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1 ch gene by selecting exons classified as not alternatively spliced.
2 d genes; over 95% human multi-exon genes are alternatively spliced.
3 Numerous eukaryotic genes are alternatively spliced.
4 Nearly 50% of genes are alternatively spliced.
5 nctional classes determine whether a gene is alternatively spliced.
6 that 60.3% of honey bee multi-exon genes are alternatively spliced.
7 l exons have been identified and shown to be alternatively spliced.
8 Two viral mRNAs are alternatively spliced.
9 approximately 42% of multi-exonic genes were alternatively spliced.
10 ur results indicate that the presence of the alternatively spliced 1/4 CTLA-4 isoform can further pro
11 ng activities of full-length, truncated, and alternatively spliced 57kT forms of MCPyV large T antige
14 assessed the transforming properties of the alternatively spliced AE isoform AE9a (or alternative sp
15 However, the unique functions of various alternatively spliced amelogenins in enamel formation ar
16 ibing SR proteins as NXF1 adaptors that flag alternatively spliced and polyadenylated mRNA isoforms a
18 Previous work suggests that ced-4 can be alternatively spliced and that the splice variants funct
22 The Zasp52 primary transcript is extensively alternatively spliced, and we describe its splicing patt
23 ved in blood that correlate with tics or are alternatively spliced are involved in the pathophysiolog
25 ity of a SERS platform to monitor individual alternatively spliced (AS) variants and miRNA copies wit
27 minus because BBP (also known as 53BP2S), an alternatively spliced ASPP2 isoform lacking the N termin
28 Arterial smooth muscle cell Ca(V)1.2 mRNA is alternatively spliced at exon 1 (e1), generating e1b or
30 -Barr virus-infected epithelial cancers, the alternatively spliced BamHI A rightward transcripts (BAR
33 merase is a key example of a protein that is alternatively spliced, but it is expressed at very low l
36 that il12rb1-the mouse homolog of IL12RB1-is alternatively spliced by leukocytes to produce a second
37 into introns can lead to their activation as alternatively spliced cassette exons, an event called ex
39 associated with increased production of the alternatively spliced CD137 isoform, soluble CD137, whic
40 hancer region regulates the expression of an alternatively spliced CD33 isoform lacking exon2 (D2-CD3
44 TCF7 and TCF-4/TCF7L2) use the C-clamp as an alternatively spliced domain to regulate cell-cycle prog
45 e active GC receptor alpha (GRalpha) and the alternatively spliced dominant negative regulator isofor
46 t of ADCs based on an antibody targeting the alternatively spliced EDA of fibronectin coupled to one
47 In polarized epithelia, a low-abundance, alternatively spliced eight-exon isoform of CAR, CAR(Ex8
48 u mutations are located within or around the alternatively spliced exon 10, it is important that iPSC
50 rientation, the repeat is located within the alternatively spliced exon 2A of junctophilin-3 (JPH3),
52 h a MAPT probe that targets transcription of alternatively spliced exon 3 in frontal cortex (P=9.2 x
53 e polymorphism (rs41283526) is located in an alternatively spliced exon of ANK3 and has a strong and
54 RNAs, we identified a novel, abundantly used alternatively spliced exon of Nrxn1alpha and Nrxn3alpha
55 ads to altered levels of H3K4 methylation in alternatively spliced exon regions, which is accompanied
56 n assays demonstrated that SRSF3 binds to an alternatively spliced exon uniquely included in p53beta
60 sence or absence of three inserts encoded by alternatively spliced exons 2, 3, and 10 of the Tau gene
62 luding distinct features of branchpoints for alternatively spliced exons and a family of conserved se
63 ms motif analyses of RBPs in the vicinity of alternatively spliced exons and creates RNA maps that de
65 NPF)-binding sites and near hnRNPF-regulated alternatively spliced exons in the human transcriptome.
68 severe TS2) arise from missense mutations in alternatively spliced exons that cause the same G406R re
69 ted that RBM25 regulates a large fraction of alternatively spliced exons throughout the human genome.
71 d the transcript scanning method to identify alternatively spliced exons within the Ca(V)1.4 transcri
72 e further show that KDM5B is enriched nearby alternatively spliced exons, and depletion of KDM5B lead
78 te its abundance, the function of the large, alternatively spliced extracellular domain of CD45 has r
80 he A2440G mutation causes upregulation of an alternatively spliced F5 transcript that results in an i
84 Yet, earlier studies have shown that the alternatively spliced, flip and flop variants of GluA1 A
87 we report that activated T cells produce an alternatively spliced form of gammac mRNA that results i
88 helial abundance of soluble flt1 (sflt1), an alternatively spliced form of the VEGF receptor Flt1 enc
89 end, we documented the UPR by detecting the alternatively spliced form of the XBP1 protein as well a
91 II BMP receptor (BMPRII) is expressed as two alternatively spliced forms, a long and a short form (BM
93 precipitated with wild-type (gammaA/gammaA), alternatively-spliced (gamma'/gamma'), and alphaC-trunca
94 the splicing mechanism of EWS-FLI1, showing alternatively spliced gene patterns that significantly o
95 process of subfunctionalization, in which an alternatively spliced gene upon duplication divides dist
98 tal genes, suggesting that a specific set of alternatively spliced genes may be regulated through DNA
99 ify networks of differentially expressed and alternatively spliced genes resulting from haploinsuffic
106 ome sequencing has skyrocketed proportion of alternatively spliced genes; over 95% human multi-exon g
107 ier all require a heretofore uncharacterized alternatively spliced giant exon of ankyrin-G (AnkG).
114 the mechanisms controlling the expression of alternatively spliced HTLV-1 mRNAs and suggest a link be
116 ation of novel protein isoforms derived from alternatively spliced ie3 transcripts prompted the const
119 identified approximately 190 genes that are alternatively spliced in a GSK-3-dependent manner, suppo
121 temperature range and FLM is transcribed and alternatively spliced in a temperature-dependent manner.
123 lk is not only differentially methylated and alternatively spliced in Apis, but also seems to be regu
124 tely 147 genes, and 18% of these were either alternatively spliced in human tumors or involved in apo
126 owed that exon alpha in MEF2C was aberrantly alternatively spliced in RMS cells, with the ratio of al
127 identified a small subset of genes that were alternatively spliced in the spinal cord compared with c
129 of palmitoylated cysteine residues within an alternatively spliced insert in the C terminus of the la
130 e we show that Drosophila Nmnat (DmNmnat) is alternatively spliced into two mRNA variants, RA and RB,
131 his locus suggested it encoded a single gene alternatively spliced into two transcripts: a 555 amino
132 of the GFP coding sequence interrupted by an alternatively spliced intron of SCL33, we investigated w
134 cations within stable mRNAs tend to occur in alternatively spliced introns, suggesting they regulate
135 y to oligomerize differentiates GAC from its alternatively spliced isoform and the cycling of phospha
136 dtype KLF6 (KLF6(WT) ) and its antagonistic, alternatively spliced isoform KLF6(SV1) in cultured HSCs
140 with increased expression of Kv11.1-3.1, an alternatively spliced isoform of Kv11.1, are correlated
141 ociated with the upregulation of p53beta, an alternatively spliced isoform of p53 that promotes p53-m
147 esidue insert unique to the muscle-specific, alternatively spliced isoform of vinculin, termed metavi
148 n results in the induction of CD6Deltad3, an alternatively spliced isoform that lacks the ligand-bind
149 stent with subfunctionalization partitioning alternatively spliced isoforms among duplicate genes and
150 s a large fraction of transcripts, including alternatively spliced isoforms and transcripts from rece
153 ver, a complete characterization of PTMs and alternatively spliced isoforms in cTnT present in vivo i
154 basis of the relative abundance of multiple alternatively spliced isoforms mRNAs generated by the sa
156 ach to comprehensively characterize PTMs and alternatively spliced isoforms of cTnT purified from hea
158 ound that MKs regulate the expression of two alternatively spliced isoforms of Pyk2 in OBs, which may
160 ed from HeLa cells for the quantification of alternatively spliced isoforms of the Fas gene, involved
162 musculus myosin-18A gene is expressed as two alternatively spliced isoforms, alpha and beta, with rep
163 base machine learner and other species with alternatively spliced isoforms, and shifts the current g
164 NA-seq) data for predicting the functions of alternatively spliced isoforms, and we discuss their app
167 t to predict and differentiate functions for alternatively spliced isoforms, instead of genes, using
168 , AtRTD2-QUASI, for use in Quantification of Alternatively Spliced Isoforms, outperform other availab
170 of TF-initiated coagulation produced in two alternatively spliced isoforms, TFPIalpha and TFPIbeta.
175 enes have multiple alternative promoters and alternatively spliced isoforms; 6) NF-kappaB family gene
177 the four isomer cDNAs that we prepared from alternatively spliced KDM2A transcripts, only one stimul
179 eridone caused greater in vitro block of the alternatively spliced Kv11.1-3.1 isoform than full-lengt
182 findings suggest that studies on the role of alternatively spliced MBSs affecting transcript levels a
185 -4 (sCTLA-4) protein isoform generated by an alternatively spliced mRNA of CTLA4 lacking transmembran
186 n eukaryotic cells to produce a multitude of alternatively spliced mRNA products during development a
187 ate that AtNSRs interact not only with their alternatively spliced mRNA targets but also with the ASC
189 tein level, corresponding to full-length and alternatively spliced mRNA transcripts, decreasing mRNA
192 to any cohort of tissues expressing several alternatively spliced mRNAs generated by the same gene,
194 very rates, we estimate that at least 25% of alternatively spliced NAGNAGs undergo tissue-specific re
195 We report here the identification of six alternatively spliced Orf50 transcripts that are generat
196 t- and shoot-specific differential ratios of alternatively spliced OsPCS2a and OsPCS2b transcript exp
197 yza sativa) cultivar, the OsPCS2 produces an alternatively spliced OsPCS2b transcript that bears the
198 ing that some of these PTC mutations--if not alternatively spliced out of the transcript--have neutra
199 LIM domain-binding protein 3-encoding Z-band alternatively spliced PDZ motif gene (ZASP) in a patient
200 the 90-kDa band as the protein ZASP (Z-band alternatively spliced PDZ motif protein), a minor compon
201 ent up-regulation of alpha-actinin-2, z-band alternatively spliced PDZ-motif and myotilin at the Z-li
204 cing donor site than does WT and produces an alternatively spliced product of LMNA called progerin, w
205 ed action of which creates a distribution of alternatively spliced products in a given cell type.
212 s most of the SMN2-derived transcripts to be alternatively spliced resulting in a truncated and unsta
213 most dicot plants, the SYP13II transcript is alternatively spliced, resulting in two isoforms, SYP13I
218 of Nrxn1alpha and Nrxn3alpha (referred to as alternatively spliced sequence 6) that encodes a 9-resid
223 rane (7TM) receptors, the MOR gene codes for alternatively spliced six-transmembrane (6TM) isoforms,
225 pite previous reports in the mouse model, no alternatively spliced, soluble form of Tim-3 was observe
226 show here that hypoxia specifically induces alternatively spliced species encoding for truncated for
229 y pathway of 1 nt intron shift, involving an alternatively spliced stwintron intermediate is proposed
232 t is currently not known whether the soluble alternatively spliced TF form (asTF) is expressed in BrC
234 y, we identified mutations in a 75 base pair alternatively spliced TGFbetaRII exon, exon 1a that prod
235 ally methylated genes were more likely to be alternatively spliced than not differentially methylated
238 irus genome encode mRNA transcripts that are alternatively spliced to express two different viral pro
239 a A virus encodes an mRNA transcript that is alternatively spliced to express two viral proteins, the
240 e (JNK) kinase MAP kinase kinase 7 (MKK7) is alternatively spliced to favor an isoform that lacks exo
241 one receptor alpha gene (THRA) transcript is alternatively spliced to generate either thyroid hormone
244 plicing regulator in the nucleus, it is also alternatively spliced to produce cytoplasmic isoforms.
248 brafish genome was found to contain a single alternatively-spliced tor1 gene, derived from a common a
249 binding results in a reduction of a specific alternatively spliced transcript expressed from the earl
251 nd that the IVS7 + 2T > G allele produces an alternatively spliced transcript lacking exons 4-7, enco
252 identification and functional analysis of an alternatively spliced transcript of human AQP4, AQP4-Del
254 of 40,064 genes, 65,167 transcripts, 31,909 alternatively spliced transcript variants and 2,367 non-
255 gene that causes increased expression of an alternatively spliced transcript, which encodes a previo
256 RT-PCR validation, we found that a subset of alternatively spliced transcripts and 5'-extended mRNAs
257 erlapping changes in coding genes, including alternatively spliced transcripts and noncoding RNAs.
258 F followed by RNA sequence analysis, several alternatively spliced transcripts are significantly chan
259 er genes, in this way reducing the number of alternatively spliced transcripts duplicate genes produc
260 ased access to changes in RNA expression and alternatively spliced transcripts during human cortical
261 of highly expressed genes and the number of alternatively spliced transcripts expressed per gene, an
262 of highly expressed genes and the number of alternatively spliced transcripts expressed per gene, wh
263 we cloned full-length open reading frames of alternatively spliced transcripts for a large number of
265 t- and shoot-specific differential ratios of alternatively spliced transcripts in indica rice under C
268 wo protein isoforms are generated from three alternatively spliced transcripts of C9orf72; a long for
269 the cell types that express more variants of alternatively spliced transcripts per gene are those tha
270 ing novel loci, and by identifying candidate alternatively spliced transcripts that are differentiall
271 by the effector TH2 lineage consists of four alternatively spliced transcripts that regulate the expr
275 nging because BDNF is generated by multiple, alternatively spliced transcripts with different 5'- and
276 Given that human IRF5 exists as multiple alternatively spliced transcripts with distinct function
277 ribe a revised protein annotation policy for alternatively spliced transcripts with more divergent pr
278 ing the differential effects of a variant on alternatively spliced transcripts, as well as the diffic
279 OCIATED1 (CCA1) splice variants, among other alternatively spliced transcripts, which is exacerbated
284 pain through effects mediated in part by the alternatively spliced truncated isoform of the BDNF rece
285 acquired vemurafenib resistance caused by an alternatively spliced, truncated BRAF(V600E) that promot
286 recently uncovered the existence of a novel alternatively spliced, truncated GLI1 (tGLI1) that has a
288 n-level analyses classified > 1,000 mRNAs as alternatively spliced under hypoxia and uncovered a uniq
289 differentially expressed and differentially alternatively spliced upon Fe deficiency, indicating a c
292 uble fms-like tyrosine kinase 1 (sFlt-1), an alternatively spliced variant of the vascular endothelia
293 ade urothelial carcinoma cell lines, whereas alternatively spliced variants and transcribed pseudogen
294 tifying interactions between brain-expressed alternatively spliced variants of ASD risk factors.
299 ture of the genomic region that gave rise to alternatively spliced YAP1 transcripts in different meta
300 conserved lysine-rich domain encoded by the alternatively spliced Zfp318 exon 10 abolished IgD expre
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