ライフサイエンスコーパス: alternative splicing

1 s of the early spliceosome and regulators of alternative splicing.

2 ave secondary effects on DNA methylation and alternative splicing.

3 panied by partial correction of misregulated alternative splicing.

4 mechanisms by which branchpoint usage drives alternative splicing.

5 e of exon repression mechanisms that control alternative splicing.

6 e the pharmacological importance of OPRM1 3' alternative splicing.

7 al role for RNA G quadruplexes in regulating alternative splicing.

8 porting a broad role for GSK-3 in regulating alternative splicing.

9 auxiliary proteins recruit human U1 snRNP in alternative splicing.

10 from human/mouse, fly and worm, to regulate alternative splicing.

11 ctivity-dependent and independent control of alternative splicing.

12 gene that is known to undergo highly complex alternative splicing.

13 FUS and TDP-43, TAF15 has a minimal role in alternative splicing.

14 s at the post-transcriptional level, such as alternative splicing.

15 ecreted isoform (sCD55) that is generated by alternative splicing.

16 protein exists in two forms as the result of alternative splicing.

17 a specific region of UPF1 and triggered UPF1 alternative splicing.

18 st-transcriptional RNA processing, including alternative splicing.

19 opmental regulation, and evolutionary age of alternative splicing.

20 ng from microRNA-dependent gene silencing to alternative splicing.

21 tome reveals extensive network remodeling by alternative splicing.

22 caine-induced changes in gene expression and alternative splicing.

23 XI and GLXII isoforms can be derived through alternative splicing.

24 nificantly enriched among genes that undergo alternative splicing.

25 sitively with changes in gene expression and alternative splicing.

26 vides insights into the functional impact of alternative splicing.

27 n quantifying gene expression and can detect alternative splicing.

28 through post-translational modification and alternative splicing.

29 NA motifs in introns and exons and regulates alternative splicing.

30 strong evidence that GSK-3 broadly regulates alternative splicing.

31 splicing branchpoints are indicators for the alternative splicing.

32 signaling in PV interneurons is mediated by alternative splicing.

33 ing the distribution of Titin mutations: (1) alternative splicing, (2) whether the internal promoter

34 Over 95% of human multi-exon genes undergo alternative splicing, a process important in normal deve

35 Coordinated alternative splicing across developmental stages pointed

36 be insufficient to interpret the patterns of alternative splicing across samples and restrains the ap

37 We report the complexity of alternative splicing along isoforms, including 683 intra

38 Alternative splicing also changes the activity of sodium

39 pipeline for transcript-level expression and alternative splicing analyses.

40 or of nuclear mRNA processing events such as alternative splicing and 3 end mRNA processing.

41 , including a mutation that appears to cause alternative splicing and a premature stop codon in sweet

42 Pre-mRNA alternative splicing and alternative polyadenylation hav

43 se results demonstrate the interplay between alternative splicing and alternative polyadenylation, an

44 demonstrated to encode two proteins through alternative splicing and alternative polyadenylation.

45 y, FgSRP1 had two transcript isoforms due to alternative splicing and both of them were required for

46 ing dopamine receptor D2) is associated with alternative splicing and cognitive functioning; however,

47 Aberrant alternative splicing and epigenetic changes are both ass

48 SMN2, a paralogous gene to SMN1, undergoes alternative splicing and exclusion of exon 7, producing

49 approaches to model the association between alternative splicing and histone posttranslational modif

50 Therefore, understanding the mechanism of alternative splicing and identifying the difference in s

51 or 1 (AUF1) has four isoforms resulting from alternative splicing and is critical for miRNA-mediated

52 3), a brain-enriched neurotrophin, undergoes alternative splicing and is implicated in several neurol

53 We investigate alternative splicing and its functional consequences in

54 t CnnT is expressed exclusively in testes by alternative splicing and localizes to giant mitochondria

55 as for more specialized functions including alternative splicing and packaging of unspliced genomic

56 ession in this region on gene expression and alternative splicing and performed quantitative chromati

57 We identify prominent alternative splicing and polyadenylation abnormalities i

58 e dysregulation of developmentally regulated alternative splicing and polyadenylation in congenital m

59 Thus, SRSF3 and SRSF7 couple alternative splicing and polyadenylation to NXF1-mediate

60 of the protein biosynthesis pathway, such as alternative splicing and post transcriptional and transl

61 We also found that Domain 2 is subject to alternative splicing and provide evidence that this doma

62 a crucial role played by the tissue-specific alternative splicing and relative abundance of the OsPCS

63 Because of alternative splicing and repetitive sequences, a ribosom

64 role for RBM25 as an essential regulator of alternative splicing and reveal a new potential mechanis

65 eneration, transcript fusion identification, alternative splicing and sequence variant calling.

66 of protein interaction capabilities through alternative splicing and suggests that many alternative

67 stage, suggesting a novel connection between alternative splicing and the cell cycle.

68 However, whether JMJD6 is widely involved in alternative splicing and the molecular mechanism underly

69 Alternative splicing and the usage of alternate transcri

70 Here we report alternative splicing and transcriptional events among su

71 Alternative splicing and transcriptional events detected

72 rived from the BCR-ABL junctional region and alternative splicing, and of adoptively administering th

73 intact proteins to study genetic variation, alternative splicing, and post-translational modificatio

74 tion in sensitivity and inability to observe alternative splicing, and should enable many larger scal

75 we interrogate the noncoding transcriptome, alternative splicing, and upstream molecular regulators

76 and demonstrates that proteins involved with alternative splicing are important factors in T cell fat

77 as RNA polymerase II (RNAPII) elongation and alternative splicing are largely unknown.

78 e gene, exons 9beta and 9gamma, generated by alternative splicing, are the targets of inactivating mu

79 alth of genomic information, a comprehensive alternative splicing (AS) analysis of pancreatic ductal

80 ediated phasiRNA production was coupled with alternative splicing (AS) and alternative polyadenylatio

81 the bamboo genome, and identify genome-wide alternative splicing (AS) and alternative polyadenylatio

82 highlighted the fact that most genes undergo alternative splicing (AS) and that these patterns are ti

83 Networks of coordinated alternative splicing (AS) events play critical roles in

84 Alternative splicing (AS) generates isoform diversity fo

85 Pre-mRNA alternative splicing (AS) generates protein variants fro

86 Alternative splicing (AS) has emerged in the postgenomic

87 aluation of the roles of gene expression and alternative splicing (AS) in autoimmunity.

88 ng technologies have highlighted the role of alternative splicing (AS) in increasing transcriptome co

89 cellular alga, is a good model to understand alternative splicing (AS) in plants from an evolutionary

90 Alternative splicing (AS) is a crucial regulatory mechan

91 Alternative splicing (AS) is a genetically and epigeneti

92 Alternative splicing (AS) is a key post-transcriptional

93 her isoforms from the same gene generated by alternative splicing (AS) is essential to the maintenanc

94 Alternative splicing (AS) patterns have diverged rapidly

95 Messenger RNA alternative splicing (AS) regulates the expression of a

96 on of EMT has been well studied, the role of alternative splicing (AS) regulation in EMT remains rela

97 Alternative splicing (AS) that occurs at the final codin

98 s) play a critical role in the regulation of alternative splicing (AS), a prevalent mechanism for gen

99 Most eukaryotic genes are subject to alternative splicing (AS), which may contribute to the p

100 ranscriptome involves both transcription and alternative splicing (AS).

101 The presence of the exclusive alternative splicing at exon 19 was not associated with

102 The use of alternative promoters and alternative splicing at the foraging locus creates diver

103 Alternative splicing at the human glucuronosyltransferas

104 gy can greatly facilitate the exploration of alternative splicing biomarkers in disease diagnosis and

105 ns have well-established roles in regulating alternative splicing, but specific Rbfox isoforms lack n

106 h the use of different genes, promoters, and alternative splicing, but the functional significance of

107 ore and an array score, a decision regarding alternative splicing can be made.

108 hlight the novel and hierarchical role of an alternative splicing cascade that is involved in the dev

109 exon 1, which occurs in vivo as a result of alternative splicing, causes toxicity.

110 t of individual regulators to a target exon, alternative splicing choices also depend on the higher-o

111 Alternative splicing contributes to gene expression dyna

112 were considered to be the putative target of alternative splicing-coupled nonsense-mediated decay mec

113 n part by RNA-binding proteins that regulate alternative splicing decisions through interactions with

114 erived induced pluripotent stem cells showed alternative splicing defects that were restored upon rep

115 We thus report a novel mechanism of alternative splicing deregulation that may play a role i

116 c to adult mouse muscle and demonstrate that alternative splicing developmental transitions impact mu

117 he role of chromatin structure in modulating alternative splicing during development.

118 Furthermore, analysis of alternative splicing during human myogenesis reveals tha

119 in isoforms as well as the broader impact of alternative splicing during muscle postnatal development

120 The alternative splicing effects of FTO KO anti-correlate wi

121 In this study, we sought to analyze alternative splicing events (ASE) that could alter gene

122 We identified 593 differential alternative splicing events between HD and control brain

123 HnRNP A1 regulates many alternative splicing events by the recognition of splici

124 and retained intron to be the most abundant alternative splicing events during lens development.

125 We reveal 14,353 alternative splicing events in 17,669 novel isoforms at

126 anscriptional initiation and elongation, and alternative splicing events in ES cells.

127 (SPR) biosensor for label-free monitoring of alternative splicing events in real-time, without any cD

128 start and end sites, as well as hundreds of alternative splicing events in these B1a cells.

129 NOVA proteins regulate at least 700 alternative splicing events in vivo, yet relatively litt

130 eins and in tex1 plants the ratio of certain alternative splicing events is altered.

131 oform, reveals that NOVA2 uniquely regulates alternative splicing events of a series of axon guidance

132 ovides a work flow for the identification of alternative splicing events relying on the established l

133 d resistant mosquitoes revealed evidences of alternative splicing events with three transcripts of 20

134 d alternative splice form in plants ( 50% of alternative splicing events).

135 ranscription factor network interactions and alternative splicing events, little of which can be reso

136 for, at least partially, their co-regulated alternative splicing events, suggesting both JMJD6 enzym

137 primary mammalian species used for studying alternative splicing events.

138 addition, 46.2% of detected mRNAs displayed alternative splicing events.

139 Splicing (REIDS), for the identification of alternative splicing events.

140 D6 and U2AF65 co-regulated a large number of alternative splicing events.

141 D2 target genes, and induce H3K36me3-coupled alternative splicing events.

142 In PH, miR-124, through the alternative splicing factor PTBP1, regulates the PKM2/PK

143 We hypothesized that alternative splicing factors RBFOX2 and RBFOX1 might med

144 site recognition and is a frequent target of alternative splicing factors.

145 the histone methyl transferase SEDT2 affects alternative splicing fates of several key regulatory gen

146 methods are available to study differential alternative splicing, few tools for detection of isoform

147 Intron retention is the major type of alternative splicing, followed by alternate "intron in e

148 importance of assessing naturally occurring alternative splicing for clinical evaluation of variants

149 visualization, differential gene expression, alternative splicing, functional analysis, gene fusion d

150 as the long-sought regulator of Neurofascin alternative splicing, further establishing the role of Q

151 propionate (AMPA) receptors, RNA editing and alternative splicing generate sequence variants, and tho

152 Alternative splicing generates a diversity of messenger

153 Alternative splicing generates multiple isoforms of the

154 Alternative splicing generates multiple transcript and p

155 Alternative splicing generates two different regions tha

156 Although alternative splicing has been studied during development

157 bunits, distinct GIRK2 isoforms generated by alternative splicing have been identified.

158 lecular mechanism underlying JMJD6-regulated alternative splicing have remained incompletely understo

159 The role of alternative splicing in beta cells remains unclear, but

160 g indicating they play a significant role in alternative splicing in brain reward tissue.

161 arious cancers, but epigenetic regulation of alternative splicing in cancer is largely unknown.

162 and regional H3K36me3 alterations influence alternative splicing in ccRCC.

163 ibitor of splicing in vitro and modulator of alternative splicing in cells.

164 saffron stigma allowed the determination of alternative splicing in CsCCD2, being intron retention (

165 intron retention (IR) the prevalent form of alternative splicing in CsCCD2.

166 e further demonstrated the JMJD6 function in alternative splicing in jmjd6 knockout mice.

167 We found that all homologs can regulate alternative splicing in mouse cells, with some regulatin

168 in missense codon changes and modulation of alternative splicing in mRNA, and modification of regula

169 corresponded well with genes susceptible to alternative splicing in response to Microcystis stress.

170 s of KIDINS220 KIDINS220 undergoes extensive alternative splicing in specific neuronal populations an

171 umber of mRNA isoforms generated entirely by alternative splicing in the 5'-untranslated region (5'-U

172 The RNA binding protein Celf1 regulates alternative splicing in the nucleus and mRNA stability a

173 making it possible to characterize genes and alternative splicing in unprecedented detail.

174 DR77 in MDA-MB-231 cells leads to defects in alternative splicing, including inclusion of A-T rich ex

175 Taken together, alternative splicing increases the complexity of the S.

176 Alternative splicing increases the diversity of transcri

177 tes genome-wide transcriptional profiles and alternative splicing induced by cocaine.

178 nd demonstrate the complex interplay between alternative splicing, inner ear development, and auditor

179 Alternative splicing involving an N1-Src-specific microe

180 Alternative splicing is a complex process that provides

181 Alternative splicing is a critical mechanism for expandi

182 Overall, this study demonstrates that CPEB2 alternative splicing is a major regulator of key cellula

183 The extent to which alternative splicing is active and functional in unicell

184 ortant for conidiation, and pathogenesis and alternative splicing is important for its normal functio

185 In the heart, alternative splicing is increasingly being recognized as

186 While alternative splicing is known to diversify the functiona

187 Alternative splicing is known to remodel protein-protein

188 clear and cytoplasmic Esrp1 isoforms through alternative splicing is phylogenetically conserved; stro

189 In contrast, alternative splicing is rare in P. vivax but its associa

190 Alternative splicing is the critical process in a single

191 An alternative splicing isoform switch is where a pair of t

192 short RNA-seq reads into transcriptomes with alternative splicing isoforms.

193 In addition, we show that alternative splicing likely regulates this phenomenon.

194 n compared to normal tissue, suggesting that alternative splicing may play a role in shaping the tumo

195 Isoforms, however, generated from alternative splicing, may provide a novel and complement

196 78-786) generated by a focal deletion-driven alternative splicing mechanism as well as novel VAV1 gen

197 Alternative splicing modifies sodium channels, but the f

198 uman beta-cell function and survival, namely alternative splicing modulated by key splicing regulator

199 e amount of transcript being made as well as alternative splicing, novel transcript identification, m

200 ave discovered that NOVA2 uniquely regulates alternative splicing of a coordinate set of transcripts

201 coding RNAs (lncRNAs), downregulation of the alternative splicing of activity-dependent neuron-specif

202 Loss of m(6)A also affects alternative splicing of additional genes, predominantly

203 liced out, as occurs most of the time during alternative splicing of amelogenin pre-mRNA, a novel mat

204 in prostate cancer has been associated with alternative splicing of androgen receptor (AR) and speci

205 TRAF6 ubiquitination of hnRNPA1 regulated alternative splicing of Arhgap1, which resulted in activ

206 mphibian neural development and suggest that alternative splicing of C-Src in the developing vertebra

207 Alternative splicing of CA transcripts appears common; c

208 While 1C8 affects the alternative splicing of cellular transcripts controlled

209 d the role of the functional consequences of alternative splicing of CXCR3, we measured signaling in

210 show here that Nova deficiency disrupts the alternative splicing of Dcc, and that restoring Dcc spli

211 This is the first case of alternative splicing of duplicated exon in a mollusc tha

212 Alternative splicing of ErbB4 transcripts is dysregulate

213 expressed in Down syndrome brains, regulates alternative splicing of exogenous tau exon 10.

214 Alternative splicing of exon 10 in the tau primary trans

215 he related SMN2 gene is retained, but due to alternative splicing of exon 7, produces insufficient le

216 Alternative splicing of fibronectin increases expression

217 Alternative splicing of GAD1 and epigenetic state appear

218 raction with the CFIm complex fine-tunes the alternative splicing of Glutaminase (GLS) by selecting t

219 infection, such as genome-wide alteration in alternative splicing of host protein-coding genes, enhan

220 f host noncoding transcripts, as well as the alternative splicing of host protein-coding genes.

221 eceptor alpha chain gene (sIL7R) produced by alternative splicing of IL7R exon 6.

222 On the other hand, alternative splicing of Intron-2 generates a longer tran

223 amin-related protein 1 (Drp1) arise from the alternative splicing of its single gene-encoded pre-mRNA

224 pre-mRNA undergoes DNA methylation-sensitive alternative splicing of its terminal exon 3' untranslate

225 ack of available MBNL1 leads to misregulated alternative splicing of many target pre-mRNAs, leading t

226 Alternative splicing of mRNA precursors enables cells to

227 ancer are linked to increased expression and alternative splicing of muscle-specific isoforms of ANK1

228 Thus, PV-cell-specific alternative splicing of neurexins is critical for neuron

229 tissue-specific paralogue that regulates the alternative splicing of neuronal pre-mRNAs.

230 ctivity is modulated by the highly regulated alternative splicing of Nf1 exon 23a.

231 Therefore, the regulated alternative splicing of Nf1 is an important mechanism fo

232 across splice junctions, we determined that alternative splicing of p53/hypoxia pathway-associated m

233 Alternative splicing of Ppp2r2a decreased PPP2R2A protei

234 Alternative splicing of pre-mRNAs significantly contribu

235 NP particles and subsequently regulating the alternative splicing of pre-mRNAs, a plausible link betw

236 act binding protein 1) expression to control alternative splicing of pyruvate kinase muscle (PKM) iso

237 imidine tract binding protein), resulting in alternative splicing of pyruvate kinase muscle isoforms

238 Qk RNA levels by promoting accumulation and alternative splicing of Qk RNA, whereas Qk6 promotes its

239 two isoforms, CPEB2A and CPEB2B, derived by alternative splicing of RNA into a mature form that eith

240 ctivating the mTOR pathway by modulating the alternative splicing of S6K1.

241 We find that MBNL1 regulates alternative splicing of SCN5A mRNA and that the splicing

242 on to PKM splicing, BORIS also regulates the alternative splicing of several genes in a DNA methylati

243 ns and pyrido-pyrimidinones) that modify the alternative splicing of SMN2, a paralogous gene to SMN1,

244 ptimized representative compounds modify the alternative splicing of SMN2, increase the production of

245 ecause m(6)A is required for female-specific alternative splicing of Sxl, which determines female phy

246 Alternative splicing of SYP13II allows plants to replace

247 Alternative splicing of tau exon 10 generates tau isofor

248 phosphorylating tau and by dysregulating the alternative splicing of tau exon 10 in AD.

249 n the regulation of tau phosphorylation, the alternative splicing of tau exon 10, and cognitive perfo

250 l function of DGCR8 in the modulation of the alternative splicing of Tcf7l1 mRNA in addition to its e

251 d D2S, which are generated by a mechanism of alternative splicing of the Drd2 gene, raises the questi

252 Extensive 3' alternative splicing of the mu opioid receptor gene OPRM

253 Alternative splicing of the oncogene murine double minut

254 Alternative splicing of the Pkm gene product generates t

255 its role in alternative polyadenylation and alternative splicing of the single MVC pre-mRNA.

256 y unidentified complex,SNORD27 regulates the alternative splicing of the transcription factor E2F7p r

257 Chromatin structure can also influence alternative splicing of transcripts; however, the mechan

258 e standard method for quantifying changes in alternative splicing on a genome-wide scale.

259 The functional consequences of alternative splicing on altering the transcription rate

260 a epigenetic modulations, through regulating alternative splicing, or by acting as molecular sponges.

261 Our data demonstrate that the NMD and alternative splicing pathways regulate p53beta in a syne

262 raction and thereby alter the expression and alternative splicing pattern of target mRNAs.

263 orms increases significantly due to numerous alternative splicing patterns, resulting in a prioritiza

264 transcriptional activation, or modulation of alternative splicing patterns.

265 ly, we unraveled large-scale changes in mRNA alternative splicing patterns.

266 splicing isoforms supporting the notion that alternative splicing plays a central role in human genom

267 Regulation of gene expression by alternative splicing plays a pivotal role in brain, wher

268 e alterations resulting from gene mutations, alternative splicing, post-translational modifications,

269 8 delineates a key role for this gene in the alternative splicing program occurring during terminal e

270 gulators, and sequence elements generated by alternative splicing promote axonal mRNA translation.

271 idues) domain found in RBM5 is important for alternative splicing regulation and mediates interaction

272 an intimate link between JMJD6 and U2AF65 in alternative splicing regulation, which has important imp

273 2AF65, all of which are known to function in alternative splicing regulation.

274 e spliceosomal SmN/B/B' proteins in FAS/CD95 alternative splicing regulation.

275 MBNL proteins are alternative splicing regulators that bind to the consens

276 between particular histone modifications and alternative splicing remains unexplored.

277 onsensus motif patterns and association with alternative splicing (splicing factors), transcript abun

278 diverse mechanisms of gene rescue, including alternative splicing, stop codon readthrough, alternativ

279 literature has described chromatin-regulated alternative splicing, suggesting a novel function for dr

280 oncogenic event mainly depends on a specific alternative splicing switch.

281 S. commune exhibits more alternative splicing than any other studied fungus.

282 orpha UVR8 gene expresses two transcripts by alternative splicing that encode functional UVR8 variant

283 otein with multiple isoforms produced though alternative splicing that exhibit tissue-specific expres

284 ne encodes the tumor suppressor p53 and, via alternative splicing, the p53beta and gamma isoforms.

285 rally thought that splicing factors regulate alternative splicing through binding to RNA consensus se

286 d TET2 as active regulators of CTCF-mediated alternative splicing through conversion of 5-methylcytos

287 patocellular carcinoma, modulating oncogenic alternative splicing through SRSF1 upregulation.

288 antisense pairs and the exon skipping during alternative splicing, through interacting with RNA molec

289 superoxide dismutase (CSD1) is eliminated by alternative splicing to bypass miR398-mediated gene down

290 The XBAT35 transcript undergoes alternative splicing to produce two protein isoforms, XB

291 dynamic for differential gene expression and alternative splicing transitions, and calcium-handling f

292 with a tandem duplication of exon 10, and 3' alternative splicing using either the first or second ex

293 However, a LDAH alternative-splicing variant missing 90 amino acids at C

294 e 4 (ErbB4), whose function is influenced by alternative splicing, we tested the hypothesis that prun

295 tion by premature truncating codon bypass by alternative splicing when evaluating the functional sign

296 able therapeutic target, is characterised by alternative splicing which generates three principal iso

297 eliminated in AhCSD1-2.2 as a consequence of alternative splicing, which bypasses miRNA-mediated down

298 We have analyzed chromatin regulation of alternative splicing, which is implicated in cocaine exp

299 or KDM5B in regulating RNAPII elongation and alternative splicing, which may support the diverse mRNA

300 Inhibition of alternative splicing with digitoxin followed by immunopr