ライフサイエンスコーパス: amblyopia

1 ions in macaques with experimentally induced amblyopia.

2 utcomes for children with moderate to severe amblyopia.

3 ignificant tilt after-effects in adults with amblyopia.

4 tral field in humans with moderate-to-severe amblyopia.

5 ontinuous ophthalmic care, most commonly for amblyopia.

6 of which all had myopic maculopathy or deep amblyopia.

7 normalities could prevent the development of amblyopia.

8 ndently with an increased risk of unilateral amblyopia.

9 only, or both, and 112 had no strabismus or amblyopia.

10 al hyperopia were risk factors for bilateral amblyopia.

11 dependently with increased risk of bilateral amblyopia.

12 yopia, and 144 children (3.7%) had bilateral amblyopia.

13 re present in 76% of children with bilateral amblyopia.

14 e present in 91% of children with unilateral amblyopia.

15 ikely to develop oblique astigmatism-related amblyopia.

16 tive errors were risk factors for unilateral amblyopia.

17 pared with related findings in attention and amblyopia.

18 llary density in the macula of patients with amblyopia.

19 volumes were associated with development of amblyopia.

20 ke certain they do not develop anisometropic amblyopia.

21 ith a congenital form of ptosis demonstrated amblyopia.

22 to 6 hours in children with stable residual amblyopia.

23 obstruction is associated with anisometropic amblyopia.

24 in identifying preschoolers with unilateral amblyopia.

25 ing leading to deprivation and/or refractive amblyopia.

26 bility, poorer stereoacuity, and more severe amblyopia.

27 ual cortex suggest a potential treatment for amblyopia.

28 ren had previous diagnoses or treatments for amblyopia.

29 preexisting corneal, retinal pathology, and amblyopia.

30 improvement in BCVA when not compromised by amblyopia.

31 ures using OCTA in children (<18 years) with amblyopia.

32 sitive predictive value (PPV) for strabismic amblyopia.

33 omparing atropine with patching for moderate amblyopia.

34 %) were found to have amblyopia or suspected amblyopia.

35 ty may underestimate the depth of strabismic amblyopia.

36 ocular form deprivation reduces the depth of amblyopia.

37 cular approach in the treatment of childhood amblyopia.

38 with the observed reduction in the depth of amblyopia.

39 abismus and both ametropic and anisometropic amblyopia.

40 lf as an effective, noninvasive treatment of amblyopia.

41 on of treatment in adults with anisometropic amblyopia.

42 he retinal capillary layers in children with amblyopia.

43 active error, and 43000 (25%) from bilateral amblyopia.

44 of perceptual tasks in subjects with treated amblyopia.

45 sary to fully recover deficient functions in amblyopia.

46 d binocular suppression that is unaltered in amblyopia.

47 a key component of the perceptual losses in amblyopia.

48 rch into visual development and the disorder amblyopia.

49 eriods may provide clues how to better treat amblyopia.

50 ed a great deal about the pathophysiology of amblyopia.

51 rtex can cause impaired binocular vision and amblyopia.

52 e a promising additional option for treating amblyopia.

53 atment is comparable to patching in treating amblyopia.

54 -year-old persons with unilateral persistent amblyopia.

55 eatment of uncorrected refractive errors and amblyopia.

56 Specificity of the PVS for strabismus and amblyopia (0.87; 95% CI, 0.80-0.95) was significantly hi

57 ence of strabismus (1.73%-2.24%, P = .91) or amblyopia (0.9%-2.08%, P = .13) among first grade studen

58 sitivity of the PVS to detect strabismus and amblyopia (0.97; 95% CI, 0.94-1.00) was significantly hi

59 ar vision (strabismus, 2.3%; diplopia, 2.2%; amblyopia, 0.9%; and nystagmus, 0.2%).

60 corneal scars (15.7%), refractive error and amblyopia (12.1%), optic atrophy (6.4%), phthisis bulbi

61 isual acuity only (pure refractive error and amblyopia); 13% (50) had non surgical treatment for cont

62 rs (47.1%), keratitis/corneal opacity (16%), amblyopia (14.3%), ocular trauma (11.8%), cataract (6.3%

63 n aged 5 years to younger than 13 years with amblyopia (20/40 to 20/200, mean 20/63) resulting from s

64 aged 13 to <17 years (mean 14.3 years) with amblyopia (20/40 to 20/200, mean approximately 20/63) re

65 ejection (1), recurrence of disease (1), and amblyopia (3).

66 bismic amblyopia than for combined-mechanism amblyopia (3.2 vs 2.3 lines; adjusted P = 0.003).

67 cular features of vision and refraction were amblyopia (32%), myopia (40%), and astigmatism (52%).

68 perceived by 11 of the 24 participants with amblyopia (45.8%) and all 9 controls (100%) (adjusted od

69 diagnosed with simple congenital ptosis had amblyopia, 7 (8.6%) cases of which solely were the resul

70 ildren had a higher percentage of unilateral amblyopia (8% vs. 2%), larger mean IAD (0.07 vs. 0.05 lo

71 ence during the sensitive period can lead to amblyopia, a developmental disorder of vision affecting

72 misalignment or unilateral blur often causes amblyopia, a disorder that has become a standard for und

73 The neural basis of amblyopia, a visual deficit affecting 3% of the human po

74 In amblyopia, a visual disorder caused by abnormal visual e

75 In amblyopia, abnormal visual experience leads to an extrem

76 sual potential such as macular degeneration, amblyopia, advanced glaucoma, and other optic neuropathi

77 children 7 to 12 years of age with residual amblyopia after patching therapy, oral levodopa while co

78 auses of vision abnormalities in children is amblyopia (also known as "lazy eye").

79 ited strabismus, 1.8% were suspected to have amblyopia and 0.5% had reduced acuity of likely organic

80 woman with Marfan's syndrome presented with amblyopia and a history of gradual bilateral vision loss

81 BVI) were recruited, with either persistent amblyopia and age-related macular degeneration (AMB + AM

82 erly patients with BVI, caused by persistent amblyopia and age-related macular degeneration (AMD) or

83 cular imbalance may be useful for diagnosing amblyopia and as an outcome measure for recovery of bino

84 onance imaging analysis in participants with amblyopia and compared the projections from the amblyopi

85 agnosed with anisometropic and/or strabismic amblyopia and had not undergone previous treatment.

86 duced the deleterious effects of crowding in amblyopia and in the normal periphery.

87 rce (USPSTF) recommendation on screening for amblyopia and its risk factors in children.

88 Amblyopia and nystagmus limited visual outcome, indicati

89 have important therapeutic applications for amblyopia and other visual brain disorders.

90 er understand the patterns of strabismus and amblyopia and potentially inform planning for preschool

91 Two strabismus-specific questionnaires, the Amblyopia and Strabismus Questionnaire and the Adult Str

92 secondary outcome: The Amblyopia and Strabismus Questionnaire scores demonstrat

93 and standardized Diplopia Questionnaire and Amblyopia and Strabismus Questionnaire were used to quan

94 may thus be based on diagnostic detection of amblyopia and strabismus rather than the estimation of r

95 During the study period, the rates of amblyopia and strabismus remained stable, indicating the

96 Start preschool children, the prevalence of amblyopia and strabismus was similar among 5 racial/ethn

97 ctive surgery is an option for children with amblyopia and strabismus who fail treatment with spectac

98 Pad game was effective in treating childhood amblyopia and was more efficacious than patching at the

99 ipants included 59 children (<18 years) with amblyopia and without amblyopia examined at a pediatric

100 ed to detect hyperopia >5 D in any meridian, amblyopia and/or strabismus had an area under the curve

101 55 (8.39%) received glasses, 873 (1.37%) had amblyopia, and 1125 (1.76%) had strabismus.

102 = 3869), 296 children (7.7%) had unilateral amblyopia, and 144 children (3.7%) had bilateral amblyop

103 fect of age, sex, refractive errors, type of amblyopia, and adherence to glasses wearing on improveme

104 storted skull development causing strabismic amblyopia, and OPG) were difficult to treat adequately a

105 oportion of children with refractive errors, amblyopia, and/or strabismus.

106 The gold standard treatments in amblyopia are penalizing therapies, such as patching or

107 This is consistent with an explanation of amblyopia as an immature system with a normal complement

108 ere implanted, and patients were treated for amblyopia, as applicable.

109 The functional importance of amblyopia at an individual level is unclear as data are

110 d level of anisometropia at which unilateral amblyopia became significant was lower than current guid

111 attentional blink in each eye of adults with amblyopia before and after 40 hours of active video game

112 ildren with strabismic or combined-mechanism amblyopia before initiating other therapies.

113 that age (beta = -0.535; P = .001), type of amblyopia (beta = -0.347; P = .02), and adherence to gla

114 Effects of amblyopia, binocularity, and strabismus type on success

115 Overall, other factors including amblyopia, binocularity, strabismus type, and primary or

116 ing has long been the standard treatment for amblyopia, but it does not always restore 20/20 vision o

117 motion sensitivity deficits associated with amblyopia can be explained by abnormal development of MT

118 Amblyopia can be treated with binocular games that rebal

119 While it is widely believed that amblyopia cannot be treated successfully after the age o

120 brate our portable acuity screening tools so amblyopia could be detected quickly and effectively at s

121 severely disrupted in adults with strabismic amblyopia, could be a potential test to detect and monit

122 There was a low amblyopia detection rate in this preschool population, w

123 e and by 100% of participants whose onset at amblyopia developed at or after 5 years of age.

124 al/abnormal classification was compared with amblyopia diagnosis by gold standard early treatment dia

125 t disorders of binocular vision (strabismus, amblyopia, diplopia, and nystagmus) may have on musculos

126 pothesis that the PVS detects strabismus and amblyopia directly.

127 id, accurate identification of children with amblyopia early in life when it is most amenable to trea

128 Despite the extensive animal studies on how amblyopia emerges, we know surprisingly little about the

129 of learning onto the known deficit space for amblyopia enabled the identification of tasks and stimul

130 Children with a history of amblyopia, even if resolved, exhibit impaired visual-aud

131 ldren (<18 years) with amblyopia and without amblyopia examined at a pediatric ophthalmology clinic o

132 ract corneal opacities, refractive error and amblyopia, globe damage due to trauma, infection and nut

133 nal capillary plexus was 54.4% (4.7%) in the amblyopia group and 60.1% (3.3%) in the control group, w

134 with oblique astigmatism-related refractive amblyopia (Group 1) and 82 children with orthogonal asti

135 All subjects with amblyopia had orbitotemporal plexiform neurofibroma volu

136 Children with amblyopia had significantly larger BCEAs for amblyopic e

137 ach to treating anisometropic and strabismic amblyopia has recently been advocated.

138 udy suggests that children with a history of amblyopia have impaired visual-auditory speech perceptio

139 gery was not associated with the presence of amblyopia, high hyperopia, or the total amount of millim

140 52 (0.16) logMAR (P = .01), a slower rate of amblyopia improvement, and higher prevalence of parental

141 [SD] age, 7.0 [1.5] years) had a history of amblyopia in 1 eye, with a visual acuity of at least 20/

142 in 31 (43.6%), strabismus in 25 (35.2%), and amblyopia in 10 (14.1%).

143 rdable tools provide sensitive screening for amblyopia in children from public, private and home scho

144 The mechanism of amblyopia in children with congenital cataract is not un

145 cylinder power of astigmatism (in D) causing amblyopia in Group 1 of 2.48 (0.82) was lower than that

146 urprisingly little about the neural basis of amblyopia in humans and nonhuman primates.

147 roportional to the reduction in the depth of amblyopia in individual monkeys.

148 l to utilize this test to detect and monitor amblyopia in infants and preschool children.

149 The causes of amblyopia in the remaining 5 patients were significant r

150 ivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice.

151 its in auditory perceptual acuity, much like amblyopia in the visual system.

152 ential test to detect and monitor strabismic amblyopia in young children.

153 ting the targeted conditions, strabismus and amblyopia, in children aged 2 to 6 years.

154 The percentage of unilateral amblyopia increased significantly with SE anisometropia

155 plasticity in adults, allowing recovery from amblyopia induced by chronic monocular deprivation.

156 itical period adults, allowing recovery from amblyopia induced by chronic monocular deprivation.

157 While amblyopia involves both binocular imbalance and deficits

158 SIGNIFICANCE STATEMENT: Amblyopia is a common developmental vision disorder in h

159 Amblyopia is a developmental visual disorder of cortical

160 s vision in amblyopes.SIGNIFICANCE STATEMENT Amblyopia is a developmental visual disorder that alters

161 The neural basis of amblyopia is a matter of debate.

162 Amblyopia is a neurodevelopmental disorder that affects

163 Amblyopia is an alteration in the visual neural pathway

164 Treatment of amblyopia is associated with moderate improvements in vi

165 e good visual acuity, although mild residual amblyopia is common.

166 Although amblyopia is diagnosed in terms of a monocular letter ac

167 With abnormal visual cortical development, amblyopia is generally associated with high spatial freq

168 Utility of visual impairment caused by amblyopia is important for the cost-effectiveness of scr

169 h animal and human work has established that amblyopia is not simply a monocular deficit, and therefo

170 Amblyopia is the most common cause of visual impairment

171 avior, both during visual development and in amblyopia, is discussed, and several potential resolutio

172 e evidence on screening for and treatment of amblyopia, its risk factors, and refractive error in chi

173 ciated with higher percentages of unilateral amblyopia, larger IAD, and worse stereoacuity (P<0.001 f

174 e associated with the presence of unilateral amblyopia, larger IAD, and worse stereoacuity.

175 for the cost-effectiveness of screening for amblyopia (lazy eye, prevalence 3-3.5 %).

176 sual deprivation early in life can result in amblyopia (lazy-eye), a prevalent childhood disorder com

177 The evidence-based recommendations for amblyopia management have not been translated widely int

178 By treating children early, amblyopia may be prevented, quality of life improved, an

179 Interventions to resolve amblyopia may not only influence visual acuity but may a

180 and 9 girls) and 20 with strabismic or mixed amblyopia (mean [SD] age, 4.90 [1.36] years; 10 boys and

181 Group 1 achieved a noninferior resolution of amblyopia (mean final VA 0.18 vs 0.16 logMAR) after long

182 The percentage with unilateral amblyopia, mean IAD, and mean stereoacuity were compared

183 The percentage with unilateral amblyopia, mean IAD, and mean stereoacuity.

184 The exclusion criteria included amblyopia, mental retardation, and concomitant ocular di

185 esting to measure the depth of the resulting amblyopia, microelectrode-recording experiments were con

186 essful visual-auditory fusion, by which time amblyopia must have either resolved or begun.

187 ocular abnormalities in childhood, including amblyopia, myopia, astigmatism, strabismus, limited ocul

188 Visuomotor comorbidities (eg, amblyopia, nystagmus, foveopathy, optic neuropathy) acco

189 Amblyopia occurred in 1 in 7 children diagnosed with pto

190 Resolution of amblyopia occurred in 32% (95% CI, 24%-41%) of the child

191 In our series, amblyopia occurs in more than half of NF1 children with

192 Initial treatment for amblyopia of the fellow eye with patching and atropine s

193 Moreover, monocular deprivation elicited amblyopia only during a discrete period of development i

194 f the 300 patients, 188 had strabismus only, amblyopia only, or both, and 112 had no strabismus or am

195 hen of the underlying cellular mechanisms of amblyopia or 'lazy eye', the commonest childhood disorde

196 children younger than 6 years, 1% to 6% have amblyopia or its risk factors (strabismus, anisometropia

197 in all children aged 3 to 5 years to detect amblyopia or its risk factors.

198 Of the 804 without strabismus, amblyopia or organic conditions, 6.0% were myopic </= -

199 The PVS identified children with amblyopia or strabismus with high sensitivity and specif

200 jects with greater than 4 D of hyperopia, or amblyopia or strabismus, have more variable lags and the

201 ability of the PVS to identify patients with amblyopia or strabismus, particularly anisometropic ambl

202 Assuming a 5% prevalence of amblyopia or strabismus, the inferred positive and negat

203 devices assess refractive risk factors, not amblyopia or strabismus, underreferring affected childre

204 nd specificity were 96% for the detection of amblyopia or strabismus.

205 sual acuity (VA) and cover testing ruled out amblyopia or strabismus.

206 months, of whom 27 (1.9%) were found to have amblyopia or suspected amblyopia.

207 ng functional risks (eg, visual obstruction, amblyopia, or feeding difficulties), ulceration, and sev

208 In approximately half of those with amblyopia, or less than 10% of all patients, the disease

209 l dichoptic letter chart in individuals with amblyopia, or normal vision.

210 lar lags, while those with higher hyperopia, amblyopia, or strabismus had more variable lags.

211 tion, for instance, after stroke or to treat amblyopia, or training for various precision-demanding j

212 In anisometropic amblyopia patients treated successfully, the BIN improve

213 Amblyopia related to refractive error was the most commo

214 rror--either uncorrected refractive error or amblyopia resulting from refractive error.

215 on and patching, some patients have residual amblyopia resulting from strabismus or anisometropia.

216 t alone of strabismic and combined-mechanism amblyopia results in clinically meaningful improvement i

217 the benefits are moderate because untreated amblyopia results in permanent, uncorrectable vision los

218 Among children with amblyopia risk factors (eg, strabismus or anisometropia)

219 teles Falls, New York, USA) for detection of amblyopia risk factors in children aged 6 months to 3 ye

220 sensitivity and specificity for detection of amblyopia risk factors in this young cohort, particularl

221 likelihood ratios were between 5 and 10 for amblyopia risk factors or nonamblyogenic refractive erro

222 almology and Strabismus (AAPOS) criteria for amblyopia risk factors.

223 Visual acuity, amblyopia, school performance, functioning, quality of l

224 plications are identifiable through existing amblyopia screening methods.

225 Amblyopia secondary to the orbitotemporal plexiform neur

226 capillary hemangiomas at risk of developing amblyopia seen between January 2009 and January 2012 at

227 uggest that the real-life adverse effects of amblyopia should be characterised and screening and diag

228 sensitivity (27%-12%) and PPV (57%-50%) for amblyopia, similar to grating acuity (sensitivity = 38%,

229 Amblyopia, strabismus, and refractive errors are common

230 d a standardized eye examination to identify amblyopia, strabismus, significant refractive error, and

231 used to classify vision disorders, including amblyopia, strabismus, significant refractive errors, an

232 Behavioral observations in humans with amblyopia suggest that much of their visual loss is due

233 radial deformation hyperacuity stimulus for amblyopia support the potential to utilize this test to

234 nce had greater ability to detect unilateral amblyopia than cylinder, SE, J0, or J45 (P<0.001).

235 degree of initial oblique astigmatism caused amblyopia than did orthogonal astigmatism.

236 treatment effect was greater for strabismic amblyopia than for combined-mechanism amblyopia (3.2 vs

237 way for new strategies for the treatment of amblyopia that attempt to remove molecular brakes on pla

238 Refractive Error is one of the leading cause amblyopia that exposes children to poor school performan

239 Chronic monocular deprivation induces severe amblyopia that is resistant to spontaneous reversal.

240 of visual immaturity for possible causes of amblyopia that might be treatable, such as refractive ch

241 t was perceived by 100% of participants with amblyopia that was resolved by 5 years of age and by 100

242 However, only 18.8% of participants with amblyopia that was unresolved by 5 years of age (n = 16)

243 ntrast in the other eye, but in monkeys with amblyopia the balance of gain modulation is altered so t

244 For severe amblyopia, the cohort (n = 52) was prescribed a mean of

245 For moderate amblyopia, the cohort (n = 71) was prescribed a mean of

246 In patients with strabismus, even without amblyopia, the deviated eye is more variable in position

247 search for other projection abnormalities in amblyopia, the pathway from V1 to V2 was examined using

248 ometropic, strabismic, or combined mechanism amblyopia, there is a decrease in amblyopic eye spherica

249 he pediatric population, already at risk for amblyopia, this can be especially damaging.

250 al acuity (VA) improvement in teenagers with amblyopia treated with a binocular iPad game vs part-tim

251 ual acuity (VA) improvement in children with amblyopia treated with a binocular iPad game vs part-tim

252 binocular iPad (Apple Inc) adventure game as amblyopia treatment and compare this binocular treatment

253 The gold standard of a successful amblyopia treatment is full recovery of visual acuity (V

254 lts indicate that improvement occurring with amblyopia treatment is maintained until at least 15 year

255 cuity with spectacles was measured using the Amblyopia Treatment Study HOTV visual acuity protocol at

256 acuity using the computerized version of the Amblyopia Treatment Study VA testing protocol that limit

257 ticipants (aged 5 to <7 years) without prior amblyopia treatment, amblyopic-eye VA improved by a mean

258 r children (age 5 to <7 years) without prior amblyopia treatment.

259 or the development of training protocols for amblyopia treatment.

260 cal equivalent refractive error, and type of amblyopia treatment.

261 to detect any changes in BIN resulting from amblyopia treatment.

262 roved visual outcomes in patients undergoing amblyopia treatment.

263 nterventions: Binocular game and patching as amblyopia treatments.

264 alance as a function of spatial frequency in amblyopia using a novel computer-based method.

265 s the dominant eye.SIGNIFICANCE STATEMENT In amblyopia, vision in one eye is impaired as a result of

266 ulticenter clinical trial, 419 children with amblyopia (visual acuity, 20/40 to 20/100) were randomly

267 patients, the mean (SD) age of patients with amblyopia was 8.0 (4.0) years and 10.3 (3.3) years for t

268 Amblyopia was categorized into unilateral and bilateral

269 nilateral and bilateral subtypes: Unilateral amblyopia was defined as a 2-line difference in reduced

270 Unilateral amblyopia was defined as an interocular difference in be

271 Bilateral amblyopia was defined as best-corrected VA in each eye w

272 a, and/or visual axis obstruction; bilateral amblyopia was defined as bilateral reduced VA with eithe

273 Unilateral amblyopia was defined as IAD of 2 lines or more in logar

274 Amblyopia was defined as unilateral if there was >/=2 li

275 al acuity between 20/40 and 20/80 and severe amblyopia was defined as visual acuity between 20/100 an

276 Using PEDIG criteria, moderate amblyopia was defined as visual acuity between 20/40 and

277 Amblyopia was detected in 1.81% (95% CI, 1.06-2.89) of A

278 Amblyopia was diagnosed in 16 (14.9%) of the 107 patient

279 Amblyopia was found in 1.9% of this Australian preschool

280 Refractive amblyopia was found in 9% of those examined, or 0.8% of

281 n-Hispanic white children; the prevalence of amblyopia was higher for each subsequent older age categ

282 controlling for age, gender, and ethnicity, amblyopia was significantly associated with hyperopia (o

283 Prevalence of amblyopia was similar among all groups (P=0.07), ranging

284 Risk of amblyopia was summarized by the odds ratios and their 95

285 The prevalence of amblyopia was the same in Asian and non-Hispanic white c

286 Developmental delay, strabismus, and amblyopia were common in this cohort.

287 years (range, 17-69 year) and anisometropic amblyopia were enrolled.

288 dominance in binocular rivalry in "treated" amblyopia were largely comparable to those of normal sub

289 One or more causes of amblyopia were present in 29 of these patients, 19 patie

290 s of age, most children treated for moderate amblyopia when younger than 7 years have good visual acu

291 e that can be predicted from the severity of amblyopia, whereas suppression from both eyes is prevale

292 an 19 years for the prevalence and causes of amblyopia who were diagnosed with childhood ptosis and w

293 explore the potential for treating childhood amblyopia with a binocular stimulus designed to correlat

294 ously in 35-year-old persons with unilateral amblyopia with good vision in the other eye.

295 S identified children with strabismus and/or amblyopia with high sensitivity, outperforming the SureS

296 There were no significant associations of amblyopia with low birthweight (<2500 g), preterm birth

297 ia or strabismus, particularly anisometropic amblyopia with no measurable strabismus.

298 to measure loss of utility in patients with amblyopia with recent decrease of vision in their better

299 norganic visual loss and bilateral ametropic amblyopia with strabismus.

300 ing work aimed at understanding and treating amblyopia, yet its physiological basis remains unknown.