ライフサイエンスコーパス: alteration

1 t 32% of brain tumors had at least one ctDNA alteration.

2 h as water content variations and permafrost alteration.

3 ctivation appear to be responsible for these alterations.

4 emodeling as well as extensive morphological alterations.

5 ancer hotspot mutations among the identified alterations.

6 with tumors bearing specific genetic driver alterations.

7 lmark of cancer and can be due to epigenetic alterations.

8 lectrophysiological, and synaptic plasticity alterations.

9 ons for patients harboring oncogenic genomic alterations.

10 ved conservation of the central pathogenetic alterations.

11 etrospectively for NOTCH1/FBXW7/RAS and PTEN alterations.

12 d into the current surgical workflow with no alterations.

13 hitecture, somatic mutations, and structural alterations.

14 was enriched in tumors with specific genetic alterations.

15 s by uncovering several novel driver genetic alterations.

16 tion with long-term behavioral and cognitive alterations.

17 eased mortality compared to patients without alterations (17.7%, 12.7%, 4.9%, and 5.8%, respectively;

18 Overall, 80% of patients exhibited ctDNA alterations; 66% (290/442) >/=1 characterized alteration

19 uals had at least one potentially actionable alteration (94.7%), with the median number of potentiall

20 irmed this prediction and also showed gating alterations, a reduced glutamate affinity associated wit

21 ects, and will highlight how these metabolic alterations affect malignant phenotypes.

22 work affecting multiple aspects of metabolic alterations after burn injury and as a novel potential m

23 vor the appearance of dystonia-like movement alterations after oxotremorine.

24 umors exhibit potentially actionable genetic alterations against which targeted therapies have been e

25 However, these alterations alone are insufficient for cells to acquire

26 Antibiotic inactivation, antibiotic target alteration and antibiotic efflux were the dominant resis

27 cribe new mechanisms of coding and noncoding alteration and identify ten recurrently altered pathways

28 a significant insight into understanding the alteration and role of MEG3 in nickel-induced lung tumor

29 hibitor response, including WNT/beta-catenin alterations and cell-cycle-gene (CDK4 and CDK6) mutation

30 Genetic alterations and genomic reprogramming underlie the innat

31 r heterogeneity for both somatic copy-number alterations and mutations.

32 ments with uneven distributions of oncogenic alterations and signaling networks.

33 Links between microbial alterations and systemic inflammation have been demonstr

34 Both alterations are also detectable in PDAC cell lines and p

35 These neural alterations are associated with habit learning and thus

36 DNA methylation alterations are hallmarks of CRC, and epigenetic driver

37 al treatment efficacy requires that targeted alterations are present in all tumour cells.

38 These findings suggest that network-level alterations are present in individuals with a first epis

39 These findings establish SETD2 alteration as a mechanism of resistance to DNA-damaging

40 Therefore, metabolic and immunological alterations associated with chronic oral corticosterone

41 ct on decision making, and identification of alterations associated with recurrent and metastatic dis

42 A similar alteration between the subcellular pools of the E2(WT) p

43 R111, and (18)F-AV45 all detected pathologic alterations between TG and WT mice, only (18)F-AV45 coul

44 sults show that m6A-dependent RNA structural alterations can promote direct binding of m6A-modified R

45 f the immune response to trauma, with immune alterations consistent with both activation and suppress

46 ein abundance, but the extent to which these alterations contribute to the expression of T helper (TH

47 nactivation of L-type Ca(2+) channels, whose alteration contributes to the dramatic disease Timothy S

48 hronize neuronal ensembles in the PFC, these alterations could contribute to deficits in behavioral c

49 These metal-induced alterations decrease RcnR-DNA binding affinity, leading

50 asthma or arthritis and seemed to be due to alterations during mast cell development as augmented ma

51 Proliferating cells acquire genome alterations during the act of DNA replication.

52 urther exacerbate loss of taxa and ecosystem alteration, especially in drying climates.

53 This study reveals distinct cingulo-insular alterations for FND and PTSD symptoms and may advance ou

54 by increased accumulation of DNA copy number alterations, greater genetic diversity and improved adap

55 In schizophrenia, brain-wide alterations have been identified at the molecular and ce

56 In contrast to fixed genomic alterations, here we show that GR-mediated antiandrogen

57 is associated with a large set of behavioral alterations; however, its motivational aspects remain po

58 adaptive changes can result from the drastic alterations humans impose on ecosystems.

59 9S/C162S mutants did not exhibit appreciable alteration in activating dual phosphorylation.

60 for Ube3A/E6AP in ASD-related developmental alteration in dendritic arborization and synapse formati

61 Is an alteration in early prediction abilities the common caus

62 h condition based on experimentally measured alteration in elastic fiber composition, alveolar geomet

63 ir possible role in phosphorylation-mediated alteration in enzymatic activity.

64 his mother detected a heterozygous c.305T>C alteration in exon 3, which causes a leucine to serine s

65 te that ovarian cancer exhibits a targetable alteration in iron metabolism.

66 ually important, OPPNs can cause significant alteration in physical appearance secondary to proptosis

67 e hypothesis that SIDS is associated with an alteration in serum 5-HT levels.

68 Our results suggest alteration in subthreshold voltage-activated currents mi

69 ifferent transcriptional signatures imply an alteration in the mode of action under combined stresses

70 This phosphorylation-dependent alteration in the PDZ domain-ligand interaction was expl

71 in the sediment element composition and the alteration in the plant growth.

72 ed to extract a snapshot of tumor-associated alteration in the serum.

73 pendently associated with a higher number of alterations in a multivariable analysis (P = 0.019).

74 let size, increased basal lipolytic rate and alterations in adiponectin and leptin secretion.

75 osine kinase-inactivating (ADK-inactivating) alterations in all resistant clones and determined that

76 As GI TB can cause morphological alterations in and around the small bowel, MDCTE seems t

77 ld be attributed to the methylation-elicited alterations in base pairing properties of the nucleobase

78 Instead, CS discharge most often leads alterations in behavior.

79 d keratinocytes in two distinct steps due to alterations in both growth rate and lifetime.

80 responders and nonresponders show different alterations in brain grey matter, but the findings are i

81 on, dampened intracellular calcium handling, alterations in cardiac morphology, and elevated cardiomy

82 Cell death introduces alterations in cell morphology and tissue micro-structur

83 nsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of

84 CNS region to another and are complicated by alterations in cellular composition during disease.

85 These findings identify a mechanism by which alterations in cellular glucose metabolism can influence

86 f human infant adipocyte- or myocyte-related alterations in cellular metabolic pathways that correspo

87 Of importance, these alterations in centrosome integrity do not result from l

88 Complex alterations in cerebral energetic metabolism arise after

89 ing that paralleled previously reported gait alterations in Chn1KO/KO and Epha4KO/KO adult mice.

90 the insula together with previously observed alterations in chronic pain offer a novel interpretation

91 SIGNIFICANCE STATEMENT: Regional gray matter alterations in chronic pain, as detected with voxel-base

92 ght speak to the social-emotional functional alterations in cocaine addiction.

93 This leads to alterations in cognitive processes known to be impaired

94 ous work indicates that hippocampal-specific alterations in CREB signaling and synaptic plasticity ma

95 and function after tooth loss, with smaller alterations in current tobacco smokers, increased produc

96 amin A/C in cell nuclear mechanics and their alterations in disease.

97 ugh changes in epigenetic processes, such as alterations in DNA methylation, and perhaps through alte

98 cells with micronuclei and LST and specific alterations in DNA repair pathways that essentially moni

99 Notably, animals with cocaine-associated alterations in dopamine signals for reward magnitude fai

100 -based mechanisms for brain region-dependent alterations in dopaminergic parameters.

101 Alterations in electrophysiological pathways became prom

102 tion is accompanied by massive and recurrent alterations in enhancer activity.

103 These results suggest that systemic alterations in enterohepatic circulation, as well as hos

104 e for virus-resistant genes that derive from alterations in essential host factors.

105 n 2 (IRP2) recapitulates many aspects of the alterations in free iron and iron-related proteins in ca

106 in changes of mitochondrial homeostasis and alterations in GC and antibody-secreting cells.

107 Although alterations in gene expression are well known to modulat

108 Multiple somatic mutations and copy-number alterations in genes that are therapeutic targets were i

109 dehydrogenase (IDH) mutations, but metabolic alterations in glioblastomas with wild-type IDH are poor

110 We used that model to investigate potential alterations in global DNA hydroxymethylation in the nucl

111 f oxidative and glycolytic ATP production to alterations in glycolysis and oxidative reactions, respe

112 ain glucose uptake and glucose transporters, alterations in glycolytic and acetate metabolism in neur

113 expression of VEGF-A isoforms culminates in alterations in gonadotroph function opposite to those of

114 This review focuses on alterations in hematopoietic TFs in the pathobiology of

115 Alterations in hepatic free fatty acid (FFA) uptake and

116 gest that these effects are mediated through alterations in hepatic mitochondrial function.

117 cifically, which co-occurred with epigenetic alterations in histone H3 N-terminal lysine 4 trimethyla

118 ct, with potential utility for investigating alterations in homeostatic mechanisms associated with br

119 a set and observe that bi-allelic pathogenic alterations in homologous recombination (HR) DNA repair-

120 ded evidence of viscerally-mediated sweating alterations in humans during exercise brought about by w

121 Structural alterations in individual posterior lobules, in which co

122 sence of the INSR, which was associated with alterations in intracellular signaling pathways.

123 Although alterations in intrinsic excitability have been shown to

124 nding (W116C) site of 11beta-hydroxylase, or alterations in its stability (L299P and G267S), may pred

125 different secretagogues and was mediated by alterations in KATP channel subunit expression and activ

126 restricted immunity and further suggest that alterations in lipid metabolism may affect iNKT cell hom

127 Thus, alterations in M-channel activity rapidly trigger unique

128 ses suggest reduced antioxidant capacity and alterations in macronutrient metabolism contribute to in

129 Recent evidence highlights the importance of alterations in mechanical properties of single cells and

130 In conclusion, alterations in methylation and expression of genes invol

131 thology in hypertension were associated with alterations in microbial communities relevant in blood p

132 imensional categorization of neuroanatomical alterations in mild cognitive impairment and Alzheimer's

133 Together with the finding of age-associated alterations in mitochondrial function and morphology in

134 s from the mouse model exhibit proexcitatory alterations in Na channel activity, some of which were n

135 pendent protein kinase II (CaMKII)-dependent alterations in NaV1.5 channel inactivation are emerging

136 tive sexual behavior that is associated with alterations in neural activation in mPFC and OFC.

137 ysis and comparison of synaptic transmission alterations in neurodegenerative disorders.

138 nistic underpinnings of hypertension-induced alterations in neurovascular function during cold exposu

139 actor in Alzheimer disease, induces profound alterations in neurovascular regulation through the inna

140 anscription start site to be responsible for alterations in Nkx3.1 expression patterns under various

141 udy, we have investigated the serum proteome alterations in non-severe vivax malaria patients before

142 al programs associated with specific genetic alterations in oncogenes and tumor suppressors are highl

143 cribe postinvasion morphologic and rheologic alterations in P cynomolgi-infected human reticulocytes

144 g mutations in KRAS are the hallmark genetic alterations in pancreatic ductal adenocarcinoma (PDAC) a

145 edly increases the proportion of chromosomal alterations in pancreatic primary tumors and liver metas

146 usly proposed biological mechanisms, such as alterations in parasympathetic vagal tone, did not appea

147 ene expression analysis revealed significant alterations in pathways regulated by peroxisome prolifer

148 S-GPA index plus 2 new factors: EGFR and ALK alterations in patients with adenocarcinoma (mutation st

149 he involvement of DNA methylation-associated alterations in patients with monogenic autoinflammatory

150 nal changes in astrocytes are accompanied by alterations in phagocytic capacity and effects on neuron

151 were fungus specific, as opposed to general alterations in phagocytosis.

152 Alterations in PIK3CA, the gene encoding the p110alpha s

153 dylinositol 4,5-bisphosphate (PIP2) and that alterations in PIP2 at the immunological synapse regulat

154 a chemical antagonist abrogated not only the alterations in PPARgamma-regulated metabolic pathways, b

155 erns [2], relationships to behavior [3], and alterations in processes such as aging [4] and brain dis

156 We detected the alterations in protein phosphorylation and signaling pat

157 ction of chronic hyponatremia induces severe alterations in proteostasis characterized by diffuse pro

158 untargeted metabolomics, we identified novel alterations in purine metabolism, glutamate metabolism,

159 of all terminal fields, which could lead to alterations in sensory coding and taste-related behavior

160 d largely invariable, we observed pronounced alterations in several proteins linked to autophagy and

161 on analysis of the liver and ileum indicated alterations in several steps of bile acid metabolism, in

162 We identified alterations in signaling pathways and proteins with rela

163 Here, we studied genomic alterations in single primary tumor cells and circulatin

164 l defeat stress in mice produces progressive alterations in sleep and circadian rhythms that resemble

165 What alterations in sleep quantity and quality occur as we ag

166 mechanisms responsible for the ppDIO-induced alterations in sleep, we focused on the lateral hypothal

167 tes, deficiency of the Pals1 ortholog caused alterations in slit-diaphragm-like structures.

168 agonism were not associated with significant alterations in steady-state lipid composition of produce

169 lead to a blunted ischemic AMPK activation, alterations in substrate metabolism, and an increased se

170 of PD.SIGNIFICANCE STATEMENT Disruptions or alterations in the activation of pathways that regulate

171 Alterations in the Cdk/Cdc14-dependent phosphorylation s

172 Although alterations in the cortex and hippocampus of MIA offspri

173 al neurobiological basis of structural brain alterations in the disorder, highlighting impediments to

174 network connectivity and identified distinct alterations in the distributed metabolic activity patter

175 e from cassava to A. thaliana, suggests that alterations in the electrogenicity of the transporters a

176 heir abundances and activities change due to alterations in the environment or in the host.

177 Additionally, significant alterations in the expression of well characterized cell

178 Obesity is linked to alterations in the functional connectivity of dorsal str

179 ions in DNA methylation, and perhaps through alterations in the gut microbiome.

180 Alterations in the inorganic ions level could be evidenc

181 These observations suggest that alterations in the KEAP1/NRF2 pathway may promote surviv

182 environmental redox potential, and resulting alterations in the oxidation states of intracellular met

183 Furthermore, alterations in the proteins associated with mammalian ta

184 However, genetic alterations in the RB-regulated E2F family of transcript

185 s with addiction in terms of neurobiological alterations in the striatum and related clinical manifes

186 Infection caused temporal alterations in the transcriptome of both the cerebellum

187 from repeated cocaine also produces dramatic alterations in the transcriptome of NAc MSNs, but how su

188 Alterations in the VHL tumor suppressor stabilizing the

189 6 lived significantly longer than those with alterations in these genes (p = 0.018 and p = 0.006, res

190 , but how these changes relate to subsequent alterations in transcription and the process of tumorige

191 s in Nab3 binding are largely independent of alterations in transcription rate during the early stage

192 man biopsies of prostate cancer, we identify alterations in tumours affecting the production of decar

193 Despite exhibiting alterations in various response attributes, including te

194 regular cannabis users, which could support alterations in vision.

195 ve cone dystrophy accompanied by significant alterations in visual function.

196 Actionable genetic alterations included 25 EGFR mutations, 5 BRAF mutations

197 subjected to these studies of site-selective alteration including polyketides, glycopeptides, terpeno

198 1 knock-out (KO) male mice exhibit cognitive alterations, including defects in a novel object recogni

199 gests that mtDNA undergo naturally occurring alterations, including mutations and polymorphisms, whic

200 the transcriptome of NAc MSNs, but how such alterations influence cocaine's effects on dendritic spi

201 dies need to explore whether DNA methylation alterations influence the risk of AD-ND codependence or

202 We investigated how dams and hydroclimatic alterations interact with species ecological and life hi

203 Dams and hydrologic alterations interact with species traits to influence co

204 initiation of BCR signaling caused by actin alteration is associated with a decreased humoral immune

205 mulation in ECM, and complement pathway gene alteration, it impacted the composition of drusen-like d

206 metagene expression and somatic copy number alteration levels (rho = -0.484, P = 2 x 10-10).

207 icates that additional genetic or epigenetic alterations may account for neoplastic progression.

208 lear, but recent data indicate that splicing alterations modulated by both inflammation and susceptib

209 The pattern of alteration observed suggests vascular redistribution eff

210 es IDH1 and IDH2 are among the first genetic alterations observed during the development of lower-gra

211 nuated the glycolytic-to-oxidative metabolic alterations occurring in SBMA muscles and induced hypert

212 changes in ciliary morphology accompanied by alteration of acetylated tubulin and IFT88 expression.

213 Activation of transcription requires alteration of chromatin by complexes that increase the a

214 In sunlit waters, photochemical alteration of dissolved organic carbon (DOC) impacts the

215 s a capacity to contract and support dynamic alteration of DT caliber and resistance analogous to the

216 Mechanistically, this occurs through alteration of endothelial cell metabolism.

217 The current study investigated the alteration of estimated effective communication spaces a

218 specifically that such effects occur through alteration of floral attractants.

219 We hypothesize that an alteration of gene expression in the network may improve

220 fundamental genetic event leading to global alteration of imprinting gene expression in the molar tr

221 s, which leads to detachment of myocytes and alteration of intracellular signal transduction.

222 and core formation, as reflected by a quick alteration of its radius of gyration.

223 We aimed at investigating whether alteration of miR-194-dependent MMPs and PARP-1 causes r

224 ond, H. pylori also induces VacA-independent alteration of mitochondrial replication and import compo

225 imits proliferation of TFH cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 ex

226 ss this challenge is the systematic backbone alteration of natural protein sequences, through which a

227 The alteration of O-GlcNAcylation was also seen in the ische

228 se of place field stability and (2) a strong alteration of overdispersion (i.e., firing variability).

229 We propose that rapid alteration of PTEN activity through changes in its phosp

230 Loss of synapses or alteration of synaptic activity is associated with cogni

231 nslation in neuronal processes is key to the alteration of synaptic strength necessary for long-term

232 xplored implication of sulfate enrichment is alteration of the content and speciation of sulfur in di

233 , entailing a drop in viscosity and possible alteration of the degree of ionization, and also by othe

234 e disturbances in the human fetal testis and alteration of the germ cell biology.

235 Only limited studies have quantified the alteration of the nano-pore structure due to ME-CBM trea

236 eling of the chromatin landscape, as well as alteration of the transcriptional profiles.

237 ure of NKp65 to recruit Syk is not due to an alteration of the triacidic motif, which rather affects

238 its normal function in healthy cells and how alteration of this process leads to cancer remain poorly

239 and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp.

240 of astrocyte proteins may support microscale alterations of adjacent synapses.

241 Despite recent developments in neuroimaging, alterations of brain functional connectivity in major de

242 icine seeks to target the underlying genetic alterations of cancer; however, it has been challenging

243 for immune evasion: near-uniform copy number alterations of chromosome 9p24.1 and the associated PD-1

244 Genetic or experimental alterations of cilia function lead to various developmen

245 significant spectrum of powerful, catalytic alterations of complex natural products now exists such

246 cohol seeking was associated with structural alterations of dendritic spines in the CeA and, moreover

247 Alterations of GCS not only affect membrane integrity, b

248 Nevertheless, NK cells were able to sense alterations of HLA-C expression demonstrated by increase

249 cted lymphatic tissues, we revealed numerous alterations of host transcripts associated with inflamma

250 We conclude that alterations of KDM family members represent a disease-dr

251 ost cancers develop following random somatic alterations of key oncogenic genes, which are favoured b

252 Visualization of cancer-associated alterations of molecular phenotype using radionuclide im

253 in healthy ageing, structural and functional alterations of muscle fibres occur.

254 f schizophrenia (SCZ) is proposed to involve alterations of neural circuits via synaptic dysfunction,

255 Common among these changes are alterations of neurons releasing dopamine in the ventral

256 ulture was demonstrated by the corresponding alterations of sodium TQ/SQ MR signals.

257 rogenic and angiogenic cytokines and related alterations of the bone marrow microenvironment are comm

258 examination of melittin-induced biophysical alterations of the cells.

259 to investigate CBGT-induced structural brain alterations of the gray and white matter (WM).

260 morphological, intracellular, and mechanical alterations of the RBCs were analyzed quantitatively.

261 ization events control DNA repair as well as alterations of the transcriptome and proteome, enabling

262 ent carbon sources, and quantify how readily alterations of their chemical reactions create the abili

263 pon validation in additional study sets, the alterations of these three candidate serum biomarker pro

264 e new insights into our understanding of the alterations of this biofluid during tumor development.-K

265 monstrate that obesity and aging precipitate alterations of TRIM28-dependent transcriptional dynamics

266 Structural and functional alterations of vessels accumulate throughout life, culmi

267 netic assay that distinguishes effects of TL alterations on the rate at which ECs terminate from effe

268 umors and did not harbor similar copy number alterations or demonstrate significant mutational overla

269 the median number of potentially actionable alterations per patient being 2 (range, 0-13).

270 ing on potatoes nutrients, and the potential alterations resulting from the use of different monounsa

271 lterations; 66% (290/442) >/=1 characterized alteration(s), excluding variants of unknown significanc

272 rior research focused on somatic copy-number alterations (SCNAs) affecting cancer genes, yet the exte

273 /MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the

274 Patients without pathogenic BRCA1 and BRCA2 alterations showed elevated disease-free survival rates

275 r therapies aim at targeting tumour-specific alterations, such as mutations or neo-antigens, and maxi

276 a high-risk subtype characterized by genomic alterations that activate cytokine receptor and kinase s

277 novel concept of functional connectome-wide alterations that are linked to dystonia phenotype and ge

278 enotypic consequences of genomic copy-number alterations that are repeatedly observed in iPS cells.

279 utational profiles for cyst type and genetic alterations that coincide with the development of pancre

280 the identification of genomic and molecular alterations that fuel the tumour, average patient surviv

281 rosclerosis and cardiac electrophysiological alterations that invariably lead to premature aging and

282 hyroid cancer is common, yet the sequence of alterations that promote tumor formation are incompletel

283 h the excitability and short-term plasticity alterations that we observed.

284 ility, the frequency of actionable molecular alterations, the effect on decision making, and identifi

285 Alteration to the expression and activity of androgen re

286 Alterations to pilin sequence can also block phage infec

287 ady-myelinated axons may also be mediated by alterations to the axon itself.

288 their scale has not resulted in substantial alterations to the comet's landscape.

289 Alterations to the epigenome are thought to capture and

290 The presented design consisted of minimal alterations to the front-end of the instrument and provi

291 Atomic Force Microscopy showed significant alterations to the surface of S. epidermidis, and electr

292 We explain how alterations to their profiles and functions under condit

293 e physiological mechanisms and circuit-level alterations underlying this aberrant behavior remain poo

294 Mechanistically, these alterations were found to be due to calcium entry into t

295 Reciprocal alterations were made to enlarge the adenosine pocket of

296 Patients with PD and MCI had global network alterations when compared with both control subjects and

297 We also observed metabolic alterations which may relate to oxidative stress respons

298 aft models harboring various Ph-like genomic alterations with 4 discrete PI3K pathway protein inhibit

299 ETV6-RUNX1 pB-ALL revealed recurrent genomic alterations, with a relevant proportion affecting genes

300 These memories are thought to be encoded by alterations within specific patterns of sparsely distrib