ライフサイエンスコーパス: alteration in

1 pendently associated with a higher number of alterations in a multivariable analysis (P = 0.019).

2 9S/C162S mutants did not exhibit appreciable alteration in activating dual phosphorylation.

3 s suppressed TCR-signaling cascades, reduced alterations in activation markers, and inhibited cytokin

4 as a constellation of somatic structural DNA alterations in acute lymphoblastic leukemia.

5 ses and associate the abundance thereof with alterations in acylcarnitines, a metric of beta-oxidatio

6 let size, increased basal lipolytic rate and alterations in adiponectin and leptin secretion.

7 osine kinase-inactivating (ADK-inactivating) alterations in all resistant clones and determined that

8 culum (ER) is becoming a common pathological alteration in ALS, representing one of the earliest defe

9 As GI TB can cause morphological alterations in and around the small bowel, MDCTE seems t

10 f tumors neither expressed TERT nor harbored alterations in ATRX or DAXX.

11 osome during CSR, SHM, and other chromosomal alterations in B cells, and discuss implications relevan

12 ors and transposon-mediated gain-of-function alterations in B-cell lymphoma-extra large (Bcl-xL), Mdm

13 ld be attributed to the methylation-elicited alterations in base pairing properties of the nucleobase

14 izumab therapy with milk OIT led to distinct alterations in basophil reactivity but not T-cell respon

15 Instead, CS discharge most often leads alterations in behavior.

16 light source induced significant behavioral alterations in birds, even in good visibility conditions

17 d keratinocytes in two distinct steps due to alterations in both growth rate and lifetime.

18 nets of cancer biology and is underpinned by alterations in both protein-coding genes and noncoding r

19 Genetic alterations in BRAF, NRAS and NF1 that activate the ERK

20 neonatal procedural pain precedes long-term alterations in brain development.

21 responders and nonresponders show different alterations in brain grey matter, but the findings are i

22 We discuss how some of these genetic alterations in brain tumors rewire metabolism.

23 Disturbances in cellular Ca(2+)-handling and alterations in Ca(2+)-dependent gene expression patterns

24 nscriptional control is disrupted by genetic alterations in cancer cells, why transcriptional depende

25 on, dampened intracellular calcium handling, alterations in cardiac morphology, and elevated cardiomy

26 Cell death introduces alterations in cell morphology and tissue micro-structur

27 llular seal to physiological or pathological alterations in cell shape or movement.

28 worse overall survival, and further observe alterations in cell-cycle and immune checkpoint regulati

29 y of the genome by the prevention of genetic alterations in cells but also plays a role in regulating

30 nsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of

31 CNS region to another and are complicated by alterations in cellular composition during disease.

32 These findings identify a mechanism by which alterations in cellular glucose metabolism can influence

33 f human infant adipocyte- or myocyte-related alterations in cellular metabolic pathways that correspo

34 Of importance, these alterations in centrosome integrity do not result from l

35 Complex alterations in cerebral energetic metabolism arise after

36 ing that paralleled previously reported gait alterations in Chn1KO/KO and Epha4KO/KO adult mice.

37 the insula together with previously observed alterations in chronic pain offer a novel interpretation

38 SIGNIFICANCE STATEMENT: Regional gray matter alterations in chronic pain, as detected with voxel-base

39 educed fibrinolytic potential resulting from alterations in clot architecture and elevated levels of

40 ght speak to the social-emotional functional alterations in cocaine addiction.

41 emphasizing core features of mood change and alterations in cognitive content and psychomotor behavio

42 This leads to alterations in cognitive processes known to be impaired

43 es, the triple mutant additionally displayed alterations in comparison with ss4 and dpe2-1/phs1a The

44 In this study, alterations in conjunctival microvascular hemodynamics w

45 scitation and were clinically stable with no alteration in consciousness.

46 0 min- and 24 h-CMR accompanied by transient alterations in contractile and mitochondrial proteins.

47 in influencing epithelial dynamics, and that alterations in contraction and/or substrate adhesion can

48 -TrkB signaling, and could contribute to the alterations in cortical development underlying the senso

49 ous work indicates that hippocampal-specific alterations in CREB signaling and synaptic plasticity ma

50 and function after tooth loss, with smaller alterations in current tobacco smokers, increased produc

51 for Ube3A/E6AP in ASD-related developmental alteration in dendritic arborization and synapse formati

52 amin A/C in cell nuclear mechanics and their alterations in disease.

53 ncert, these findings suggest that molecular alterations in DLPFC L3 and L5 pyramidal cells might be

54 We detected significant alterations in DNA copy numbers (CN), gene expression le

55 show that copy number variations (CNVs) and alterations in DNA methylation contribute to the observe

56 cation cohorts, to identify disease-specific alterations in DNA methylation in B cells.

57 ugh changes in epigenetic processes, such as alterations in DNA methylation, and perhaps through alte

58 cells with micronuclei and LST and specific alterations in DNA repair pathways that essentially moni

59 Notably, animals with cocaine-associated alterations in dopamine signals for reward magnitude fai

60 -based mechanisms for brain region-dependent alterations in dopaminergic parameters.

61 Is an alteration in early prediction abilities the common caus

62 Alterations in early steps of cortical circuit assembly

63 h condition based on experimentally measured alteration in elastic fiber composition, alveolar geomet

64 Alterations in electrophysiological pathways became prom

65 ent genomic signaling is affected by genetic alterations in endocrine therapy resistance.

66 ne tension induce significant spatiotemporal alterations in endocytic clathrin coat dynamics.

67 tion is accompanied by massive and recurrent alterations in enhancer activity.

68 mmatory cytokines results in signal-specific alterations in enhancer landscapes and associate with co

69 These results suggest that systemic alterations in enterohepatic circulation, as well as hos

70 ir possible role in phosphorylation-mediated alteration in enzymatic activity.

71 ted memory impairment.SIGNIFICANCE STATEMENT Alterations in episodic memory and the accumulation of A

72 e for virus-resistant genes that derive from alterations in essential host factors.

73 his mother detected a heterozygous c.305T>C alteration in exon 3, which causes a leucine to serine s

74 muscle conditions such as denervation induce alterations in exosomal miR profile which could influenc

75 low-dose PEITC for >1 month exhibited stable alterations in expression profile of epigenetic writers/

76 ll complex (GCC) thickness and photoreceptor alterations in eyes with intermediate age-related macula

77 with advanced solid tumors harboring genetic alterations in fibroblast growth factor receptors (FGFRs

78 Alterations in fire activity due to climate change and f

79 ts over others; (3) The direction of circuit alterations in Fmr1 KO mice changes across development.

80 ss is known regarding the role of microbiome alterations in food allergy development.

81 n 2 (IRP2) recapitulates many aspects of the alterations in free iron and iron-related proteins in ca

82 to be of significance, the contribution that alterations in GABAergic inhibition play in the pathophy

83 This change appears to be separable from the alteration in gB quaternary structure.

84 in changes of mitochondrial homeostasis and alterations in GC and antibody-secreting cells.

85 Although alterations in gene expression are well known to modulat

86 emonstrate that there are robust age-related alterations in gene expression in the human brain and th

87 tal for disease diagnostics and to follow up alterations in gene expression profiles.

88 Persistent DNA damage induces profound alterations in gene expression that, in turn, influence

89 connectivity and widespread transcriptional alterations in genes involved in synaptic signaling, a n

90 Multiple somatic mutations and copy-number alterations in genes that are therapeutic targets were i

91 ing natural microbial community responses to alterations in geochemical factors beyond the bulk phase

92 dehydrogenase (IDH) mutations, but metabolic alterations in glioblastomas with wild-type IDH are poor

93 globe have cataloged genomic and epigenomic alterations in gliomas across ages, grades, and histolog

94 We used that model to investigate potential alterations in global DNA hydroxymethylation in the nucl

95 cells exhibit decreased proliferation rates, alterations in global protein synthesis, and perturbatio

96 ia during aging, which is believed to be due alterations in glucose homeostasis in the skeletal muscl

97 creasing data indicate that inflammation and alterations in glutamate neurotransmission are two novel

98 f oxidative and glycolytic ATP production to alterations in glycolysis and oxidative reactions, respe

99 ain glucose uptake and glucose transporters, alterations in glycolytic and acetate metabolism in neur

100 expression of VEGF-A isoforms culminates in alterations in gonadotroph function opposite to those of

101 ors, and that this effect is associated with alterations in gut microbiota and their metabolites.

102 ardioprotective function was associated with alterations in HDL remodeling and functionality.

103 MetS is associated with significant alterations in heart rate dynamics, including HRV and co

104 Further analysis of tumoral epigenetic alterations in hematopoietic CDRs points to sets of gene

105 This review focuses on alterations in hematopoietic TFs in the pathobiology of

106 Alterations in hepatic free fatty acid (FFA) uptake and

107 gest that these effects are mediated through alterations in hepatic mitochondrial function.

108 kinetic analysis of Trm10 and variants with alterations in highly conserved residues, using crystal

109 airment can be attributed to obesity-induced alterations in hippocampal structure and function in som

110 cifically, which co-occurred with epigenetic alterations in histone H3 N-terminal lysine 4 trimethyla

111 ct, with potential utility for investigating alterations in homeostatic mechanisms associated with br

112 a set and observe that bi-allelic pathogenic alterations in homologous recombination (HR) DNA repair-

113 oosteoblast and proinflammatory gene network alterations in human NOTCH1 heterozygous endothelial cel

114 ded evidence of viscerally-mediated sweating alterations in humans during exercise brought about by w

115 flagellin perception, did not exhibit robust alterations in immune responses.

116 Age-related alterations in immunity have been linked to increased in

117 no discernible effect on dependence-related alterations in incentive salience/'wanting'.

118 , we systematically introduced site-directed alterations in individual phosphorylation and acetylatio

119 Structural alterations in individual posterior lobules, in which co

120 sence of the INSR, which was associated with alterations in intracellular signaling pathways.

121 Although alterations in intrinsic excitability have been shown to

122 te that ovarian cancer exhibits a targetable alteration in iron metabolism.

123 nding (W116C) site of 11beta-hydroxylase, or alterations in its stability (L299P and G267S), may pred

124 different secretagogues and was mediated by alterations in KATP channel subunit expression and activ

125 self-administration and compared these with alterations in less activated non-ensemble neurons (FosG

126 le infectivity by SERINC5 does not depend on alterations in lipid composition and organization of HIV

127 restricted immunity and further suggest that alterations in lipid metabolism may affect iNKT cell hom

128 re, we investigated the relationship between alterations in lipogenesis pathway and gemcitabine resis

129 tigate the impact of grey matter (GM) volume alterations in lobules VI to VIIIb on IPS in persons wit

130 mporal changes in LV structure (volume) with alterations in LV functional characteristics (strain, )

131 e New Zealand Black Slam locus have profound alterations in Ly108, CD150, and Ly9 expression that is

132 Alterations in lysosomal positioning contribute to diffe

133 Thus, alterations in M-channel activity rapidly trigger unique

134 ses suggest reduced antioxidant capacity and alterations in macronutrient metabolism contribute to in

135 non-obese diabetic (NOD) strain, we detected alterations in MAIT cells, including increased productio

136 biome were necessary and sufficient to drive alterations in major proliferation and apoptosis signali

137 Recent evidence highlights the importance of alterations in mechanical properties of single cells and

138 Furthermore, specific activating alterations in members of the receptor tyrosine kinase/R

139 ls, which represents the most common somatic alteration in men.

140 Although acute alterations in mental status due to inflammation are a h

141 In conclusion, alterations in methylation and expression of genes invol

142 INTERPRETATION: Alterations in microbial communities occur in the lower

143 thology in hypertension were associated with alterations in microbial communities relevant in blood p

144 rstanding and predicting the disease-related alterations in microbial communities.

145 imensional categorization of neuroanatomical alterations in mild cognitive impairment and Alzheimer's

146 Together with the finding of age-associated alterations in mitochondrial function and morphology in

147 Here, we investigate how alterations in mitochondrial homeostasis modulate stem c

148 c acetylation, and that signals derived from alterations in mitochondrial metabolism are the key medi

149 d for label-free means to detect the dynamic alterations in mitochondrial morphology.

150 We further validate the presence of these alterations in multiple independent HNSCC data sets and

151 tically detect all statistically significant alterations in mutants, and to map them onto a brain atl

152 s from the mouse model exhibit proexcitatory alterations in Na channel activity, some of which were n

153 Alterations in nasal microbiota but not of throat microb

154 pendent protein kinase II (CaMKII)-dependent alterations in NaV1.5 channel inactivation are emerging

155 tive sexual behavior that is associated with alterations in neural activation in mPFC and OFC.

156 Alterations in neural processing of negative affective s

157 ysis and comparison of synaptic transmission alterations in neurodegenerative disorders.

158 phenotypes, and there is growing evidence of alterations in neuronal circuits in the sensory cortex o

159 Our findings indicate that alterations in neuronal mitochondria structure are very

160 nistic underpinnings of hypertension-induced alterations in neurovascular function during cold exposu

161 actor in Alzheimer disease, induces profound alterations in neurovascular regulation through the inna

162 anscription start site to be responsible for alterations in Nkx3.1 expression patterns under various

163 udy, we have investigated the serum proteome alterations in non-severe vivax malaria patients before

164 sitivity of our pipeline by detecting subtle alterations in normal cells when subjected to small mech

165 Here we show that cocaine induces alterations in nuclear F-actin signaling pathways in the

166 es have attributed certain visual perceptual alterations in older adults to a likely decrease in GABA

167 al programs associated with specific genetic alterations in oncogenes and tumor suppressors are highl

168 cribe postinvasion morphologic and rheologic alterations in P cynomolgi-infected human reticulocytes

169 Alteration in palatal shelves growth resulted in cleftin

170 g mutations in KRAS are the hallmark genetic alterations in pancreatic ductal adenocarcinoma (PDAC) a

171 edly increases the proportion of chromosomal alterations in pancreatic primary tumors and liver metas

172 usly proposed biological mechanisms, such as alterations in parasympathetic vagal tone, did not appea

173 ene expression analysis revealed significant alterations in pathways regulated by peroxisome prolifer

174 ave examined functional and structural brain alteration in patients diagnosed with major depressive d

175 S-GPA index plus 2 new factors: EGFR and ALK alterations in patients with adenocarcinoma (mutation st

176 ks clinical outcomes to co-occurring genetic alterations in patients with advanced-stage EGFR-mutant

177 he involvement of DNA methylation-associated alterations in patients with monogenic autoinflammatory

178 In NSCLC alterations in PDGF receptors are markers of worst progn

179 Additional genomic alterations in Ph-like ALL activate other kinases, inclu

180 nal changes in astrocytes are accompanied by alterations in phagocytic capacity and effects on neuron

181 were fungus specific, as opposed to general alterations in phagocytosis.

182 ually important, OPPNs can cause significant alteration in physical appearance secondary to proptosis

183 Alterations in PIK3CA, the gene encoding the p110alpha s

184 dylinositol 4,5-bisphosphate (PIP2) and that alterations in PIP2 at the immunological synapse regulat

185 Alterations in plasma metabolites in these groups were e

186 lfate content and distribution contribute to alterations in postsynaptic function.

187 a chemical antagonist abrogated not only the alterations in PPARgamma-regulated metabolic pathways, b

188 erns [2], relationships to behavior [3], and alterations in processes such as aging [4] and brain dis

189 mplying that these mutations cause different alterations in properties of NLRC4.

190 ection against different natural enemies, no alteration in protection was observed in the presence of

191 quantitative proteomic study that evaluates alterations in protein expression and histone post-trans

192 We detected the alterations in protein phosphorylation and signaling pat

193 ction of chronic hyponatremia induces severe alterations in proteostasis characterized by diffuse pro

194 cardiovascular system, to seek evidence for alteration in pulmonary arterial hypertension (PAH) in w

195 untargeted metabolomics, we identified novel alterations in purine metabolism, glutamate metabolism,

196 Alterations in regulatory networks contribute to evoluti

197 pulse disturbance can interact with chronic alterations in resource availability to increase ecosyst

198 n of pupillary response characteristics with alterations in retinal architecture.

199 jectory of the brain, resulting in long-term alterations in reward-associated behaviors.

200 ins poorly understood, a subcellular spatial alteration in RNA metabolism is thought to play a key ro

201 y a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK c

202 of all terminal fields, which could lead to alterations in sensory coding and taste-related behavior

203 e hypothesis that SIDS is associated with an alteration in serum 5-HT levels.

204 across mice tissues and revealed significant alteration in several biomarkers that indicate potential

205 Neuroimaging studies have shown structural alterations in several brain regions in children and adu

206 d largely invariable, we observed pronounced alterations in several proteins linked to autophagy and

207 on analysis of the liver and ileum indicated alterations in several steps of bile acid metabolism, in

208 We identified alterations in signaling pathways and proteins with rela

209 Here, we studied genomic alterations in single primary tumor cells and circulatin

210 d to characterize the global transcriptional alterations in skin biopsy samples of EM lesions from un

211 l defeat stress in mice produces progressive alterations in sleep and circadian rhythms that resemble

212 What alterations in sleep quantity and quality occur as we ag

213 mechanisms responsible for the ppDIO-induced alterations in sleep, we focused on the lateral hypothal

214 tes, deficiency of the Pals1 ortholog caused alterations in slit-diaphragm-like structures.

215 wealth of information on tumour biology, and alterations in some immune subtypes, such as tumour-asso

216 A C-terminus is responsible for differential alterations in some, but not all, host cell signaling pa

217 To characterize alterations in Spanish language medical interpretation d

218 agonism were not associated with significant alterations in steady-state lipid composition of produce

219 sexes and MRI-detected brain microstructural alterations, in studied males, demonstrating a requireme

220 lead to a blunted ischemic AMPK activation, alterations in substrate metabolism, and an increased se

221 Our results suggest alteration in subthreshold voltage-activated currents mi

222 Drugs of abuse cause persistent alterations in synaptic plasticity that may underlie add

223 creased thalamic NAA/Cho and microstructural alterations in thalamocortical pathways.

224 s from wild-type and bumble mice revealed no alteration in the cellular MZ microenvironment, and anal

225 otein structures indicate that the resulting alteration in the enzyme induces a significant structura

226 d shrimp products without any degradation or alteration in the major fragments.

227 ifferent transcriptional signatures imply an alteration in the mode of action under combined stresses

228 This phosphorylation-dependent alteration in the PDZ domain-ligand interaction was expl

229 in the sediment element composition and the alteration in the plant growth.

230 ed to extract a snapshot of tumor-associated alteration in the serum.

231 Amblyopia is an alteration in the visual neural pathway in a child's dev

232 of PD.SIGNIFICANCE STATEMENT Disruptions or alterations in the activation of pathways that regulate

233 Alterations in the activity/levels of the extralarge G p

234 There was evidence for alterations in the autophagy-lysosome pathway.

235 Reflux therefore develops via alterations in the balance of aggressive and defensive f

236 s unclear how irradiation induces persistent alterations in the brain.

237 INTERPRETATION: Alterations in the carbohydrate, lipid, and apolipoprote

238 Alterations in the Cdk/Cdc14-dependent phosphorylation s

239 Alterations in the complement pathway may contribute to

240 Alterations in the composition and functions of the inte

241 Although alterations in the cortex and hippocampus of MIA offspri

242 These observed synaptic alterations in the cortex were mediated by peripheral-mo

243 al neurobiological basis of structural brain alterations in the disorder, highlighting impediments to

244 network connectivity and identified distinct alterations in the distributed metabolic activity patter

245 e from cassava to A. thaliana, suggests that alterations in the electrogenicity of the transporters a

246 heir abundances and activities change due to alterations in the environment or in the host.

247 Consequently, in schizophrenia, alterations in the expression of gene products regulatin

248 Additionally, significant alterations in the expression of well characterized cell

249 Obesity is linked to alterations in the functional connectivity of dorsal str

250 and adaptive immune responses, resulting in alterations in the functions of the kidney and, in some

251 Alterations in the genome integrity and accumulation of

252 The observed alterations in the genome integrity maintenance may be p

253 ions in DNA methylation, and perhaps through alterations in the gut microbiome.

254 report that this diminution correlates with alterations in the gut microbiota, particularly enrichme

255 Age-related alterations in the human blood system occur in B cells,

256 Alterations in the inorganic ions level could be evidenc

257 Alterations in the integrity of the mucosal barrier have

258 Alterations in the intestinal microbiome are prospective

259 These observations suggest that alterations in the KEAP1/NRF2 pathway may promote surviv

260 80%-90% reductions in AcCoA and significant alterations in the levels of key tricarboxylic acid (TCA

261 We found that emulsifier-induced alterations in the microbiome were necessary and suffici

262 er chronic social defeat produces structural alterations in the mPFC in mice.

263 kine IL-6 in the hippocampus, followed up by alterations in the mRNA and protein expression of astroc

264 lationship between prenatal iAs exposure and alterations in the neonatal metabolome could reveal crit

265 ice lacking p63 transcription factor display alterations in the nuclear shape accompanied by a marked

266 scence staining we tested whether there were alterations in the number and size of presynaptic struct

267 E/I imbalance model cannot account for joint alterations in the observed neural firing rates and corr

268 environmental redox potential, and resulting alterations in the oxidation states of intracellular met

269 For this end we decided to evaluate their alterations in the pathologic states ending in cSCC.

270 of immunometabolism and, in particular, mTOR alterations in the pathophysiology of sepsis-induced T c

271 Furthermore, alterations in the proteins associated with mammalian ta

272 However, genetic alterations in the RB-regulated E2F family of transcript

273 Dramatic alterations in the renal transcriptome, including a sign

274 s with addiction in terms of neurobiological alterations in the striatum and related clinical manifes

275 t Salt Lake in late 2013 documented dramatic alterations in the system in response to the elimination

276 Concomitantly, alterations in the task-related spike activity of medial

277 We found that these subtle alterations in the timing of action potential firing dif

278 ction in neuronal density is responsible for alterations in the tissue-wide editing patterns upon inj

279 Infection caused temporal alterations in the transcriptome of both the cerebellum

280 from repeated cocaine also produces dramatic alterations in the transcriptome of NAc MSNs, but how su

281 several morbidities in burn patients through alterations in the urinary microbiome and antimicrobial

282 Alterations in the VHL tumor suppressor stabilizing the

283 elopment of-and the schizophrenia-associated alterations in-the DLPFC circuitry that subserves workin

284 moreceptors are the carotid bodies (CBs) and alteration in their function has been described in CHF.

285 6 lived significantly longer than those with alterations in these genes (p = 0.018 and p = 0.006, res

286 Whether germ-line or somatic alterations in these genes or other members of the HR pa

287 Despite recent identification of metabolic alterations in this lethal malignancy, the metabolic dep

288 Alterations in this process impair chromosome segregatio

289 leukocytes; however, this might not reflect alterations in tissue-specific immunity.

290 Here we addressed the hypothesis that alterations in TJ structure and remodeling of the actomy

291 , but how these changes relate to subsequent alterations in transcription and the process of tumorige

292 s in Nab3 binding are largely independent of alterations in transcription rate during the early stage

293 -) thymocytes showed increased apoptosis and alterations in transcriptome, but these changes were sub

294 rapeutic strategies that seek to address the alterations in translational regulation and energy metab

295 man biopsies of prostate cancer, we identify alterations in tumours affecting the production of decar

296 le venular function in OZR may contribute to alterations in upstream capillary pressure profiles and

297 etic and experimental evidence suggests that alterations in various intracellular trafficking events,

298 Despite exhibiting alterations in various response attributes, including te

299 regular cannabis users, which could support alterations in vision.

300 ve cone dystrophy accompanied by significant alterations in visual function.