ライフサイエンスコーパス: aluminum hydroxide

1 ent tolerance when the Ag is provided as OVA-aluminum hydroxide.

2 sion proteins in the absence and presence of aluminum hydroxide.

3 were reduced in neonates immunized with OVA-aluminum hydroxide.

4 et v 1-specific antibodies in the absence of aluminum hydroxide.

5 lymphocytes than unmodified nanoparticles or aluminum hydroxide.

6 ately Th2-biased responses with the adjuvant aluminum hydroxide.

7 ogenic effects of an authentic Th2 adjuvant, aluminum hydroxide.

8 nti-tumor immunity to the adjuvant action of aluminum hydroxide.

9 ccine at 30, 15, or 7.5 microg per dose with aluminum hydroxide.

10 e and equal to purified proteins absorbed to aluminum hydroxide, a standard adjuvant.

11 e poorly immunogenic in mice vaccinated with aluminum hydroxide-absorbed formulations.

12 microgram of the III-alpha2r vaccine with an aluminum hydroxide adjuvant and bred.

13 ated from the formulation, which included an aluminum hydroxide adjuvant for analysis.

14 educing the particle size of the traditional aluminum hydroxide adjuvant into nanometers represents a

15 dose of vaccine (7 or 15 microg of HA) with aluminum hydroxide adjuvant or 2 doses (7 microg of HA e

16 d using standard i.p. OVA sensitization with aluminum hydroxide adjuvant.

17 3p-N vaccine is effective when combined with aluminum hydroxide adjuvant.

18 fective against S. aureus when combined with aluminum hydroxide adjuvant.

19 G (IgG) responses in serum as effectively as aluminum hydroxide adjuvant.

20 Mice were primed with aluminum hydroxide-adjuvanted UV-inactivated DENV prior

21 We tested a human-safe, aluminum hydroxide-adjuvanted whole-cell T. vaginalis va

22 studies demonstrated that immunization using aluminum hydroxide adjuvants induces Ag-specific Th2 res

23 Aluminum hydroxide (AH) salts are the most widely used a

24 valent formulations, while still adsorbed on aluminum hydroxide (AH) suspension.

25 eres containing different vaccine adjuvants (aluminum hydroxide (Al(OH)(3)) or calcium phosphate).

26 Treatment with aqueous and aluminum hydroxide (Al[OH](3))-adsorbed purified honeybe

27 bovine serum albumin were better adsorbed to aluminum hydroxide (Alhydrogel).

28 n the canine rOspA vaccine was combined with aluminum hydroxide, all vaccinated hamsters developed ar

29 ion exchange accompanied by precipitation of aluminum hydroxide allows progress of the cation exchang

30 We evaluated the dose-sparing potential of aluminum hydroxide (AlOH) adjuvant.

31 ith Helicobacter antigen in combination with aluminum hydroxide (AlOH) was evaluated in a murine mode

32 glutinin (HA), with or without 600 microg of aluminum hydroxide (AlOH), or 3.75 microg of HA, with or

33 oduced in Vero cell cultures and adsorbed to aluminum hydroxide (alum) adjuvant.

34 tetanus toxin (yP2P30Pv20019), formulated in aluminum hydroxide (alum) and block copolymer P1005.

35 min(323-337) peptide, using either U1 RNA or aluminum hydroxide (alum) as the adjuvant.

36 ) versus either SE alone or the mineral salt aluminum hydroxide (alum) at the muscle injection site o

37 Aluminum hydroxide (Alum) is the only adjuvant approved

38 Rowett rats were injected with aluminum hydroxide (alum) with buffer, alum-GTF, or alum

39 d with phosphonates to allow adsorption onto aluminum hydroxide (alum), a formulation commonly used i

40 lux; dithiocarbamate, a metal ionophore; and aluminum hydroxide (alum), an immunological adjuvant.

41 responses both in quantity and quality than aluminum hydroxide (alum), which is currently the most w

42 from Escherichia coli or subcutaneously with aluminum hydroxide (Alum)-adsorbed rBet v 1.

43 stimulates low Ab levels when combined with aluminum hydroxide (alum).

44 eek intervals with MOMP and CpG suspended in aluminum hydroxide (alum).

45 rgp120 with MF59 (n=48), VaxGen rgp120 with aluminum hydroxide (alum; n=49), or placebo (n=19) betwe

46 ken gamma-globulin (NP-CGG) and the adjuvant aluminum-hydroxide (alum) have been proposed to be matur

47 xpressed in Escherichia coli and adsorbed to aluminum hydroxide, an adjuvant approved for human use,

48 or 120 microg of recombinant OspA (rOspA) in aluminum hydroxide and challenged with B. burgdorferi se

49 h a killed bacterial vaccine adjuvanted with aluminum hydroxide and the involvement of gammadelta T c

50 xt of both traditional protein/adjuvant (OVA/aluminum hydroxide) and CD8(+)-specific heat shock prote

51 a human hepatitis B vaccine adjuvanted with aluminum hydroxide, and a human papillomavirus vaccine a

52 mice with each of the proteins adsorbed onto aluminum hydroxide as adjuvant, we measured serum IgG re

53 kout mice with an i.p. injection of OVA with aluminum hydroxide as an adjuvant and treated the mice w

54 age with rLigA (rLigAcon and rLigAvar) with aluminum hydroxide as an adjuvant.

55 with formalin-inactivated B. burgdorferi in aluminum hydroxide, but not recombinant OspA.

56 ne boosting effect of four common adjuvants: aluminum hydroxide, calcium phosphate, incomplete Freund

57 d that induction of tolerance to proteins in aluminum hydroxide can be achieved in Foxp3-deficient mi

58 ately, despite its favorable safety profile, aluminum hydroxide can only weakly or moderately potenti

59 of aluminum salts (i.e., up to ~1%, w/v, of aluminum hydroxide) can be converted into a dry powder b

60 The epsilon-Al(13) Keggin aluminum hydroxide clusters are essential models in esta

61 f a block copolymer water-in-oil emulsion or aluminum hydroxide combined with CpG oligodeoxynucleotid

62 keyhole limpet hemocyanin adsorbed to Imject aluminum hydroxide-containing adjuvant or mixed with alp

63 e vaccinated with these proteins adsorbed to aluminum hydroxide developed strong antibody responses a

64 e antibody response, whereas the addition of aluminum hydroxide did not.

65 When dispersed in an aqueous solution, aluminum hydroxide forms particulates of 1-20mum.

66 Adsorption of the conjugates onto aluminum hydroxide further increased the antibody respon

67 uctures of six model proteins, adsorbed onto aluminum hydroxide gel (Alhydrogel) or in aqueous soluti

68 eund adjuvant but not when it is adsorbed to aluminum hydroxide gel (alum).

69 nensis with human rIL-12 (rhIL-12) and alum (aluminum hydroxide gel) as adjuvants.

70 major SEAgs coadministered with either alum (aluminum hydroxide gel) or recombinant murine interleuki

71 inflammation than recombinant PA adsorbed to aluminum hydroxide gel.

72 or with, but not after, H1/CAF01 or H1/CpG/ aluminum hydroxide immunization.

73 ence of Act1 expression in T cells after OVA/aluminum hydroxide immunization.

74 SIV vaccine with and without gp140 boost in aluminum hydroxide in rhesus macaques.

75 he combined vaccine antigens formulated with aluminum hydroxide induced antibodies with opsonophagocy

76 F4 agonists were potent costimulators of OVA/aluminum hydroxide-induced CD4(+) Tconv proliferation, b

77 roup A streptococcal vaccine formulated with aluminum hydroxide into the deltoid muscle of alternatin

78 Aluminum hydroxide is an efficient binder; however, its

79 Aluminum hydroxide is used as a vaccine adjuvant in vari

80 protein antigens adsorbed on the traditional aluminum hydroxide microparticles of around 9.3mum.

81 Finally, the local inflammation induced by aluminum hydroxide nanoparticles in the injection sites

82 showed that protein antigens adsorbed on the aluminum hydroxide nanoparticles induced a stronger anti

83 In the present study, we synthesized aluminum hydroxide nanoparticles of 112nm.

84 The potent adjuvant activity of the aluminum hydroxide nanoparticles was likely related to t

85 , or parenterally immunized with urease plus aluminum hydroxide or a glycolipid adjuvant, challenged

86 g ovalbumin as a model antigen adsorbed onto aluminum hydroxide or aluminum phosphate, a commercially

87 unotherapy (ILIT) with MAT-Feld1 adsorbed to aluminum hydroxide or just aluminum hydroxide (placebo)

88 y either systemic administration of OVA with aluminum hydroxide or mucosal administration of OVA with

89 the season, Bet v 1 COPs (50 and 100 mug in aluminum hydroxide) or placebo (saline and aluminum hydr

90 that adsorption onto hydrophilic surfaces of aluminum hydroxide particles did not alter the secondary

91 laining its role as a precursor to amorphous aluminum hydroxide phases.

92 Feld1 adsorbed to aluminum hydroxide or just aluminum hydroxide (placebo) in a double-blind setting.

93 P adjuvanted with human-applicable alum-MPL (aluminum hydroxide plus 3-O-desacyl-4'-monophosphoryl li

94 oulant molecules along with any carried-over aluminum hydroxide precipitates evidenced by increasing

95 on pathway from aqueous aluminum monomers to aluminum hydroxide precipitates.

96 sponses, whereas incorporation of IL-12 with aluminum hydroxide produces a Th1 inducing adjuvant.

97 s (CFP), prepared in a variety of adjuvants (aluminum hydroxide, Quil-A, and dimethyldioctyldecyl amm

98 The i.p. injection of OVA/aluminum hydroxide restored development of the AHR enhan

99 ic Th17 cells transferred in vivo to OVA and aluminum hydroxide-sensitized mice also maintained IL-17

100 mouse, and adsorption of the conjugates onto aluminum hydroxide significantly increased the antibody

101 We compared classical adjuvants such as aluminum hydroxide to new preclinical adjuvants and adju

102 immunization with tetanus toxoid adsorbed to aluminum hydroxide (TT/Alum).

103 igate the mechanism of phosphate sorption on aluminum hydroxides under different environmental condit

104 able with the historical recombinant PA plus aluminum hydroxide vaccine administered s.c.

105 ts are important because an rOspA vaccine in aluminum hydroxide was approved by the Food and Drug Adm

106 n aluminum hydroxide) or placebo (saline and aluminum hydroxide) were administered as 5 subcutaneous

107 re Ag sensitized by i.p. injection of OVA in aluminum hydroxide, with or without 50 mug of Salp15, on

108 ) whether adsorption of conjugate vaccine to aluminum hydroxide would improve immunogenicity and (ii)