ライフサイエンスコーパス: alter

1 Ca(2+)- or Na(+)-handling proteins were not altered.

2 MPA significantly altered 35 proteins mainly related to nucleotide-depende

3 The same peptides significantly altered a nicotinic receptor induced behaviour in C. ele

4 In polyploid species, altering a trait by random mutagenesis is highly ineffic

5 s (histone deacetylases) can be modulated to alter acetylation of nonhistone proteins during an immun

6 Therefore, any observations of altered adipose tissue insulin sensitivity with extended

7 These results suggest that altering ADP inhibition may be a mechanism of Hsp90 regu

8 stigate sex differences in LV mechanics with altered adrenergic stimulation achieved through post-han

9 ghtning strikes are known to morphologically alter and chemically reduce geologic formations and depo

10 How cortical circuits are altered and contribute to the intense sensation associat

11 Equi-osmotic sorbitol did not alter any variable.

12 se formation in these fish was significantly altered as a result of delayed AChR expression.

13 for childhood or current pet keeping did not alter associations with allergies.

14 ns indicated that the E46K mutation does not alter aSyn protein turnover.

15 Of these, 176 proteins were altered at least 1.5-fold (p-value < 0.05) in abundance

16 ful delivery and uptake in cells resulted in altered ATP levels, decreased glycolytic flux, Nrf-2 and

17 several properties, including the ability to alter bacterial biofilm formation.

18 terone, estrogen, and hydrocortisone did not alter basal CatSper currents, whereas the neurosteroid p

19 ame redox transformations can occur, causing altered behavior and effects compared to the pristine NP

20 ailability and we hypothesized that this may alter biodiversity-invasion relationships.

21 is brain effect to trait anxiety and acutely altered bodily sensations-both of which are known to be

22 her this relationship remains reliable under altered brain states associated with acetylcholine (ACh)

23 rders of various etiologies, yet its role in altering brain function as a consequence of neuroinfecti

24 e amplitude modulation was not significantly altered by head-on-trunk position, but the phases shifte

25 B-rearranged neoplasms has been dramatically altered by imatinib.

26 "immutable" time (which cannot plausibly be altered by interventions under study) varies by day, wee

27 es and females and were not sex-specifically altered by letrozole, the findings suggest sex-specific

28 th America and has potential to dramatically alter C cycling and accumulation in these ecosystems.

29 Our results demonstrate how stress alters CA1 circuit function through the impairment of en

30 de range of concentrations in the absence of altered caffeine sensitivity as well as increased Ca(2+)

31 n-of-function experiments show that Pth4 can alter calcium/phosphorus levels and affect expression of

32 enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis.

33 nnels in non-CAD versus CAD, resulting in an altered capacity for vasodilation during disease.

34 intrinsic cardiac nervous system neurons and alter cardiac repolarization.

35 Here we studied how this mutation alters caveolin-1 function, using patient-derived fibrob

36 rogression, and tissue stiffness is known to alter cell behaviors including proliferation, migration,

37 This smaller pool of OPCs results from altered cell cycle and reduced cell proliferation.

38 We observed altered cell morphology and disrupted organization of F-

39 Finally, we show that USP36 down-regulation alters cell proliferation in human cancer cells by induc

40 cetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues.

41 developing vascular system of the brain, and altered cellular positioning.

42 ene revealed that in vitro SLC16A5-silencing altered cellular responses to cisplatin treatment, suppo

43 We explore the associations between altered cerebellar metabolite profiles and brain injury

44 ion in cell-free membrane patches and showed altered channel gating and current flow through open cha

45 infection of ESC impairs decidualisation and alters chemokine release.

46 assify TFs by their differential capacity to alter chromatin and promote expression.

47 gests that CNVs may repress recombination by altering chromatin structure in meiosis.

48 ess CLCb, exhibit increased rates of CME and altered clathrin-coated pit dynamics.

49 sed at lower levels than AaCCA1, which could alter clock output traits.

50 rs11161721 is significantly associated with altered COL24A1 expression.

51 administration in FAP patients significantly altered colorectal stem cell dynamics, which might expla

52 Specifically, we observed dramatically altered community composition and function after tooth l

53 atively, remaining mutualists may respond to altered competition by reducing the breadth or intensity

54 , these differences were correlated with the altering concentration of calcium and sulfur.

55 unclear whether this difference is due to an altered conformation upon RNAP binding or to differences

56 There is gathering consensus that altered connectivity is a hallmark of the autistic brain

57 These changes are associated with altered cortical myo-inositol and glycine levels, sugges

58 al influence on infectious disease patterns, altering density of pneumococcal nasopharyngeal carriage

59 ion of EP300-ZNF384 and CREBBP-ZNF384 fusion altered differentiation of mouse hematopoietic stem and

60 utions, affecting annual/seasonal cycles, or altering disease incidence and severity.

61 to both non-familial and familial NSCLP and altered DNA methylation may be a second hit contributing

62 ociated with Se-induced oxidative stress and altered dopaminergic neurotransmission in the brain.

63 ing evidence that brain-gut interactions are altered during development of inflammatory bowel disease

64 such extremes and climate regime shifts may alter ecological communities have rarely been demonstrat

65 re is an essential Earth system process that alters ecosystem and atmospheric composition.

66 AnkG did not alter ENaC delivery to the membrane from biosynthetic pa

67 f BCO2 causes dysfunctional mitochondria and altered energy metabolism, which further leads to system

68 mutations may provide a useful strategy for altering epigenetic landscapes in organisms where histon

69 MSI2 alters ESR1 by binding specific sites in ESR1 RNA and by

70 Several new biomarkers were identified with altered expression in aneuploid cells, including overexp

71 d repression of the SHH pathway, as shown by altered expression levels of several target genes.

72 l studies as one of a handful of genes whose altered expression levels or allelic variations are asso

73 ranscriptome and m(6)A-seq analyses revealed altered expression of certain ALKBH5 target genes, inclu

74 e from gestational day 7 to postnatal day 21 altered expression of genes and transcription factors an

75 Metabolite disruptions were not explained by altered expression of genes associated with the PG or tr

76 SCC is genetic instability, which results in altered expression of genes located in amplified/deleted

77 nduces global changes in DNA methylation and altered expression of metabolism-relevant genes.

78 ontrols, and performance was associated with altered expression of proteins regulating GABAergic and

79 Furthermore, the linkage of LSD1 to an altered expression pattern of lung-lineage specific tran

80 t diversified throughout the Cretaceous also altered fire behaviour, which should link more strongly

81 This is because the mechanism of altering focus, termed accommodation, is not fully under

82 ve implications for our understanding of how altered folate availability causes human diseases such a

83 ellite cells, skeletal muscle stem cells, is altered following a burn injury and likely hinders regro

84 nticancer agent that selectively targets the altered form of mitochondrial energy metabolism in tumou

85 cinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with im

86 of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to asses

87 herapy regimens and to assess the benefit of altered fractionation within the context of concomitant

88 The mass-transport regime is altered from "linear" at very short time, where the ampe

89 na, absence of prominent aggregates suggests altered function as the likely cause of retinal patholog

90 of RCrusI in neurotypical humans resulted in altered functional connectivity with the inferior pariet

91 looded rice plants is controlled not only by altered gas diffusion but also by gravity and light.

92 hanges in the 3'UTR composition of mRNAs can alter gene expression by regulating transcript localizat

93 ntrast, deficiency of TUT4 and TUT7 does not alter gene expression in a variety of somatic cells.

94 analyses provide a high-quality resource of altered gene expression patterns under severe OXPHOS def

95 d as a critical control point in dynamically altering gene expression during stress or disease.

96 The synergy of diabetes and SM16 in altering gene expression was not observed in the lung.

97 d transcripts within it to show that editing alters gene expression by modulating translation (but no

98 tonin (5-HT) neuronal precursors, leading to altered global serotonergic neuroarchitecture and increa

99 e reduced glutamate receptor field size, and altered glutamate receptor composition.

100 6-phosphate transporter and characterized by altered glycogen/glucose homeostasis.

101 on by inducing dysbiosis and that the FODMAP-altered gut microbial community leads to intestinal path

102 bolites in both the intestine and plasma via altered gut microbiota composition.

103 Thus, ultrafine particles ingestion alters gut microbiota composition, accompanied by increa

104 Venous thromboembolism (VTE), caused by altered hemostasis, remains the third most common cause

105 ote that some facultative symbionts directly alter host thermotolerance.

106 slow, high-duty ratio, monomeric motor, this altered hydrolysis rate would reduce activity to extreme

107 immune activation in HIV-1+ infants did not alter IgA responses associated with protection from rota

108 Altered IgA recognition patterns in children with allerg

109 arcinoma (HNSCC) and biomarkers that predict altered immunity, thereby enabling personalized treatmen

110 functions, including the PI3K/mTOR pathway, altered in 60% of lines; BRCA DNA repair, 44%; and SYNE1

111 showed that JUN/FOS and FOXM1 activities are altered in almost all MM patients and identified two sur

112 n levels and colocalization with CAMK2G were altered in amygdala and mPFC of male mice.

113 eover, the nuclear localization of PINN-1 is altered in dapk-1 mutants.

114 ng has not been explored, nor whether ADS is altered in inflammatory pain conditions.

115 autoinflammation-associated H443P mutant is altered in interaction with SUG1 and ubiquitinated prote

116 ut half (60/110) and management was directly altered in nearly a quarter (26/110) of families based o

117 PFC spontaneous default activity is altered in neuropsychiatric disorders, including schizop

118 upregulated by mutated TP53, a gene commonly altered in ovarian cancer.

119 ors in adult rostral ventromedial medulla is altered in persistent inflammation.

120 summary, lipoprotein levels and function are altered in RRMS patients, especially in low-BMI patients

121 nuclear magnetic resonance spectroscopy was altered in septic patients.

122 and a major tumor-suppressor protein that is altered in several human malignancies.

123 agmented, cut, thinned, cleared or otherwise altered in structure, local climates and microclimates c

124 The leading molecular pathways altered in subjects with SZ involved mitochondrial energ

125 to neurotransmission and cell adhesion were altered in the brain of Crmp4-KO mice, mostly in a gende

126 cylic acid) response genes are significantly altered in the F1 hybrids relative to the parental lines

127 n addition, spikelet meristem determinacy is altered in the mutants, which produce two florets per sp

128 n to HIFs, multiple histone demethylases are altered in their expression and activity, providing a se

129 eby global and regional brain metabolism are altered in those with prolonged cannabis exposure.

130 Cell wall components are altered in transgenic plants.

131 manganese (Mn), a common dietary supplement, alters infection remain unexplored.

132 non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF.

133 IS treatment alters innate antimicrobial defenses and disrupts the gu

134 deacetylase, senses environmental stress to alter intestinal integrity.

135 he phagolysomal marker LAMP1; this signified altered intracellular trafficking and decreased degradat

136 cortex (ACx), and early auditory deprivation alters intrinsic and synaptic properties in the ACx.

137 me anxiety and differentiate between old and altered items during periods of threat.SIGNIFICANCE STAT

138 ion, or that conformational changes in KCNQ1 alter its interaction with KCNE1.

139 matically improve visuospatial perception or alter its tuning.

140 ntrol beta-synuclein (betaS) aggregation via altering its charge distribution, thus opening new possi

141 content in individual muscle fibres were not altered; (iv) the muscle proteome went through quantitat

142 Without exception, SMIT1 altered KCNQ ion selectivity, sensitivity to extracellul

143 n of woody deciduous shrubs in arctic tundra alters key ecosystem properties including carbon balance

144 t is unclear how changes in chromatin states alter kinetics of transcription.

145 introducing DA or GABA receptor antagonists alters kinship preference.

146 d water balance, but also have significantly altered land-atmosphere CH4 emissions for this region, p

147 bserved included the development of a porous altered layer, flow channeling, and increasingly limited

148 ally believed that RASopathies are caused by altered levels of pathway activation, the signaling chan

149 ical model to understand the significance of altered levels of SERCA, IP3R, and RyR on the intracellu

150 ing in elevated sphingolipid turnover and an altered lipid composition of both MAM and mitochondrial

151 ponse to acute cocaine administration and an altered locomotor sensitization profile, as well as incr

152 EP-dependent lung recruitment correlate with altered lung lining fluid composition independent of age

153 Climate change and ocean acidification are altering marine ecosystems and, from a human perspective

154 fects such as dislocations can significantly alter material properties and functionality.

155 As expected, LSD did not alter measured GFR and increased the abundance of total

156 cycling bipolar disorder is linked to highly altered membrane phospholipid metabolism.

157 pid serous ovarian cancer diagnosis based on altered metabolic signatures.

158 However, how this altered metabolism contributes to tumour metastasis rema

159 se expression and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemore

160 ress immunosuppressive cytokines and show an altered metabolism.

161 ch Mn(II)-phyllomanganate reactions may thus alter metal uptake by blocking key reactive sites.

162 Here we probe how the crystal packing alters microsecond dynamics, using solid-state NMR measu

163 ers, showed decreased complex I activity and altered mitochondrial network morphology.

164 e molecular clock regularly render mice with altered mood-associated phenotypes.

165 pecialization and their greater capacity for altering network states in response to multiple and dive

166 onomous clock properties, but rather through altered networking within the suprachiasmatic nuclei (SC

167 overy of molecular targets or compounds that alter neuronal function can lead to therapeutic advances

168 Epileptic seizures represent altered neuronal network dynamics, but the temporal evol

169 severe asthma, suggesting the presence of an altered neutrophil phenotype.

170 g that sensory experience during development alters nociceptive behavior and circuit physiology in Dr

171 mitotic reorganization of PCP proteins must alter not only proteins intrinsic to the dividing cell b

172 Recently, we showed an altered ocular surface homeostasis in unmanipulated NK1R

173 licing diversity leading to the formation of altered open reading frames (ORFs) that appear to be und

174 to traditional Fourier-based methods, which alter or destroy subtle waveform features.

175 ychiatric diseases that are characterized by altered or inappropriate neural function and behaviour.

176 mmune system occurs when the mannan layer is altered or removed in a process called unmasking.

177 tion of the larval stem cell niches, without altering other midgut cell types.

178 stabilized the wound microbiota, rather than altering overall diversity or relative abundance of spec

179 rophoblast barriers that had been exposed to altered oxygenation caused similar morphological changes

180 Our findings suggest that altered P2X7R function in heterozygote individuals distu

181 ding alteration and identify ten recurrently altered pathways, with associations between mutated gene

182 Parkinson's disease patients demonstrated an altered pattern of activation within the motor circuitry

183 tween mutant p53 and NFkappaB that underlies altered patterns of cancer-promoting gene expression.Inf

184 and variants E31A and E61A show dramatically altered pH sensitivity for fibril formation supporting t

185 or manipulate insect behavior and fitness by altering plant quality and defense.

186 hat AD-associated neurodegeneration links to altered PNS regulation during mental effort in older adu

187 iment to assess the influence of warming and altered precipitation on the temporal stability of plant

188 cts of climate change and deforestation have altered precipitation patterns in the Amazon.

189 polyoma virus middle T-driven tumors showed altered primary and metastatic profiles in previous stud

190 on in ONJ pathogenesis and help delineate an altered profile in wound-healing markers during ONJ deve

191 although we do not find evidence implicating altered proliferation in the rescue, we observe a signif

192 bryo transition by activating transcription, altering protein-coding sequences, producing noncoding R

193 tivity in the uterotrophic assay and did not alter puberty in male and female rats or mammary gland d

194 fied proteinogenic amino acids, which can be altered readily by site-directed mutagenesis and express

195 al GalNAc-T2 flexible linker constructs show altered remote prior glycosylation preferences, confirmi

196 Altogether, our data suggest that the altered response of B cells in tolerant recipients may c

197 These altered responses could be corrected in vitro by treatme

198 ay suggest that amygdalar rtfMRI-nf training alters responses to emotional stimuli in a manner simila

199 m6A can also alter RNA structures to affect RNA-protein interactions

200 posing Atlantic salmon (Salmo salar) parents alter selection pressures on their offspring with import

201 ht with a higher fluence rate also exhibited altered sensitivities to BL, further suggesting a connec

202 naling can proceed independently of Dapk1 or altered Ser-1303 phosphorylation.

203 ligand Sonic Hedgehog (SHH) and consequently altering SHH-guided neural cell-fate decisions.

204 cal strength of the powder-laden MNA did not alter significantly before and after more than two month

205 by the C-box YSY motif, which, when mutated, alters species stoichiometry and proteasome-dependent tu

206 rus strain that targets this splicing factor alters splicing of cell mRNAs involved in the maturation

207 Altered states of consciousness, such as psychotic or ph

208 with increase lateral PFC-STN coherence and altered STN neuronal spiking.

209 ling subtype, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE1, and a cortic

210 rearrangements in RNAi seeds resulted in an altered sulfur-associated metabolism, such as lower amou

211 The hybrid transcription factor SS18:SSX alters SWItch/Sucrose Non-Fermentable (SWI/SNF) chromati

212 weaker FC temporal similarity together with altered switching between FC states.

213 ole for HCN channels, given their ability to alter synaptic integration, in the expression of forelim

214 The ability to dynamically alter systolic function is significantly diminished, whi

215 We revealed that altering T-cell receptor stimulation influenced recruitm

216 Global environmental change is altering temperature, precipitation patterns, resource a

217 roliferation and neuronal differentiation by altering TGF-beta signaling.

218 n the protein scaffold in biology, which may alter the apparent DeltaDeltaGsc(o).

219 f successful, this program may significantly alter the current paradigm of AHF patient care.

220 distinct synaptic processes that profoundly alter the discharge rate and sensitivity of first-order

221 Climate change is expected to alter the distribution of tree species because of critic

222 lusion, insulin and glucose exposure acutely alter the DNA methylation profile of skeletal muscle, in

223 d not just thermodynamics, can significantly alter the efficiency of self-assembly in a biological co

224 vely inactivate the corresponding thiols and alter the electronic and physical properties of modified

225 standing how MkMPs target, deliver cargo and alter the fate of HSPCs is important for exploring such

226 voked NVC responses, indicating that ACh may alter the fidelity of hemodynamic signals in assessing c

227 at variations in dietary Na(+) intake do not alter the glomerular filtration rate but alter the total

228 hesion, we hypothesized that radiation could alter the glycosylation pattern of endothelial cells and

229 Antibiotic exposure can alter the gut microbiome.

230 How this may alter the outcome of disease remains to be determined.

231 le the variation of the side chains does not alter the photoconductive properties of GNRs, the edge s

232 trans addition of alcohols implies that they alter the planar membrane structure and thereby increase

233 These in turn alter the predicted mechanical response of the myosin in

234 ve attention and examine how these varieties alter the processing of stimuli by neurons within the vi

235 Binding by MAb 36D5 does not substantially alter the proportions of the two CD4-bound conformations

236 skin lipids and proteins, which may in turn alter the protective skin barrier function.

237 The majority of editing events alter the sequence of the 3'UTR of targeted transcripts,

238 ime, as epistasis and historical contingency alter the strength of selection on different genes.

239 alidated that this Ser-to-Arg mutation could alter the structure of the CDR3beta loop, as well as the

240 contrast, treatment with dynasore failed to alter the surface membrane expression of SK2 channels.

241 Beta-receptor blockade does not alter the tachycardia phase to low intensity VNS, but ca

242 ization of water within a binding pocket can alter the thermodynamics of protein-ligand association.

243 not alter the glomerular filtration rate but alter the total and cell-surface expression of major Na(

244 IVIG can alter the viability of human neutrophils via agonistic a

245 2,4-D but not IAA altered the actin structure in long-term and short-term

246 These demographic shifts have profoundly altered the coevolved relationship between host and micr

247 nnel binding and its effects on gating, also altered the conformational displacement between the VAMP

248 proteins like RING1A, RING1B, EZH2 and also altered the expression of proteins associated with the B

249 Human participants altered the learning rates used for the outcomes selecti

250 iconic predator-prey interaction and likely altered the many ecological functions that result from b

251 transporter substrate channel differentially altered the potency for individual URAT1 inhibitors.

252 PCs or overexpression in aCPCs significantly altered the quality of their secretome.

253 te analysis showed that echinocandin therapy altered the risk of clinical failure.

254 icrobial communities in the rhizosphere, but altered the soil communities where hybrid maize was grow

255 increasing the rate dramatically, as well as altering the apparent order of reaction.

256 ticularly active in lymphomas with mutations altering the BCR subunit CD79B and MYD88.

257 ectly or indirectly regulate their influx by altering the chemotactic milieu in the islets.

258 nanoparticles in the ITO counter-electrode, altering the optical extinction response.

259 ircadian pacemaker to its 24.84-h rhythm and altering the pacemaker's phase-relationship to sleep in

260 loop flexibility, their largest effect is in altering the solvent accessibility of the active site by

261 indirectly affect termination efficiency by altering the time window in which termination can occur.

262 on activity, we demonstrate that PNN removal alters the balance between inhibitory and excitatory spi

263 Here, we show that the behavioral state alters the baseline activity levels and the temporal tun

264 es the incorporation of Shs1 vs Cdc11, which alters the curvature of filamentous septin rings.

265 ines, we found that induction of cell stress alters the cytoskeleton in IECs via changes in the actin

266 ure of the nanophotonic system significantly alters the design criteria for the necessary conducting

267 to fundamental changes in the way attention alters the early cortical responses that support selecti

268 We revealed that DC3000 significantly alters the expression levels of 71% effector targets and

269 to urban living causes landscape changes and alters the functionality of soil ecosystems.

270 suggesting that the R753Q TLR2 polymorphism alters the functions of the myeloid differentiation prim

271 otoxin, and proinflammatory mediator, and it alters the integrity and cohesion of the blood-brain bar

272 ypothesis that extensive behavioral training alters the neural mechanisms that support selective atte

273 H2AZ and H3.3 and that depletion of Repo-Man alters the peripheral localization of a subset of these

274 n object in our hand, the mass of the object alters the physics of our arm, changing the relationship

275 hesis that cytosolic metabolite availability alters the response of isoprene emission to changes in a

276 Here we show that genetic knockout of Gsto1 alters the response of mice to three distinct inflammato

277 sm (rs16260) linked to increased cancer risk alters the secondary structure of the paRNA, with the ri

278 each extra layer of graphene can drastically alter their electronic and structural properties.

279 The redesign of enzyme active sites to alter their function or specificity is a difficult yet a

280 eriods of ECM detachment), cancer cells must alter their metabolism in a fashion that promotes surviv

281 production by attracting potential mates and altering their behavior and physiology.

282 sensitive Env glycoproteins, likely through altering their conformation.

283 We find that lysosome inhibition alters their mobility and also decreases dendritic spine

284 ents, small molecules, and host factors that alter these relatively conserved splicing patterns.

285 In contrast, Ang II did not alter total or surface KV 2.1, or KV 1.5 or KV 2.1 cellu

286 latory variants, of which at least six (35%) alter transcription factor-DNA binding in neuroblastoma

287 In both cases, altered transcription appears to be the progenitor, with

288 JQ1 alters transcription of genes controlled by the host pro

289 While altered TSPO binding or expression may indeed mirror ong

290 lated to tumor metabolic phenotype, and that altering tumor metabolism could change therapeutic outco

291 Although these processes alter tumour progression, their regulation is poorly und

292 ool to optimize the material bandgap without altering ultrafast photophysics is reported.

293 probe ([Fe(CN)6](3-)/[Fe(CN)6](4-)) that is altered upon binding of PSMA with PSMA-Ab immobilized on

294 tract infection-positive burn patients with altered urinary antimicrobial peptide activity developed

295 re and resulting high drug concentration can alter vascular transport rate constants along with havin

296 We then purposely altered water distribution and myofibrils shape by means

297 n, such as NOV and ST6GalNAc1, were markedly altered, which indicated reduced androgen action.

298 -dependent processes involved in release are altered with age.

299 ccurs, the quality and quantity of meibum is altered, with a negative impact on the ocular surface.

300 365, 368, and 373 exhibited a significantly altered ZO-1 interaction profile, while mutants with S r