ライフサイエンスコーパス: amblyopic

1 visual cortex, and the deprived eye becomes amblyopic.

2 mounted display in a sample of anisometropic amblyopic adults and to evaluate the potential usefulnes

3 al acuity was tested twice in each eye of 32 amblyopic and 11 normal children.

4 Of the 63 eyes evaluated, 13 (21%) were amblyopic and 50 (79%) were control eyes.

5 13 (39%) and 27 of 46 (54%) patients in the amblyopic and control groups, respectively, were identif

6 ifferences were observed in visual acuity of amblyopic and fellow eyes at 15 years of age (P = .44 an

7 rence in macular thickness was found between amblyopic and fellow eyes, with amblyopic eyes having gr

8 Treatment Diabetic Retinopathy Study test in amblyopic and fellow eyes.

9 s were found in the foveal structure between amblyopic and fellow eyes.

10 ination thresholds were elevated in both the amblyopic and fellow fixing eyes but were within the nor

11 lyopia and compared the projections from the amblyopic and fellow normal eye in the visual cortex.

12 rly impairs object perception in peripheral, amblyopic and possibly developing vision.

13 We tested the responses of ten amblyopic and six normal observers to illusions of perce

14 and grating acuity were identified as normal/amblyopic based on age-matched norms.

15 These results show that the mature amblyopic brain is surprisingly malleable, and point to

16 f a range of spatial visual functions in the amblyopic brain.

17 play also alters temporal processing in the amblyopic brain.

18 ale macaque monkeys (Macaca nemestrina) made amblyopic by artificial strabismus or anisometropia in e

19 gratings (0.5-4 cyc/deg) were measured in 24 amblyopic children (<7 years of age) before eye patching

20 BIN scores of amblyopic children and controls were measured, and 21 ch

21 Only 3 of the 27 amblyopic children had previous diagnoses or treatments

22 onal cartoon that explains without words why amblyopic children should wear their eye patch improves

23 ence in repeatability between the normal and amblyopic children tested.

24 Prior to the study, amblyopic children were hypothesized to less frequently

25 Fifty amblyopic children with a mean age of 5.6+/-1.3 years we

26 Amblyopic children with unilateral high myopia tend to h

27 mic changes may be present in the retinas of amblyopic children with unilateral high myopia.

28 um angle of resolution) acuity in normal and amblyopic children, while adequately controlling for opt

29 l learning can improve visual performance in amblyopic children.

30 g the eyes dichoptically, we showed that, in amblyopic cortex, the binocular combination of signals i

31 correspondence between the magnitude of the amblyopic deficits and the reduction in retinal image co

32 ptotype acuity and sweep VEP acuity revealed amblyopic deficits in both pseudophakic and aphakic eyes

33 binocular summation of contrast and that the amblyopic deficits of binocularity can be simulated with

34 Amblyopic deficits using the 0.5 degrees radius 8 RF pat

35 ity, assessments of optotype acuity revealed amblyopic deficits; contrast sensitivity was impaired as

36 opic amblyopes, strabismic amblyopes and non-amblyopic esotropes.

37 thout anomalous BSV, in exotropes and in non-amblyopic esotropes.

38 al visual experience during development, the amblyopic eye (AE) loses visual sensitivity whereas the

39 found that reduced excitatory input from the amblyopic eye (AE) revealed a form of balanced binocular

40 .0001) in the mean visual acuity (VA) of the amblyopic eye (AE) was demonstrated, from 0.51 +/- 0.27

41 Fourteen anisometropic amblyopes (VA amblyopic eye 6/12 or lower; better eye greater than 6/7

42 After patching, amplitudes increased in the amblyopic eye across all spatial frequencies (ANCOVA; P

43 hed a suppressive action of the fovea of the amblyopic eye acting on the companion, non-amblyopic eye

44 The amblyopic eye acuity at the 7- to 12-month visit in the

45 The amblyopic eye acuity on the 3- to 6-month visit in the c

46 Improved function of the amblyopic eye after visual loss in the non-amblyopic eye

47 ncluding loss of contrast sensitivity in the amblyopic eye and abnormal binocular vision.

48 ic visual training, aimed at stimulating the amblyopic eye and eliminating the interocular supression

49 e amblyopic eye acting on the companion, non-amblyopic eye and indicate that correction of ocular mis

50 isk of serious vision loss affecting the non-amblyopic eye and its results are greater than that prev

51 tifying T2 200 ms after T1) seen through the amblyopic eye and this improvement in performance transf

52 At baseline, the mean (SD) amblyopic eye BCVA was 0.48 (0.14) logMAR (approximately

53 At the 2-week visit, improvement in amblyopic eye BCVA was greater with the binocular game c

54 Measures: The primary outcome was change in amblyopic eye best-corrected visual acuity (BCVA) at the

55 y impaired after loss of vision in their non-amblyopic eye but had no other disorder affecting their

56 pia), patching improved visual acuity of the amblyopic eye by a mean of less than 1 line on a standar

57 ea and thinner inner and outer macula in the amblyopic eye compared to the normal fellow eye.

58 e amblyopic eye after visual loss in the non-amblyopic eye could be a model for residual neural plast

59 ehavioral performance; neurons driven by the amblyopic eye had even shorter integration times than th

60 in modulation is altered so that the weaker, amblyopic eye has little effect while the stronger fello

61 Mean BCVA in amblyopic eye improved significantly from a logMAR value

62 ed an expanded foveal representation for the amblyopic eye in one early-onset strabismic subject with

63 In anisometropes, the amblyopic eye influenced a relatively small proportion o

64 useful should they lose vision in their non-amblyopic eye later in life.

65 Mean visual acuity in the amblyopic eye measured in 147 participants at 15 years o

66 luation the principal visual deficits in the amblyopic eye of each subject were identified using the

67 A greater decrease in amblyopic eye refractive error was associated with bette

68 petitive practice of a visual task using the amblyopic eye results in improved performance in both ch

69 Before patching, the amblyopic eye showed decreasing amplitude with increasin

70 he pooled responses of neurons driven by the amblyopic eye showed reduced sensitivity to coherent mot

71 mechanism amblyopia, there is a decrease in amblyopic eye spherical equivalent refractive error to l

72 riod, and achieve a level of vision in their amblyopic eye that would be useful should they lose visi

73 We conclude that a weakened ability of the amblyopic eye to modulate cortical response gain creates

74 rmed to compare the macular thickness of the amblyopic eye to that of the fellow eye.

75 to the relative strength of the input of the amblyopic eye to the cortex only for the more seriously

76 The main outcome measure was change in amblyopic eye VA from baseline to 16 weeks.

77 Ten weeks after randomization, amblyopic eye VA had improved an average of 1.2 lines in

78 Mean amblyopic eye VA improved from baseline by 3.5 letters (

79 When amblyopic eye VA stops improving with 2 hours of daily p

80 enagers aged 13 to <17 years, improvement in amblyopic eye VA with the binocular iPad game used in th

81 ults in clinically meaningful improvement in amblyopic eye visual acuity for most 3- to <7-year-old c

82 Overall, amblyopic eye visual acuity improved a mean of 2.6 lines

83 Average (+/- SD) LogMAR VA in the amblyopic eye was 0.96 +/- 0.31.

84 mpared with one in which the contrast in the amblyopic eye was adjusted (normalized) to equate monocu

85 The projection from the amblyopic eye was found to have a normal cortical magnif

86 resolution of cortical neurons driven by the amblyopic eye were substantially and significantly lower

87 not amplified further by attenuation of the amblyopic eye's projections from V1 to V2.

88 ia, binocular vision status, fixation of the amblyopic eye, and the age of the subject at the start o

89 s full recovery of visual acuity (VA) in the amblyopic eye, but there has been no systematic study on

90 represent more parafoveal locations for the amblyopic eye, compared with the fellow eye, in some sub

91 ho had newly acquired vision loss in the non-amblyopic eye, resulting in acuity of worse than 6/12 or

92 Using the amblyopic eye, strabismic amblyopes counted inaccurately

93 on to the benefits of improved vision in the amblyopic eye, treatment of amblyopia during childhood i

94 al and temporal cortex when viewing with the amblyopic eye.

95 -dependent (BOLD) signal was reduced for the amblyopic eye.

96 4 people had improved visual acuity in their amblyopic eye.

97 nt attributable to loss of vision in the non-amblyopic eye.

98 ye but had no other disorder affecting their amblyopic eye.

99 ine that are aimed at forcing the use of the amblyopic eye.

100 l loss is due to active suppression of their amblyopic eye.

101 However, the pRF sizes are enlarged for the amblyopic eye.

102 al disarray within the representation of the amblyopic eye.

103 nd often only method of treating a 'lazy' or amblyopic eye.

104 tive error from hyperopia to less hyperopia (amblyopic eye: -0.65 diopter, 95% CI -0.85, -0.46; fello

105 70 (Snellen equivalent, 20/29), 0.50 (20/40 [amblyopic eye]), and 1.20 (20/17).

106 Main Outcomes and Measures: Change in amblyopic-eye VA from baseline to 16 weeks.

107 At 16 weeks, mean amblyopic-eye VA improved 1.05 lines (2-sided 95% CI, 0.

108 <7 years) without prior amblyopia treatment, amblyopic-eye VA improved by a mean (SD) of 2.5 (1.5) li

109 At 18 weeks, amblyopic-eye VA improved from randomization by an avera

110 In children aged 5 to younger than 13 years, amblyopic-eye VA improved with binocular game play and w

111 amblyopia had significantly larger BCEAs for amblyopic eyes (mean = 0.56 log deg(2)) than fellow eyes

112 ience in making Vernier judgments with their amblyopic eyes (with the lines at a different orientatio

113 0.14 logMAR (approximately 20/25); 59.9% of amblyopic eyes had visual acuity of 20/25 or better and

114 ound between amblyopic and fellow eyes, with amblyopic eyes having greater foveal thickness but reduc

115 Fixation instability in amblyopic eyes of children with strabismus and/or anisom

116 The 31 treated amblyopic eyes showed: logMAR HOTV = 0.97(logMAR E-ETDRS

117 macular thickness was less in deprivational amblyopic eyes than in age-matched normal eyes, but ther

118 Mean spherical equivalent for the amblyopic eyes was +3.57 diopters, with a mean VA of 20/

119 Mean spherical equivalent in amblyopic eyes was -10.79 +/- 3.40 diopters.

120 n making psychophysical judgments with their amblyopic eyes, and experienced observers (n = 5), who h

121 esholds were significantly correlated in the amblyopic eyes, as were sVEP and optotype interocular th

122 ce in repeatability among normal, fellow, or amblyopic eyes.

123 xation accuracy was significantly reduced in amblyopic eyes.

124 uperficial capillary plexus was lower in the amblyopic group than in the control group in both 3 x 3-

125 those tested second in either the normal or amblyopic groups.

126 Although the vision of amblyopic humans is often described as being noisy by pe

127 nsible for a range of perceptual deficits in amblyopic humans, the neural basis for the elevated perc

128 ction in primary visual cortex and V2 of six amblyopic macaque monkeys (Macaca nemestrina) and two vi

129 e properties of visual cortex neurons in six amblyopic macaques; three monkeys were anisometropic, an

130 along the horizontal axis of the ellipse for amblyopic (mean = 3.53 degrees ) than fellow (mean = 1.9

131 ty in the adult restores binocular vision in amblyopic mice.

132 nteractions in visual cortex of anesthetized amblyopic monkeys (female Macaca nemestrina), using 96-c

133 eurons and the perceptual performance of our amblyopic monkeys.

134 The CV(2) was pronounced in amblyopic neurons for high-contrast stimuli and the m-FF

135 stimuli and the m-FF was abnormally high in amblyopic neurons for low-contrast gratings.

136 In amblyopic neurons, the contrast versus response function

137 f spontaneous activity were also elevated in amblyopic neurons.

138 We found that some amblyopic observers show markedly abnormal templates for

139 Two groups of amblyopic observers were tested: novice observers (n = 6

140 ate with perceptual visibility in normal and amblyopic observers.

141 cal and sVEP vernier acuity were measured in amblyopic observers.

142 The difference between foveal structure in amblyopic participants relative to structure in subjects

143 se tools reliably detected acuity in treated amblyopic patients and Bangerter blurred normal subjects

144 Amblyopic patients performed critical line, then thresho

145 ed evidence of generalized learning, several amblyopic patients showed evidence for improvement that

146 sful treatment restored normal BIN scores in amblyopic patients without strabismus.

147 ts consisted of eight normal adults and five amblyopic patients, with the amblyopic subjects added to

148 or the first time, a dynamic retuning of the amblyopic perceptual decision template and a substantial

149 Amblyopic performance could be simulated in normal obser

150 l basis for the elevated perceptual noise in amblyopic primates is not known.

151 rea V2 could limit the visual performance of amblyopic primates.

152 Twenty-six amblyopic subjects (mean age, 39 +/-12 years) were train

153 adults and five amblyopic patients, with the amblyopic subjects added to gauge whether the outcome wa

154 All amblyopic subjects demonstrated a functional loss in eac

155 n, against which the learned improvements in amblyopic subjects was compared.

156 primary deficit in visual function, and when amblyopic subjects were divided according to their prima

157 as held constant and when data from the five amblyopic subjects were included to expand the range of

158 Of the amblyopic subjects, 77% were unilateral.

159 tern of learned visual improvements in adult amblyopic subjects.

160 n plasticity after action video game play by amblyopic subjects.

161 is significant transfer of learning from the amblyopic to the dominant eye, suggesting that the learn

162 sults suggest that neural connections in the amblyopic visual cortex, at least in V1, may have profou

163 Excitatory drive from the FE dominated amblyopic visual cortex, especially in more severe ambly

164 Using the amblyopic visual system as a model, we discuss genetic,

165 vel limitation in the number of features the amblyopic visual system can individuate.

166 Reduced efficiency in the amblyopic visual system may reflect a poorly matched tem

167 that blur is veridically represented in the amblyopic visual system.

168 ost of the variability in performance of the amblyopic visual system.

169 al frequency information is available to the amblyopic visual system?