ライフサイエンスコーパス: alteration of

1 a dramatic increase in S100A4, COX-2 and the alteration of 30 tumor-related genes as measured by Nano

2 Copy number alterations of 9p24.1/CD274(PD-L1)/PDCD1LG2(PD-L2) contr

3 trate a common genetically driven functional alteration of a synaptic mechanism both in schizophrenia

4 tory efficacy and associated gene expression alterations of a specific, curcumin preparation containi

5 Ras- and TGF-beta-induced EMT that involves alterations of accessible chromatin, which are partly re

6 changes in ciliary morphology accompanied by alteration of acetylated tubulin and IFT88 expression.

7 rough investigation of autonomic arousal and alterations of activation and functional connectivity wi

8 for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection,

9 of astrocyte proteins may support microscale alterations of adjacent synapses.

10 better correlated with clinical benefit than alterations of allergen-specific CD4(+) T-cell or IgG re

11 Structure-guided alterations of amino acid residues in FePYR1 generated A

12 Although we observed no alterations of AMPA and NMDA receptor properties, we fou

13 n of liver regeneration was not secondary to alteration of APAP-induced hepatotoxicity, which remaine

14 restitution of organ mass but with permanent alteration of architecture.

15 t invasive carcinoma data set indicates that alterations of ASIC1 alone or combined with other 4 ASIC

16 irway infiltration, cellular remodeling, and alteration of asthmogenic gene expression.

17 thers, climate warming, solar radiation, and alterations of atmospheric components.

18 er the past decade, many studies have linked alteration of autophagy with cancer initiation and progr

19 +)]i in Abcc8(-/-) islets contributes to the alteration of beta-cell identity, islet cell numbers and

20 fate can be altered in three possible ways: alteration of bifurcation geometry, alteration of cell t

21 ant knowledge gap given ongoing human-caused alteration of biodiversity and plant community structure

22 The aberrant alterations of biological functions are well known in tu

23 rare genetic disorder resulting in variable alterations of bone formation and mineralization that ar

24 hifts of up to sixfold, which happen through alteration of both association and dissociation rates.

25 se in adipose tissue, which is likely due to alterations of both fat mass quantity and qualitative ch

26 nditions, while it prevented seizure-induced alterations of both STP and LTP.

27 us imaging-based biomarkers would detect the alteration of brain perfusion (flow), as well as the opt

28 ylation dysregulations are implicated in the alteration of brain tissue properties associated with la

29 The aim of this study was to investigate alterations of brain activity during the resting state i

30 urodevelopmental trajectory likely result in alterations of brain connectivity relevant to behavior.

31 Despite recent developments in neuroimaging, alterations of brain functional connectivity in major de

32 icine seeks to target the underlying genetic alterations of cancer; however, it has been challenging

33 a-adrenergic stimulation without significant alteration of cardiac structure and function, which is a

34 ng the procarcinogenic role of NOTCH in vivo Alteration of cell cycle pathways was seen in murine ren

35 ies using BmN4 cell system, and suggests the alteration of cell density as a useful tool to monitor p

36 le ways: alteration of bifurcation geometry, alteration of cell trajectories, or both.

37 Alteration of cell wall xylan acetylation caused by ESK1

38 esults provide a testable hypothesis for how alterations of cell wall stiffness affect periplasmic vo

39 membranes, accumulation of lipid bodies, and alterations of cell-surface morphology.

40 esis and breakdown of SA; and MEcPP-mediated alteration of cellular redox status in particular glutat

41 te and adaptive immune cells instructs rapid alterations of cellular processes to promote effective r

42 Alteration of cholinergic activity produced a reduction

43 Activation of transcription requires alteration of chromatin by complexes that increase the a

44 Cancer cells exhibit dramatic alterations of chromatin organization at cis-regulatory

45 for immune evasion: near-uniform copy number alterations of chromosome 9p24.1 and the associated PD-1

46 Genetic or experimental alterations of cilia function lead to various developmen

47 s increased alveolar dead space explains the alteration of CO2 clearance.

48 of enzymatic catalysts to the site-selective alteration of complex molecules, the focus of this Revie

49 significant spectrum of powerful, catalytic alterations of complex natural products now exists such

50 ine-tuning of binding and sequence-dependent alterations of conformational space by structural analys

51 me animal with two strains can result in the alteration of conversion of both strains under condition

52 This oncogenic capacity was acquired through alteration of critical signaling networks, including AR,

53 SF1R, and PDGFRB that phenocopy BCR-ABL1 and alterations of CRLF2, JAK2, and EPOR that activate JAK/S

54 ate devices demonstrate large and reversible alteration of cross-plane thermal conductance as a funct

55 ival and altering cell polarity) for genetic alterations of CTCF in endometrial cancer.

56 gp96 from CD11c(+) cells in mice results in alteration of dendritic cell and T cell subsets in the g

57 cohol seeking was associated with structural alterations of dendritic spines in the CeA and, moreover

58 obial activity of thiostrepton tolerates the alteration of Dha16 to a range of amino acids.

59 In sunlit waters, photochemical alteration of dissolved organic carbon (DOC) impacts the

60 n this article: 1) recent findings regarding alterations of DLPFC layer 3 circuitry in schizophrenia,

61 t of this mechanism depends on whether photo-alteration of DOC produces or removes molecules used by

62 s a capacity to contract and support dynamic alteration of DT caliber and resistance analogous to the

63 opment, and it suggests that transcriptional alterations of EBF1 by the AHR are involved in the under

64 facilitate nutrient cycling, leading to the alteration of ecosystem structure and functions.

65 Alterations of endo/exocytic proteins have long been ass

66 Mechanistically, this occurs through alteration of endothelial cell metabolism.

67 The current study investigated the alteration of estimated effective communication spaces a

68 he ectopic pregnancy that is associated with alteration of estrogen signals.

69 Alteration of ex vivo magnetic resonance imaging transve

70 s than to the appearance of new pathogens or alteration of existing pathogens.

71 In this study, we found that genetic alterations of FBW7, an E3 ubiquitin ligase and a tumor

72 al enzymes are useful for the extraction and alteration of fish protein from a low value source to pr

73 specifically that such effects occur through alteration of floral attractants.

74 te the modulation of circRNA biogenesis with alteration of FUS nuclear levels and with putative toxic

75 Alterations of GCS not only affect membrane integrity, b

76 We hypothesize that an alteration of gene expression in the network may improve

77 This metformin-induced H19 repression and alteration of gene methylation are recapitulated in endo

78 ast cancer samples, we also observed similar alterations of gene expression.

79 hese events include depletion and functional alteration of GI-resident CD4(+) T cells, loss of antige

80 dent reduction in seed dormancy, mediated by alteration of gibberellin and abscisic acid signalling.

81 HIM revealed the serial alteration of glomerular features including effacement a

82 ing exposure to an HIV-1 neurotoxin in vivo, alteration of GluN2B-containing NMDAR signaling suppress

83 There is increasing evidence that alteration of glycogen metabolism in the brain contribut

84 However, little is known about the alterations of glycosylation and glycoproteins in ASD.

85 p3 double-reporter mice, we demonstrate that alteration of gut microbiota during cohousing experiment

86 ABX treatment (P14-P21) results in long-term alterations of gut microbial genera (predominantly Lachn

87 quatic organisms indirectly through physical alterations of habitat.

88 7 patients from three centers, we identified alterations of Her2 at the DNA, RNA and protein level, a

89 In contrast, the late alteration of HF cycle and appearance of inflammation we

90 Nevertheless, NK cells were able to sense alterations of HLA-C expression demonstrated by increase

91 which respond to pathogen-induced damage or alteration of host membranes, were necessary for inflamm

92 open new perspectives on global and specific alterations of host cell transcription by viruses.

93 cted lymphatic tissues, we revealed numerous alterations of host transcripts associated with inflamma

94 of the HR pathway and if mono- or bi-allelic alterations of HR-related genes have a phenotypic impact

95 Smoke-mediated alterations of immunoproteasome activity and MHC I surfa

96 fundamental genetic event leading to global alteration of imprinting gene expression in the molar tr

97 gy of ALS, the present study aims to examine alterations of interhemispheric structural and functiona

98 s, which leads to detachment of myocytes and alteration of intracellular signal transduction.

99 e FosGFP-transgenic rats to assess selective alterations of intrinsic excitability in Fos-expressing

100 th Brugada syndrome through a HEY2-dependent alteration of ion channel expression across the cardiac

101 lts in the destabilization of complex IV and alteration of its enzymatic properties.

102 al rearrangement of the capsid and a complex alteration of its equilibrium dynamics.

103 and core formation, as reflected by a quick alteration of its radius of gyration.

104 ation of the lncRNA sequence and a predicted alteration of its secondary structure, potentially expla

105 rage diameter of NaCas nanoparticles without alteration of its surface charge suggesting a complexati

106 display high levels of BMPR1b expression and alterations of its cellular localization.

107 ract, and the cerebellum and is activated by alterations of its membrane environment.

108 We conclude that alterations of KDM family members represent a disease-dr

109 As many as 40% of HCCs are clonal, with alteration of key tumor-suppressor pathways in stem cell

110 ost cancers develop following random somatic alterations of key oncogenic genes, which are favoured b

111 Alteration of KFB(CHS) expression negatively correlates

112 increase in leaf stearic acid content and an alteration of leaf structure and morphology in addition

113 rvation in adults and children, resulting in alterations of linear growth and bone mass and increased

114 aging mass spectrometry (IMS), we determined alterations of lipid profiles specifically localized to

115 P-28 has contributory roles in emphysema via alteration of macrophage numbers and activation.

116 brain gene expression, DNA methylation, and alteration of magnetic resonance imaging transverse rela

117 The hydrothermal alteration of mantle rocks (referred to as serpentinizat

118 In conclusion, alteration of MBGs expression and their sialoglycosylati

119 These results suggest greater alteration of membrane phospholipid metabolisms in rapid

120 riction of HIV particle infectivity involves alterations of membrane lipid composition.

121 ecologically relevant insights into temporal alterations of microbial communities.

122 To investigate the alterations of microbiota in the distal gut of pigs fed

123 We aimed at investigating whether alteration of miR-194-dependent MMPs and PARP-1 causes r

124 A mitochondrial role in Ld-induced alteration of miRNA activity and stability is further co

125 Its mechanism of action involves alteration of mitochondrial lipid metabolism and differe

126 ond, H. pylori also induces VacA-independent alteration of mitochondrial replication and import compo

127 In addition, alteration of MMPs-9, -13 and -14 expression, PARP-1, HI

128 tration reproducible, but also the selective alteration of mobility separation factors is closely lin

129 Visualization of cancer-associated alterations of molecular phenotype using radionuclide im

130 neously emitted repetitive behaviors without alteration of motor coordination, balance, or locomotion

131 nd target messenger RNAs (mRNAs), leading to alterations of mRNA translation and/or stability.

132 imits proliferation of TFH cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 ex

133 The simultaneous alteration of multiple homoeologs by CRISPR-Cas9 mutagen

134 This systemic alteration of murine gut commensal diversity may be the

135 ging was associated with profound structural alterations of murine uterine arteries, including the oc

136 in healthy ageing, structural and functional alterations of muscle fibres occur.

137 B, and a better understanding of HIV-induced alterations of Mycobacterium tuberculosis-specific CD4(+

138 ers and suggest that this activity-dependent alteration of myelination is important for modifying the

139 Alterations of N-terminal residues outside of the NFM15-

140 To explore possible alterations of NAD(+) homeostasis in the failing heart,

141 erve as a synthetic platform for ring system alteration of natural products.

142 ss this challenge is the systematic backbone alteration of natural protein sequences, through which a

143 In particular, seasonal-mean alterations of near-surface winds associated with the No

144 Alteration of neocortical cytoarchitecture, such as disr

145 f schizophrenia (SCZ) is proposed to involve alterations of neural circuits via synaptic dysfunction,

146 ganglia disorder, we discovered large-scale alterations of neural communities that are significantly

147 Addiction relies on persistent alterations of neuronal properties, which depends on gen

148 These findings suggest that cocaine-induced alterations of neuronal three-dimensional genome organiz

149 Metabolic and functional alterations of neurons in the dorsolateral prefrontal co

150 Common among these changes are alterations of neurons releasing dopamine in the ventral

151 ons of HES1 and NOTCH3 expression reflecting alteration of NOTCH signalling.

152 ation of the HIV LTR and with the subsequent alterations of NPC neurogenesis.

153 nhibition of nucleocytoplasmic transport and alteration of nuclear integrity as a central component o

154 nges of insulin sensitivity that result from alteration of nutritional or metabolic status is a funda

155 The alteration of O-GlcNAcylation was also seen in the ische

156 arrhythmia likelihood and its modulation by alterations of other cellular mechanisms.

157 se of place field stability and (2) a strong alteration of overdispersion (i.e., firing variability).

158 exposed to ionizing radiation, modelling the alteration of oxygen permeabilization in blood vessels a

159 uring cone degeneration revealed significant alteration of pathways related to cell metabolism.

160 These alterations of pERK occurred in CaMKII-expressing neuron

161 throughout development, along with a strong alteration of phenylpropanoid contents, resulting in acc

162 We find that alteration of Pol II catalytic rate, either fast or slow

163 to-snR-DPG switch, which was associated with alterations of Pol II-CTD phosphorylation at the target

164 Recently, recurrent genetic alterations of potential importance for its pathogenesis

165 y in phase transition (theta --> alpha), and alteration of powder morphology, particle dimensions, an

166 Here, we show that activating alterations of PPARG or RXRA lead to a specific gene exp

167 ered an adverse reaction, because it induces alterations of protein and cell properties.

168 We propose that rapid alteration of PTEN activity through changes in its phosp

169 the first observations of direct biological alteration of REE distributions in oceanic systems.

170 co-expression analysis helps further detect alterations of regulatory activities in case/control com

171 Alteration of residues unique to the acetyltransferases

172 essing suggests that CD experience a general alteration of reward function and may be motivated to co

173 unction is a common mechanism underlying the alterations of reward processing observed in patients ac

174 rovide a predictive framework for when human alterations of risk in oceans should lead to cascading e

175 Alteration of ryanodine receptor (RyR)-mediated calcium

176 rectly repressed by miR-27a with concomitant alteration of sclerostin expression, and pharmacological

177 Alterations of selected numbers of PTMs of Htt fragments

178 chemosensors that recognize progesterone by alteration of self-aggregation state is described, and t

179 wed decreased social interaction and several alterations of sensory responses.

180 differential treatment- and region-dependent alterations of several CREB target genes that are well-k

181 CRISPR/Cas9-mediated alteration of smchd1 in zebrafish yielded arhinia-releva

182 athogenic manipulation, and we show that the alteration of social pheromones can be beneficial to the

183 ulture was demonstrated by the corresponding alterations of sodium TQ/SQ MR signals.

184 ults may be useful for inferring how thermal alteration of soil by wildfire can affect water quality.

185 n affected embryo development and led to the alteration of steroidogenesis gene transcripts at nanogr

186 selection of specific genomic mutations and alteration of stress responses, ultimately restoring nor

187 The current results demonstrate significant alterations of structural networks in CAE patients, and

188 These effects occurred without alterations of surface transporter levels, and mutants a

189 Loss of synapses or alteration of synaptic activity is associated with cogni

190 Although the alteration of synaptic plasticity is thought to contribu

191 nslation in neuronal processes is key to the alteration of synaptic strength necessary for long-term

192 plasticity uncovers important insights into alterations of synaptic efficacy and intrinsic neuronal

193 drug-seeking behavior are causally linked to alterations of synaptic strength onto nucleus accumbens

194 Neuronal atrophy and alterations of synaptic structure and function in the me

195 miRNA involvement in the inflammation-driven alterations of synaptic structure and function, collecti

196 est that some of the pathologic and clinical alterations of T2D might be transmissible through a simi

197 ns at any time in their lifespan and through alterations of target protein activity, localization, pr

198 onal truncation and point mutants mapped the alterations of TCL biochemistry to amino acids 17-20.

199 AaIPPI1 in the cytosol can lead to metabolic alterations of terpenoid biosynthesis, and show that the

200 ese data suggest that genetic and epigenetic alterations of TERT are associated with TERT upregulatio

201 Genetic alterations of TET2 occur in myeloid malignancies, and h

202 1-mediated suppression of TFH cell motility, alteration of TFH cell differentiation, reduced TFH abun

203 Alteration of thalamofrontal connectivity has been invol

204 ing the release of 609 protein fragments and alteration of the abundance of >1500 peptides that deriv

205 nuclein with spectrin initiates pathological alteration of the actin cytoskeleton and downstream neur

206 In particular, we observe that most of the alteration of the adiabatic potential in early times com

207 The lasting alteration of the asthmatic epithelial cell transcriptom

208 oal-directed behaviour is likely mediated by alteration of the average reward representation produced

209 ailed computational simulations to probe the alteration of the biomechanical, rheological, and dynami

210 in endothelial-pericyte interactions during alteration of the blood-retinal barrier in diabetic reti

211 The product selectivity can be tuned by alteration of the catalyst loading on the nanotube surfa

212 in systematic changes in gene expression via alteration of the chromatin landscape at the transcripti

213 droxy)carbonates and Fe sulfides, as well as alteration of the composition and amount of OM.

214 xplored implication of sulfate enrichment is alteration of the content and speciation of sulfur in di

215 , entailing a drop in viscosity and possible alteration of the degree of ionization, and also by othe

216 ion of the FRET fluorescent protein pair and alteration of the fluorescent emission spectrum.

217 Importantly, alteration of the folding capacity of the endoplasmic re

218 e disturbances in the human fetal testis and alteration of the germ cell biology.

219 nflammation is frequently associated with an alteration of the gut microbiota, termed dysbiosis, whic

220 several gB antigenic sites were reversible, alteration of the H126 epitope was irreversible.

221 DnaC also causes an alteration of the helical hairpins in the N-terminal dom

222 through proteomic analysis, associated with alteration of the HIS2 transcription start due to transf

223 ates is critically required for Legionella's alteration of the host endocytic pathway, an activity re

224 hat the induction of EAE led to a surprising alteration of the lung milieu, converting an effective s

225 en Dioxygenase-1 (TET1-CD) for loci-specific alteration of the methylation state at the promoter of A

226 in the cells of the microalga, indicating an alteration of the microalga's physiology.

227 difficile infection (CDI) is facilitated by alteration of the microbiome following antibiotic admini

228 These newer studies have shown the frequent alteration of the mitogen-activated protein kinase pathw

229 to a number of bilayer properties and their alteration of the MscL-bilayer interface.

230 This mutant exhibited an alteration of the mycolic acid composition and a pronoun

231 Only limited studies have quantified the alteration of the nano-pore structure due to ME-CBM trea

232 ning of retinal morphology and a significant alteration of the outer retinal layer.

233 ttern of HIV inhibition that involves direct alteration of the physical chemistry of the virus membra

234 One strategy involves alteration of the presentation of the antigen by combini

235 gulate DNA target site accessibility through alteration of the rate of spontaneous dissociation of DN

236 al difference of the peroxisome network, nor alteration of the respiratory machinery was noticed.

237 on specificity without requiring significant alteration of the surrounding protein architecture, refl

238 eling of the chromatin landscape, as well as alteration of the transcriptional profiles.

239 ure of NKp65 to recruit Syk is not due to an alteration of the triacidic motif, which rather affects

240 dysregulation of translation initiation via alteration of the Tsc2-mTor-Eif4e axis was further valid

241 After the alteration of the wetting state, the trapping of N2 was

242 provided preliminary evidence for structural alterations of the A-, B- and/or C-helices within each o

243 In addition, alterations of the atrial cardiomyocytes, increase of no

244 Alterations of the B cell population are not correlated

245 rogenic and angiogenic cytokines and related alterations of the bone marrow microenvironment are comm

246 examination of melittin-induced biophysical alterations of the cells.

247 To investigate the tractional alterations of the central bouquet (CB) in idiopathic ep

248 ATIONALE: Increasing evidence indicates that alterations of the cerebral microcirculation may play a

249 Ozonation resulted in two measurable alterations of the composition of the organic carbon.

250 ent HSV-1 corneal infections cause long-term alterations of the corneal microenvironment that provide

251 so evaluated the robustness of algorithms to alterations of the dataset.

252 Systemic drivers of disease, such as alterations of the endocrine system, metabolism, and abe

253 The most prominent alterations of the gene program linked to CREM-induced a

254 nometer scale resolution the ultrastructural alterations of the glomerular filtration apparatus in mi

255 to investigate CBGT-induced structural brain alterations of the gray and white matter (WM).

256 Alterations of the gut microbiome are associated with de

257 We conclude that alterations of the gut microbiota, specifically a deplet

258 genome-wide infection-linked transcriptional alterations of the host and colonizing extracellular pat

259 iated with greater pro- and antiinflammatory alterations of the innate immune system, similar to thos

260 ve as an easily accessible basis to identify alterations of the innervation produced by experimental

261 Alterations of the MHC class I antigen-processing and pr

262 This suggests that alterations of the microbiota for improving downstream m

263 icient mitochondrial division, morphological alterations of the mitochondrial inner-membrane (IMM) ha

264 in an MU-specific manner, before structural alterations of the NMJ.

265 volution, and ultimately through large-scale alterations of the ocean's carbon and nutrient cycles.

266 ntegrity of the optic nerve, suggesting that alterations of the opposing forces governing mitochondri

267 Alterations of the protein microstructure were closely r

268 sease is incomplete, since information about alterations of the pulmonary vasculature in pulmonary ar

269 morphological, intracellular, and mechanical alterations of the RBCs were analyzed quantitatively.

270 , although it remains unclear how functional alterations of the region contribute to the observed dis

271 leading to marked structural and functional alterations of the retina.

272 Mutations or chemical alterations of the rRNA nucleotides in the drug binding

273 he acrosome, we aimed to investigate whether alterations of the sialome of epididymal spermatozoa and

274 une response but also causes electrochemical alterations of the titanium surfaces, i.e., corrosion, t

275 ization events control DNA repair as well as alterations of the transcriptome and proteome, enabling

276 ance to anti-angiogenic therapy will involve alterations of the tumor microenvironment.

277 tentially masking the effects of biochemical alterations of the variations.

278 r in S. pombe (and humans) is accompanied by alteration of their function from a transposase/endonucl

279 to pre-historic cooking methods show a clear alteration of their initial oxygen isotopic composition.

280 ent carbon sources, and quantify how readily alterations of their chemical reactions create the abili

281 These mDCs exhibit alterations of their fine-tuned homeostatic function and

282 d P40 for WFA/PNN+PV neurons, accompanied by alterations of their firing properties.

283 Third, we demonstrate alteration of these relationships in older adults, sugge

284 ting these animals' communication spaces and alteration of these spaces due to anthropogenic underwat

285 pon validation in additional study sets, the alterations of these three candidate serum biomarker pro

286 We discuss the shared genomic alterations of these tumors independently of their site

287 its normal function in healthy cells and how alteration of this process leads to cancer remain poorly

288 Furthermore, alteration of this residue modulated interactions with t

289 e new insights into our understanding of the alterations of this biofluid during tumor development.-K

290 e body information regarding therapy-induced alterations of this dynamic T-cell population provides n

291 Significant alterations of three-dimensional joint kinematics were i

292 milar across languages, suggesting that such alterations of timbre may be universal.

293 ge across the cell membrane, with subsequent alteration of transmembrane potential that is a function

294 monstrate that obesity and aging precipitate alterations of TRIM28-dependent transcriptional dynamics

295 order (PTSD), this study aims to explore the alteration of triple network connectivity in a specific

296 and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp.

297 Structural and functional alterations of vessels accumulate throughout life, culmi

298 rely noticed by the subject as blink-induced alterations of visual input are blanked out without jeop

299 e efficiency by enhancing thrust through the alteration of vortex ring geometry.

300 dy aimed to investigate the insolubility and alteration of wheat allergens in processed foods and the