ライフサイエンスコーパス: amebic

1 encoded protein correlates with detection of amebic 170-kDa antigen in serum and feces.

2 Children with mucosal IgA antibodies to the amebic adherence lectin were found to be resistant to re

3 re-treated erythrocytes but had no effect on amebic adherence to or destruction of cell monolayers or

4 and required intact parasite, since blocking amebic adherence with galactose inhibited tyrosine depho

5 Moreover, disruption of amebic adherence with galactose promoted recovery of pho

6 stent with a primary defect in regulation of amebic adherence, EhMSP-1 silencing also resulted in red

7 ce metalloprotease involved in regulation of amebic adherence, with additional effects on cell motili

8 In contrast, amebic alcohol dehydrogenase 1 and ferredoxin, which are

9 dies to be identical to or an isoform of the amebic alcohol/aldehyde dehydrogenase (EhADH2).

10 ns (excluding the viral hepatitides) include amebic and pyogenic liver abscess and cholangitis.

11 All patients had 170-kDa amebic antigen in serum, compared with 1 of 50 cyst pass

12 ba histolytica protein (SREHP), a protective amebic antigen, fused to a maltose binding protein (MBP)

13 ik Chek assay developed by Techlab to detect amebic antigens in fecal samples collected from independ

14 lution, the role of lateral gene transfer in amebic biology and the adaptations required for eukaryot

15 of a C-terminal KDEL peptide, identified on amebic BiP, retained chitinase in a putative endoplasmic

16 amoeba histolytica requires adherence via an amebic cell surface lectin.

17 he molecule central to these processes is an amebic cell surface protein that recognizes the sugars g

18 In a mouse model of amebic colitis and a hamster model of amebic liver absce

19 ntamoeba histolytica, the causative agent of amebic colitis and liver abscess, would reduce childhood

20 istolytica is the cause of potentially fatal amebic colitis and liver abscesses.

21 Amebic colitis is an important worldwide parasitic disea

22 nowledge of host-parasite interaction during amebic colitis, and highlights a potential immunomodulat

23 In conclusion, in amebic colitis, development of humoral and mucosal IgA r

24 dying this early step in the pathogenesis of amebic colitis, we demonstrate that E. histolytica troph

25 utes to the tissue damage that occurs during amebic colitis, with tumor necrosis factor alpha (TNF-al

26 vanced by the use of a novel murine model of amebic colitis.

27 and contribute to the tissue damage seen in amebic colitis.

28 kDa subunit were determined in patients with amebic colitis.

29 pithelial cell lines and in a mouse model of amebic colitis.

30 minish epithelial apoptosis may be useful in amebic colitis.

31 Entamoeba histolytica is the agent of amebic colitis.

32 lytica is the protozoan parasite that causes amebic colitis.

33 chanisms in amebic liver abscess compared to amebic colitis.

34 of amebic disease: amebic liver abscess and amebic colitis.

35 tor alpha (TNF-alpha) in the pathogenesis of amebic colitis.

36 erythrocytes, suggesting the existence of an amebic coreceptor specific for PS.

37 7 and CRAMP were rapidly cleaved by released amebic cysteine proteases.

38 In contrast to the other amebic cysteine proteinases characterized so far, which

39 channels was highly effective in preventing amebic cytotoxicity in intestinal epithelial cells and m

40 ded that K(+) channels are host mediators of amebic cytotoxicity in multiple cells types and of infla

41 mice was found to increase susceptibility to amebic cytotoxicity in single cells.

42 signaling mutants showed that resistance to amebic cytotoxicity was dependent on activation of STAT3

43 n signaling increased cellular resistance to amebic cytotoxicity, including caspase-3 activation.

44 hozoites in models of the two major forms of amebic disease: amebic liver abscess and amebic colitis.

45 tozoan parasite Entamoeba histolytica causes amebic dysentery and amebic liver abscess, diseases asso

46 parasite Entamoeba histolytica, the cause of amebic dysentery and amebic liver abscess, is an obligat

47 tamoeba histolytica, the protist that causes amebic dysentery and liver abscess, are of great interes

48 al ameba Entamoeba histolytica, which causes amebic dysentery and liver abscesses.

49 tolytica, the protozoan parasite that causes amebic dysentery, phagocytose bacteria in the colonic lu

50 Granulomatous amebic encephalitis (GAE), an infection of immunocomprom

51 soil sample associated with a fatal case of amebic encephalitis in a northern California child.

52 free-living ameba that causes granulomatous amebic encephalitis in both immunocompromised and immuno

53 alamuthia antibody-containing serum from the amebic encephalitis patient.

54 We report a unique case of granulomatous amebic encephalitis that was proven pathologically with

55 ual Balamuthia mandrillaris and Acanthamoeba amebic encephalitis with neurotoxoplasmosis coinfection.

56 and Balamuthia mandrillaris and Acanthamoeba amebic encephalitis with Toxoplasma gondii coinfection.

57 ons of other organs, and fatal granulomatous amebic encephalitis.

58 Amebic erythrophagocytosis is characteristic of invasive

59 resent in over 75% of phagocytic cups during amebic erythrophagocytosis.

60 ecause of the critical role of EhADH2 in the amebic fermentation pathway and the lack of known eukary

61 tained mucosal IgA antibody responses to the amebic galactose-inhibitable lectin and a high level of

62 stinal and humoral antibody responses to the amebic galactose-inhibitable lectin and to determine whe

63 ing a mechanism that requires contact via an amebic galactose-specific lectin.

64 osis, and E. histolytica phagocytosis alters amebic gene expression in a feed-forward manner that res

65 gh it is not clear from which bacteria these amebic genes derive.

66 upport the idea of coincidental selection of amebic genes encoding proteins that mediate destruction

67 We used this approach to silence multiple amebic genes, including an E. histolytica Myb gene, whic

68 lture medium in quantities commensurate with amebic growth when studied in a novel culture system.

69 Like Hsp60 of mitochondria, amebic Hsp60 RNA and protein were both strongly induced

70 he possible function and localization of the amebic Hsp60 were explored here.

71 demonstrating the chaperonin function of the amebic Hsp60.

72 ulin A (IgA) monoclonal antibodies (MAbs) on amebic in vitro galactose-specific adherence.

73 A subjects demonstrated greater clearance of amebic infection after an anti-lectin IgA antibody peak

74 Amebic infection also induced an 18-fold increase in int

75 itor ZVAD decreased the rate and severity of amebic infection in CBA mice by all measures (cecal cult

76 These results indicate that amebic infection in the colon induces the expression of

77 cell apoptosis in the intestine facilitates amebic infection in this mouse model.

78 rotective role in the early host response to amebic infection of the liver.

79 al epithelial cell inflammatory responses to amebic infection were inhibited by the intraluminal admi

80 specimens from two individuals negative for amebic infection were spiked with Balamuthia amebas.

81 educed inflammation and intestinal damage in amebic infection, while inhibition of IL-1 reduced cytok

82 e enhanced epithelial permeability seen with amebic infection.

83 ugh cyclooxygenase-2 to the host response to amebic infection.

84 ase in intestinal permeability observed with amebic infection.

85 y human intestinal xenografts in response to amebic infection.

86 on and intestinal epithelial apoptosis after amebic infection.

87 Amebic infections involving the central nervous system a

88 While no subsequent amebic infections occurred in the three organ recipients

89 earlier attention had focused on Giardia and amebic infections, the other "emerging" protozoan beside

90 eba histolytica trophozoites, and 12 h after amebic inoculation, reduced the mean liver abscess size

91 ies suggest that the acute host response and amebic invasion result from a complex interplay of paras

92 host factors that control susceptibility to amebic killing.

93 In support of this idea, the amebic lectin and pore-forming peptide are involved in b

94 l the extracellular adhesive activity of the amebic lectin and provide in vivo demonstration of the l

95 xenografts with a monoclonal antibody to the amebic lipophosphoglycan-peptidoglycan molecules can pre

96 We monitored 93 subjects cured of amebic liver abscess (ALA) and 963 close associate contr

97 We followed 93 subjects with amebic liver abscess (ALA) and 963 close associate contr

98 Durban, South Africa, were recently cured of amebic liver abscess (ALA) with or without concurrent En

99 ls of the two major forms of amebic disease: amebic liver abscess and amebic colitis.

100 The complications of amebic liver abscess are underappreciated in developed c

101 amage may proceed by different mechanisms in amebic liver abscess compared to amebic colitis.

102 mbined immunodeficient (SCID) mouse model of amebic liver abscess formation and compared liver damage

103 or their ability to delay the development of amebic liver abscess formation in an E. histolytica infe

104 s a significant but not an exclusive role in amebic liver abscess formation in the mouse model.

105 rominent role in the host cell death seen in amebic liver abscess in a mouse model of disease and sug

106 CID mice while NO is required for control of amebic liver abscess in immunocompetent mice.

107 oked at the effect of inhibiting caspases on amebic liver abscess in the mouse model of infection.

108 In most cases, amebic liver abscess is associated with an excellent pro

109 Amebic liver abscess is characterized by extensive areas

110 In the United States, amebic liver abscess occurs largely in individuals from

111 gamma plays a role in the innate immunity to amebic liver abscess seen in SCID mice while NO is requi

112 We next used a hamster model of amebic liver abscess to determine the effect of immuniza

113 Amebic liver abscess usually occurs in individuals from

114 An association of this allele with amebic liver abscess was also determined in an independe

115 or full virulence in the SCID mouse model of amebic liver abscess, but E. histolytica trophozoites th

116 oeba histolytica causes amebic dysentery and amebic liver abscess, diseases associated with significa

117 We report a 16-month-old male child with amebic liver abscess, initially misdiagnosed with pneumo

118 stolytica, the cause of amebic dysentery and amebic liver abscess, is an obligate anaerobe, and deriv

119 del of amebic colitis and a hamster model of amebic liver abscess, oral auranofin markedly decreased

120 In contrast to amebic liver abscess, pyogenic liver abscess is associat

121 typhimurium SREHP-MBP were protected against amebic liver abscess, the most common extraintestinal co

122 ddition to highlighting the complications of amebic liver abscess, this case demonstrates the value o

123 mbined immunodeficient (SCID) mouse model of amebic liver abscess.

124 ) infection are at an increased incidence of amebic liver abscess.

125 ng added to the diagnostic armamentarium for amebic liver abscess.

126 l-depleted animals have significantly larger amebic liver abscesses at early stages of infection and

127 Diarrhea and amebic liver abscesses due to invasive Entamoeba histoly

128 on of hamsters reduced development of severe amebic liver abscesses following intrahepatic injection

129 the prominent inflammatory cell ring seen in amebic liver abscesses in control SCID mice.

130 ent amebae may exacerbate the damage seen in amebic liver abscesses.

131 use as a vaccine antigen to protect against amebic liver abscesses.

132 ose inhibited tyrosine dephosphorylation and amebic lysates had no effect on phosphotyrosine levels.

133 Amebic lysates have also been shown to activate the prec

134 contrast to the activation of proIL-1beta by amebic lysates, the purified proteinase cleaved proIL-18

135 E. histolytica trophozoites and accelerated amebic lysis via activation of the classical complement

136 tral nervous system infection called primary amebic meningoencephalitis (PAM) in healthy children and

137 Primary amebic meningoencephalitis (PAM) is a fulminant central

138 Primary amebic meningoencephalitis (PAM), caused by the free-liv

139 Primary amebic meningoencephalitis (PAM), which is almost univer

140 Primary amebic meningoencephalitis (PAM), which is almost univer

141 rtunistic pathogen that causes granulomatous amebic meningoencephalitis in animals, including humans.

142 amebas from brain tissue from cases in which amebic meningoencephalitis is a diagnostic possibility,

143 eria fowleri, the causative agent of primary amebic meningoencephalitis, is resistant to complement l

144 scription via nuclear run on analysis and an amebic nuclear protein was demonstrated to specifically

145 We demonstrate that amebic nuclear protein(s) bind specifically to four of t

146 r abscess is typically either of pyogenic or amebic origin.

147 a mammalian signaling pathway that restricts amebic pathogenesis and represents an important advance

148 an evolutionary dead end, it is likely that amebic pathogenicity is coincidentally selected, i.e., t

149 Here amebic phagocytosis of bacteria, RBC, and mucin-coated b

150 is, we used a flow cytometry-based assay for amebic phagocytosis, a method for making single-ligand p

151 he collectins alone were adequate to trigger amebic phagocytosis, because single-ligand particles coa

152 trometry analyses identified calreticulin in amebic phagosome preparations, and, in addition to its f

153 cA-V12) overexpression, wortmannin abolished amebic pinocytosis of dextrans but had no inhibitory eff

154 . histolytica trophozoites, one of the first amebic products to interact directly with components of

155 unction with published findings showing that amebic proteinases are responsible for the induction of

156 activated by caspase-1, we evaluated whether amebic proteinases had a similar effect.

157 The activity of amebic proteinases was examined by zymography.

158 raction F3, but not F1, F2, or F4, inhibited amebic proteinases.

159 e complex of surface-associated and released amebic proteinases.

160 ance between degradation of cathelicidins by amebic released cysteine proteinases and upregulation of

161 We conclude that the amebic secretory pathway is similar to those of other eu

162 ction of mucosal and immune responses to the amebic SREHP antigen is dependent on the level of SREHP-

163 When five of these genes were silenced, amebic strains with significant decreases in the ability

164 o studying the specific interactions between amebic trophozoites and human intestine, we used a SCID

165 Extracellular cysteine proteinases from amebic trophozoites are key virulence factors and have a

166 appears to involve the initial attachment of amebic trophozoites to intestinal epithelial cells, foll

167 rine-rich E. histolytica protein (SREHP), an amebic vaccine candidate.

168 Inhibition of amebic vacuolar acidification by bafilomycin also decrea