ライフサイエンスコーパス: alternative

1 aracetamol) may represent a viable nonopioid alternative.

2 2: 46 min, beta(+): 97%) represents a viable alternative.

3 ing health concerns regarding the use of BPA alternatives.

4 -based precision estimate, are more reliable alternatives.

5 arization, first and last intron processing, alternative 5 and 3'ss usage and exon skipping are marke

6 quently displayed ERG gene fusions involving alternative 5'-partners to TMPRSS2, specifically SLC45A3

7 ost frequently reported adverse event in the alternative ACT group.

8 genetic reduction of Hck activity suppresses alternative activation of tumor-associated macrophages a

9 anions when the macrocycle is located on an alternative (ammonium) binding site, stabilizing the in

10 rther incorporation of decision science into alternatives analysis would advance the ability of compa

11 There is great interest in developing alternative and sustainable strategies to achieve textil

12 ntal and analytical approaches are important alternatives and complements to standard approaches that

13 des the relative value of competing decision alternatives and strongly predicts behavioral value bias

14 omplement C3 is important for the classical, alternative, and lectin pathways of complement activatio

15 mprise three activation pathways (classical, alternative, and lectin) and a terminal cytolytic pathwa

16 address the advantages and disadvantages of alternative antibiotic choices, and suggest areas for fu

17 of equipoise raises the question of whether alternative anticoagulants may have a therapeutic role.

18 el pyro-phototronic effect is invented as an alternative approach for performance enhancement of self

19 lorimetric DNA sensor has potential to be an alternative approach for simple, rapid, sensitive, and s

20 An alternative approach is digital holography where wave-ph

21 An alternative approach is presented where pyridines and di

22 Cell-based HRT (cHRT) is an alternative approach that may allow certain physiologica

23 We sought an alternative approach to commonly used nanoparticle carri

24 be affected by Trpc3 expression requires an alternative approach.

25 Here, we demonstrate an alternative approach: we looked for SNPs associated with

26 Finally, we present alternative approaches and provide recommendations for s

27 vant, being simpler than currently available alternative approaches.

28 hallenge may be appropriate when 1) no safer alternatives are available, 2) the objective benefit exc

29 oid, myeloid, and dendritic, and B-cell fate alternatives are excluded by different mechanisms.

30 helps dissociation of the EF-G by providing alternative base-pairing options.

31 forecasting, but here we consider a serious alternative based on collective human judgment.

32 that drive the state transition toward each alternative cell fate and their relationships with speci

33 process, it is of great interest to explore alternative cell sources capable of generating functiona

34 of a number of experimental models, several alternative cell types have been proposed as the source

35 ecific gene variants or mutations provide an alternative cellular model more relevant to humans upon

36 ias latipes); but etomidate could provide an alternative choice.

37 2.3.4.4 viruses, suggesting consideration of alternative clade 2.3.4.4 CVVs.IMPORTANCE Highly pathoge

38 Alternative cleavage and polyadenylation (APA) generates

39 njured axons, including the newly discovered alternative cleavage and polyadenylation of NaV1.8 mRNA.

40 An alternative computational approach is to match the detec

41 This paper proposes a first step toward an alternative computational framework in which neural acti

42 otein Data Bank (PDB), only 22% of them have alternative conformations and the remaining proteins hav

43 s that can lead to weight gain and potential alternatives, currently approved anti-obesity medication

44 Sensitivity analyses were performed to test alternative definitions of aggressiveness.

45 guide synthetic approaches for the design of alternative device architectures and approaches.

46 and genetic neurodegenerative disorders were alternative diagnoses in more than half of the CJD mimic

47 We evaluated the cost-effectiveness of two alternative direct-acting antiviral (DAA) treatment poli

48 ered every 12 weeks is a suboptimal regimen; alternative dosing strategies are being investigated.

49 RNR) and proteins that facilitate the use of alternative electron acceptors generally increased in th

50 Alternative end-joining (alt-EJ) repair of DNA double-st

51 within the retained intron and overlaps the alternative exon.

52 rval) of highly expressed genes with distant alternative exons exhibit coordination, showcasing the n

53 No alternative explanation for clinical hemolysis was found

54 gical plausibility, strength of association, alternative explanations, cessation, dose-response relat

55 microbial biosensors potentially provides an alternative, fast, and efficient method.

56 stochastic expression, setting the ratio of alternative fates and ultimately determining color prefe

57 genes and down-regulating genes specific to alternative fates.

58 tructed using low cost materials presents as alternative for conventional flow analysis systems becau

59 tion (PPI) is rapidly becoming an attractive alternative for drug development.

60 This device presents a feasible alternative for fractionating blood for transfusion, cel

61 Electrochemistry offers a convenient alternative for metal determination, but the traditional

62 le, highlighting that this assay is a viable alternative for monitoring Ag-specific plasmablast respo

63 Solid-state NMR is becoming a viable alternative for obtaining information about structures a

64 o-edge leaflet repair, is a well-established alternative for patients with severe primary mitral regu

65 tralizing antibodies (bNAbs) may be a viable alternative for short-term prophylaxis or treatment.

66 ed computational framework provides a useful alternative for the characterization of sequence-level d

67 des (AMPs) represent a promising therapeutic alternative for the treatment of antibiotic-resistant ba

68 hould be considered as a non-pharmacological alternative for these disorders.

69 herefore, human iPSCs can replace nt-ESCs as alternatives for generating patient-specific differentia

70 ur experiments used pointing or left/right 2-alternative forced choice tasks to examine perceptual ju

71 We developed a two-alternative forced-choice task in an automated modified

72 The authors tested an alternative formulation of this model: genes may buffer

73 An alternative functional formulation was also prepared by

74 PC4 can bind alternative G4DNA topologies with a low nanomolar Kd val

75 Here we report an alternative grafting-from strategy for directly engineer

76 aves has not been adequately studied to test alternative hydraulic architectural rules such as da Vin

77 We also tested alternative hypotheses for the phylogenetic positions of

78 tential harm to patients under both null and alternative hypotheses using NCI and Alliance data, and

79 We found little support for the alternative hypothesis that forest loss is most detrimen

80 n this study, we present data supporting the alternative hypothesis that S Typhi preferentially targe

81 We tested an alternative hypothesis, that captive rearing induces epi

82 prefrontal cortex (PFC)-as predicted by our alternative hypothesis.

83 A coupled model was used to test alternative hypothesized controls on water quality in a

84 column chromatography represents a promising alternative in sorption studies to reveal sorbent proper

85 type, because there does not appear to be an alternative in vivo reconstitution path, most likely due

86 We thus show that these BPA alternatives induce similar toxic and estrogenic effects

87 Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipp

88 Conversely, the alternative initiation factor eIF2A is essential for can

89 mation' or 'microglial activation' calls for alternative interpretations and complimentary approaches

90 Alternative interpretations of the trace call had little

91 he spontaneous drive of the brain to explore alternative interpretations of unchanging stimuli, we re

92 ncies in Africa and has been associated with alternative invasion pathway usage.

93 Sn, Ge, Cu, Bi, and Sb ions could be used as alternative ions in perovskite configurations to form a

94 ols are not available for most organisms and alternative labeling methods are very limited.

95 These studies show the potential of an alternative LAIV platform for the development of IBV vac

96 zation procedures, there are few therapeutic alternatives, leading to amputations and death.

97 Alternative lengthening of telomeres (ALT) is a telomera

98 N-heterocyclic carbenes (NHCs), a promising alternative ligand class regarding stability and variabl

99 Possible alternative ligands include proteoglycans, polysaccharid

100 ubtypes and critical developmental stages of alternative lineage specifications.

101 t other species, exactly as predicted by the alternative loss of either of the internal introns at th

102 s account for half their operating costs, so alternative, lower energy approaches are equally critica

103 Sequence2Vec outperforms alternative machine learning methods as well as the stat

104 acement of pharmaceutically relevant PEGs by alternative macromolecules offering a suite of similar o

105 Although a few alternative markers have been reported, the aadA has rem

106 obust to species-delimitation schemes and to alternative measures of both rates.

107 key research directions needed to reconcile alternative measures of WUE.

108 Here, we report an alternative mechanism for entosis in human epithelial ce

109 Allosteric modulators offer an alternative mechanism of action to traditional alpha1-ad

110 We then used the model to compare alternative mechanisms for binding nonspatial features.

111 To investigate alternative mechanisms for osmolyte effects, we performe

112 , we report an example of how nature evolved alternative mechanisms to fine-tune the activity of a cy

113 s, or relapse while receiving treatment with alternative medications were included in this trial.

114 ess, ineligibility to receive treatment with alternative medications, or relapse while receiving trea

115 Therefore, ASL perfusion CMR may be an alternative method for quantifying the AAR following AMI

116 in situ Hybridization' ('LISH'), which is an alternative methodology for the analysis of FFPE RNA.

117 is used to compare our approach against two alternative methods mostly used in the literature and wi

118 dovascular interventions are noninvasive and alternative methods to surgery, especially in cases of a

119 any of which are not readily accessible with alternative methods.

120 Included are six alternative MHC reference sequences of the human genome

121 The development of analytical alternatives might have advantages such as greater effic

122 Estimates were broadly robust to alternative model assumptions.

123 Accordingly, we present an alternative model of relative force of infection that be

124 extracts, using the different extractions as alternative model-input.

125 An alternative multivariate modeling approach that categori

126 ajority of DSBs are processed toward a safer alternative, namely noncrossovers (NCOs), via nonrecipro

127 An alternative neuraminidase selective for 2-3 sialic acid

128 or disease conditions, however, animals use alternative neuronal pathways to adapt to the metabolic

129 management, a behavioral treatment that uses alternative non-drug reward to maintain abstinence.

130 Thus, it provides an alternative non-invasive and on-body quantification of g

131 pic candidate that could be considered as an alternative noncatecholaminergic support in the setting

132 In an alternative "notch-pre-patterns-growth" model, a persist

133 nsion relative to 8-oxoG bypass is due to an alternative nucleotide binding conformation in the preca

134 organization may be regarded as a biomimetic alternative of columnar K(+)-water wires observed for th

135 r report is vastly inferior in efficiency to alternative off-the-shelf technologies.

136 means by which the protein might dictate an alternative oxo position.

137 social separation, but infants carrying the alternative OXTR allele did not exhibit as great a separ

138 ctly deduced from the experimental data, and alternative pairing geometries could not be ruled out.

139 In the alternative "parallel" loop, the expected distance betwe

140 , the 12 segments were each derived from the alternative parent.

141 ical specialization therefore constitutes an alternative path in the evolution of acoustic diversity

142 sential positive regulator of the complement alternative pathway (AP) providing stabilization of the

143 , the prevalence of anti-C3b/anti-FB Abs and alternative pathway activation is similar in Ig-MPGN and

144 Activation of complement through the alternative pathway has a key role in the pathogenesis o

145 A competitive alternative pathway is also found where the decarboxylat

146 utations in genes that encode the complement alternative pathway proteins or the molecules that regul

147 se findings indicate that Leishmania uses an alternative pathway to mTOR to induce autophagy in host

148 ic reaction of the amplification loop of the alternative pathway.

149 sistent with the effects of retinoic acid on alternative pathways for ceramide generation.

150 etworks, accountable care organizations, and alternative payment methods evolve, these new systems of

151 d that camelina seed lecithin is a promising alternative PI-rich emulsifier for various food applicat

152 ld-reporting deficiencies and the value that alternative, politically unbiased yield estimates could

153 Alternative polyadenylation (APA) is a widespread gene r

154 irect, previously unappreciated link between alternative polyadenylation and chromatin signaling.

155 ogate transcriptome-wide gene expression and alternative polyadenylation signatures associated with e

156 ivity of positive and negative regulators of alternative polyadenylation.

157 (PEMFCs) running on hydrogen are attractive alternative power supplies for a range of applications,

158 Aberrant alternative pre-mRNA splicing (AS) events have been asso

159 ng erythroid differentiation is regulated by alternative pre-mRNA splicing.

160 In this study, we tested the alternative prediction that VWFA development is in fact

161 sibly due to a maladaptation in digestion of alternative prey items.

162 tational-wave Observatory opened the door to alternative probes of stellar and galactic evolution, co

163 Because more patients are being treated with alternative programs, comparison of results will require

164 Transcription start-site (TSS) selection and alternative promoter (AP) usage contribute to gene expre

165 ated tissues, and that it is regulated by an alternative promoter whose activity is repressed by the

166 The use of alternative promoters and alternative splicing at the fo

167 Two alternative propagation mechanisms have been proposed: m

168 curacy enables a user to distinguish between alternative protein structures.

169 The putative alternative proteins translated from altORFs have orthol

170 However, recent improvements on alternative pulse sequences provide attractive alternati

171 a set number of bins (quantization B) and an alternative quantization with bins of fixed width (quant

172 ney exchange paired recipient, the naming of alternative recipients, and the potential to unfairly ad

173 d environmental competitiveness of renewable alternatives relative to conventional generation.

174 e of Dna2, MRN together with CtIP mediate an alternative resection initiation pathway where the nucle

175 o the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose

176 gated connexin-assembled gap junctions as an alternative route for discharging lactate from pancreati

177 Intranasal (IN) administration, an alternative route for non-invasive drug delivery to the

178 development with that of skin, undergoing an alternative route of cell death, namely cornification ra

179 potentially be addressed therapeutically by alternative routes for oocyte formation.

180 assessment of benefits and tradeoffs of the alternative schedule without disturbing existing clinica

181 Alternative schemes, such as those that use high-dimensi

182 via secretory autophagy, an autophagy-based alternative secretion pathway.

183 raits in a single plant, there is a need for alternative selectable marker genes.

184 es of the IDP amyloid-beta42 (Abeta42) to an alternative sequence in which a nitroxide spin label att

185 ved conditions was a result of activation of alternative signaling pathways mediated by factors secre

186 cancer phenotypes via distinct classical and alternative signaling pathways, with implications for im

187 Alternative splicing (AS) that occurs at the final codin

188 We report the complexity of alternative splicing along isoforms, including 683 intra

189 Alternative splicing also changes the activity of sodium

190 approaches to model the association between alternative splicing and histone posttranslational modif

191 ession in this region on gene expression and alternative splicing and performed quantitative chromati

192 of the protein biosynthesis pathway, such as alternative splicing and post transcriptional and transl

193 However, whether JMJD6 is widely involved in alternative splicing and the molecular mechanism underly

194 The use of alternative promoters and alternative splicing at the foraging locus creates diver

195 Alternative splicing contributes to gene expression dyna

196 n part by RNA-binding proteins that regulate alternative splicing decisions through interactions with

197 for, at least partially, their co-regulated alternative splicing events, suggesting both JMJD6 enzym

198 the histone methyl transferase SEDT2 affects alternative splicing fates of several key regulatory gen

199 lecular mechanism underlying JMJD6-regulated alternative splicing have remained incompletely understo

200 The role of alternative splicing in beta cells remains unclear, but

201 tes genome-wide transcriptional profiles and alternative splicing induced by cocaine.

202 clear and cytoplasmic Esrp1 isoforms through alternative splicing is phylogenetically conserved; stro

203 mphibian neural development and suggest that alternative splicing of C-Src in the developing vertebra

204 Alternative splicing of CA transcripts appears common; c

205 Alternative splicing of exon 10 in the tau primary trans

206 On the other hand, alternative splicing of Intron-2 generates a longer tran

207 n the regulation of tau phosphorylation, the alternative splicing of tau exon 10, and cognitive perfo

208 Our data demonstrate that the NMD and alternative splicing pathways regulate p53beta in a syne

209 splicing isoforms supporting the notion that alternative splicing plays a central role in human genom

210 Regulation of gene expression by alternative splicing plays a pivotal role in brain, wher

211 h the use of different genes, promoters, and alternative splicing, but the functional significance of

212 eliminated in AhCSD1-2.2 as a consequence of alternative splicing, which bypasses miRNA-mediated down

213 NA motifs in introns and exons and regulates alternative splicing.

214 s of the early spliceosome and regulators of alternative splicing.

215 ctivity-dependent and independent control of alternative splicing.

216 However, a LDAH alternative-splicing variant missing 90 amino acids at C

217 Here we adopt an alternative statistical method that substitutes space fo

218 Alternative strategies with new drugs, both antiplatelet

219 to traditional organic nitrate therapies, an alternative strategy to restore NO-cGMP signaling is via

220 in metabolic engineering of plants offers an alternative supply option.

221 version of cholesterol to bile acids via the alternative synthesis pathway.

222 Compared to drainfields, alternative systems had similar median and higher maximu

223 ersification rates compared to lineages with alternative systems while considering additional traits

224 For a seamless transition to alternative targeted agents, patients progressing with C

225 d of patients, which has led to a search for alternative techniques such as multisite pacing, His bun

226 luorination efficiencies compared to leading alternative technologies.

227 ietary data, (2) choosing Random Forest over alternative tested Machine Learning methods, and (3) bal

228 ical issue that calls for the exploration of alternative testing methods to reduce the number of subj

229 technology and predictive methodologies into alternative testing strategies (ATS).

230 tible - in fact, much more in line - with an alternative that does not rely on syntactic representati

231 The recommended techniques cover alternatives that may suit various biological goals, exp

232 trant IDH1 mutant-selective inhibitors as an alternative therapeutic option.

233 Phytochemicals have gained attention as alternative therapeutics for managing cardiovascular dis

234 ial appendage closure has emerged as a valid alternative to anticoagulation therapy for the preventio

235 that targeting PAR4 represents an attractive alternative to blocking PAR1 for antiplatelet therapy in

236 stem cell-conditioned medium (CM-MSC) as an alternative to cell therapy in an antigen-induced model

237 dustry-grade CMOS camera as a cost-efficient alternative to commonly used scientific cameras.

238 with mandibular advancement device, the main alternative to continuous positive airway pressure, impr

239 Tissue-engineering can serve as an alternative to conventional donor corneal transplantatio

240 release of drugs is an effective therapeutic alternative to conventional immediate-release dosage for

241 gnostics first emerged in 2007 as a low-cost alternative to conventional laboratory testing, with the

242 ferent drug classes and might be a promising alternative to conventional procedures.

243 erial CO2 has the capability to evolve as an alternative to current pharmacologic vasodilators used f

244 e showed that passive samplers were a viable alternative to grab sampling since between 3 and 17 grab

245 onitoring, SRM) is emerging as an attractive alternative to immunoassays for protein quantification.

246 icating the use of PGJ and GSF is a feasible alternative to increase the functional properties of yog

247 or elements with Z </= 20 was proposed as an alternative to ion chromatography to obtain information

248 a fast, economical and potentially accurate alternative to laboratory mutagenesis.

249 ytosolic malate dehydrogenase 1 (MDH1) is an alternative to LDH as a supplier of NAD.

250 ium ion batteries are being considered as an alternative to lithium ion batteries in large-scale ener

251 Fibrinolytic therapy offers an alternative to mechanical reperfusion for ST-segment ele

252 outcomes of this operation, making it a safe alternative to orthotopic liver transplantation for pati

253 stant temperature, have emerged as promising alternative to PCR and greatly simplify the implementati

254 This strategy may be a valid alternative to routine full-course antibiotic therapy.

255 x may help better select patients needing an alternative to SIC, including ASCT.

256 cellular cleft separation as a compliment or alternative to sodium channels.

257 ve pressure delivery systems may be feasible alternative to standard direct laryngoscopy approach.

258 absorption methods have become a competitive alternative to state-of-the-art isotopic ratio mass spec

259 S) microarray is a low-cost, self-producible alternative to the commercial ImmunoCAP ISAC in allergy

260 e TVT registry model should be considered an alternative to the Society of Thoracic Surgeons Predicte

261 MC algorithm for static model is a promising alternative to the state-of-the-art approach for simulat

262 We rise to the challenge with an alternative to the wave function-centered interpretation

263 tion) from VOO has been developed, giving an alternative to the widely used GC (FID/MS) methodologies

264 r, thus representing an operationally simple alternative to traditional cross-coupling macrocyclizati

265 r breakthrough in this field and a promising alternative to traditional medical stainless steel and p

266 s of reporter proteins in living cells as an alternative to traditional optical fluorescence.

267 As an alternative to urethral swabs, meatal swabs have been re

268 Administration (FDA) as a stroke prevention alternative to warfarin for patients with nonvalvular at

269 ved renal function and might be a reasonable alternative to warfarin for stroke prevention in patient

270 one of the standards of care as a less toxic alternative to WBRT for this patient population.

271 method is an efficient and less deleterious alternative to wild-type Cas9 for gene-knockout studies.

272 ternative pulse sequences provide attractive alternatives to 1D NOESY presat and CPMG presat.

273 nology makes it possible to quickly engineer alternatives to conventional automation infrastructure t

274 bility of companies and regulators to select alternatives to harmful ingredients and would also advan

275 lity of donor organs has led to a search for alternatives to liver transplantation to restore liver f

276 ient specificity to make them cost-effective alternatives to manual grading alone.

277 attract increasing attention as sustainable alternatives to petroleum-derived surfactants.

278 esented implantation techniques are feasible alternatives to the standard 3-incision subcutaneous imp

279 tion method (Lasso-AL) are fast and powerful alternatives to the standard univariate analysis in geno

280 s, have also been developed and evaluated as alternatives to traditional Bacillus Calmette-Guerin nee

281 sorghum, millet, quinoa and amaranth can be alternatives to wheat and corn as ingredients for whole

282 n variants of 2504 subjects, while a popular alternative tool required around one day.

283 ast, several other studies have recovered an alternative topology in which ctenophores are the sister

284 ram Interagency Center for the Evaluation of Alternative Toxicological Methods developed the Integrat

285 UG-uORFs and are less subject to removal via alternative transcription initiation under normal growth

286 en promoter methylation and expression of an alternative transcriptional start site, including AKT3 T

287 e of antimicrobial resistance, necessitating alternative treatment options.

288 dict poor response to omalizumab therapy and alternative treatment strategies for children with these

289 ancers (HGS-OvCa) has motivated a search for alternative treatment strategies.

290 s reviewed by several specialists to develop alternative treatments for IgG4-related disease.

291 Complementary and alternative treatments, such as cardiovascular exercise,

292 ices, and the opportunity cost of water when alternative uses compete.

293 , and harvest stage should be considered for alternative uses of end-products with high bioactivity.

294 Here, we describe the development of an alternative vaccine strategy encompassing the expression

295 through Monte Carlo simulations and running alternative variants of the model.

296 An alternative via formation of a higher-energy protonated

297 We reasoned that an alternative way to cultivate species with unknown requir

298 To test between these alternatives we used a task in which participants were r

299 To investigate these alternatives, we evaluated the contributions of intersex

300 The test is very powerful against alternatives with a shift in variance and is accurate in