gadW, and gadE, were already known to be involved in an acid resistance syste

111 9% (19 of 39) of X-chromosomal PSD genes are already known to be involved in human psychiatric disord

112 In addition to two enzymes already known to be involved in its biosynthesis (homoge

113 In addition to identifying genes already known to be involved in leg development, we iden

114 This screen indeed identified 13 genes, some already known to be involved in longevity, plus candidat

115 helial Krts, Krt6a and Krt6b; and Tgm 1 were already known to be involved in nail abnormalities when

116 Although some of the genes were already known to be MarA regulated, the majority were ne

117 Thus Avy expression, already known to be modulated by imprinting, strain-spec

118 re region in the minimal left-end origin not already known to be occupied by NS1.

119 Some of the genes identified are already known to be overexpressed in ovarian cancer, but

120 nd antiapoptotic pathways, some of which are already known to be regulated by NS5A.

121 Many of these genes were already known to be regulated by particular transcriptio

122 and sequencing of the same gene or of genes already known to be regulated in the system of interest

123 d genes including some novel as well as some already known to be relevant to bone metabolism.

124 including multiple protein products of genes already known to be responsible for renal and systemic d

125 nels other than the TRPV1 and TRPA1 channels already known to be targets in rat and mouse sensory neu

126 gene may be responsible for both conditions, already known to bear clinical resemblance.

127 Although BAFF is already known to bind two receptors, BCMA and TACI, we h

128 Even if a gene has variants already known to cause a disease, rare disruptive varian

129 ctors, of which some may be related to genes already known to cause the phenotypically related Mendel

130 STAT1 and STAT2 are already known to combine with p48, a DNA-binding protein

131 tent to which whole-gene lateral transfer is already known to confound evolutionary reconstruction.

132 1) and its G-protein-coupled receptor CXCR4, already known to control many types of normal and pathol

133 bited some of the structural characteristics already known to demonstrate this activity, all of them

134 The guidance molecules Semaphorin 3A and 3F, already known to direct oligodendroglial migration in de

135 re we show that proximal regulatory elements already known to direct promoter activity in T cells are

136 on to increased implementation of strategies already known to effectively prevent and manage acute di

137 here classical singular spectrum analysis is already known to fail dramatically.

138 ng of the roles of miRNAs in EMT, which were already known to form important regulatory loops with ke

139 ndings reveal new properties of this protein already known to function as a circadian photoreceptor a

140 genes were identified, several of which were already known to function in chromatin modification and

141 ralizing antibodies [Abs]); some of them are already known to hamper HBsAg recognition by humoral res

142 HIV-1 is already known to have an extremely fast mutation rate, b

143 unction to a given list of genes (the query) already known to have closely related function.

144 mologs of the components of this pathway are already known to have key roles in cell motility and int

145 cle)), orbiting the star Kepler-20, which is already known to host three other, larger, transiting pl

146 Two mutations already known to inactivate the F(1)F(0) ATP synthase co

147 as well as how Mycobacterium tuberculosis is already known to influence various other cell signaling

148 it diaphragm linker protein MAGI-1, which is already known to interact with several critical podocyte

149 These include genes already known to mediate EGFR inhibitor resistance as we

150 orphan G protein-coupled receptor, which are already known to modulate cell migration.

151 A number of eukaryotic proteins are already known to orchestrate key steps of mRNA metabolis

152 orted by triple evidences, including 6 genes already known to perform specific roles in RA and 6 gene

153 functions; some of these have family members already known to phosphorylate microtubules, actin or th

154 A gene already known to play a crucial developmental role in ch

155 avefront model in which oscillator coupling, already known to play a key role in oscillator synchroni

156 This cluster includes 56 of 115 genes already known to play roles in stationary phase.

157 used on Amborella trichopoda, because it was already known to possess one horizontally acquired gene

158 ts whose diagnosis, therapies, and course is already known to predict not only disease severity, but

159 C2 of the substrate to C3 of the product is already known to proceed intramolecularly with retention

160 icoid-induced leucine zipper protein (GILZ), already known to regulate effector versus regulatory T c

161 s revealed mutations in MIG1 and REG1, genes already known to regulate glucose repression, as well as

162 components of a histone deacetylase complex already known to repress early meiosis-specific genes in

163 e following intranasal immunization (a route already known to result in high-level systemic anti-TTFC

164 n-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed as

165 Some of these problems were already known to the authors of the minimizers technique

166 FAT2, ZNF750 and KMT2D, in addition to those already known (TP53, PIK3CA and NOTCH1).

167 bout the underlying mechanisms for novel and already known trait loci.

168 phobic surface properties, compared with the already known vertebrate beta-defensins.

169 ell epitope prediction programs can identify already known viral epitopes of FMDV in the context of t

170 The analysis identifies already known warheads but also reveals hydrazide, pyraz

171 veral HLA-A2-restricted HCV CTL epitopes are already known, we aimed to identify CTL epitopes restric

172 man traits for which the causal variants are already known, we successfully placed the known causal v

173 rom those groups in which the phenomenon was already known, we suggest that state-dependent valuation

174 domain, whose three-dimensional structure is already known, will facilitate future drug development s

175 The already known X-ray structures of lipases provide little